Notch Signaling Pathway | Purpose and Mechanism

Lesson on the Notch Signaling Pathway. The Notch signaling pathway is a highly conserved and critically important pathway in homeostasis and the development of sensory hair cells and branched arterial networks. The Notch signaling pathway derives its name from the NOTCH receptors, which are activated through ligands located on the cell membrane of other cells (sending cells). The NOTCH receptor is composed of three domains, the extracellular domain, a single transmembrane domain, and a notch intracellular domain (NICD). Upon ligand binding to the Notch receptor, the Notch receptor undergoes cleavage reactions, releasing the NICD into the cytosol. The NICD binds to the complex of proteins, which translocate into the nucleus and activate Notch target genes involved in cellular proliferation, differentiation and apoptosis.
Hey everyone! Here is a lesson on the Notch signaling pathway. In this lesson, you learn what the Notch signaling pathway is, why it is important in development and homeostasis, what ligands activate the Notch receptors and the Notch signaling pathway, and how the Notch pathway leads to the expression of Notch target genes.
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[@Brickkzz]

Brilliant concise video! I think the cleavage of intracellular domain of Notch is usually called gamma-secretase.

[@Endymion5000]

Excellent! Clear, concise, and very understandable. Just subscribed!

[@ReginaHüttner]

great explanation, thanks!

[@michellew4634]

so helpful! thanks for making this!

[@roabashmail8433]

Thaank you soo much it is more than helpful it is treasure !! thanks a gain

[@animatedbiologywitharpan]

Nice explanation

[@christopherchen6937]

Wow!!! It's very brilliant!!!!! Thanks!!!!

[@ExploreWithMe15-y8w]

very informative and helpful

[@sanjaisrao484]

Thanks

[@marwaali4821]

Thank you

[@bluemug111]

Thank you so much

[@danielgladish2502]

4:38 by p21 are you referring to RAS or CDKN1?

[@elizabethhu4508]

From what I read, I thought the NICD translocates into the nucleus first and then binds CSL? Am I wrong?

[@jazminefulgencio1543]

you're right. NICD translocates to the nucleus where it interacts with CSL

[@victorf.martins8296]

JJ Medicine make a video explaining the erbb4 signaling pathway please

[@woodbinson457]

Love of my life

[@nasranaizi2714]

what does the NOTCH acronym stand for?

[@SeeWoelfin]

It is not an acronym. It comes from Drosophila research: the phenotype which showed a little 'notch' in the wing. As this is a highly conserved pathway, similar genes are found in humans.

[@dukherdohonekorunrodone6346]

mind bomb!!

[@alexkmile]

the whole video is a mind bomb!!

[@ezfit3367]

1:27

[@Archana2234-t5u]

4.57 what is the name of ligand?

[@mohammedelberawi8440]

Thanks very much