Isoniazid (inh) - A narrow spectrum antibiotic for tuberculosis

Isoniazid (INH) is a narrow spectrum antibiotic used in the treatment of tuberculosis. This drug is a nicotinic acid derivative with hydrazide as functional group.
Isoniazid is a prodrug that is activated within the mycobacterial cell by one of the important enzyme catalase-peroxidase in presence of hydrogen peroxide. This enzyme is coded by the gene Kat G which can be mutated by the organism to produce resistance.
Finally this drug forms an adduct with NADH molecules which inhibits synthesis of mycolic acid within the mycobacteria.
#isoniazid
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#isoniazidb6

[@qinghaoliu9267]

Clear diagrams and comprehensive commentary on explaining the pharmacology and its side-effects. Keep up this good work!

[@alyafei1997]

Thank you sooo much it was really helpful and you made it soo easy thank u again

[@077jankipambhar2]

Such a excellent explaination ,by these vedios med chem structure nd mechanism cleared very well

[@meenakshimakhijani5851]

Enjoyed🙂.Nice video.Thankyou Sir

[@Jerm133]

What if patient is Isonazid high-level resistance?

[@doni_sinha]

Thanks a lot u explained it really well keep uploading 😃😃😃

[@egpat]

Thank you, definitely I will upload more videos. Thank you.

[@namukolokwalombota1740]

Can isoniazid be given together with ART treatment or not?

[@OusSamaKunSensei]

hello everyone, can you give me the references please ? i need them today for a project :) it's gonna be so kind from you if you do that it was perfectly explained by the way, clear as day light, thank you so much

[@deepeshsuthaar]

Kadak

[@user-xj1ml3uc7r]

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[@MohammedMohammed-ue2ou]

Please sir chloroquine mode of action

[@egpat]

Sure, I will upload a video on that shortly.

[@kashifshaikh6867]

thanks you sir

[@egpat]

You are welcome.