Decoding the Aging Process: The Impact of Blood Dilution on Biological Age (Irina Conboy at EARD)

[@LifespanIO]

Find more discussion of longevity science and technology on our EARD playlist at kzbin.info/www/bejne/oIPCpH-ge9qoZrM

[@RyanOShea00]

Huge fan of Irina Conboy. Great talk!

[@rodneybaker5562]

Recently read an article out of Berkley that mentioned Irina was a researcher who pushed her research out to the research community/public in effort to move this field forward as quickly as possible. I was unaware of this. And I am very excited about her attitude. Wishing they all did the same. So a BIG THANKS to Irina for doing what she thinks is right. And being right about it. A heartfelt thanks you Irina from Rod Baker. 😀😀😀

[@rodneybaker5562]

Don't misunderstand, I'm a fan of her and her husband's work and all the folks working on it. Been watching for years. Am 70 and frustrated with how slow it takes to get things to market. In the time I've been following this saga on anti-aging I've gotten a good lesson on people's motivations. Even in the scientific community, it is always about the money. But in the scientific community where colleges are involved, I'd have thought less of that was involved.

[@stefanallard3084]

Go to Mexico n get stem cells, what are you waiting for?

[@janchristian514]

Between poor microphones and Irina's accent I am missing her more complicated expressions. I am not a scientist. I think she would reach a lot more people if she would let a native speaker of English read her results on KZbin. Thank you Irina!

[@tinox12]

aweome presentation. much appreciated

[@zaryadka-seplitza-live]

Thank you, Irina! Great info! We are a group of longevity fans. Could you recommend a test to measure biological age with means available in regular labs? We do some exercises and diet protocols that make followers look younger, it would be wonderful to get some proof with their biological age dynamic.

[@rodneybaker5562]

Heard this conversation many times over last few years. The question is where are we in getting something to the public. Unfortunately for the public, these scientists have not been able to synthesize something original out of this to patent.

[@nozhki-busha]

Well given its in clinical trials at the moment, I guess we will see wont we?

[@rodneybaker5562]

@@nozhki-busha Thansk Jensen. Could you be more specific about the trials? I link would be great.

[@andymack8178]

Actually, it is performed for the public. Dopri does it in his office in San Francisco. 6 treatments of plasma blood exchange. Once per month. The cost you say? $6000 each for a total of $36,000. Her presentation might be a promotion for his business, their business

[@rodneybaker5562]

@@andymack8178, You can donate plasma for cash. Yep, they'll give YOU money. Will replace your plasma as Dr. Dopri Just not near as much. only one pint at a time. So why the 6k per session? Just thinking this is all taking too long with everyone racing to monetize anti-aging. If they like their fellow man so much, let's start doing something. These are universities often using public money.

[@Nelis1324]

Not really a properly done double blind clinical with controls.. so who is going to take that seriously?

[@JacobAFarmer]

Is anyone studying people who regularly donate blood plasma? I imagine that neutral blood exchange is the same process involved in plasma donation.

[@garvintimmann]

In past papers it is not the replacement of albumin that is causing the rejuvenation. It is just the removal of old plasma from middle age onwards. Replacing just saline. The more interesting therapeutic application is for removal of amyloid plaques that attach to albumin.

[@JacobAFarmer]

@@bestgtor22 the interesting thing is that there are companies that actually pay you to donate plasma. Supposedly they can accept a donation twice a week, although Red Cross will take only once a month, and only for type ab male donors.

[@Matt-jv3mk]

@@bestgtor22 Do you have a reference (doi) for that study?

[@nickjunes]

Great talk.

[@Montie-Adkins]

So, how long until this is something anyone can have done?

[@warioland523]

Not long. A typical medical process requires an approval that generally takes a few years provided things go well. You can read the rejuvenation roadmap. It outlines future medicine that's in clinical trials as well as those released.

[@nozhki-busha]

They are already using an FDA method to achieve this called plasmapheresis. Clinical trials are already underway with Dr. Dobri Kiprov, so it probably is not too far away from being available.

[@peterz53]

you can do a light version of plasma dilution by making monthly plasma donations (in US). I switched from normal whole blood donation to plasma (or platelet) donation in early 2022. They take about 25% of my plasma each donation, with some of volume loss made up by saline. Since early 2022 I've replaced about 4 plasma volumes. There are also plasma-only clinics which will allow two donations per week, so you can quickly turnover your entire plasma. All free of charge. Just have to pass medical screen. Suggest getting before and after blood work

[@garvintimmann]

@@peterz53 Peter I already donate 700ml of plasma monthly, is that therapeutic as I am 44 years old?

[@garvintimmann]

@@bestgtor22 that is a lot of donations, I am in the UK and we have "Give blood" they take the blood plasma at 700ml, which i already do monthly. They ask the donor to drink a lot of water before hand as their plasmapheresis machines do not return saline. After i drink 2 litres of water the donation flows at top speed and works every time. It does leave a little scar spot where the 16 gauge catheter needle went in, I am told by the nurses the vein over time scars. Can you link the study you replied on " 5 year reduction in DNAm test age" after 8 monthly donations?

[@peterz53]

Wish Irina's lab would profile/evaluate older humans who do normal plasma donation on a regular basis which takes about 25% of plasma out and no albumin added back in. This could have profound implications if shown to be positive and would undercut all the quacks who are trying make fortunes selling this process for thousand per exchange.

[@kathb1683]

How long does the results last from the dilution treatment?

[@iWatchFromBehind]

How to ensure you're taken seriously: wear a tie-die hoodie (hood up) during your very serious academics talk

[@garvintimmann]

its not like she is in her pyjamas

[@coffeebreakchat2450]

When talking about that senolytic drug, cant it be preceded with Olive Oil? I believe Olive Oil reliably opens the blood brain barrier.

[@stefanallard3084]

Dmso

[@Seeker_of_sense]

So she still hasn't figured out which blood factors are responsible for the rejuvenation? As someone who has been in biomedical research for decades, I can only shake my head. She represents everything that's wrong with the current state of academia.

[@nozhki-busha]

Read their papers starting from 2005, in those papers they have suggested most likely molecules, including TGF-beta. Start with "Rejuvenation of aged progenitor cells by exposure to a young systemic environment" and work your way through her publications. While the entire picture is not yet revealed, the Conboys have made solid progress in this direction over the years.

[@garvintimmann]

that is a bit harsh. there are many plasma proteins that change from gene expression from young to older blood. Finding what is causing that change in gene expression is not easy, it could take decades. For now just removing middle aged/old blood plasma with saline replacement will help somewhat. As you are working in the biomedical research field you have access to mesenchymal stem cells using Flow cytometry - Fluorescence-activated cell sorting. You can donate blood plasma today.

[@Nelis1324]

Their therapy works by substraction, dilution, not adding new factors, so what is your point? Would this not be more relevant for research that adds young blood?

[@coffeebreakchat2450]

@@bestgtor22 If I understand the Conboys work correctly, I think they are claiming that once the detrimental factors in blood are removed/reduced, expression of Klotho and many other good genes will dramatically increase.