JAK-STAT Pathway - Non-receptor Tyrosine Kinase (NRTK) - Cell Signaling - Endocrinology Playlist

[@MedicosisPerfectionalis]

🍱 Endocrine Pharmacology Course: www.medicosisperfectionalis.com/products/

[@BallyBoy95]

The number of times I've seen the term, 'JAK-STAT Pathway...' Glad to know there's finally a good educational video on it.

[@MedicosisPerfectionalis]

Thank you 🙏

[@emel8571]

I had lost track of the number of videos I watched to understand this topic. You, mister, are my hero. I loved the way you explained this, many thanks!

[@MedicosisPerfectionalis]

Thank you 😊

[@floodedbrain9564]

When they started with "lovely day" and "makes perfekt sense", my heart melted. My day just got much better

[@MedicosisPerfectionalis]

I am so delighted to hear this!

[@shreyapatel9433]

Perffffffeccccttttttt, had been trying to understand this topic since agggges😮‍💨🤧 These 7 mins changed my life😭

[@MedicosisPerfectionalis]

Thank you 😊

[@ABC-fv7ow]

Nobody else can teach it like you.🙏

[@MedicosisPerfectionalis]

Thank you 😊

[@lakep7798]

Professor MP, you’re such a lifesaver. Thanks for this video!

[@MedicosisPerfectionalis]

Happy to help!

[@Annie-bn6yi]

I'm crippled in pain revising for my viva in a few weeks I've never laughed so much - this is fantastic.

[@MedicosisPerfectionalis]

Thank you 😊 Best of luck!

[@mimouchette]

I'm french girl so i'm no really good with english videos (lol), but with this video, I understand all ! thanks for speak slowly et repeat importants notions !

[@MedicosisPerfectionalis]

Thank you so much 😊

[@StrengthInNinjas]

Absolutely perfect timing. Just missed a quiz question on this exact topic, and now I understand. Much appreciated!

[@MedicosisPerfectionalis]

Thank you 🙏

[@allencrider]

They told me I didn't know jak stat, but now I do.

[@MedicosisPerfectionalis]

Haha 😂 Thank you 😊

[@zhuleiyamarfie3464]

absolutely simplified, thank you for this

[@MedicosisPerfectionalis]

My pleasure!

[@ZitaDanyi-mt5dc]

such high level explanation! many thanks!

[@MedicosisPerfectionalis]

My pleasure 😇 Would you please help me by sharing?

[@kaioformentini8050]

Love from Brazil! Thank you for this great explanation!

[@MedicosisPerfectionalis]

My pleasure!

[@lovelypatience1274]

You are a life saver,, thank you so much

[@MedicosisPerfectionalis]

You are most welcome!

[@ChemBioInfo]

Thank you so much. Please Why does the inhibition of JAK3 and JAK1, along with major factors, help reduce rheumatoid inflammations compared to JAK2 and TYK2?

[@mrsamandabernier]

So excited to see this topic pop up! Commenting before I even hit play. Lol Thanks.

[@MedicosisPerfectionalis]

Thank you 😊

[@BarelySaneGenius]

Thank you for this very simple explanation

[@MedicosisPerfectionalis]

You are welcome!

[@nishantsen6820]

Ohh medicosis💚 you explain very well thanks

[@MedicosisPerfectionalis]

Thank you 🙏

[@lewarzebari2894]

This is f en hilarious XD, this is soo amazing every med student should see this!!!

[@MedicosisPerfectionalis]

Thank you 😊

[@ΦαίδραΔημητροπούλου]

omg this was so fun to watch

[@MedicosisPerfectionalis]

I appreciate you!

[@ayahassan1050]

The video is awesome and very interesting... thank you ❤

[@MedicosisPerfectionalis]

Glad you enjoyed it!

[@Selva-2318]

Explanation was very good and easy to understand thank you so much

[@MedicosisPerfectionalis]

You are welcome!

[@lionsinescanor373]

Magnificent video!

[@MedicosisPerfectionalis]

Thank you very much!

[@蒙姚]

wonderful job

[@MedicosisPerfectionalis]

Thank you so much!

[@sanjivprasad6846]

Foremost the best video on jak A$$ (beep)

[@adamfitrah3634]

big thanks for explaining

[@MedicosisPerfectionalis]

My pleasure!

[@UBUYoga-pq2yx]

Thanks!

[@MedicosisPerfectionalis]

Thank you so much for your support!

[@eylemb1562]

You are awesome!! Thank you ♡

[@MedicosisPerfectionalis]

My pleasure!

[@DrNeshOne]

Good afternoon sir! Great video and explanation but I think there is a mistake here or perhaps my understanding of Non-receptor Tyrosine Kinase is incorrect. According to the Eshaq and Flanagan et al: "In contrast to the RTKs, the members of NRTKs lack both the extracellular ligand-binding domain and the transmembrane-spanning region, which are characteristic of RTKs. The different members of NRTKs are either localized in the cytoplasm or anchored to the cell membrane via significant modification in their amino terminus" So when you mention the structure of the "NRTK" around minute 3:25 as a receptor made of 2 monomers, it is my understanding that this is incorrect as NRTK as the name implies are not actual receptors in the sense they do not have a regular hydrophilic-hormone like ligand binding site or even a transmembrane anchoring portion like the RTK does. A lot of these molecules are actually just free cytosolic enzymes but some are indeed anchored to the intracellular membrane and often in close association to a receptor but they, themselves, are not the receptor. From my understanding and based on the following from the same source mentioned earlier: "Unlike other receptor tyrosine kinases, the cytokine receptors lack intrinsic protein kinase domains; therefore, the cytokine receptor cannot cause rapid tyrosine phosphorylation of intracellular proteins [77,78,79]. Consequently, the cytokine receptors recruit and activate a variety of NRTKs, including the JAK family, to induce downstream signaling pathways" So the JAKs molecules are actually the NRTK themselves not the receptors for GH, Prolactin, etc as you mentioned. Please correct me if I'm wrong.

[@CanArslan-oy8tn]

THANKS THANKS THANKS.

[@MedicosisPerfectionalis]

My pleasure 😇

[@chandanareddy7287]

Very nice 🙂🙂🙂🙂 explanation

[@MedicosisPerfectionalis]

Thank you 😊

[@zer0sy51]

Thanks for the amazing explanation

[@MedicosisPerfectionalis]

My pleasure 😇

[@alanwaterman1328]

Brilliant. Very funny!

[@MedicosisPerfectionalis]

Thank you 🙏

[@ayatalabyad6589]

Bro I love you

[@MedicosisPerfectionalis]

Thanks!

[@geethkarunakar3977]

Mechanism of seduction : phosphorylation😂😂😂 Awesome!

[@MedicosisPerfectionalis]

Thank you!

[@walaalani8355]

perfect but doctor what about C-Src family kinase

[@fatimanasir5347]

Love you sir.

[@MedicosisPerfectionalis]

Thank you 🙏

[@startingpointformedicose1731]

Thanks for This Video

[@MedicosisPerfectionalis]

My pleasure 😇

[@ABC-fv7ow]

Keep it up !

[@MedicosisPerfectionalis]

Thank you!

[@Shivoham2243]

Wooowww❤

[@MedicosisPerfectionalis]

Thanks!

[@SchmittsPeter]

When I get twins, I will call them Ja(c)k. Both of them.

[@MedicosisPerfectionalis]

:)

[@sarashafiepour7006]

What's your reference?

[@joshuaherrmann9865]

You would be good on Tik tok

[@Istabragh]

``Mechanism of seduction`` lamo

[@MedicosisPerfectionalis]

:)

[@DocThinks]

that's was funny 😂

[@MedicosisPerfectionalis]

:)

[@zoekiriakidou7595]

me on my biology exam writing the story of a non-independent woman who depends on jack,a narcissist a$$ that only hugs himself

[@MedicosisPerfectionalis]

Facts 🤣

[@alialsayed2214]

I think you are arabic cuz iam arabic and you seem like arabic 😂

[@applepie4585]

ngl the "strong independent women" joke was kind of condescending and not funny at all

[@lillianotuokwu7876]

❤❤

[@MedicosisPerfectionalis]

Thanks!