"Gottlieb body" (eosinophilic inclusion) & Touton-like vacuolated melanocytes in nevus (pathology)

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Multinucleated melanocytes with fibrillary or vesicular cytoplasm and eosinophilic cytoplasmic inclusions are usually found benign long-standing nevi. Thus, this finding is a clue for benign melanocytic lesions (I don't recall ever seeing one of these inclusions in a melanoma). I really love this little eosinophilic inclusion because if you zoom in close you can see that it has little radial projections around the periphery and a bright dot in the middle. It reminds me of a tiny sun. ☀️ And I also love this particular multinucleated melanocyte because of it's lovely Touton-esque ring of multiple nuclei. If you look carefully for these multinucleated vacuolated melanocytes, you will easily find them (in big polypoid congenital pattern nevi especially). And some of them will contain these little eosinophilic inclusions. They are often overlooked, but they aren’t rare. Thanks to my friend, Silvija Gottesman, MD, who taught me via Twitter that these inclusions are called Gottlieb Bodies.
References:
Gottlieb G. A cytopathologic finding as a clue to diagnosis: eosinophilic cytoplasmic inclusion bodies in melanocytic nevi. Dermatopathol Pract Concept 2002; 8: 4.
Shon W, Wada DA, Gibson LE, Flotte TJ, Scheithauer BW. Distinctive eosinophilic cytoplasmic inclusion bodies in melanocytic nevi: an immunohistochemical and ultrastructural study. J Cutan Pathol. 2011 Nov;38(11):865-70. doi: 10.1111/j.1600-0560.2011.01764.x. Epub 2011 Aug 8. PMID: 21819442.
pubmed.ncbi.nl...
Patino WD, Hutchens KA, Kapil J, Chiou Y, Gottlieb GJ. Eosinophilic cytoplasmic inclusion bodies in vesicular multinucleated melanocytes: a clue to the diagnosis of benign melanocytic lesions. Am J Dermatopathol. 2012 Jun;34(4):424-7. doi: 10.1097/DAD.0b013e318216a822. PMID: 22617134.
pubmed.ncbi.nl...
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This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
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[@tahadirim3811]

TY for sharing good lecture for us as always

[@alexanderp7402]

Thank you for sharing!😊

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❤