Plasma Dilution Rejuvenates Cognition and Reduces Neuroinflammation

[@hyperkeimeno]

Thanks LEAF for helping us solve the human aging problem! This video has a bunch of exciting info!

[@BrentNally]

Exciting stuff from Steve and these brilliant scientists! Thanks everyone!

[@SolvingAging]

The Conboy’s are extremely underrated in my opinion. They’re soooo brilliant!

[@neilchristensen538]

This was an awesome journal club as always. Thanks to Irina and Michael for joining us and for doing this incredible research! Thanks to LEAF for arranging this! There is so much to be excited about NBE and TPE, and I can’t wait to see there next paper discussing enlarged testing parameters for TPE in humans. (Coming out in a few months! See 39:00).

[@Health.First.]

I hope Oliver is ok

[@nozhki-busha]

Thanks for the concern, he is having a hard time at the moment but we are supporting him best we can. His laptop had a meltdown this week, which is why he was late.

[@georgefairweather1990]

This was such an exciting discussion! Thank you for posting this. I'm looking forward to more.

[@peterz53]

On the blood donation issue - it takes about 6 donations to remove about 50% of whole blood. For blood donation to work, the old factors would have to stay suppressed and not grow back in between donations to any significant degree. i.e continue to decline with each donation. Only way to know is to do this and test. If we knew the identities of the major negative factors and their biological half lives and production rates it would help a lot in tailoring interventions.

[@surfreadjumpsleep]

Would be nice to see a study which tracks the effects on LDL and arteriosclerosis.

[@catorepublic]

Thank you for this terrific interview. Does neutral blood exchange reverse skin aging, or is there an expectation that it might do so after a certain amount of time? Please bring the Conboys back on the channel after they publish results from their human trial!

[@nozhki-busha]

We will have to find out in human trials! Once there is more data we will be reporting on it for sure.

[@Pyriphlegeton]

0:15 ...Oliver is detained? I'm not a native english speaker, does this have a meaning besides being held by the police?

[@Danuxsy]

No you're right, Oliver tried to rejuvenate folk on the street by giving them syringes filled with blood from the young ones, he was later taken by police and is now being questioned.

[@AgingsAProblemFPS]

@@Danuxsy Are you serious?

[@Danuxsy]

@@AgingsAProblemFPS No but it does sound plausable, doesn't it?

[@altargull]

It can mean he is busy or otherwise engaged. It doesn't necessarily mean held by the police.

[@Pyriphlegeton]

@@altargull Ah, I see! Thank you! :D

[@surfreadjumpsleep]

Excellent. Nobody asked about using an epigenetic clock to verify and see if actual reversal of aging occurs after the nbe. I understand that there was a paper maybe a year ago that did this. So is this the reason why everyone was talking about doing clinical trials rather than using the epigenetic clock?

[@nozhki-busha]

Matthew, based on my many conversations with them, the Conboys are not fans of the epigenetic clocks and consider tissue rejuvenation more than enough to support their work. I would personally be very interested to see it tested with several clocks and perhaps during trials this will happen. - Steve H

[@surfreadjumpsleep]

​@@nozhki-busha Hello Steve Hill the Englishman. I love that you rock Games Workshop & role playing paraphernalia in the videos. I too used to be a big time gamer with my bag of many sided dice and stacks of adventures. We called it D&D and AD&D (the new thing back then). If all this life extension stuff works, I'd like to yet return to those days. Could you recommend a certain commercial epigenetic clock test? In your opinion will the cost of these services come down soon or will it take a long time?

[@peterz53]

Look up their May/June paper on same subject. They did a lot of proteomics analysis which might me as good or better than meth clocks. But admit I would like to see meth clock data too. just to see what the trend is.

[@garvintimmann]

Steve Hill how can we read more on this?

[@romaniamyland6191]

amazing work

[@peterz53]

After learning of this work by the Conboy Lab I noticed that my local blood bank, which I occasionally donate too, was asking for plasma donors. When I asked about their process, I learned that they take out about 20% of old plasma (plasma makes up about 55% of blood volume) and that the body will make up the volume within 48 hours. I'm assuming that the body makes up the volume without an immediate rebound of old factors and therefore there will be a time period where repression of youth factors will be diminished. Anyhow, I'll be doing plasma donation starting in about 6 weeks and doing three donations in a row, 4 weeks apart. And do CBC and CMP blood testing before and after along the way to see what changes. At 66 yo, hoping for something positive. As for albumin, if your liver is in good health the albumin should rebound fairly quickly, but I'll know for sure with my blood work.

[@billyjean9484]

Peter, How did the donations go? Did they rejuvenate you?

[@peterz53]

@@billyjean9484 I've been doing plasma and platelet donations steadily, more or less, last two years, turning over at least 7 plasma volumes. But I don't have any objective markers even though my blood work is very good for my age (Levine Phenoage is about 17 years younger). I am going to start using a few of the human markers, like DNA damage and Immune system cells, from the Conboy 2022 paper, and start tracking those as well. Outwardly, I can't see anything, although my graying seems to have stalled (probably imagination). I suspect that if it helps it will be evident over a much longer period of time.

[@viktornilsson93]

GUYS. The most potent combination would be low light laser after, to trigger new bone marrow stem cells. This would be nr.1 synergy, and ne.2 a NAD+ infusion iv

[@ortcloud99]

Why would those work better after plasma dilution?

[@viktornilsson93]

@@ortcloud99 cause you remove the gunk with dilution and will trigger stem cell growth so the body will get superchaged with LLLT n nad+ iv

[@ortcloud99]

@@viktornilsson93 LLLT and NAD are great and all but why those things after plasma dilution. Do you have any research on that? Research says oxytocin and gdf11 and young plasma should synergize with plasma dilution or any old factor removal procedure

[@viktornilsson93]

@@ortcloud99 it says itself that it will have synergy, just like blood donation n LLLT nad after

[@ortcloud99]

@@viktornilsson93 How do you know blood donation and llt and nad have synergy?