MAD HONEY Toxin Synthesis (Educational): Science & Chemistry of Grayanotoxin & Kalmanol

[@totalsynthesis]

Thanks for watching! Hope you learned something new or liked it!

[@user-mp4bc9qp2x]

great video really interesting. it's great you split up the topics. as a practicing organic chemists i personally prefer the second half but you do a good job of making even me interested from the beginning, even though it's more biology than i can normally stomach.

[@KwK-c7t]

This content is amazing, i love to dive deep. Of course i learn something and i like it a lot. Thanks for your work 🖖

[@totalsynthesis]

Thanks, love to hear that!

[@mickaelfer5621]

The main reason why we try the synthesis ? The fun bro 😎

[@TheMcSebi]

well researched

[@mimortal1000]

Loved your exercises, I would love to do more of them !

[@seankinney3797]

At 18:39, why does the Gringard reagent not react with its own ketone group? I don't see why that ketone group would be any less reactive than the ketone of the other fragment, but I am only an undergrad.

[@KrasaGalyaShararam]

Coordination with LiCl prevents Grignard reagent from reaction with its own carbonyl group. You should definitely check out 'turbo Grignard reagents' to learn more about it

[@mickaelfer5621]

That s indeed a nice question :)

[@KevinChen-u2n]

I suppose it is more about controlling the temperature. Mg-halogen exchange is relatively facile and can happen under low temperatures, while additions often require higher temperature. If you add the aldehyde to the prepared grignard reagent solution at low temperature and then increase the temperature, the addition will happen at the aldehyde, since an aldehyde is much more electrophilic than a conjugated ketone.

[@seankinney3797]

@ thank you for the explanation!

[@Chemicator]

The synthesis route of Kalmanol was really interesting, particularly the ring closure of the core macrocycle. Great job!

[@exoric7408]

Great content and in-depth explanations as always !

[@kekaodotexe443]

good videos first of all

[@totalsynthesis]

You were fast af

[@Thaumius]

In the michael addition of the vinyl group (20:12), what explains that it occured from the top face?

[@Khalastas]

I expect it's the hindrance arising due to the vinyl group on the other ring

[@dannyagunbia206]

One of my favorite accounts

[@totalsynthesis]

🙏🏻

[@Nepetaa]

Sollux reference?

[@Farvadude]

did hussie know about this stuff before it went viral? he knows a lot of esoteric shit

[@pzkmpfIV]

waht

[@Trizzer89]

If it cures epileptics, why not use it in medicine?

[@totalsynthesis]

Their claims were cap, it doesnt

[@MandrakeFernflower]

It really doesn't it just gets you fucking munted It does seem to have antibacterial and painkiller effects however - there is an unusual drug called "Labrador tea"

[@Nvortex15]

unsubbed for AI trash

[@dvdvelde]

Where?

[@bigironenthusiast9343]

whats the ai?