JAK-STAT Signalling Pathway

In this video we the JAK STAT Signalling pathway has been discussed.
The JAK-STAT Pathway is mediated via Cytokine signals. The JAK comes from Janus Kinase , where as the STAT is the Signal Transducer and Activator of Transcription.
The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis. The JAK-STAT signalling cascade consists of three main components: a cell surface receptor, a Janus kinase (JAK) and two Signal Transducer and Activator of Transcription (STAT) proteins. Disrupted or dysregulated JAK-STAT functionality can result in immune deficiency syndromes and cancers.
The binding of various ligands, usually cytokines, such as interferon, interleukin, and growth factors to cell surface receptors, activate associated JAKs, increasing their kinase activity.Activated JAKs then phosphorylate tyrosine residues on the receptor, creating binding sites for proteins possessing SH2 domains. SH2 domain containing STATs are recruited to the receptor where they are also tyrosine-phosphorylated by JAKs. These activated STATs form hetero- or homodimers and translocate to the cell nucleus where they induce transcription of target genes. STATs may also be tyrosine-phosphorylated directly by receptor tyrosine kinases, such as the epidermal growth factor receptor, as well as by non-receptor (cytoplasmic) tyrosine kinases such as c-src.
The pathway is negatively regulated on multiple levels. Protein tyrosine phosphatases remove phosphates from cytokine receptors and activated STATs. More recently identified suppressors of cytokine signaling (SOCS) inhibit STAT phosphorylation by binding and inhibiting JAKs or competing with STATs for phosphotyrosine binding sites on cytokine receptors.[4] STATs are also negatively regulated by protein inhibitors of activated STAT (PIAS), which act in the nucleus through several mechanisms.[5] For example, PIAS1 and PIAS3 inhibit transcriptional activation by STAT1 and STAT3, respectively by binding and blocking access to the DNA sequences they recognize.

[@Galfromdownunder]

I have to say, compared to all the fancy hi-tech motion graphics videos, this was the most charming - and easiest to understand! Thank you Hussain!

[@hussainbiology]

Really Glad to hear that,,, You know it really boosts my confidence when i hear these kind of words.......Thanks dear ,

[@marcelschinner6576]

@@hussainbiology i thought the exact same thing. Thank you so much

[@Galfromdownunder]

And now 4 years later - I’m actually working on a JAK inhibitor drug! I better watch this pronto! Thank you again, Hussain. Keep it crayola, keep it fun!

[@thelazy250]

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[@hussainbiology]

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[@joyiwan]

Love how simple this video is and yet delivers the whole concept efficiently! Thank you!

[@hussainbiology]

Thanks Joyi for appreciation.....It really inspires me to put more videos like that.... thanks again

[@godsmagic9656]

Teachers in the USA are very shitty, I had 50 min long lecture on this and could not get the big picture. US professors just read out the powerpoints. They are not teachers. I got a clear concept in 5 mins in this video. I can't believe how the US professors dragging 5 min thing into an hr.

[@yuvraj66]

I watched this video once and all my concepts are cleared . As compared to all other study channels this is the best one . Thank you sir for making such difficult concepts easy .

[@hussainbiology]

Thanks Yuvraj for appreciation.... Really glad to know that it helps and also thanks for kind and nice words it inspires me to make more awesome videos...

[@emeree9575]

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[@hussainbiology]

Glad to hear that

[@denisseorriola-guijosa8723]

I love these videos! short and simple but detailed enough to correlate with my professors' notes. Thank you!

[@hussainbiology]

thanks for appreciation..

[@nicj2561]

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[@hussainbiology]

Thanks Nic for appreciation... Really Glad to know that it helps.

[@tamanna4574]

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[@hussainbiology]

@@tamanna4574 thanks Tamana for appreciation..Glad it helps

[@taynishh]

Thank God I saw this video.... I thought I'd never be able to understand this pathway

[@hussainbiology]

✌️... All the best ahead

[@Waiss786]

Extremely wonderful clarification. I have watched many videos and lectures but yours was better one 👍🏻

[@hussainbiology]

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[@mbbsgoals3536]

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[@hussainbiology]

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[@ibtihelnemri3848]

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[@hussainbiology]

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[@amritasriv87]

thanks sir for making such informative videos... extremely useful for students

[@hussainbiology]

thanks Amrita for appreciation......Really Glad to know that it helps

[@teocosma1146]

Really appreciate this video! Very helpful :)

[@hussainbiology]

Glad it was helpful!

[@anushkasupakar3305]

Amazing! Just to add that, the JAK and STAT types involved vary depending on the ligand that binds to the receptor.

[@hussainbiology]

Thanks...Yes it was a basic overview... and also i am yet to answer ur question from the RAN GTP cycle.✌️

[@Explore_with_lissu01]

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[@maminabhoi2228]

Thank you so much sir

[@hussainbiology]

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[@godsmagic9656]

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[@hussainbiology]

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[@hussainbiology]

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[@hussainbiology]

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[@mistarelentless5722]

Brilliant and concise GRATEFUL

[@hussainbiology]

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[@Pariisony]

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[@hussainbiology]

Most welcome

[@chhayachandran4773]

Better than others ❤️

[@lavanyakumari6603]

Very easy to understand... thank you soo much for this video

[@hussainbiology]

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[@hussainbiology]

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[@netalsharma1012]

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[@hussainbiology]

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[@mohibhasankhan5630]

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[@hussainbiology]

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[@Xx-cu5zm]

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[@hussainbiology]

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[@milenasarkowicz3080]

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[@hussainbiology]

Glad you like them!

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[@hussainbiology]

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[@ehsanmir9846]

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[@hussainbiology]

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[@kiasersaakib4651]

Thanks for Clearing the concept,,,,, keep it up

[@inshithkaur577]

Thankyou for uploading this video, helped a lot.

[@ashms809]

Nice video brother

[@ayaaahmed2416]

Thanks From Sudan

[@hussainbiology]

You are welcome....Keep sharing and supporting

[@sayuriyamagata6853]

Could please explain how SOCS3 and PTP1B inhibit JAK STAT signaling in a negative feedback loop?

[@madhusu8621]

U R MADE IT EASY SIR...TYSM

[@hussainbiology]

Thanks Buddy for appreciation....

[@user-qx6nh6sj2s]

Thank you 🙏

[@hussainbiology]

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[@sayantansaha53]

Thank you sir

[@punit6253]

short, sweet and easily understandable thank you sir.......

[@pharmaboy1510]

Excellent

[@128yamnabilal.2]

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[@hussainbiology]

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[@dr.mohamedabdulhaleem3268]

Great Show , Thank You Soo Much for sharing : )

[@hussainbiology]

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[@sohelrana865]

Tyrosine phosphorylation by activated JAKs of cytokine-receptor cytoplasmic domains then provides binding sites for the Src-homology-2 domain of the STAT proteins.

[@anonymous-xr4we]

Phenomenal 👏

[@hussainbiology]

thanks for appreciation

[@aboutstudies123]

Easy to understand

[@nihalanazernalakath3703]

So good. Thank you.

[@hussainbiology]

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[@tahanazl9106]

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[@hussainbiology]

thanks Taha for appreciation.... and yes i am

[@tahanazl9106]

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[@statisticserinokripperino]

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[@hussainbiology]

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[@queenrani6840]

Thank u for your dedication and excellent teaching.

[@hussainbiology]

Thank you bro , for ur support and love...it really boosts me

[@junkmail8883]

Nice video, thanks

[@kp63988]

Thank u !!

[@hussainbiology]

Glad to know that it helps......Keep it up

[@rashidashraf9551]

Nice sir

[@BhavyaKansal18]

can you pls explain what's the difference between mapk pathway and jak stat pathway. also how are jak stat recptor any different from tyrosine kinase receptor?

[@hussainbiology]

Kindly watch both of the videos first.... if problem persists then write back✌️✌️

[@System9down]

he said in another video that the JAKSTAT receptor is just one type of tyrosine kinase receptors.

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[@hussainbiology]

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[@joshfink3436]

excellent explanantion

[@galdahham895]

Thanks

[@mohsinrana5205]

it s useful for me thnx.......

[@hussainbiology]

Thanks Mohsin for appreciation.....Keep sharing and supporting

[@ramchandrasuthar2848]

Very nice sir

[@hussainbiology]

Thank you Ramchandra

[@iRSubscriber1]

Better than my prof

[@hussainbiology]

Thanks for appreciation....it really inspires me to put more videos like that....

[@user-vf8tl3yk1c]

Thanknyou so much

[@jyothylakshmirajan3953]

Please add estrogen receptor concept

[@hussainbiology]

okay

[@SheDaresLIVE]

Hello I really enjoyed your video… but where is STAT3? In other places it seems that stat1 and stat2 are labelled stat3, as well as the two stat molecules stuck together. Can you explain where Stat3 is please? Really appreciate your help. X

[@hussainbiology]

First of all thank you so much for appreciation and feedback.... Secondly i can see the STAT 2 rarely forms Homodimer that is why u can't see STAT2-STAT2 complex in all papers or literature.... Phosphorylated STAT2 was found to be capable of forming homodimers in response to IFNα. These STAT2 homodimers were shown to interact with IRF9 to form an ISGF3-like complex....

[@hussainbiology]

we mostly get to see stat2-stat1... stat3 and other heterodimers ....

[@hussainbiology]

mostly we get to se heterodimers of stat2-stat1.. stat3..

[@SheDaresLIVE]

@@hussainbiology so are you saying you just add up the stat heterodimers to get to stat3? Eg a stat1+stat2 = stat3? Stat3 is an important pathway for many cancers.

[@hussainbiology]

@@SheDaresLIVE no no..... i mean we don't have Stat2-stat2 homodimers very often..... rather we have stat3-stat1.... stat2-stat1

[@cutyteeshu8068]

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[@kounsarsheikh4857]

VERY NICE

[@saimamubashshira7665]

Thank U

[@hussainbiology]

Thanks Saima for ur support......

[@sunidhim.ghatikar3625]

Sir if we take the erythropoietin action on its receptor of cytokine receptor superfamily, does it also form complex that binds to gene for expression or is it via secondary messengers?

[@sunidhim.ghatikar3625]

Sir I have a request... Please can you make a tutorial on extravascular erythrocyte destruction mechanism ...

[@hussainbiology]

Hi , Sunidhi , currently i am working for Molecular Biology videos , but i assure u that your video will be made in future. thanks

[@kuldeepsbiology4496]

thanks sir

[@hussainbiology]

Thanks....Glad to know that it helps......

[@anjanasaji6557]

❤️❤️❤️

[@sandhiyavaradharajan5442]

STAT JAK structure link pls

[@hussainbiology]

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[@Goodmandoinggoodtings]

I love you.

[@hussainbiology]

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[@hussainbiology]

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[@ashb6136]

Thanks very nice, just work on your accent and pronunciation a bit. Some times I can't understand you properly.

[@tatsumiogawa1107]

Its not pronounced Jack its pronounced yak, but other than that very nice video.

[@hussainbiology]

Thanks for the correction , Will consider pronouncing it yak from now.

[@tatsumiogawa1107]

Haha its not a big problem. Very nice video! thank you for explaining everything so clearly.@@hussainbiology

[@hussainbiology]

Well thanks for appreciation..

[@tamanna4574]

Trust me really helpful and far better from other available videos so easy to understand. Thank you ❤

[@Boost_Concepts]

Thank you so much sir ❤🎉

[@madhushree.r101]

thank you very much sir

[@hussainbiology]

Thanks Madhu for appreciation....

[@ramchandrasuthar2848]

Thanks sir

[@aboutstudies123]

Thank you Sir