Ethanol Absorption and Metabolism | Alcohol Metabolism Pathway

Lesson on Ethanol Absorption and Metabolism.
Hey everyone. In this lesson, you will learn about how ethanol is absorbed, the factors affecting alcohol absorption, where ethanol is metabolized in the body, and how ethanol is metabolized with alcohol dehydrogenase and through the microsomal ethanol oxidizing system in the liver.
In the next lesson, we will be looking at the consequences of ethanol metabolism on other cellular metabolic processes, including glycolysis, gluconeogenesis, TCA cycle and fatty acid synthesis and oxidation.
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***EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only.***
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@lisa-rouletlawfirm9307]

Great explanation, and loved how you mention that flushing is a sign of higher acetaldehyde levels triggering catecholamine release, which also implies that cyp2e1will be employed, increasing ROS

[@bodycareforhealth8656]

excellent, clear understanding of the process, shame our lecturers cannot do the same as you. thank you so much for sorting these pathways out

[@charleefr]

I'm a french speaking student and it was crystal clear, thank you so much! Much better than the stuff we have in our textbooks here (in France).

[@treasuretrails]

I chugged Heineken beer to this video on an empty stomach, I feel great right now!

[@temijimoh1529]

thi is so funny

[@Silentsister]

So helpful! Thank you for breaking this down concisely!

[@Janicemar1]

Watching when buzzed 🥂😄

[@lily-lb7xc]

Thank you so much! You made it super clear and easy to understand. Very helpful!!!!

[@ramkumartc8800]

Among acetaldehyde and acetic acid which is responsible for alcoholic effects like confusion,dare, unbalanced body etc

[@kullps6130]

Idky but I like learning when I'm drunk

[@yousifmakimahdialatraqchi6245]

😂

[@viczsomers5904]

As do I

[@damirinho14]

Pretty nicely explained and helpful. It made me understand a lesson I just couldn't grasp. So thank you sensei.

[@Komalsinghal612]

Thanku sir great ,,,,material bahout help full h sir dekte hi samj aa gya h

[@jbsilveradoo8788]

Great video, now I understand why it can be so difficult to lose weight when drinking, and how alcohol consumption can lead to major excess calories in the diet.

[@jjmedicine]

Hey John! Thanks for the comment! Glad you found it informative :)

[@yeseniarobles4289]

I think we’re also missing another key. I read somewhere else that if we have Candida it can turn sugar and carbs into alcohol because that’s it’s main food source, another reason why we can’t lose weight.

[@Angelo80907]

The idea is to include the calories from alcohol as part of your daily caloric intake so you don’t over consume making the body store carbs and fats.

[@JC-vu6sn]

Excellent! Thank you for the breakdown

[@TheFawe26]

Finally a good description. Thank you :)

[@mateofarfan8254]

Hey JJ thanks very much for the succint and descriptive lecture. Would you mind referencing where you draw your data from? It would be helpful for those of us needing to cite the information beyond your KZbin video. Thanks in advance!

[@shouldigetit]

Agreed! That would have been super helpful

[@SiegePerilousEsauMaltomite]

Mateo Farfan Just Google it and tons of medical articles will pop up, from which you can cite.

[@59shayestakhan81]

amazing!! thanku for the xplanation

[@bombbay7529]

Thank you so much. You explained it so well and understandable which i wish my professors did

[@ceciliaherpai2788]

Fantastic explanation of this proces!! Thank you!!! Excited to see how my exam goes tomorrow… 🥴😄

[@mrsjuanitabarnard]

The NASM course I’m taking says first pass metabolism happens in the gastric muscosa of the stomach lining?

[@jogeshsaini9002]

Awesome explanation

[@lalaloopsy9763]

Hi where does the H+ come from when NAD+ is reduced to NADH. Could you please explain this to me! Also your videos are amazing xxx

[@gristlevonraben]

I turn blue when I exercise, have since I was very young, i didn't start drinking until I was 32, got a book about whiskey making and I tried one (hate beer smell, so never drank it) anyway, after drinking one shot, 1st time, I got dizzy, but my hand eye coordination improved. Second time a few days later, I didn't get as woozy, but felt like I could breathe easier and hand eye coordination improved. Thinking improved too. I stopped drinking for a few years, had wine once in a while, but got some the other day, whiskey, and suddenly there was this feeling of breathing easier, and sweating. I usually sweat very little. I crave bread, wheat bread. Am I riboflavin deficient?

[@ravanabrahmarakshas4263]

great presentation. thansk.

[@keurinrin16]

Wow thanks so much❤

[@kikibear12146]

Greatttt video!!!! Ur amazing!!!!!

[@onatovonatovic526]

what will happen the excess amout of acetyl coa and nadh

[@heidihi547]

Perfect thank you

[@yogayantra]

Thank you so much

[@tibormalinsky8751]

Do you gain energy after consuming alcohol?

[@alloypaulson7520]

Psychological energy, or Caloric energy?

[@tibormalinsky8751]

@@alloypaulson7520 Caloric.

[@alloypaulson7520]

@@tibormalinsky8751 You actually do, about 7 food calories per gram of ethanol.

[@tcorourke2007]

9:15 The average drink contains 14 grams of alcohol, NOT 7 grams. 12 ounces of 5% abv beer contains 0.6 ounces or 17.74ml of alcohol, weighing 14.19 grams (0.8g of alcohol per ml). A 167 lb male consuming 1 beer over 1 hour will have a BAC of 0.013%, NOT 0.0%. If you drink one drink per hour, you will not remain sober.

[@dr_chiropractor]

His point was the entire metabolic process from CYP 450 together with ADH yields 7 grams an hour not the drink per se

[@Ivan_1791]

Great video.

[@katarinala]

Amazing!

[@googleplay9522]

Why do we get dehydrated when we drink too much alcohol?

[@Sveccha93]

Google Play alcohol inhibits ADH, a hormone that helps the kidney put water back into the blood, so we lose more water than normal to the bladder.

[@googleplay9522]

@@Sveccha93 Thanks 😊

[@merenish]

I think it's mainly to do with osmoregulation... Water is the universal solvent.. and alcohol readily dissolves in water.. so to compensate the concentration water moves towards alcohol.. so alcohol draws out water from our body cells.. that's why we get dehydrated...

[@willshepherd4544]

YESSSSSSSSSSSSSS...... thank you for teaching me how to get right proper drunk...... or I mean teaching me about what I am doing when I chug my next case.

[@badshark2740]

you killed it

[@schweizerd6303]

That acetate ion is like dissolved acetic acid flowing around the blood... no wonder why i can smell the stink of vinegar after having a few beers or wines...

[@JBgroovy]

Please say actually one more time. Just messing with you, but thanks for painting such a clear picture of alcohol metabolism! :)

[@alexanderbrandt9816]

Okay, but ... like ... when does it become something that you can absorb calories from? How does it effect blood sugar? Is metabolism not the word i'm looking for?

[@donovanlucibello6420]

Metabolism is biology-speak for converting chemical energy from one form to another. Acetyl CoA, the last molecule mentioned in the video, which should quite readily feed into the Krebs cycle (taking place within the mitochondria) - but there is a problem . . . there is too much NADH around, and through Le Chatlier's principles, it will run the reaction the other way meaning the Kreb's cycle is thwarted. Where does all of the NADH come from? Alcohol metabolism, technically catabolism, goes from ethanol to acetaldehyde (eventually to acetate to acetyl CoA). In the first and second reaction there, two enzymes are doing the work, alcohol dehydrogenase and acetaldehyde dehydrogenase. The name "dehydrogenase" is a dead give away that we are doing an oxidation reaction, and in electrochemistry, if something is oxidized, something else must be reduced; here NAD+ is reduced to NADH. The trouble starts with the excess of NADH (we actually run out of NAD+ to reduce), and a reduced molecule means "satiety or a fed state" in the cellular respiration world, signaling to the hepatocytes that no further energy is needed in the body. This inhibits to processes conducted in the liver that provide sustenance for the rest of the body: B oxidation and gluconeogenesis. What is worse is that the high [NADH] starts another process: fatty acid synthesis leading to a fatty liver (not good). The high [NADH] has another consequence, it inhibits isocitrate dehydrogenase and alpha-ketoglutarate in the Kreb's cycle. Metabolically this is equivalent to a pile up of products. Remember the Acetyl CoA product? To deal with all of that acetyl CoA, the body will make ketones (to keep the brain fed) and lacate which lower blood pH inducing metabolic acidosis - again, majorly not good. Does that help?

[@zanapoli5954]

Isn't very little ethanol met in first pass metabolism?

[@thedisturbedsoul]

🍺

[@SoakerCity]

Canadian impaired driving law does not recognize any of this science.

[@user-tq3zd7vi6h]

I suggest the author edit the subtitles, they're off.

[@RobertSelig]

Another stellar video, and thank you for mentioning zinc, but the other enzyme, ALDH, is Mo dependent, which happens to be one of the most deficient minerals in the body. Since minerals are the spark plugs of life, I hope you continue to mention the mineral cofactors bc understanding the mineral matrix is where we can move the needle to better health. Meanwhile, we can break the chains of our dependency on big pharma that have single handily destroyed the health of our population as they run and control our government hospitals FDA and all medical schools as the trillion-dollar drug cartels are a criminal family; with unlimited power and money...

[@maadeychannel8038]

Wow it so go Go on

[@ThaRealChuckD]

What is CoA....

[@tiisetsofakude3962]

coenzyme A

[@5602KK]

Watching when too drunk (too much acetaldehyde rn)

[@sean..L]

I get very red when I drink and yet I’m not asian.

[@jjmedicine]

Hi Sean. Ethanol itself can cause vasodilation, which also causes some flushing in some individuals (regardless of whether they have an ALDH-2 deficiency). Hope that helps!

[@kapikapi2195]

All lies