Transport inside the brain: The basic mechanisms of neuronal trafficking

The primary aim of the Hoogenraad research lab at the University of Utrecht, the Netherlands, is to understand how intracellular transport underlies the development and function of nerve cells. During this animation, we will follow a presynaptic cargo during its journey through a nerve cell, illustrating the basic mechanisms, regulation and relevance of proper intracellular transport that occurs inside the cells of our brain.
cellbiology.science.uu.nl
dejongeakedemie.nl
redrumbureau.nl
Permission to use this video is not required. When you use our materials in print, on the Web or in a video or audio format, we simply request that you credit the "Hoogenraad lab at the Utrecht University" and refer to our website at cellbiology.science.uu.nl

[@revenger211]

Actually insane. I'm learning neuroscience at the moment for the fun of it and wanted to actually see how it looks because I couldn't imagine it and oh boy this way crazier than I had imagined!

[@Cozy.Mood.B]

This is endlessly incredible. I have no words. Nature is out of this world!

[@deadly.desai2]

its only 1% related to my Studies, but damn! i just enjoyed watching the animation

[@miramardream]

Wow, that trailer was amazing. When's the movie coming out?

[@caseyalakwa5263]

Hahaha

[@quinattasneemrafique536]

Really want one movie on cell🥺

[@ThomasConover]

YOU are the movie bro.

[@user-kv6vh5ug4i]

I can sign now or you can wait till dead I me technically the gov marked me dead already 🎉

[@user-kv6vh5ug4i]

I dont mind

[@Neurosoul22.0]

Dear Hoogenraad lab, thank you indebtedly for this animation - it is one of the most superb renditions of sci animation ive encountered... could i ask how the graphics were constructed/what software/which company etc.? Im a neuro graduate interested in getting into scie animating myself Many thanks!

[@phebewulf9722]

That info is at the end of the movie.

[@quinattasneemrafique536]

@@phebewulf9722 I wasn't there😟

[@12centuries]

This is so unbelievably, inconceivably complex. There's no way this wasn't designed.

[@dhaneshtg8395]

Ya true .. we are come from a rock it seems ..my ass..

[@huntercurts9998]

More like we have has literally billions of years to perfect this process

[@12centuries]

@@huntercurts9998 With all respect, I think you might not be realizing the full complexity of what's happening here.

[@iamBlackGambit]

@@huntercurts9998 hey this animation video of the brain had no designer, it took a while for this video to make and order itself..but it did, all on its own.............

[@aykoc2001]

@@huntercurts9998 literally billions of years are not enough to perfect such a process. Today's computers are capable of doing trillions of calculations per second. But no company on earth uses random and natural selection mechanism to create software that delivers value. Please try to do a probabilistic calculation and you will see that it is impossible that the life is the result of a random process. There is one God. It is obvious by the witness of every tiny little cell's processes.

[@goldengaming4911]

Omg the 3D animation

[@anonymousplayer6378]

Really a wonderful animation for a difficult topic to teach.

[@mshisha]

Great animation

[@santrolli]

Awesome visualisation! Thank you 🙏

[@quillclock]

this one is way better than the one you did back in 2013. this is way more why and how than the other one that just covered what

[@bindasskanya3509]

I m an accountant but I m enjoying watching it, Beautiful

[@Sushilajangid1989]

This much clearity before 7 yrs

[@tonioverton9]

INCREDIBLE!!! Learning can be fun and interesting as well as educational. Thank you very much.

[@im__Anonymous]

to make all this complicated mekanisme, is the soul

[@ellios5734]

Please upload more videos your animations are the best

[@CurtisLongkeep-uu3sm]

This was very fascinating to watch. Thank you for the upload. 10/10.

[@shadowsidesoamplified]

holy shit the graphics are mindblowing

[@user-qu2qe2qy8c]

Классно , молодцы. Побольше бы таких интересных видео.

[@rossanaperrone3611]

Hello! Thanks for this amazing video. I am a neuroscientist and a teacher in the School of Psychology in Uruguay. Can I use this video for teaching? Thank you very much.

[@Ta3allamOnline]

An Amazing video!

[@paulaojala177]

Makes me want delve even deeper into this cellular and molecular world!🤩

[@aboutstudies766]

Thank you Madam/Sir!

[@vitus008]

awesome video ....!!

[@tanveerasarhadi8872]

Never have I ever tripped so bad on an educational video before

[@maimai-bd2iw]

More videos like this should be made

[@Dr.Zubair]

Exactly what i was searching for

[@smurProductionz]

My god these types of animations are amazing! What sort of software do they use?

[@noahwilliams8996]

David Murphy IDK about this video but if you're interested in 3D animation you can check out programs like blender, Maya, or 3D Max.

[@ClaraWang32356]

I believe they use ray tracing to make it seem 3d -- you should check it out!

[@iamBlackGambit]

"My God" your exactly right! He made the brain

[@Nonamelol.]

How exactly though does that entire process give me this experience??

[@VLionV]

What a great animation🔥🔥

[@checkpointame]

Hey we are making a school project about social media and how it affects the brain. Can I use short clips from your video to support the meaning? Looks amazing!

[@michaelb1785]

What is the role of sleep and regulation of micro-tubules?

[@kikithepupper6774]

This is so beautiful.... WHo made this animation?

[@seanotuleit]

What a masterpiece in animation of the synapse. It is outstanding. Thank you. I still foster a doubt about which structures help neurotransmitters travel along the axone. Could you please point if those are the microtubles or the microfilaments? Cheers!

[@ninjatiger1163]

hey what is the name of the mucis when it transistion into the brain 0:19

[@AsiPtl]

ASTONISHING!!

[@Queen-fq4nk]

Lil bro is really strong

[@TheMraaqib]

How Great the Creator would be. 🤯

[@gosangel]

Buenos días, me gustaría saber si ustedes podrían subtitular todos los videos de este magnífico canal, pensando en las personas que NO hablamos inglés o poco lo entendemos. Gracias por su atención!!!

[@ahntrjmpr]

Yo podria hacerlo si lo necesiten!!!

[@abdulirhouma911]

3:26 yeeeeeet

[@user-ff9hd9yw6x]

How incredible it is!!!❤

[@BlueUKLouis]

Amazing!!!

[@paftaf]

Thanks!

[@BanginUKBeats01]

I get so excited watching this stuff. I'm like a kid in a sweet shop. 😂😊

[@chizauz]

how many kinesin and dynein are moving through an axon?

[@Nbokar]

Need more videos

[@jiahuiang1923]

I like your video

[@meghapaul9013]

They behave like ants. Fighting for a cargo to take it according to their direction. 😂

[@chizauz]

how fast do the kinesin and dynein move? Do they move fast like the electrical light in the video moving fsat through the brain?

[@flory6901]

250 steps per second

[@flory6901]

Watch on utube A Day in the Life of a Motor Protein

[@RecoveryJimmy89]

This stuff is so cool

[@jamesl1014]

Intro song is Renascentiae, Sexually Assault. That is, some rendition of it I'd love to find an extended mix of- Hoogenrad sound persons I hope you're listening. 🙃

[@entisarnasser265]

Why u are stop posting video ?? your video is too useful

[@isaiacaluza6712]

yall really ate with this, the microtubules popped off so dramatically lmao

[@DaddyBg69]

Wow damn animation as well as damn sound..

[@anemari5809]

It's like a suspense/thriller movie hahaha

[@aaronj7081]

"The human brain, one of our most complex organs" Our most complex organ. The most complex organ in the animal kingdom. Why undermine the feat of understanding from the start, but ok.

[@codyharrison771]

I've hear people say it's the most complex object in the known universe

[@chizauz]

Ignore my previous comments and questions. I just watched a day in the life of John the walking motor protein. thanks for the video

[@elviscaragea4433]

amazing

[@vehicleboi5598]

realistic john

[@jinanarzary5677]

Wow!!

[@petercareer439]

Have you ever done a video of how estrogen receptor positive cancer cells find and feed off of the over produced estrogen in a man or a woman’s body?

[@siddharthannandhakumar6187]

Do the motor proteins really transport like walking?

[@flory6901]

Yes this protein called Kinesin walks 250 steps per second

[@flory6901]

If something goes wrong and there is traffic of this protein, it results in Brain Disease

[@siddhikocharekar213]

Background music?

[@bryzvyy1674]

This is one of the most Biopunk I have ever seen in my entire life.

[@ifhtfilms]

I'm only here for the shooting star meme loop

[@hajnalkakoller31]

Danke GOTT

[@markopolofan5652]

omg so cool

[@markshilhavy8326]

Brain diseases like what, I wonder. I've had several small brain injuries, one that left me unconscious for several minutes. Is depression or anxiety considered brain disease, I wonder. Cool video

[@melissamiller8063]

It is the universe inside.

[@TARUN.2.2]

Best

[@ahmedkhaled2641]

that was better than breaking bad🥵

[@ahmedtzaki4476]

AMAZING! It's very mind-blowing that reality is even more beautiful and complex and much faster than this! It's also unbelievable how there still atheists in the 21th century after all of these discoveries!

[@protoborg]

Imagine if you managed to hack even a single neuron. The human brain is sooooo easy to hack if you control even just a few dozen neurons.

[@kellogscornflakes2430]

Mind control

[@paftaf]

Nope. It's a very stable system with many redundancy. Otherwise you'd fall from your bed on your head, and in the morning you'd be different person..

[@sitthuson]

wow feels like I'm watching a horror movie

[@36yovan]

*Through the 3D animation video we are able to understand a little bit how marvelously and wonderfully we are formed in our mother's womb by our Creator ! Praise be to God 🙏*

[@sulimansal2990]

الله هو المهندس الأعظم.

[@Mioochii]

Now my brain knows how it looks like 😂

[@DjDiDAS]

Damn... definitely need to watch this on mushrooms or LSD trippie as FAh-Q! lol

[@kenconcepts]

damnnn who ever created us is a fucking genius. this some posthuman futuristic shit that we'd create in the future but as megastructures and dyson spheres.

[@BSin8413]

God is amazing

[@blackbliz8246]

is not god

[@pietajunior3437]

Which one?

[@JohnTepopo]

its like our brain is its own universe. and the universe we live in is someones synapses brain nerve and so on 😂

[@DENTiins]

It seems like i am watching the trailer of Neurons…

[@froggo7215]

This is sureal. Like a protein stick figure walking on some kind of molecular thread carrying a gooey information. how all of them know how to do all of this?

[@DJSHaKa]

Umm, what did i just watch, how did i get here - What has my life become? I did not search for this... HELP!

[@user-jv8ys8ju6p]

سبحان الله العظيم ، كل من يقول لك أن كل هذا أتى بالعشوائية والصدفة فقط إضحك

[@higherresolution4490]

Absolutely extraordinary 3D animation. Definitely produced by Europeans, and not North Americans. More detail is desirable (but probably too expensive).

[@Novak2611]

Are North Americans bad in 3D animation?

[@wormhole331]

@@Novak2611 No, I'd say Disney is pretty good with 3D animations, and many others. This guy is a typical pretentious European.

[@coloradoing9172]

🤓

[@colerobison6916]

I didn't understand anything in this video.

[@alphagonist4748]

Damn

[@dhavalpandav4440]

This theory 50% true but not expect protocol brain save in memory

[@SomaUlte]

Jimmy Neutron Intro hahahahaha

[@sportdutch]

Don't have too much water on the brain.

[@adamogilvie6951]

So based on the complexity and need I say design of systems like this, why do people still believe in Evelution? Something like this would simply not evolve. Glory to God!!!

[@pietajunior3437]

Billions of years. Do you understand how much time that is?

[@adamogilvie6951]

​@pietajunior3437 To be honest, not enough time. Look, if you're an evolutionist, that's cool, but I just don't see all these complex processes coming into existence randomly.

[@pietajunior3437]

@@adamogilvie6951 It has been conclusively proven that a plethora of organic compounds can be abiotically synthesised on meteors, comets etc. People have demonstrated how to synthesise such compounds from simple chemicals. Those processes potentially happen all the time in the universe. If the building blocks of life are so readily created, then I don't see what stops them from forming yet even more complex structures on planets, which give them the opportunity to do so, like Earth. Things on the nanoscale aren't organised. It's constant chaos, atoms flying in every direction, hitting each other and potentially creating bonds, only for that bond to break a moment later. Now think about trillions of atoms participating in this chaos, and then think about a trillion trillions. That still isn't even close to the actual amount. Billions of years is a ton of time for these organic compounds to merge and modify and form strange chemical systems. Then one of such "systems" could reach a, more or less, stable form; for example, a lipid membrane, which then might work as a storage for other strange chemical systems, etc.

[@pietajunior3437]

@@adamogilvie6951 It has been conclusively proven that a plethora of organic compounds can be abiotically synthesised on meteors, comets etc. People have demonstrated how to synthesise such compounds from simple chemicals. Those processes potentially happen all the time in the universe. If the building blocks of life are so readily created, then I don't see what stops them from forming yet even more complex structures on planets, which give them the opportunity to do so, like Earth. Things on the nanoscale aren't organised. It's constant chaos, atoms flying in every direction, hitting each other and potentially creating bonds, only for that bond to break a moment later. Now think about trillions of atoms participating in this chaos, and then think about a trillion trillions. That still isn't even close to the actual amount. Billions of years is a ton of time for these organic compounds to merge and modify and form strange chemical systems. Then one of such "systems" could reach a, more or less, stable form; for example, a lipid membrane, which then might work as a storage for other strange chemical systems, etc.

[@mikekellerman4736]

God the Almighty doesn't get his title from man. He gives that title to hiself. All praise and glory go to him for he is our lord and redeemer the master of the universe!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

[@silviaalexandrecordeiro8400]

🌹🌎🌍🌏🌹

[@s.papadatos6711]

Movie directed by Zack Snyder...

[@frankem4837]

What did I just watch? 🤔😁

[@davehibbs9111]

Thankless JOB 😂

[@mahmouddridi386]

Quran "We will show them Our signs in the horizons and within themselves until it becomes clear to them that it is the truth. But is it not sufficient concerning your Lord that He is, over all things, a Witness?" Quran "Travel through the land and observe how He began creation. Then Allah will produce the final creation. Indeed Allah, over all things, is competent." Quran "Recite in the name of your Lord who created - Created man from a clinging substance. Recite, and your Lord is the most Generous - Who taught by the pen - Taught man that which he knew not.

[@lostplanet1931]

Muhammad is a false prophet

[@lostplanet1931]

He didn't get the Quran from God, he got it from the devil, he even choked him

[@mraravindbaku6338]

*_stop procrastinating_*

[@lacamendry1731]

Supercomputer That God Made Is Human Brain. Think about it. Human can make a Car. Making A Rocket to fly around the Galaxy, Not really. Can make a Artificial Intelligence.