Making a Hypnotic Sedative from Acetone

[@emmanueleferrarotto2986]

Some time ago i worked in a factory that (next to other stuff) made this bloody stuff in the tons range Gave us all sorts of problems with the centrifuge and discoloration and quality control Edit: The reason you can't find any literature about the reaction mecanism is, that the mecanism is not fully understood yet. I searched for it for the better part of a year and could only obtain some information on side products and reaction conditions Never again but very nice video once again

[@Standing.W.Israel]

Why would anyone make this stuff in the "tons range"?

[@emmanueleferrarotto2986]

@@Standing.W.Israel it is used as a preservative in cosmetics and pharmaceuticals

[@bigredinfinity3126]

@@emmanueleferrarotto2986 imagine accidentally ingesting some lipstick and go to sleep for a month

[@snoowbrigade]

You are actually my favourite chemistry youtuber Apoptosis, you always cover reactions that I am interested in.

[@integral_chemistry]

Thank you so much! I'm very glad to hear it. Feel free to shoot me an email if there's anything specific you'd like me to try

[@twirlyturd4364]

He is the GOAT 🐐

[@integral_chemistry]

@@twirlyturd4364 :) I wish I was better at taking compliments lol. So happy you guys like my videos!

[@twirlyturd4364]

@@integral_chemistry pls adrenochrome synthesis lol

[@sinisterrectus6010]

The half-life is long because it's a tertiary alcohol, which cannot be readily oxidized like chloral, or trichloroethanol, or ethanol.

[@integral_chemistry]

Yeah thats what I figured. I honestly am not sure if your body can even oxidize it at all, I think I read somewhere that it is metabolized by glucuronidation or sulphation, and then eliminated renally.

[@user-nu8in3ey8c]

@@integral_chemistry I wonder if it could worsen liver or kidney function if there is already a reduced function of those organs. With its half life, I wonder if it could cause a stead and long term decrease in renal function for someone that has CKD and does not know it.

[@isaackimball6716]

@@user-nu8in3ey8cif it’s that hydrophobic, probably not. Kidneys typically filter out H2O soluble compounds, that’s why the CYP enzymes and glucoronidation exists. I bet there is some reactive intermediate from depletion of glutathione from glucoronidation pathway saturation.

[@user-nu8in3ey8c]

@@isaackimball6716 That sounds reasonable.

[@TjallieBrrr]

Just like 2m2b, i need a video about that

[@samsonsoturian6013]

Excuse me, does this cloth smell like chlorobutanol?

[@PiotrBaczek87]

very clever Jimmy Carr reference +1

[@V8-friendly]

😂🤣😂

[@CamelGarage]

Why yes! Yes it does in fact smell of chlorobutanol! Might I have another whiff?

[@alllove1754]

They just haven't eaten before. It's loveliness smell is too nasty to consume, but to make that joke more fun, the question would have to be, "excuse me, does this cloth smell like chloroform?"

[@amandahugankiss4110]

*thump*

[@carelessanonymous6570]

Feeling crossed for a month sounds like absolute hell on earth

[@integral_chemistry]

Yeah sounds like the worst torture possible. Tbh this chemical got scarier and scarier the more I read about it

[@jamiemoore1056]

Some people looking to not be in this reality would find its extended action a positive, but the hat man will not have that 🎉

[@MRblazedBEANS]

It doesn't work like that with super long acting benzos or phenobarbital. The high is still like 20 hours, and yes with phenobarbital it's half life is like 20 days, you are not feeling the phenobarbital for 20 days more like 10 to 12 hours yet you will test postive for weeks after it wears off.

[@saschalinz5847]

Oh, yes, this is the longest acting substance, ever heard! 😮

[@Rossin816]

Facts

[@charlesnathansmith]

We hibernating through winter with this one, boys!

[@DontKnowDontCare6.9]

Yeah good luck with that.

[@CassidyGentry-lq8qf]

Very well done!! Very informative 😊😊

[@BlackSoap361]

Narrator: all these hydrogens are replaced with chlorine. Graphics: bromine, everywhere. Audience: let’s make chloroform jokes.

[@integral_chemistry]

Lol honestly that is my bad 😅 I should have made my own graphics with chlorine instead of bromine but the ones I found looks so clean I couldn't help it

[@PirateJohnson]

That's shamefully inconsiderate,​@@integral_chemistry

[@lagrangiankid378]

You could easily further purify the chlorbutanol through sublimation. Mix it well with some calcium chloride in a beaker to further dehydrate, then heat from the bottom and crystallize on top on the exterior surface of a round bottom flask filled with ice water.

[@michaelevans6216]

Is this a common method for recrystallizing compounds that sublimate? I’m not far along in my chem education but it seems like that would cause a bit of loss.

[@hugostiglitz6823]

​@michaelevans6216 as with any re-x there's always a loss.

[@gyanjury6753]

Where do you guys learn this stuff? Genuinely curious

[@lagrangiankid378]

@@gyanjury6753 Sciencemadness forum, wikipedia and youtube obviously. Also, textbooks and college chemistry classes are also an option...

[@jeffcarey3045]

I don't know how I got to this video, but now I bet I'm on a list.

[@jeffcarey3045]

Somebody liked my comment. I get a notification. Now I'm back again. I'm definitely on a list now.

[@MachenSS666]

​@@jeffcarey3045YES JEFFREY...YOUR ON OUR GOVERNMENT WATCH LIST...BE SEEING YOU JEFFREY...

[@chemistryofquestionablequa6252]

I've made this, definitely don't try taking it since a lot of the dosage information is incorrect and it's got a half life of something like 37 DAYS. I wasn't back to normal for nearly a month, my wife still brings it up occasionally...

[@V8-friendly]

Good job man! 😎👍 🛋️ 😴 💤

[@lagrangiankid378]

I'm gonna take it anyway. What dosage would you reccomend? I was thinking something like 200 mg would be active yet not too overwhelming.

[@chemistryofquestionablequa6252]

@@lagrangiankid378 I'd keep it under 300mg which was the medical dose for sleep and I wouldn't take it more than once a month.

[@jacobbrown7367]

​@lagrangiankid378 if you aren't going to listen to the SERIOUS AND EMPHATIC warnings to not do this, I would not recommend starting with something so large as 200mg. With a halflife of over a month, you would not process out all of the chlorobutanol for 5-8 months, with 6mg remaining at 5 months and finally reducing to >1mg at 8 months. I will not provide a suggested dosing amount as I am not a pharmacist not do I want to encourage anyone to attempt this, but anyone stupid enough to do this needs to be aware that a half-life time is the time to half the original dosage and should plan accordingly. You will be in a highly suggestive state for at least a month, you will have a bad time and you will make regrettable actions.

[@lagrangiankid378]

@@jacobbrown7367 200 mg is not that large of a dose for something with this level of psychoactivity. For comparison chloral hydrate is dosed at 500 to 1000 mg. The OP of this thread ingested a gram or so if I remeber correctly and this lead to overdosing. And (unlike you) I know precisely what the elimination half-life is (which by the way usually refers to blood levels, not to the total amount in the body). And by the way 37 days is the half-life as measured in vitro at a pH of 7.4, terminal elimination half life in vivo in healthy human subjects is reported to be only 10.3 days (C Tung et al., Biopharm Drug Dispos 1982). I have quite some free time as I'm currently taking a vacation so there's plenty of time to recover and this self experimentation won't have any significant consequence. I know what I'm doing and I'm highly prepared, experienced and equipped. I just asked some anecdotal dosage information as there is little or no human data on this obscure and very old CNS depressant.

[@octymocty132]

This has given the confidence to go on dates again thank you !

[@markrix]

Heh long lasting for repeated pleasure

[@markrix]

Don't tell diddy

[@prestonburton8504]

hahahahaha! Nice! 'first date- you seem kind of odd'. Why yes, yes i'm going through a spell'

[@bigjoe8922]

You are on at least 100 lists right now expect a visit 😅😅😅😅

[@fungoose2195]

sounds fun, let's watch this video before it gets shadow banned by youtube. Love your stuff bro keep up the good work, i know KZbin can be a cruel mistress sometimes.

[@Kyu_97]

Whoah, loved to see a haloform reaction taken into practice!!! This is such a scary chemical... You have great video ideas!!

[@integral_chemistry]

Thank you so much! The haloform reaction is super cool, been trying to think of ways to implement it lately.. maybe iodoform next?

[@Pr0toPoTaT0]

I liked and subscribed for more dope chemistry dude! 10 minute's and you somehow managed to explain like everything and anything i couldve wanted to know

[@Mis73rRand0m]

The smell becoming overwhelming and gross is probably due to how our scent receptors oxidize aromatic compounds, something about them becoming overloaded or the accumulation of side-products of oxidation forming complex molecules with other organics (from your tissues - hence the cancer/degenerative disease risk from many volatiles) that also get processed but register as rancid or acrid due to similarity with rotting meat or spoiled fruit smells.

[@integral_chemistry]

Huh.. to be completely honest I've never considered that explanation before but it does make perfect sense. Also would explain possibly why the more reactive molecules (like pyridine) just smell bad instantly from the get-go

[@AsmodeusMictian]

This sounds like a terrifying chemical. Neat synthesis, mind you...and fantastic video. Scary as shit substance though o__o.

[@integral_chemistry]

Thank you so much! And yeah it got worse the more I read about it. Interestingly enough in my research I came across what is absolutely the most horrifying chemical I've ever heard of: EA-3167. It has the same effect as datura or extremely high dose Benadryl but with a psychoactive peak of 10 days instead of a few hours..

[@AsmodeusMictian]

@@integral_chemistry Why do I get the feeling that EA-3167 got some research done on it by a certain 3 letter agency here in the states? They had a period where if it caused hallucinations or removed you from reality they figured they might be able to use it as a weapon of war. (Spoiler Alert: Not really, no.)

[@davidfetter]

@@integral_chemistry on the scale of the things they were making and testing on people at Edgewood Arsenal, that stuff was relatively tame.

[@Spencisuar]

​@@integral_chemistryI cannot begin to fathom how terrible this would be. I sitting here after the video thinking it would be like being on Ambien for a month... I thought about how bad my ketamine treatment experiences lasting that long. Not I'm sitting here trying to comprehend datura for a month.. absolutely wild stuff. Thank you so much for the videos and comments.

[@aSCrouton]

this stuff smells like an artificial chemical trying to not smell like an artificial chemical

[@integral_chemistry]

LMAO that is the best way I've heard it described

[@areVekiM]

Hahahahaha

[@pigglywiggly6373]

This dude made his own tranquilizer at home way to freakin' go homie. Shit is getting deep here on KZbin.

[@experimental_chemistry]

@Apoptosis: Since this platform is ghosting all answers to my answering comments (accept for the ones from the creator himself, but even my own), I have to answer your question as a new comment: Never heard about the interfering properties of ammonium ions on detection of Mg with azo violet, so I tried it out immediately: no blue colorlack was formed nor did any other color change happen (except to yellow if the test solution is too acidic). Did you use distilled water to dissolve the ammonium salt? Azo violet is so sensitive on magnesium that it will even detect the traces present in tap water. Indeed ammonium often is an interfereing ion in analytics so it has to be boiled off as ammonia with sodium hydroxide beforehand then. But in this case it doesn't cause any problems. But there's one thing to take into account with this dye: the alkaline violet solution is sensitive to air. It becomes a brown liquid lost its indicator properties when standing open for a longer time. This can be prevented by adding a little ascorbic acid - and preparing the solution freshly everytime when needed.

[@integral_chemistry]

Thank you very much for checking and letting me know! Also I don't have any idea why it keeps hiding your comments, I almost want to ask youtube support on Twitter why that might happen. In any case I hadn't tried the ammonium ion test yet (only read about it on Wikipedia). I also didn't realize until working with it just how EXTREMELY sensitive it is to magnesium ions. It's to the point that when diluted in a sufficient quantity of tap water it is certainly more blue than violet, and when I added 2M magnesium sulfate to a freshly-prepared alkaline sample of azo violet, I got a thick blue precipitate.. which I can't remember whether or not you mentioned in your video. The intensity of the colors with this one are actually such that it's hard to get good footage, and in all honesty I might just be using to much of the azo dye. This stuff seems like a little goes quite a long way

[@ingensvidcz5390]

For anyone wondering, the effect is literally as having a flu without the pain and fever. You just get enormously letargic and dysphoric and fall asleep very easily. I imagine even hitting your head really hard is more recreational. The taste is like menthol flavoured sand.

[@integral_chemistry]

Sounds wretched.. literally the more I hear about it, the worse it sounds

[@LeonardGreenpaw]

So I cant use it to hypnotize someone into robbing a bank for me? Damn XD

[@SpecialistGuava]

@@LeonardGreenpawno that’s scopolomine. Devils breath. Which is now used as a motion sickness patch

[@LeonardGreenpaw]

@@SpecialistGuava interesting, do feel free to tell me more. For uh research purposes :D

[@Faith-bk1yg]

Yes Ii was pouring ING swat and freezing at same time. I though I was dieing

[@tireballastserviceofflorid7771]

Adding salt to your water/ice bath would help give better cooling.

[@integral_chemistry]

Yeah.. that's something I need to do more often in general. I hate using chemicals unnecessarily, but salt is literally dirt cheap lol

[@tireballastserviceofflorid7771]

@integral_chemistry I hope a 1/4 cup of salt won't break you.. lol. You can always recycl the salt.

[@alllove1754]

So I tried this back in 2017. I ate some, and despite its flavor, didn't puke. It was like plastic cloves amd didn't knock me out at all. It was a waste of chloroform, albeit the science was cool. You did it way better than myself, and you were right to not eat it. Think headache ❤

[@sciencoking]

Runaway haloforms are NO joke. I was doing one in an erlenmeyer flask and lost control of it. It sprayed hot bleach into my face and managed to get into my eyes, clouding my corneas for the rest of the evening. Instead of going to the ER, I went to sleep. Next morning I woke up fine. That was my last haloform

[@integral_chemistry]

Glad to hear you were fine, that sounds terrifying.. You aren't kidding though, the sheer heat these type of reaction generate are honestly shocking and you really have to get it as cold as you possibly can (and even then expect the worst case scenario)

[@user-nu8in3ey8c]

A 37 day half life sounds like severe and unending side effects.

[@jfwhatahwhat7408]

I took a whole measured gram and felt like I drank a 6 pak for about 6-8 hours. Yucky burps though, tastes kinda like camphor.

[@tylerj.c.3235]

I love this video. I enjoy how your videos go step by step and not too many technical terms. Would you consider doing a video on SLU PP 332 in a pill form instead of as an injection?

[@stretchstrange]

I was hoping you would do a giveaway at the end of the video

[@jamisontaylor878]

Lmfao

[@Benzene_Ring123]

Really enjoying your videos as i always leran new things everytime i come to ur channel. please keep it up and keep uploading new videos to help more students who are studying chemistry and look up for such a content 🎉🎉❤❤

[@DangerousLab]

You always take it a step further, I thought it would be just chloroform initially when I saw the title!👍 Btw, 1:52 the sep funnel is slowly dropping down, which is an alarming sign that accident could happen at some point.

[@integral_chemistry]

I like to make every video a surprise that only rewards you if you actually take the time to watch to the end. I think its fun and a nice little way to foster continued interest (jury is still out on whether it'll work lol) And yeah I actually noticed the same thing.. I think its a "settling" due to the weight of such a large sep funnel on such a tiny ring stand. I did leave it overnight once or twice and it never failed, but it is still not ideal by any means. Think I'll probably bolt some bars to the inside of my fume hood for greater flexibility but also to support some of these heavier objects.

[@DangerousLab]

@@integral_chemistry I made a custom-made lattice inside my fume hood just to accommodate different clamps, I find setting up the clamp and stand every time quite annoying, stands are also prone to tip over which I am not a big fan of.

[@integral_chemistry]

@DangerousLab thats exactly what I want to do, honestly I might have gotten the idea from one of your videos. Where did you source the metal bars you used for the scaffold?

[@DangerousLab]

@@integral_chemistry I didn't use metal bars, those are carbon fiber rods I got from Aliexpress, and the interconnection is made out of PP.

[@DangerousLab]

@@integral_chemistry Those are not metal bars, they are carbon fiber rods I got from Aliexpress, and the interconnections are made out of PP.

[@johnslugger]

*In the Diagram you show Br. Where is that coming from????*

[@Georgealey]

Nice presentation. After this I really want to ask if maybe* is it possible the synthesis of zipeprol or it's too difficult for a you tube video.i don't know. thank you.

[@integral_chemistry]

I could check it out! It would definitely be much more complex, but my main concern would be with legality. I'll check first to make sure it wouldn't get me in trouble but if it clears I'd love to give it a try

[@Jagdtyger2A]

As it is only slightly soluable in water, I take it that the historic use was mainly done as either a pill or dissolved in something like alcohol

[@integral_chemistry]

I'm assuming a pill to be honest I'm not entirely sure. It still has limited uses these days but the concentration is so low they do just dissolve it

[@magua1368]

I have been a subscriber for several months now and I find your video teaching to be hypnotic. Your intellect and education in chemistry is terrifying to me. Obviously, I know very little about chemistry and synthesis. I know you use your education for good and not evil. It's very easy to see how someone with your background could make things horrible for a lot of society in a very short time. I am in awe of your education and I am thankful for people like you. Peace

[@integral_chemistry]

Thank you so very much, that mans a lot. I worry often that the pace I go through topics is maybe too fast to the point of being confusing so I love hearing that is "hypnotic" because in a way that's what I'm going for. I love chemistry, and I get so entranced in the process that it sort of becomes this mesmerizing experience where nothing else exists for a little while. I try to channel this vibe through the very focused way I edit down the videos, which I'm very happy to hear you appreciate. I also love hearing about your interest in chemistry! Its a subject most people dislike in my experience, so its refreshing to hear people appreciate the wonder of it all.

[@magua1368]

The pace is great I wish I would have paid more attention in high school. 40 year pipefitter, no chemistry but, always did love it and was intrigued by it. I have a newfound interest in primer recharging which has fueled the desire to learn some simple synthesis for a few different labs that I will need. I'm in process of gathering equipment now. I have some really good chemists to lean on and ask questions to through a couple different groups. You guys are all top notch! Thanks again for the knowledge keep up the great work

[@atari7001]

@@magua1368have you seen the videos on nickel hydrazine nitrate? It looks like it would be a decent component of a primer composition.

[@homeopathicfossil-fuels4789]

Chemistry is one of those fields that really weed out the "ill-doers" believe it or not, the mad scientist that media portrays is a stock fiction character and nothing else. People with unmotivated malignant intent are usually addled by extreme emotion and are usually not the types to go through academic or technical education. The worst harm happens by accident, or gross negligence by administrative authorities. This is why you see most instances of mass violence committed with guns or garden variety explosive devices, and rarely with chemical, biological or radiological weapons. Media loves portraying violent anti-social types "the psychopath" as these smart, coldly calculating geniuses that hold dark secret knowledge that they apply flawlessly in the execution of sick fantasy or whatever, but real life criminally insane perps usually have very low cognitive capacity. The more intelligent ones are rarely found in violent crime or terrorism, but are the ones in business making life as a worker in corporate hell. The fear of the knowledgeable/literate dates back to early medieval times and has sadly been deeply embedded in our culture, people fear computer literates too, and respect their mechanic about as much as their dentist. Just had to point that out, dont fear the knower, the knower is likely why you survived childhood and enjoy a relatively peaceful existence :)

[@Moritz___]

@@magua1368 get into it be careful have fun start small thats all you gotta start with to have a sometimes nice and at other times annoying hobby peace

[@dondobbs9302]

This should be on the short list of true "zombie" drugs.

[@integral_chemistry]

Literally. There's some scary ones out there, this one is in the same area as benadryl where it's such a miserable experience they don't bother regulating it

[@zrazghost]

@@integral_chemistry ever done it?

[@bromine_35]

​@@integral_chemistrythey'd better Can't imagine the damage of someone unleasheing this agent on a unknowing group of people

[@fungoose2195]

​@@bromine_35 you can do worse than this,

[@L29Ah]

I wonder if ethanol could be used instead of acetone.

[@johnnyfoo8737]

I know nothing about chemistry but I find this interesting

[@jfwhatahwhat7408]

You can also use cyclohexanone, diethylketone and other ketones.

[@VoidHalo]

I was expecting this to be a synthesis of chloral hydrate. I remember hearing about 20 years ago that it's a very easy synthesis. Requiring you to just bubble chlorine gas through I think ethanol. Which sounds suspect and comes from the same source that claimed you can separate ether from hexane by mixing it with water and draining off the bottom water layer. But it's got me wondering how easy/hard the actual synthesis of chloral hydrate is. It would be a real treat if you could cover this one. If legally possible.

[@integral_chemistry]

Hmm ill definitely look into it. I'm pretty sure legally that would be fine, lately the big concern is not getting stuff removed by youtube's AI. Lots of things like that get auto-flagged

[@VoidHalo]

@@integral_chemistry Awesome. I appreciate it. Hopefully KZbin's robot army leaves you alone.

[@experimental_chemistry]

@Apoptosis: There are problems with the answers to the answers again - this time also via the PC browser. Regarding your question about textile dyeing with Para-Red: The concentration of the developer solutions influences the color depth of the dyed textile. Here is a recipe: Solution A: 10 ml diluted sodium hydroxide solution, a little beta-naphthol. The dyed material is immersed in the solution. Solution B: 25 ml water, some sodium nitrite, some p-nitroaniline, 10 ml diluted sodium hydroxide solution. The solution is cooled to below 5 degrees Celsius and then 25 ml of diluted hydrochloric acid is added until it turns yellow. The dyed textile is then transferred from solution A to solution B. The recipe is universally applicable. Depending on the desired dye, the phenol and aniline components can be exchanged accordingly.

[@integral_chemistry]

I will definitely be saving this! Thank you so much. Crazy how many azo dyes there are, might see how many I can make with what I have lying around

[@robfoster4288]

Ya better download it. The fascist Google censorship bots will eventually get around to taking all of this stuff down.

[@uncleal]

Will it base-eliminate to the 1,1-dichloro, 2,2-dimethyl oxirane? Chlorines being about the same size as methyl groups...lipophilic! Then...slowly...interesting.

[@miguelnieto83]

Very interesting indeed!!

[@peter5.056]

sounds like a drug given to hostages being interrogated

[@integral_chemistry]

Tbh I doubt it would even work for that. The whole time you're drugged you're just kinda unable to speak properly or comprehend anything around you

[@peter5.056]

@@integral_chemistry sweet jesus, "too toxic for Saddam." think about that.

[@Aaron-zu3xn]

you're thinking of sodium pentathol and it doesn't make you tell the truth you can even confess to things that never happened so it's worthless for interrogation,there was once a case where the police went looking for bodies a person claimed they buried in central park NY and there were never any bodies they just implanted the memory.

[@MathewFletcher]

These types of hypnotic sedatives would likely render the person a deadhead and rather irritable as well similar to the first generation antihistamine like phenergan - horrible in large doses and even worse in even medium ones.

[@GEODUCK9]

​@@peter5.056 You know where the WMD's are? do tell 😂

[@archangel20031]

Can you tell us the actual effect in plain English? Some of us have no idea what crossed is.

[@DXLabz]

This was my first home synthesis, it’s a classic

[@integral_chemistry]

Honestly I'm shocked it took me so long to get around to this one. Very straightforward and satisfying. I'm a big fan of any organic reaction where the products have vastly different properties than the reagents (especially a vastly different smell)

[@DXLabz]

@@integral_chemistry that’s how I knew I succeeded was the smell. Ofc the chcl3 I used was made from pool bleach and was not distilled before using it for 2nd step. Sample prolly had sodium acetate and KOH impurities even tho I tried to remove KOH via filtration. Chlorobutanol is hard to store it likes to sublimate on the lid of the jar I put it in.

[@VoidStaredBack]

the metabolism of the substance occurs in the liver and the 4 carbon chain might be more fat soluble leading to longer time for total bodily elimination. Just a thought

[@integral_chemistry]

Ooh honestly this is one of the more feasible ideas I've heard. It is unfortunate that with chemicals like this that have clearly better alternatives, nobody is ever going to really bother with clinical trials at this point and so we can really only guess at the biochemical mechanisms for such things

[@VoidStaredBack]

@@integral_chemistry went to college for pharmacology and it reminded me of other halogenated hydrocarbons beyond the basic 2 carbon structure that would be more volatile and certainly not aromatic

[@Luna-ff6rf]

Ok but what did you do with the little vial ?

[@k.d.kelley2830]

😂

[@timothythompson8269]

would it stop dts from xan or ethanol? that can be horrific

[@AnthonyMEMU]

I understood like, 4 words in this video, but I enjoyed my time here.

[@vladislavshepel6389]

Chloroform from my experience has quite high solubility in water. To reduce it I used much quantity of NaCl salt.

[@4nov1847]

I've made chlorobutanol from chloroform and acetone. It smells really nice.

[@integral_chemistry]

Right? Super unique and pleasant smell (at least at first)

[@novadeluxetwo8123]

One of my first syntheses

[@integral_chemistry]

its honestly a classic

[@mattwillis3219]

Considering how readily available the chemistry is id would not be surprised that this is actively used in bioweapon attacks, dirty little tricks indeed.

[@tomarmadiyer2698]

Thas chem. Bio would be flinging plague rats.

[@PetkesPaintings]

is someone gonna tell this guy about TATP?

[@terraria_pog2355]

@@PetkesPaintings that's not a bioweapon that's just homemade explosives

[@skyethebi]

Is it possible that the dichlorocarbene reacts to form tetrachloroethylene? That might explain why there’s still so much chloride even after completion.

[@integral_chemistry]

That is definitely possible, honestly probable. I'm convinced there are definitely multiple side reactions going on here, not least because after the formation of the deprotonated version of the chlorobutanol, there a big chance that free oxygen just displaces a chlorine and closes in a ring with the adjacent carbon

[@_arthurski1337]

Isn't there also a way to make chloral with ethanol as a starting point ?

[@chemistryofquestionablequa6252]

Yes, you bubble Cl through it and then reflux to drive off HCl and hydrate if necessary to form chloral hydrate

[@kenbrady119]

Nice synthesis! Is pursuing the fluorine analog even possible?

[@integral_chemistry]

I doubt it would be using this route, and I can't find any literature about it. May indeed be possible by another route, but fluoroform is really hard to work with (boils at like -80 degrees) and deprotonation wouldn't work due to the extreme electronegativity of fluorine. Also thank you very much! I was worried people wouldn't care much for this vid

[@christopherleubner6633]

Not by this route, also the end product would act like an acid more than an alcohol because fluorine is pretty greedy for electrons. 😂

[@thecrakp0t]

Bro you're schizing out my NSA agent

[@lettybastien4624]

Mines’ took three booths at the China Buffet.

[@H4WK6969]

So how did the date go?

[@JamesEhler]

With the chloroform, how could it go bad?

[@EricVanWinkle]

I feel like I'm probably on a list for watching, so I may as well say what a great job you did!

[@integral_chemistry]

Lol thanks! I feel all the coolest people are on a list anyway

[@unklejohn8575]

If you haven’t, you should check out the story about the Mad Gasser of Mattoon. This chemical sounds like what was used on the gasser’s victims.

[@V8-friendly]

Very essential video for knowing about the good stuff! 👍 I prefer Ambien, Lunesta, Sonata. Benzos make you chill too. 😎

[@integral_chemistry]

lol yeah tbh I'd prefer almost any other sedative to this stuff, seems like a real bad time compared to some of those others.

[@V8-friendly]

@@integral_chemistry Midazolam IV in the ER was top notch! 😱😂

[@theJOYSofANALpenetration]

even phenazepam would be better than this shit. great video nonetheless

[@13_cmi]

I’m sure acetone on its own could be a sedative just based on how nasty it smells. It might end up being a one time use kind of thing but I don’t know. I’m not a chemist.

[@duncanfeyd4056]

Is there an antidote?

[@shanepichman]

If the potassium hydroxide is just a catalyst can you use something like sodium hydroxide instead, or even just sodium carbonate?

[@RiehlScience]

I’ve used sodium hydroxide and had no problem with it. I doubt sodium carbonate would work.

[@integral_chemistry]

Yeah sodium hydroxide would work fine, I just used the KOH because it tends to dissolve easier in organic solvents. Carbonate aren't alkaline enough for effective deprotonation though

[@barrackb0325]

Where do I sign up for the month long super faded acid trip??

[@strategicbacon7349]

Chloral hydrate next?

[@experimental_chemistry]

@Apoptosis: By the way: if you have entered the same email address on your channel's AboutMe page as the one you used to set up your channel, I would strongly advise you to change your contact address as soon as possible. Otherwise, the risk of your channel being hijacked is high.

[@integral_chemistry]

Oh yeah I had considered that possibility. I didn't use that email to set up the account, but for security reasons I'm considering setting up a third email just to be safe.. I always underestimate the willingness of bored idiots to hack into people's accounts just to make their lives miserable

[@cprove5751]

Can you do ether?

[@markarca6360]

Chloral hydrate?

[@integral_chemistry]

It's a more commonly used/known chemical that is fairly similar in its effects tldr

[@kennethcarroll6545]

Okay but how much potassium hydroxide did you use to form the chloroform? How long was it reacted?

[@integral_chemistry]

I didn't add any to make the chloroform, bleach already contains a good deal of hydroxide to keep it stable over long periods of storage

[@jimjames4348]

This sounds like something I'd encourage my boss to drink.

[@JackElsworth-b4l]

Effects like ghb?

[@jimparsons6803]

Interesting and thanks. Don't think that I've heard of this one and I agree about the solubility, in fat most likely. Chloralhydrate used to be a very popular item, back in the 50s, I've heard. As it was cheap and easy to make, relatively, anyway. Medical doctors used to write a lot of prescriptions, back in the day. Never made it myself, read about it.

[@kennedy67951]

Fantastic video mate.😊

[@DragonsAndDragons777]

I love this channel

[@Baitrix1]

notice you said chloroform but the picture showed bromoform

[@nigeljohnson9820]

​@@GH-jl2tdOnce the graphic switches to bromine as the halogen it proceeds all the way to bromoform.

[@integral_chemistry]

Yeah my bad. Bromine is much more often used in this reaction and so the general mechanism I used shows bromine instead of chlorine. I made a note about it on screen but it's quite small

[@garrymcgaw4745]

Great vid mate.

[@integral_chemistry]

Thanks man!

[@fmdj]

This looks great, I could use a one month nap.

[@integral_chemistry]

lmao I feel that in my bones. TBH I think I could manage a one month nap no sedative required

[@thedoctor2102]

Br is Bromine isn’t it?

[@rebelliousfineart8202]

LD50?

[@alexnoyola4076]

I wanna learn how to make Dicyanian

[@experimental_chemistry]

Well done, but still looking forward to your azo violet video... 😉

[@integral_chemistry]

Thanks! I did wrap up the azo violet a few weeks ago, but I've just been too busy to do the voice recording and editing. Likely have it out within the next week or so. BTW I read that azo violet gives a color change with ammonium similar to the blue color change with magnesium. Would you happen to know anything about that?

[@experimental_chemistry]

​@@integral_chemistry No, but I will try it out and report about it. Ammonium often is a disturbing ion in analytics, so it has to be driven out beforehand by boiling the test substance with sodium hydroxide solution.

[@experimental_chemistry]

As a reagent one spatula tip of magneson I/azo violet in 100 ml of diluted sodium hydroxide solution is sufficient.

[@integral_chemistry]

Hm so maybe I wasn't using too much.. this stuff is just STRONGLY pigmented. As a side note I made para red as well and I want to try using it as a fabric dye, but I read that in order for the dye to be permanent it needs to be coupled with phenol or aniline. You know anything about this?

[@experimental_chemistry]

@@integral_chemistry Yes, azo violet is a fairly rich dye. The reference to phenols and amines refers to the coupling process itself and does not indicate an additional work step for fixation. I have to admit that the last time I dealt with textile dyeing was in my senior year - that was over 30 years ago. So here is a translated text from one of my school encyclopedias at the time: Developmental coloration: In contrast to direct dyes, developing dyes are created on the fiber. They are often azo dyes. Two components are required for their production, namely an aromatic as a coupling component and an aromatic diazonium salt. The coupling component is dissolved in a basic, aqueous medium. The fibers, which are mostly cellulose fibers, are soaked with it and then dried. They are then treated with the diazonium salt solution. The coupling reaction that creates the dye therefore takes place on the fiber. Like the vat dyes, the developing dyes are not water-soluble and therefore very wash-fast. Naphtol AS (3-hydroxy-2-naphthoic acid anilide), a derivative of naphthalene, is often used as the coupling component, which is why it is also referred to as naphtol-AS dyes. For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.

[@experimental_chemistry]

@@integral_chemistry The mention of phenols and amines does not mean an additional work step, but rather the well-known coupling reaction itself, which must take place directly on the textile and thus leads to a wash-fast color. For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.

[@integral_chemistry]

@experimental_chemistry oh really? Huh so I'm guessing two different dilute baths? Does order matter?

[@experimental_chemistry]

@@integral_chemistry The concentration of the developer solutions influences the color depth of the dyed textile. Here are instructions for dyeing with Para-Red: Solution A: 10 ml diluted sodium hydroxide solution, a little beta-naphthol. The dyed material is immersed in the solution. Solution B: 25 ml water, some sodium nitrite, some p-nitroaniline, 10 ml diluted sodium hydroxide solution. The solution is cooled to below 5 degrees Celsius and then 25 ml of diluted hydrochloric acid is added until it turns yellow. The dyed textile is then transferred from solution A to solution B. Following these instructions (I dug out my notes that are over 30 years old) we dyed T-shirts in our senior year of high school chemistry class (of course the amounts of the solutions were adjusted accordingly). The instructions are probably universally applicable. Depending on the desired dye, the phenol and aniline components can be exchanged accordingly.

[@justarandomname420]

A month of hypnotic suggestability? Sounds like the perfect compound for psychic driving.

[@captainchicky3744]

Nice video! Would be interesting to see if you could sublimate to purify it with a cold finger or something lol. I might go digging in literature or ask on sciencemadness if anyone can pull up a reaction scheme for the reaction tbh, curious that's not readily avialible if at all

[@Rosenthal-z7x]

Hope you’re not busy for about a month

[@seanwalton6208]

Your first chemical synthesis breakdown showed bromine not chlorine. Just FYI.

[@djisydneyaustralia]

I’m assuming this is a possible step off for 1.4bd?

[@integral_chemistry]

1.4bd?

[@amritlohia8240]

@@integral_chemistry 1,4-butanediol, he almost certainly means

[@младенец]

Fantastic

[@chadgdry3938]

"You are feeling sleepy", waggle fingers at you...

[@TestUser-cf4wj]

Am I the only one that thinks the diagram at 4:00 describing the reaction looks like one guy puking and another guy with expolsive diarrhea followed by two crosses (presumably on the graves of the previous two guys)? Just what the heck is going on in this reaction???

[@experimental_chemistry]

An influencial German chemistry creator brought about my ban, because I dared to point out his mistakes publicly. 🙄 Feel free to ask the platform if they can reverse it. I am not overly optimistic about that.

[@integral_chemistry]

Yeah youtube is not a particularly flexible platform.. and this guy doesn't sound very scientific. As scientists we are supposed to relish in and rely on other people out there with the knowledge to point out our mistakes. Can't imagine how boring science would be if I knew everything about everything and nobody out there knew enough to challenge me..

[@experimental_chemistry]

@@integral_chemistry The creators on this platform are mostly not interested in scientific discourse, but rather in being soldiers of fortune and cultivating vanity. Accordingly, openness to criticism is weak. People like us, who see mistakes not as a personal flaw but as an opportunity to grow professionally, are the exception here.

[@integral_chemistry]

@@experimental_chemistry I have noticed that to be the case unfortunately. It is to the point that I've had several commenters on here surprised by how open I've been to their critique because they've come to expect hostility and defensiveness. Its honestly quite sad considering how valuable an open discourse could be in the KZbin chemistry community..

[@spiderdude2099]

NileRed seemed to think in his synthesis the cloudiness in the chlorobutanol reaction was simply finely dispersed potassium hydroxide, not potassium chloride.

[@integral_chemistry]

Hm.. I'll have to ask him about that. Potassium hydroxide is so crazy soluble I didn't consider that a possibility, especially since it has to dissolve to react in the first place. Never know though, definitely worth looking into.

[@spiderdude2099]

@@integral_chemistry I think it’s one of those things where, it’s not super soluble in organic solvents, but moreso, it’s driven forward by the higher solubility of the product relative to the hydroxide. Also, it would make a lot more sense as you saw in your mechanism. No formation of carbines or loss of product due to some weird side reaction. I suppose also, you could filter it, dry it out and see if it’s hygroscopic, or reacts with something like calcium to make calcium hydroxide, which wouldn’t be the case with potassium chloride.

[@toseltreps1101]

It's either KCl or a KHCO3/K2CO3 impurity from CO2 uptake by KOH.

[@spiderdude2099]

@@toseltreps1101 I really don’t think that could be it just by how much there is. If you look at the equation, hydroxide is regenerated, so it would make sense that’s what it is. Also, in basic medium, conversion of KOH to K2CO3 doesn’t usually happen that readily and that quickly

[@spiderdude2099]

@toseltreps1101 also, as I stated, you could easily determine if it was potassium chloride by washing it well, drying it, redisolving it in water and adding calcium chloride. That would precipitate calcium hydroxide if it was just powdered hydroxide, but nothing would happen if it was potassium chloride.

[@andylin1587]

Officer, I swear I'm not kidnapping someone!

[@jayuk8]

Im hypnotised just looking at those crysyals 😂

[@christopernicus]

Idk how accurate this is but I´ve heard that Adolf Von Baeyer synthesized barbituric acid from human urine and apple juice, to make sodium thiopental? Maybe this is something you could try and make a video about. Definitely gives the opportunity for some good video titles; "Making anesthesia from apple juice and pee" 😂

[@integral_chemistry]

Huh I've never heard of that before but definitely worth looking into. I know you can make barbituric acid from malonic acid (which does occur in apples) and urea (which is definitely in pee lol). I'll have to check it out and see if its feasible

[@chri-k]

The halogens: Fluorine (F), Chlorine (Cl), Chlorine (Br), and Iodine (I)

[@DBxnZ]

This is what Kanye West was talking about in that song “Stronger”

[@integral_chemistry]

LMAO

[@Bloodywasher]

Did you figure out how to kill cancer cells using histotripsy yet, causing apoptosis in concentrated areas, using ultrasonic transducers?

[@jamiemoore1056]

I though you was going to make 1,4 butandiol🎉 or ghb

[@integral_chemistry]

Lol I've considered it but those are actually commonly abused so I think that might get the video taken down pretty fast

[@zodd0001]

It is interesting to hydrolyze it and make polyester with it.

[@integral_chemistry]

Huh I'll have to give that a shot. Not like I had any other ideas of what to do with this stuff lol

[@zodd0001]

@@integral_chemistry first, try to find something in literature