What is Monoclonal gammopathy of undetermined significance (MGUS)? | NCLEX-RN | Khan Academy

[@user-lj1zs3wl5l]

This is by far the very BEST explanation of MGUS vs MM. I have been diagnosed with MGUS about a year ago. Just had more blood tests ran. Will met with the Hematologist today to discuss results. 🙏 I researched like crazy to figure all this out so I could pray against it specifically, but never could quite put it into words. THIS wonderful video has made it all simple and clear. THANK YOU SO MUCH.

[@jamesgray2353]

What a happy little video! As with others who have posted, I was diagnosed with MGUS last year (aged 51). With other conditions such as Spina Bifida and osteoporosis, it seems life is really trying to tell me something. No far, no symptoms, let’s hope it stays that way. I’m a bit unnerved by the fact I’m relatively young, yet the prospect of this condition turning ugly is still one percent per year. Time will tell, I suppose.

[@micheleholden1493]

Thank you for explaining this. I was just diagnosed with MGUS at 45, And was so confused about it all until now.

[@carolweaver3269]

That you for doing this video because the more we understand, the better. Not good to be in the dark and have no idea what it is all about and what may happen or be done for your illness. Very nicely explained.

[@thomasfraser9072]

I am a 75 years old Vietnam Veteran who drank the poison waters at Camp Lejeune and exposed to Agent Orange both of which now is ruled by the VA as two presumptive causes of my now positive MGUS. So now I have allowed the VA to take on the expense to treat my Multiple Myeloma and whatever the other related cancers may be associated with it. I also now have put in claim for 100 percent service connected and know that I can go to any doctor or caregiver I deem best for me Any service Veteran who has been exposed to ares of known toxins regardless of age or symptoms. I highly recommend you run to to local VA and get tested for MGUS and if positive get treated under the New VA. Thanks for reading

[@annagreenedellera7864]

My beloved late Aunt, Major and Lt. Colonel in the USAirForce, was exposed to Agent Orange and died of multiple myeloma at the age of 79. 😞✨

[@thomasfraser9072]

@@annagreenedellera7864 I so sorry for your great loss. So far I am positive for MGUS in my urine and not my blood. So I feel luckier then most and will see the VA every 6 months to monitor my blood.

[@Ma4eto94]

This video is so good. I was reading on wiki and some other stuff and learn nothing.Here in 10 minuts I understood everything.

[@chucklepalace]

Just been diagnosed and this was a great help

[@duro123]

How are you doing today?

[@christofferjensen8068]

An excellent information on this disease.

[@unbortheredthee]

Out of everything I have read or saw this by far has been the best.

[@richardpells5974]

Great presentation. Many thanks. I have IgG kappa MGUS

[@charleycampbell4515]

Thanks for this very informative video.

[@SomarDee]

Does the ratio of those that will develop MM change if the individuals are diagnosed with MGUS at a younger age than the typical age of patients diagnosed with MGUS?

[@agladman194]

Thank you for such a clear and informative video.

[@tbone4646]

Very well explained and informative.

[@AltairKasem]

Great video and very informative. Thanks 🙏🏻

[@drjaswantsingh9970]

Thanks for the video explaining MGUS and Myeloma.It is very clear now.I have been diagnosed as having myeloma.My haematologist has put me on Inj.Zometa since 4years.Every 4months.Now they have stopped the Inj.Zometa.I am lòsing weight and having irregular heart beat.Angiogram is normal-Noblocks.I was told to review after 2years.No treatment at the moment.What should I do?Please advise.

[@apiastos76]

the best explanation so far.

[@cherylisenseecox5172]

Very good presentation.👍

[@KawaiiBaekhyun]

THANK YOU SO MUCH FOR THE VIDEO

[@stephenrichards5386]

You have made clearer a problem I've had with the 1% of people get MM. It's really 20% of MGUS patients, 1 in 5, isn't it ?

[@stephenrichards5386]

and doesn't that make the proportion of MGUS developing to MM is very high ? 20%

[@amyforrest4043]

1 in 5 of the 100 patients total. which is were 1% falls.

[@stephenrichards5386]

@@amyforrest4043 1 in 5 is 20% .1 in every 5 patients of 100 = 100/5 = 20. I think the 1% is of the whole population but it's unclear

[@alexanderschulz1731]

As I understand MGUS and MM from reading some webpages, it is a coincidence that in his example both numbers are 1% because he chosed to consider a time span of 20 years. 5% of all people of 60 years have MGUS. Therefore we have 5 out of hundred. Then each of these 5 persons has a risk of 1% PER YEAR to get MM. Since he considered a time span of 20 years (from age 60 to age 80), the risk for each of the 5 persons is 20% which results in one of them to get MM in average. And this is coincidentally 1% of all 100 persons. However, if he would consider a time span of 40 years (from age 60 to age 100), the risk for each of the 5 persons (assuming that each of them becomes old enough) would be 40% which would result in 2 persons to get MM in average. In this case, you have 2% of all 100 persons. Thus because you have 1% PER YEAR, the proportion of MGUS developing MM depends on the time span you consider. Of course, the same holds for all persons when you consider the rate for getting MGUS to be constant. But of course, this is only how I understand this situation.

[@stephenrichards5386]

@@alexanderschulz1731 Alexander, thanks. My point was that they do not seem able to clearly express exactly what they actually mean. As you say.

[@khamikos1]

thanks for the explanation .perfect

[@elbuenvivir935]

It's a great video, so educational. Thanks a lot! I just have one question. What is the reason of the patient comes to see the Doctor? if MGUS is asymptomatic, Can i only detect it with protein electrophoresis?

[@journeyon1983]

For me, I went to the doctor feeling sick and was sick for many days with a low grade fever. That's when they drew blood from me. The findings of that blood test said that I had MGUS. So the answer to your question is MGUS is discovered because you went to a doctor for some other problem and this was discovered in the process. That's what happened to my mother who was diagnosed with MGUS and years later progressed to MM and then she died almost 4 years later. I don't know how long she had MGUS before it mutated to MM. For me, I was diagnoses with MGUS about 9 to 10 years ago and have to go to an oncologist for a blood draw every year to see if it has progressed to MM or not. It's like having a time bomb in you. My mother died in horrific pain, towards the last year of her life. She fought it with all the medications they had back then. She was told that she would only have 3 years to live. Getting back to the tests, once the blood tests came back, I had to have other tests done such as a 24 hour urinalysis where you pee into a bottle for one whole day and then a bone marrow aspiration which is an extremely painful procedure to have and I vow, to this day, I'll never have that done again no matter what. Once those other 2 tests come back is when they either tell you you have MM or MGUS. Either way you have to have your blood tested once a year (MGUS) or more (MM).

[@sfom1098]

very brave of.you ...how old are you sir?

[@journeyon1983]

f umair syed If that questioned was aimed at me, I will be 60 years old on one week. If your question was for someone else, I apologise.

[@sfom1098]

YES it was for you...recently a lady came to my clinic .she is 82 yrs old and her serum protein results just came back .showing monoclonal gamopathy.apparently MGUS . Iwill be breaking news to her and family in next visit..but before that i wanted to see some valuable groups when i read yr comment here in this video....couldnt resist asking yr age....!!

[@journeyon1983]

f umair syed Right. I think I was 48 or 49 years old when first diagnosed. People can get MGUS at any age. I've read somewhere as early as in their 20's and 30's. Remember that there is no treatment for MGUS as it has no symptoms at all except elevated protein levels in the blood. The only time to worry is when MGUS turns to Multiple Myeloma or some other disease. Right now she is fine although it can be shocking and depressing to know that you have MGUS at first. I went through those feelings and it was hard but I got over it. She's 82 years old and has lived a full life already. Most people don't live to be that age, my family, for example. My mother died at age 79 (8 years ago) after being diagnosed with MM at 75. Today, there are a lot more treatments for MM than what was available at the time my mother was alive. I wish your 82 year old female all the best.

[@jessicamalki1358]

this was a great video thanks!

[@jordancz1]

You're the MVP this week 👌👌

[@patelharsh4695]

So what is different between MGUS and SMOlDERING MM ?

[@toppuerkito4462]

what about a spike in beta ? is it the same?

[@heatherdaigle822]

I'm 42 and have mgus

[@hira2349]

Mashaa'Allah 👍

[@ahmedsayyah4684]

gercekten cok iyi ellerine sagilik

[@drminamansour4218]

Many thanks

[@thomasfraser9072]

Not an Advertisement! I am not a lawyer or paid by any law firm to make this announcement If anyone worked or had family members at Camp Lejune prior to 1987; civilians or not please go to the VA regardless of symptoms to request a MGUS Test. You won’t need a lawyer if you can prove on your own that you were at Camp Lejeune prior to 1987. You can file suit directly against the Marine Corp; Veteran or not. Don’t allow a lawyer to take 40 percent of your settlement money which could be substantial. You must put in dollars what you personally are willing to settle for. If the judge rules less in your case; take it as an appeal will likely get you nothing. If you put 0 dollars you get nothing. This was an important public announcement and not an advertisement. It is the real deal. I am not a lawyer but I know because I have MGUS and will be filing on my own behalf.

[@thunderstrike-rw4hn]

No mgus is not asymptomatic I can give you links to other specialist who will say this as someone with this I can say from experience its not asymptomatic I suffer greatfly I get hyper calciumiana

[@serenitynowyolo]

It is not asymptomatic! They have just recently changed this in medical books! They need to stop saying it’s asymptomatic. It is not ! I suffered for raynauds, Idiopathic urticaria, regular illnesses, since i was young ! I was diagnosed at age 26 but was advised I acquired mgus at age 15. I wish they would stop saying it has no symptoms because they attributed this disorder in the elderly ! They need to investigate mgus in the young and listen to our symptoms ! Guys we are telling you it ain’t without symptoms! It is not asymptomatic! Mgus is now recognised as a autoimmune disorder.

[@45_purnotamahmud83]

Videotapes

[@Emsyfair]

h

[@reidhart130]

Very informative , Thank You 🙏🏿😇🙏🏿