David Sinclair on the Brink of Anti-Aging: Reprogramming Cells for Eternal Youth

In this episode of the James Altucher Show, James dives into a fascinating conversation with Dr. David Sinclair about the groundbreaking research on aging and potential ways to reverse it. They discuss the intriguing concept of using low-dose medications for unexpected benefits, the discovery of DNA by Francis Crick and Jim Watson, and Sinclair's paper on the information theory of aging. The discussion covers the difference between genetic and epigenetic information, the possibility of reversing aging by maintaining or restoring the information contained in our DNA, and the remarkable evidence from animal cloning that supports Sinclair's theories. They also explore the current challenges and future possibilities of gene therapies for age reversal, including the reprogramming of cells using Yamanaka factors, the experimental use of specific chemicals to rejuvenate cells, and the potential implications of testosterone and other supplements on aging. Sinclair's pursuit of understanding the epigenome and its role in aging, alongside the practical application of this research in treating conditions like blindness and extending lifespan, provides a tantalizing glimpse into a future where age reversal could become a reality.
00:00 Exploring the Unusual Uses of Viagra
00:12 Introducing the James Altucher Show
00:24 The Fascinating World of DNA Discoveries
00:46 Unlocking the Secrets of Aging and DNA
01:46 The Revolutionary Concept of Age Reversal
02:21 The Potential of Epigenetics in Reversing Aging
05:36 Exploring the Possibilities of Age Reversal and Genetic Therapy
05:55 Navigating the Complexities of Gene Therapy and Regulatory Challenges
08:21 The Future of Aging: Supplements and Scientific Debates
12:17 The Cutting-Edge of Age Reversal Research
18:55 The Intricacies of the Epigenome and Age Reversal
24:34 The Promising Horizon of Gene Editing and Age Reversal
28:56 Exploring the Future of Viral Gene Therapy
29:08 The On/Off Switch for Viral Therapy and Its Potential
30:13 Understanding Aging and Cellular Reprogramming
33:18 The Brain's Learning Capacity and Aging
35:35 Reversing Aging: From Theory to Practice
43:32 The Path to Human Trials and Regulatory Approval
47:33 Exploring Off-Label Uses and Future Applications
49:32 Testosterone, Aging, and Other Health Insights
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[@tocitim]

David, don't stop...Do the miracle

[@georgiaparaskevopoulou7425]

Keep doing that!!😊

[@tocitim]

@@georgiaparaskevopoulou7425 how are you Georgia?

[@georgiaparaskevopoulou7425]

@@tocitim I am doing well thsnk you!!😊

[@jozette-pierce]

At least help us keep our eyesight. I have lots of work to do. Thanks, David.

[@wideningcarrot6]

@tocitim on the tune mate 😉

[@dannyozuna]

Yes, I'm ready for the upgrade!

[@pgc6290]

At 5:30 and he is just a small kid/student asking questions. I like that. He is still so young in his brain.

[@karl3630]

The most incredible thing is that we are not that far away from reprogramming our cells, and he 's proved it. He's at the cusp of maybe restoring sight to human beings, what an incredible feat. My biggest fear is that there are many people out there who will do whatever they can to jeopardise his work, not because they can do better but out of simple spiteful jealousy! Remember every single human being on this planet will get old one day and suffer everything that goes with it, if we can do something to negate that outcome not only do we profit but all the generations to come. It is far better to prevent these illnesses happening rather than treating them with dangerous drugs, which profit nobody but the pharmaceutical industry.

[@tocitim]

David, don't stop doing it...

[@adamal-hilali6497]

Love this. James has ability to ask everything you want to know, brilliant

[@joeblow2183]

Great interview. Thank goodness the nmn protocol was held to a minimum

[@DrJK-wm9ec]

David Sinclair has lost a little of his pixie dust because of a few missteps. However, there is no denying he is pushing the Longevity space in a new direction…looking at Aging as a disease, the hypothesis that there is of a back-up copy in cells that could be used to reverse aging, and more. I do hope Dr. Sinclair does stay focused on his research and keeps pushing the envelope on Longevity science!

[@aratonit9551]

What missteps are you talking about

[@Preciouspink]

Why does this doctor go on so many different shows? Does this impair the ultimate goal of treating aging?What does he accomplish with all this video attention?

[@InfinityCelestial]

@@Preciouspink scientist

[@pgc6290]

At 34:29 and yes mindset and brain are vary important.

[@awestaguetherealtor1520]

We love David Sinckler

[@semaaral2498]

Yess missed him💙🔬🐭

[@peterm5554]

Great news about clinical trials curing blindness in human eyes starting next year. They are already talking to the FDA and see no show stoppers. This time next year (May 2025) they could be calling for volunteers for the trial. Hopefully once blind people see again the penny will drop and everyone will understand that age reversal is real and more research money will flood in so that we can all become young again as soon as possible

[@bkb2012]

Fabulous!

[@pgc6290]

At 1:22 and imagine if we could go back to who we were mentally.

[@KLTer-jo9jy]

dear lorde, imagine we'd all be dumb teenagers again. Please, no.

[@jordanong5114]

We need to do more. More progress for the business in the present and future.

[@WackyGameEngineer]

Sinclair i bet my Life on you! Keep going :)

[@labrenzjasmin85]

fantastic

[@eshaniking4421]

What I would really like to know is how much more effective any of these approaches are at increasing longevity and reversing ageing than a series of simple 72+ hr water fasts.

[@keithmarshalldds511]

Would red light therapy be helpful as viagra for endothelial health? I would think even more so due to its direct effect on mitochondrial function.

[@INDIGE_STUDIO]

Only meat eaters need viagra quit meat and eat plants and boom your young again down low 👌

[@WILLIAMMALO-kv5gz]

It may be helpful to look at the higher electrical level as in the work done by Dr. Micheal Levin PhD Microbiology. This also may tie in with "Electric Universe theory" to some degree. Thanks to Dr. David Sinclair and James Altucher for this very informative video.

[@clearlyaudible]

15:10 good question, my question too

[@brosan5404]

43:03 David Sinclair does an age reset live

[@marcusiA-immortalistMarcus]

😁😁 I love it

[@joecool7165]

David, I followed you for a very long time. Your eyes blink a lot now and they just don’t look right. I hope everything’s OK with you have a lot of hope for what you’re doing.

[@SAMSAM-rw9fc]

Wow you are a very good judge I watched this video for a long but didn't notice his eyes after I thought let me read the comments and here you are lol really his eyes are not looking just right IDK what's happening. Btw Im on NMN for 2 months I don't feel any difference but as this is just 2 months I'm continuing Have you started any same kinda supplementary, I would appreciate sharing thanks

[@andrianasotiris6681]

​​@SAMSAM-rw9fc Botox is what's wrong with his face

[@js401]

Try going to a gram and a half of NMN.

[@SAMSAM-rw9fc]

@@js401 Its written on the bottle one capsule a day so I'm following that Can you please answer if you taking any that kinda capsules of NMN if yes what brand? I'm taking "PartiQular"

[@Melungeonpeople]

It could be as simple as a draft in the room.

[@edwardbearjames2916]

So then comes the idea could he clone himself? Could you as long as you got along with them still get potential anti-aging help from their blood plasma? Then comes the question of cloning and the rights of the other person and all the others that comes with. How much longer could someone live if they were given younger blood of their own? How many clones of your own could you make?

[@RogerMimi-yq2ny]

Isn’t There some historical discussion about crick and Watson being first to discover DNA ??

[@tudyloco1726]

Question is is where in the body is the control system in the discovery of an upgrade and update of the new control system where is the component is it the brain or is it beyond that cuz now I'm hearing our gut has a lot to do with aging

[@tedchapple5991]

Where is the reference to a published paper showing the documented success of a cloned monkey living out a normal lifespan?

[@clearlyaudible]

37:00 from 5 down to 2, and now only one small molecule to permanently reset your age ? interesting 🤔

[@xeniastefanescu507]

What about taking Nitric Oxide or Taurine.,for increasing testosterone?

[@avataros111]

W and J are only the people who took the credit for discovering the DNA structure.

[@rigwatvchannel4458]

It is interesting and adventure in science Cells are key if programed age can be recet Resuch is possible

[@henryjraymondiii961]

What about programmed senesence, the telomeres shorten and it seems to be more than wear. Are we indicating that fundamental lengthening of telomeres has been done in experiments? Otherwise, there seems to be a "clock" that indicates programmed death by a body calendar. An actual time-senesent truly time aged rat may have a body clock that references an aspect of...time...that is not being addressed by artificial ageing tecniques. As scientists and anti-aging proponents, we need to have begun to look at this in a real time manner, because the time it takes to know the proven coucpome of such validative measures-- now THAT could get "expensive" in terms of lost lives. Lets proceed as individuals to try--but we also need this for the future.

[@ussupplyllc5161]

Or someone who is dying in 6 months should not become young because what if he dies in 3 months? FDA should allow exceptions

[@magsharper3268]

Can you recommend a preferred brand?

[@SAMSAM-rw9fc]

If you find a good brand pl lmk btw im taking PartiQuar past 2 months not sure if good or not

[@feltonhamilton21]

I believe free radicals should be studied more often because they put out negative waves that can get in the way of signals and charged particles pretty much everything inside the body of a living cell and stop the positive activity between molecules and other particles creativity. Unpaired electrons can carry a negative charge for a long period of time while injecting negative energy and causing confusion between molecules and charged particles and stopping them to not line up with the inner and outer cell structure and work accordingly with the cell inner umbilical cord duplex protein adjustable scaffolding operating system designed to liquefy molecules and deliver them through activities on each contact with the cell inner wall but because there have been damage to the cell internal an external tissue they begin duplication on damaged and dysfunctional tissue, so rather than breaking away into two separate cells the cells clump up into a waste field powerhouse injecting free radical material into the bloodstream and eventually causing damage to other fully developed cells outer surface and enter body. I believe stopping unpaired electrons from doing any type of damage could be much easier than looking for alien resources. I believe it's all about negative and positive charge particles and reducing the wavelength on unpaired electrons and stopping the confusion with a stronger microwave input that can convert into a negative and positive charge and balance the entire waste field of decaying cells so white blood cells can take over and stop free radicals waves interference on the human DNA and from blocking biological digitally coding from positive electrons and molecules and other particles trying to stay charged and keep up with creativity..

[@BjJackson-jr8jz]

Time is what causes ageing.no scientest or person can not stop,reverse,or extend time which cause the ageing process in every thing.

[@keithmarshalldds511]

Is it a coincidence that the URL for this podcast have three 4s? Lol

[@FrankPSF]

I'm 67 and just beginning to show some senescence. Sign me up!!!!!

[@blackpepper8941]

37 very important...

[@cynthiaaiken2424]

how does joe average get in on a trial?

[@antoniobortoni]

Why people put limits, anything is possible, but the gold rush is here, return to young treatment people will go to another country if illegal , so make it free and public the return to young mix and all, because i want to see all women young again, and at the same age all...

[@anirecapped.]

Dave WILL outlive his critiques (unless he gets hit by a bus or something) since most of them are crusty old men, with one of their feet already in their graves, lol. But they do raise some valid doubts about some of his claims, especially when it comes to Resveratrol as repeated attempts to replicate your claimed findings have yielded zero results.

[@DG123z]

Can't wait until they have something you don't have to "believe in" for it to work

[@vickybiagini8623]

You might be waiting for pigs to fly first. Hate to be like that, but it's been decades, and he has nothing, absolutely nothing. He has to keep the gravy train rolling though.

[@DG123z]

@@vickybiagini8623 They have something promising with the three yakanama factors and there are other avenues, such as with Michael Levin's work

[@monaantony9096]

How about just buying a copy of Dr Furhman , Dr Greger , Dr Goldber and Dr Neil Barnard and follow their food guides and we would need no pill n so much research Just eliminate processed food for a start … it’s that simple

[@Preciouspink]

Why does this doctor go on so many different shows? Does this impair the ultimate goal of treating aging?What does he accomplish with all this video attention?

[@SAMSAM-rw9fc]

Good Questions I always was thinking that

[@lumanliu8457]

@@SAMSAM-rw9fcfrom a positive thinking, I think he want to raise his fame and raise money for his business. You can imagine this kind of human trials need a huge amount of money and you know what's more important than the money? People's faith. Now, no one believe aging can be reversed. So no trial will even begin. That's I believe what he wants to change. One thing you can trust is that he is not doing those only for money. Come on, money does not mean too much for people at his position.

[@ScaleCrawling]

1. Will you call it the T-Virus? 2. How young will it make Milla Jovovic look?

[@ussupplyllc5161]

someone who is blind, should not get a young vision in fear of maybe getting blind? FDA wants safety?

[@josselynpierce4099]

I love ur work david sinclair plz study on me

[@MarkShinnick]

Look into Sinclair's financial and claims history: many not happy with his ethics.

[@DG123z]

"No, i don't".. "okay" 🤦 it was some lady before them though anyway

[@karinodendaal5277]

Not correct Info Dave. Molly the cloned sheep did not live a normal heathy life. She and all other animals cloned only live half a life span. They don't live a long normal life.

[@brianlebreton7011]

James keeps referring to the DNA being corrupt which is not what David’s theory is. It’s the epigenome that’s not working right. David’s being very politically correct in not correcting him.

[@techw4y]

This guy is a charlatan, be careful of what he says.

[@KapowskiGG]

37:00

[@jaykraft9523]

it's gotten to the point where I cannot believe a word this man says.

[@pavanlulla]

..snake oil salesman...David Sinclair selling Resveratrol 😂

[@jaykraft9523]

and NMN, both worthless.

[@joannajohnson5570]

So why are you here?

[@larsnystrom6698]

@@jaykraft9523 It's a B3 vitamin. An expensive one. And as any of those, it increases the NAD+ level. So, who knows if it does anything for longevity. No research has shown that yet. Not even any mice research.

[@jaykraft9523]

people need to weigh in and express doubt, but I thought that was clear to anyone with a brain

[@blackpepper8941]

Lucky enough to choose Biology as my career ❤, Even AI can't replace my career 🎉

[@pgc6290]

Are you sure about that?

[@gdok6088]

With AlphaFold AI and just recently the release of AlphaFold-3 developed by Demis Hassabis and his team at Google DeepMind based in London, UK 🇬🇧 you will certainly have some amazing and open-source AI to assist in your biology career.

[@lorettareagan7705]

Did Dr. Sinclair seriously just say he’s okay with individuals committing suicide “as long as they are mentally stable”??!! Seriously, mentally stable? What a line. I used to have some respect for him. Not any longer. Think about the statement…suicidal, yet mentally stable? I don’t think so!

[@unrealread5579]

I think... hope.. he meant medical assistance in dying.

[@EkilRevolution]

i disagree with what he said about suicide as well . i wonder if people who say such on suicide are projecting their personal struggles in life .

[@bkb2012]

He's talking about end stage life.

[@vickybiagini8623]

I thought it wasn't right either, but there are severely depressed people in the World.

[@khushsingh973]

People have misunderstood Sinclair, as usual. He very carefully pointed out that suicide is not something to be taken lightly, nor to be dismissed out of hand, since personal freedom of speech and existence is ultimately sacrosanct. So, he’s suggesting that where life is so horrifically bad for an individual, but that individual is still able to make an informed decision on what is to be done given this level of pain, then it might not be our moral right to withhold whatever treatment is to be granted once all the ethical, legal, and physiological parameters have become addressed within some communal legislative framework. Including assisted death. This is an interview and he cannot go into pacifying everyone’s sensibilities regarding his view. Listen very carefully before jumping up and down and judging an intellect that’s operating at a cutting edge level whilst constrained within the law of the land. This is an extraordinary intellect with a highly motivated and complex mindset. He doesn’t need the respect of those who cannot think for themselves or about others who need the greatest care. He has a right to an opinion. That’s what freedom and diversity is all about. He’s not looking to win the presidency of the USA. He’s explaining and exploring what science and scientific endeavours could mean for everyone’s life. Let’s just listen…

[@tudyloco1726]

DNA is like a shoelace after time its get worn down

[@RandomGuy-lu1en]

no. Thankfully that's not the case

[@larsnystrom6698]

Hah, the video title is far from the truth. More fantasy than science, unfortunatly.

[@TheNewOriginals450]

No, science, not fantasy. Maybe you don't understand the nature of incremental scientific progress.

[@PetePH]

@@TheNewOriginals450 it has nothing to do with science. It is all about money. David is nothing more than a snake oil seller. You can see through that easily if you really know about science.

[@kth6126]

Haha - and your studies to back your statement?

[@pitdog75]

He is a crook.

[@PetePH]

Agree, recently learned about that. $720M made this crook to sell snake oil.

[@WILLIAMMALO-kv5gz]

This world we live in, is full of crooks. Some are right some are wrong...Get used to it.

[@pitdog75]

@@WILLIAMMALO-kv5gz amazing insight, I am enlightened

[@shinkurt]

He is a scammer. Listen to literally anyone else

[@hannabarishnikova5496]

I don’t like the guy

[@richardbreeze7898]

Back up full genome copy. Somewhere in the cell. Do you guys actually buy this nonsense ?

[@TheNewOriginals450]

What guys? What nonsense? Do you not understand the research?

[@richardbreeze7898]

@TheNewOriginals450 So Where's the back up copy located exactly ?