IR Spectroscopy and Mass Spectrometry: Crash Course Organic Chemistry #5

[@MrShipp100]

My PhD is in advanced IR spectroscopy using femtosecond lasers, and this is a really nice concise explanation of the basics!

[@definty]

Isn't that just a laser that turns on and off very fast? Or is it something different?

[@alarcon99]

@Shippers I stan

[@extremdeath1234]

@@definty spectroscopy on the femtosecond time scale is a bit more than "very fast". It is ludicrously fast... you can actually monitor reaction on that time scale. for perspective, it takes about 300fs for molecular iodine to vibrate once...

[@0_0-f4x9z]

WAIt , u are saying this is the BASIC?

[@grad3us]

Please, I want CrashCourse Neurology! It would be really cool to understand the brain, just as it was cool to understand computer science.

[@animeandstuff5377]

My condolences to those who didn’t get to watch this series while in organic chemistry 😔

[@Laaaa]

Anime and Stuff this series is about 12 years too late for me 😩

[@dogzrzosmz]

I feel this deeply

[@saumyamathur4862]

I took it this same time last year, & while I’m happy that today’s ochem students have this at their fingertips, I’m also very jealous that I didn’t 😩😂

[@kevinconrad6156]

Condolences accepted. My lecture teacher was good when he stayed on topic which he did not do often. The lab teacher was great and often gave short lectures on what the lecture teacher missed.

[@birzhanabdikhan8175]

Totally agree brother

[@glennng7612]

As a chem major, I really love how concise the explanations are. Great job crash course!

[@joymae]

I’m digging the purple accents in your backdrop and how it matches your sweater

[@は私です彼の名前]

Joy Mae that was no accident...

[@anne12876]

Side note, during my first internship as chemistry student, I worked as a lab technician at the anti-doping centre for sports. I spent a summer analysing urine samples by IR spectrometry and sometimes by MS to check for illicite drugs. I was fun to see what happens in the lab during big big sports events and the science behind it.

[@EverythingScience]

I gotta say these videos seem much more advanced than the normal topics you guys cover

[@MysteryMan1910]

Just finished my PhD in structural mass spec. This is a pretty good intro! Although, at least in my field, no one really uses the magnetic sector MS instruments shown here anymore - we more often uses ToF, ion trap or orbitrap mass spectrometers.

[@xxstargirlxx]

I saw Abby(from NCIS) So cute

[@RedwoodGeorge]

A long time ago I worked for a company that made Fourier Transform Infrared Spectrometers. All new employees went through the two week customer training course to learn how the machines worked. In our class one of the customers was an evidence tech from the Royal Canadian Mounted Police - I was sitting next to an actual Mountie! Cool! One of the attachments for the spectrometer was a microscope - the Mountie had brought along a sample paint chip with three layers of different color paint. We focused the microscope on each layer and ran the results through the database to identify the brand, color and year of each layer! For even deeper analysis, we worked with a GC / Mass Spec to split up the sample by boiling point and molecular weight. The boiled off results were deposited on a cold plate in a labyrinth pattern and then the spectrometer sampled along the path to further analyze the components. Those were fun days working with some pretty cool machinery :-)

[@TheTwick]

I’ve always enjoyed that scene in a movie when a grizzled old detective runs his fingers through a black substance at a scene and says to the young detective “Send this back to the lab and have it analyzed.”!

[@zagisch4789]

I’m writing a home exam about the use of analytical chemistry in archaeology atm, so the timing of this is perfect 😍

[@ariame2722]

The molecules dancing made my day 😭

[@mawatake]

I'm a Japanese, but I understand this content because of English subtitle ! I want to watch this series about 1H-NMR and 13C-NMR

[@BenTajer89]

As somebody who's already been through highschool and undergrad O-Chem, I really wish your explanation of the mass spec had gone just a TINY bit more in depth, you describe all the parts and how the ion goes through, but none of how the magnet actually separates the masses as they go around the curve. This concept is actually super intuitive.

[@user-ti1tk2fu3h]

I never thought I'd be comfortably sitting and learning about all these complex stuff from one video, but here we are. Made so much sense.

[@CrossingDS]

As I biochemist, I found it very complete but also clear. Also, loved the effort put into the actual video!

[@emilyensing2184]

I love the major mass spec and abby reference in cartoon form!

[@TheTravelerww]

the T.V scientist in the graphic; is that meant to be Abby Sciuto from NCIS, great reference.

[@radunicoara8057]

I have finally learned what mass spectroscopy is. As a physics major, I never really understood it. Incredibly good course!

[@christianandrews7764]

Was not expecting this but I’m liking the progression of this series! Looking forward to episode 6

[@knate44]

Omg. Can't wait for the inevitable Crash Course Analytical chemistry!

[@farhanmendel]

Crash Course about different analytical chemistry techniques and methods would be cool!

[@pamelaevangelista434]

Im an ib chem student and lemme tell you. Youre doing gods work, youre a miracle sent down from heaven, A NATIONAL TREASON!!! So thank you🥹, i might actually pass this class💀😵

[@sheepyboi4219]

Omg omg thankk youuuu. I have my Chemistry exam next week and this is something that is the hardest for me in unit one thanks so much!!

[@timr8431]

I have a chem degree and this even helped me understand it a little better. Great video

[@RJ-nr8lh]

PLEASE BRING BACK CRASH COURSE LITERATURE. PLEASE WE LOVED THAT.

[@TriplaHHH]

Awesome :D Analytics gets often disregarded in chemistry-pop due to its complex backdrop. So thanks for the effort to lay this out somehow! Disregarding the instrumentation and datahandling though, the basic concepts of sample prep, separation and measurement in analysis are quite straightforward. Sounds like we are heading towards chromatography ;)

[@ShiwanaGhai]

I just love this channel .. their way of teaching along with case studies, various examples is just so awesome & practical.❤️👍🏻Keep it up guys !

[@Darfanatior]

Crash Course is the coolest!

[@UgoTemple]

Organic Chemistry is one of my favorite

[@Karajorma]

@vitali Mizrachi You're telling him what is his favourite?

[@thebloxxer22]

You referenced Abby from NCIS in the beginning.

[@VintageBlacklist]

Abby is the best.

[@grahamrankin4725]

Ephedrine and pseudoephedrine will have almost identical MS and IR because they are diastereoisomers. Both can be used to make meth.

[@PavanKumar-xv1hg]

thank you ?

[@enobnala90]

This is the only part of Organic Chemistry that I able to absorb!

[@sofbsilva]

You're about 5 days late. I had an exam about this on friday...

[@bidishadey3815]

🤣🤣🤣

[@xpalin1980]

ABBY! I love abby from NISC she’s so cute :3

[@atomicxfox]

please make an in-depth video on IR and proton NMR graph interpretation!

[@dangriff12]

If you have any specific questions just message me.

[@techgirl4977]

am i the only one who thinks crash course should be subscribed to by everyone in the world

[@foodaddict17]

Love love love this! :D Explained so clearly

[@geovannamartins2243]

Great video! Greetings from Brazil!

[@zarinawillows2347]

13:16 VERY SMALL Mystery ?!?!!? You call that small....

[@joshuacliftonx]

YAYYY Another video from crash course!!!!!

[@michelleelizabeth9956]

Wonderful videos and beautiful explanations , best of all. Thank you for sharing.

[@KillerTacos54]

Our SAC is next week haha. Thank you for going over all this stuff. I think what would've been really helpful would be going through the different reaction pathways as well as H-NMR and C-NMR (because that's in our SAC). Thankfully, IR Spectroscopy is in it and mass spec was going to be in it, but it got taken out as well as chirality and geometric isomers. This stuff was taken out of our study design (syllabus) because of COVID-19 and everything. Btw if anyone else does VCE in Victoria, Australia: hi :). After that, we're moving onto chromatography like HPLC, paper chromatography and stuff

[@dangriff12]

I need one on 2D NMR. It just looks like chicken pox and I have no idea what I am looking at. Any C13 NMR or DEPT 135 is fine though just message me any specifics.

[@bakryabdelmonem2066]

Amazing you making me love chemistry even more

[@Veronica-wz8ow]

I love you guys

[@sceptre1067]

the ongoing use of purple triggers my youth watching Burke’s Connections in a good way. i feel old. 🤪

[@Ogiwon]

looks great! :)

[@kai_taylor6550]

Love this i really needed to know this and its a great example thanks Crash Course Crew!!

[@saurra3953]

Yay I was just reading this from Clayden!

[@zarahasan331]

lol I have a lab final for this tomorrow... wish me luck.

[@kacibjordan]

That’s Abby from NCIS!!

[@kevinfleming9918]

Great explanation!

[@LucyRockprincess]

excellent video

[@itstotallyezra]

We use spectrometry in archaeology !!!!!!!

[@omsingharjit]

Awesome Brilliant great

[@dangriff12]

30 minutes is a long time to get a spectra! Even after running a blank to clean out the mass spec ours takes 3.5 minutes per run. So 7 minutes for the first spectra and 3.5 minutes for each subsequent spectra. It's not like the machine was super expensive either I think $4K.

[@Greenmachine305]

It was a meth lab explosion. Got it.

[@sofia.eris.bauhaus]

no it was a pseudoephedrine lab smh

[@danieljohnson3024]

Someone had sinus congestion and couldn't smell the gas from when the pilot light went out.

[@maksimghyvoronsky5641]

sofia eris bauhaus You know pseudoephedrine is like one of the main ingredients in meth right? And since it was a LAB then yeah... what Bryan C. said

[@dutchik5107]

I had an exam on this last week. I barely passed. Could've used it earlier 😓

[@jeffreypomeroy6173]

So how do you tell the difference between chiral molecules?

[@TriplaHHH]

Other techniques, like chiral column chromatography (i.e. pre-separation of chiral components, then detection with mass spec), or Raman spectroscopy (infrared-zone laser excitation. Raman optical activity experimentation is quite new, so I might make a mistake here). According to Wikipedia, there's also a possibility to apply kinetic resolution (i.e. react the isolated rasemic (both chiralities) mixture with a catalyst differentiated by the reaction rate.

[@pyritium]

What does DFTBA in the dialogue bubble over Deboki in the intro animation stand for?

[@amjadilham4174]

now i realize purple is actuallly dope

[@michaelmayhem350]

You should make an hours log video of you just reading from textsbooks for us to listen to (no video necessary but it's never a bad thing)

[@honeybeewarrior5731]

Incredible science

[@andeexists8716]

I wish I had these videos during A Level Chemistry lmaoooo

[@Ft888x]

Same!

[@finexjoshy9651]

The new app does not load and when the first screen had loaded it showed that there was some error. Then I tried again and it still did not load even after 20 minutes

[@nicholasticali4623]

This stuff is really awesome and was really fun, but it also brings back really really bad memories 😂

[@enitmarin6805]

Genial job.

[@henryelicker2403]

I'm getting mixed signals from this video.

[@jv4779]

How do these processes deal with impure samples?

[@ImmieHands]

I'm currently working on my PhD in mass spec so probably alright to answer this. There are a couple of things we do to deal with impurities, firstly couple MS with some form of chromatography like GC or LC which separates out different compounds in a mixture based on their relative affinity for either the stationary or mobile phase, meaning different compounds enter the mass spec at different times. Along with that, if whatever you're studying is in a particularly dirty matrix, for instance I work with wastewater samples, you can perform various extraction techniques to remove the chemicals of interest from the sample matrix, leaving behind the impurities. Hope this helps!

[@Azalynnnn]

I hope you teach HPLC before I need to use it 6 weeks :/

[@websurfer5772]

Has any scientist ever even seen a proton or neutron? If not, how do they even know what element they're working with? Also, how do they know they're not just detecting and measuring the electrons they bombarded the substance with instead of the "ions" from the sample?

[@emilybentley7502]

I'm not sure how to answer your first question, but as for the second one: electrons are negatively charged, whereas the ions produced in a mass spec are positively charged. They will move in different directions in response to the magnet - only the positive ions will end up on the detector. There might be other reasons too but I know that one!

[@kasualstudio7141]

Those 16 dislikes are Hollywood producers

[@papachoudhary5482]

Thanks

[@Synthetica9]

Is that tucos compound from bb?

[@gibranhenriquedesouza2843]

If I had known it would be so hard to find a job in physics, I would have done chemistry ...

[@katiefinch9414]

Boy I hope Starburns made it out ok

[@antonyandrewson5803]

where was this when I was failing my a levels :'(

[@hogo21]

Ngl, I watched this just cause I saw Abby. Video is great though!!!

[@mohamedgamaleldeen4315]

How do I review the approach of data structures and algorithms before I study software engineering course Thanks

[@Felixkeeg]

NMR best spectroscopy

[@danteller8282]

I'm not entirely sure if I agree with the way you pronounce "cation", but that's a pretty common area of contention. If we lived anywhere near each other, I would totally use that as a premise to ask you out.

[@taefasiri6999]

please we need to translation to Arbec 🙂💔

[@mist2666]

on tiktok his name is hankgreen1

[@samiebelal8700]

Dude I just finished ochem dangit

[@Adenybaloi]

Yo, it's Abby

[@ArsalanKhan-ki3rx]

Where is didi sabrina cruz

[@DennisKanji254]

Spot on!!!

[@Inadharion]

I spent the first minute coming to terms with your name. The rest of the video was obviously way above my head.

[@Vertigotrueshot]

what about an Anti-Mass Spectrometer.

[@Karajorma]

Well first you need to convert your lab to run on dark energy.

[@uneditedvideos6492]

what is the "white powder"?

[@grad3us]

Please, I want CrashCourse Neurology! It would be really cool to understand the brain, just as it was cool to understand computer science.

[@memlafeder]

Why nobody tasted the white powder? It is easier and instant result. (go hollywood science!)

[@kevinconrad6156]

Something makes me think that Dr. Chakravarti likes purple.

[@RamdomView]

Annoyed that I forgot the meaning of the wave numbers.

[@joshr.5199]

Where was this in September !? Jkjkjk i did fine

[@lokilaufeyson935]

I tried to be 1st and I failed. It think I’m about 3rd though 😊

[@bf0189]

Too early to mention chromatography specifically gas chromatography?

[@FINGERtipsandthewhispers]

Hey CrashCourse! Can you do an episode on racial fetishism? I think it's an important issue to understand, especially for BLM. Thank you!

[@zohaibhassan3786]

Please make videos on history of Pakistan and also on criminology

[@joaovitormatos8147]

Let's put a burning building on the thumbnail. What can go wrong?