Skeletal Muscle Histology & Muscle Fiber Atrophy under microscope striated muscle

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[@filipristovski7081]

Thank you for your video doctor. You are the best

[@ligmab.8572]

Thanks for the vid dr gardner! Cant wait to become a pathologist

[@wolpumba4099]

*Skeletal Muscle Histology & Muscle Fiber Atrophy* * *0:15** Skeletal Muscle Histology:* The video showcases a clear image of skeletal muscle, highlighting striations and the arrangement of peripheral nuclei. * *1:42** Identifying Skeletal Muscle:* Even without visible striations, the presence of peripheral nuclei can confirm skeletal muscle tissue. * *2:52** Muscle Fiber Atrophy:* The video introduces the concept of muscle fiber atrophy, characterized by dark, hyperchromatic, multinucleated cells with some visible striations. * *3:41** Challenges in Diagnosis:* Atrophic muscle cells can resemble pleomorphic nuclei, particularly in tumors like desmoid fibromatosis, potentially leading to misdiagnosis as sarcoma. * *4:25** Recognizing Atrophy Patterns:* Muscle atrophy typically occurs in clusters of cells with varying degrees of atrophy. * *4:51** Desmin Staining:* Atrophic muscle cells can stain positive for Desmin, further complicating diagnosis as it might be mistaken for rhabdomyoblastic differentiation in rhabdomyosarcoma. * *6:16** Alternative Atrophy Appearance:* Atrophic muscle cells can also present with enlarged nuclei and open chromatin, particularly in settings of active tissue repair or inflammation. * *7:51** Diagnostic Considerations:* This type of atrophy can be mistaken for atypical or malignant cells, especially in cytology specimens. * *8:41** Importance of Understanding Reactive Changes:* Studying reactive changes in benign settings is crucial for accurate diagnosis in challenging cases. * *10:00** Real-World Application:* Recognizing reactive changes helps avoid diagnostic pitfalls, especially when evaluating tumor margins during surgery. * *11:00** Muscle Atrophy in Different Staining:* The video demonstrates muscle atrophy visualized with a PAS stain and green counterstain. * *12:08** Longitudinal Section:* Atrophy can also be observed in longitudinal sections of muscle, showing irregular outlines and contracted fibers. I used gemini-1.5-pro-exp-0827 on rocketrecap dot com to summarize the transcript. Cost (if I didn't use the free tier): $0.02 Input tokens: 17497 Output tokens: 408

[@filipristovski7081]

I have a question: Does papillomatosis occurs in the epidermis? Thank youu

[@JMGardnerMD]

Yes