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Ion channels and membrane potential lecture - This lecture explains about the structure and function of ion channels and membrane potential. It also states the role of ion channels in cell membrane to alter the resting membrane potential. Resting membrane potential is regulated by the sodium and potassium ion channels opening and closing and the maintenance of sodium and potassium by sodium potassium ATPase transporter.
Summary of the lecture-
• The concentrations of sodium and chloride are high outside cells in the extracellular fluid, and the concentrations of potassium and organic anions are high inside cells.
• The permeability of a cell for ions depends on the number and type of ion channels in the cell membrane.
• The electrical and chemical forces for a particular ion combine to become a single force, the electrochemical gradient, which causes the movement of that ion across the cell membrane.
• In simple, non-excitable cells, the membrane potential depends only on potassium.
• Potassium comes to equilibrium when the membrane potential for the cell is -90 millivolts.
• The resting membrane potential in neurons depends on the distribution of sodium as well as potassium across the cell membrane. Resting membrane potentials in neurons are commonly around -70 millivolts.
• The sodium-potassium pump is essential for maintaining the resting membrane potential in neurons.
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