Turning vanilla flavoring into dopamine!

Warning: do not attempt the actions seen in this video!
In today's video, I'll be making a neurotransmitter called Dopamine! This compound regulates many functions in the body but is mainly associated with feelings of motivation! So follow me today as I turn vanilla flavoring into dopamine!
Enjoy! :)
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info on dopamine: en.wikipedia.org/wiki/Dopamine
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[@PyrotechnicalScience]

Since so many people seem to be asking, dopamine is not psychoactive and will not get you high. Medically it’s used to increase blood pressure as it does not cross the blood brain barrier and no I will not eat it lol.

[@dotcom9601]

Science is Fun ❤

[@WildManDanWMD]

He noted the effect early on.

[@BibleDecoded-qo2qv]

Do you have any extra Glass you don't use that you can donate to me ? Even just a few pcs that would be awesome. Thanks

[@danamullins2723]

​@@JonathanTyndallNCdoes not cross the blood-brain barrier...so no, it wouldn't help with that.

[@MyName-bq7vx]

Then why the hell is he making it ?

[@Nighthawkinlight]

A tip from someone else with a ton of random assorted chemicals: cataloge them all in a journal or word doc. Otherwise you'll never remember what things you have when you need them.

[@luamanlabs]

Personally I have an MSDS binder, and the quantity written down in the section. Though I imagine a spreadsheet would be more convenient for checking. Actually this gives me an idea. Give me a couple weeks/months

[@justineseman3741]

Yo thats wild

[@bruceanderson7762]

Yeah...I don't have any chemicals...THAT, I can remember...lol

[@aga5897]

Better to have stuff you use daily, Knowledge how to make what you need, and no Giant store of pointless chemicals that you'll probably never use, Ever. When (if) i go through my store, i'll probably dispose of it All.

[@aga5897]

@@bruceanderson7762 No Table Salt, no Black Pepper, no Soap, Bleach, Benzene, Xylene, Toluene, Oxidane, Nitrogen, Carbon dioxide, Adenosine triphosphate, Oxygen ? What kind of Alien are you ?

[@nosequiters]

I see a lot of people with these glass pipes making pure dopamine around my neighbourhood, day and night. Its so heartwarming to see how many hobbyists are taking up DIY science these days and staying off drink and drugs

[@fss1704]

Heisenberg changed everyone.

[@YerBrwnDogAteMyRabit]

You really have to admire people's "enthusiasm" for their "hobbies". Heartwarming indeed..

[@brotoriousone5735]

There methwis a little different though, they are using a lighter

[@letsdothis9063]

Dopamine for days!

[@josephsaunders8618]

Crack buddy 😂😂😂😂

[@xert15]

damn the backyard scientist really came in clutch with ths one

[@PyrotechnicalScience]

Very much!

[@GerinoMorn]

I love that, direct recycling! I think internet makers etc. should have their own network of swapping/lending/giving stuff, from what I saw everyone has just piles of stuff they don't use xD

[@1islam1]

@@PyrotechnicalScience ⚠️ God has said in the Quran: 🔵 { O mankind, worship your Lord, who created you and those before you, that you may become righteous - ( 2:21 ) 🔴 [He] who made for you the earth a bed [spread out] and the sky a ceiling and sent down from the sky, rain and brought forth thereby fruits as provision for you. So do not attribute to Allah equals while you know [that there is nothing similar to Him]. ( 2:22 ) 🔵 And if you are in doubt about what We have sent down upon Our Servant [Muhammad], then produce a surah the like thereof and call upon your witnesses other than Allah, if you should be truthful. ( 2:23 ) 🔴 But if you do not - and you will never be able to - then fear the Fire, whose fuel is men and stones, prepared for the disbelievers.( 2:24 ) 🔵 And give good tidings to those who believe and do righteous deeds that they will have gardens [in Paradise] beneath which rivers flow. Whenever they are provided with a provision of fruit therefrom, they will say, "This is what we were provided with before." And it is given to them in likeness. And they will have therein purified spouses, and they will abide therein eternally. ( 2:25 ) ⚠️ Quran

[@christopherleubner6633]

Yup moving lots of chemicals and glass across state lines is a bit dangerous for many reasons. Get cop stopped and then prove you were not planning to break bad..

[@y.a100]

@@1islam1 bro i think he jew

[@ucminhnguyentuan9013]

Man i love how he smoothly avoid saying methylamine 😂😂

[@puffthecatpuff8931]

What time was that?

[@pinohavas2030]

3:00

[@science_and_anonymous]

Hey Harrison! Great work on this one. I have been waiting for someone to post on this synthesis for years, as the synthesis of phenethylamines from vanillin is well-established in the literature, but incredibly rare to have been filmed. I remember reading and seeing many clandestine chemists use the exact same reactions you have performed today starting from vanillin to form mescaline (and analogs), MDMA, MDA, TMA, and a few other exciting drugs. I know this isn't the scope of your page, but as a chemist, I think it's notable to see how a single reaction, the Henry reaction, has been used to synthesize an incredible array of drugs from one single precursor vanillin. Few things though. First, vanillin is endothermic and will cool the solution it's being dissolved into (it's not from your evaporative losses that it became cold). Also, be very careful while drying solvents in open air like that. There is a reason chemists have shorter life spans than the general population, and solvent inhalation is one of them. Finally, the reduction you performed could've been optimized. The acid in the reaction serves not only as the "solvent" to maintain a low pH but also as a reactant. The zinc reduction goes through an organo-metallic step which is mediated by proton concentration, and available electrons in solution. The zinc serves to donate these electrons into the solution for the nitro to "pick up". The nitro however is not reduced to an amine just yet, and forgoes a N-OH intermediate which is eliminated in an acid solution. What this means in essence is that all the acid has to be added for the reaction to go to completion and reduce the product, and the reaction must be refluxed after acid addition to fully complete the reaction. I think doing this would've dramatically increased your yield.

[@PyrotechnicalScience]

Thanks for all the input I really appreciate it! I’ll probably give this another attempt to get some better yields using you’re advice!

[@science_and_anonymous]

@@PyrotechnicalScience of course! Just trying to help as another chemist. Just as an FYI, these zinc/acid reductions are pretty inefficient as is, and as you saw, are messy. My advice is for optimization, but you can only do so much with this reaction before you have to look at better alternatives (hydrides). Still, you did great for your first time! Isopropanol as a solvent definitely took me by surprise, but it seemed to work. Perhaps try another solvent that isn't very misable with water? IPA can be rather polar, so maybe change your extraction solvent if possible. Also, if you're feeling really chemically experimental, see if gallium/Zn amalgam works better in the reduction than the Zn alone, as the reduction you performed most often occurs with the Zn as an amalgam to further push yeilds.

[@PyrotechnicalScience]

I originally did a LAH reduction but during the work up the flask ignited as an ether fire and destroyed everything :( sadly I only had 6g of LAH so that was a loss. The original patent called for N-butanol but I only had isoprop so had to go with that.

[@science_and_anonymous]

@@PyrotechnicalScience Holy shit man! Lithium Aluminum Hydride is no joke! That could've been very serious, chemists have been killed from LAH fires. I'm very, very thankful you're safe. LAH should be destroyed BEFORE work up, using alcohol or water. I've done LAH reductions before, and the reaction must be scrupulously dry. I personally use THF, which is far more preferable than ether. If you would to perform the reaction use THF as a solvent and dry it vigorously, destroy the LAH with alcohol/water before workup, try and keep the solids slightly wet when you vacuum the inorganics off, and also when working up the solution be aware that some hydrogen will be evolved during the process.

[@user-xb5qt2qn6i]

​@@science_and_anonymoushello, please tell me what solvent would you recommend for this reaction? I am also planning to synthesize serotonin and dopamine, and was planning to use isopropyl alcohol, what can you advise? should water be added to the solvent, or should 35% hydrochloric acid be added to the zinc without additional water?

[@Km4rt]

Dont you dare quit bro! This is your calling, you've definitely got something special here you just need to fine tune your process now (video creation process/chemistry process) and you'll be golden. I very much enjoyed this video and I know a ton of other people did as well. You're gonna blow up and be set for life man...go for it!

[@faulderrr]

I know nothing about chemistry but I enjoyed your enthusiasm and am very impressed with your knowledge. And you succeeded, good work!

[@georgedonovan6877]

How long your thank you was is something you don't see often. Actual appreciation, that more than anything else earned my sub.😊

[@3089io]

The reaction in the segment where you put on the balloon... I mean, the whole thing is fun but that first few of it where it was spattering that chartreuse and dripping in the steam. It was beautiful in a way I didn't expect.

[@antozon5070]

05:57 The solution is actually cold because vanillin dissolving is very endothermic

[@PyrotechnicalScience]

didn’t know that, thank you!

[@rdlspmg6752]

Man that's super awesome I'm so glad I found your channel can't wait to watch the rest

[@sseeee1]

That was excellent, as an old guy who had been interested in chemistry since a child, I really enjoyed your video, I'll give you a super thanks, keep posting , thank you SE

[@TruthInLove330]

Longer videos with more breakdown please! This is so fascinating! Great work!

[@J_F_1992]

I got excited near 11:00. I thought he was teaching us a new way to synth molly lol. Literally why I started studying organic chem.

[@LiborTinka]

This is actually a very old reduction method (dissolving metal reduction). These were used extensively before the discovery of hydride reagents and catalytic reduction. Old chemistry textbooks (like pre-1950s) are full of reductions using sodium metal, zinc amalgam etc.

[@fss1704]

I think it would be easier to splice a gene using crispr, you'd have to do it once and be done.

[@vogelvogeltje]

I’m a physics major and currently in a dilemma, I love physics and organic chemistry , maybe I can minor in organic chem?

[@christophershrader8496]

I love molly 🥰

[@daves2354]

​@@christophershrader8496me too Christopher, me too lol

[@michaelhicks8603]

Cool video man. I think it’s great that you were able to make this most awesome compound! It was frustrating to watch you mess a few things up haha! There is a certain amount of TLC and patience that is required when working in the lab after all :) I think following this procedure will yield better results if you take time to purify your reagents and solvents first. And then double check your stoichiometry after you have clean reagents. This way your weights are a lot more accurate. The reaction you did to create the nitrostyrene could have benefited from some more time, and perhaps better monitoring of temperature, and defiantly would have been better to extract more times, wash more times and recrystallise with maybe some more washing. It’s always important to go for purity over time and loss, because as each step continues you are going to introduce more and more different impurities that can have all kinds of side reactions, some of which can be cyclic mechanisms that continue to attack and degrade your reagents or products the entire time they themselves are reacting or forming. I think you also over shot your ph. Overall I think you get an A for effort because hell, you actually did the reaction and went to the trouble to make a video, which is 2x more than what I’ve done haha. But when it comes to execution I think this is a D or C- Keep up the good work!!

[@user-xb5qt2qn6i]

What reducer would you recommend? can diethyl ether be used both for the synthesis and for the subsequent extraction of the product? which is better for reduction al/hcl zn/hcl Hg/al hg/Na naoh/al naoh/zn?

[@michaelhicks8603]

@@user-xb5qt2qn6i for which reaction are you referring to?

[@andresaofelipe]

Didn't need to go through the whole chemical process, just put it into ice cream and there you go, pure dopamine

[@chifreak6]

Lol

[@liazapita8384]

Ikr ice cream always mks a happy time. YaY! 😊

[@timmeh69er78]

Dude you got some talent. Keep at if. You got my attention. Shout out from Australia

[@toastyboye]

I love your videos! Keep it up, I'm sure your channel will explode in popularity soon

[@PyrotechnicalScience]

Thanks for the patreon!

[@toastyboye]

@@PyrotechnicalScience :3

[@standardnerd9840]

Is hoping a chemist's channel "explodes" like telling an actor to break a leg? xD

[@JeffersonsTree]

Excellent work, and don’t beat yourself up over the yields. As you will get better yields with more runs, I can only suggest/stress accuracy of measurements, critical note taking(something I struggle with) and as close to a filtered/clean room environment as possible. And that all is absolutely coming from positive constructive feedback, I enjoyed your video and enthusiasm very much. Personally would love to see more, and I’ve definitely subscribed.!

[@andoncroft5154]

Speaking of yields, you DON'T get much yields of pleasure from my sister Sheridan's home cooked meals, ovely cooked rubbery meat undercooked veges 😏 I have NO cooking skills yet I somehow deliver high pleasure yields in my cooking that ppl enjoy, while my sis looking at me with daggers as ppl ask for seconds ROTFLMAO 😂

[@Curiosity_lab]

Great video! Quite a storeroom you got there, think I saw a whole glove box in the back. Also I’ve lost product raw dogging a vaccum pump like that before so now I always put a piece of cotton wool in the top of the vial

[@dickheadrecs]

long nights in the lab will have you raw dogging anything

[@pound4poundmikebrown]

Yea don't raw dog. Always wear a condom especially if your using a vacuum cleaner

[@Divataster]

​@@dickheadrecsyou need to lay off them bathsalts dude

[@Divataster]

​@@pound4poundmikebrownyou really need to lay off them bathsalts dude

[@pound4poundmikebrown]

@@Divataster it's like you found my story and read each line out louuuouud

[@chemistryofquestionablequa6252]

I can think of other stuff to do with vanillin... Great video as always!

[@iamyourmuse]

Fascinating...good work, hey most people couldn't get past the first steps...well done!

[@christopherleubner6633]

Make sure your MeNH2 HCl is well sealed as it is extremely hygroscpic. Vanilla flavoring is an awesome starting point to all sorts of interesting chemicals ranging from flavorings and perfumes to incredibly potent drugs. Have fun and be safe.

[@manipuluslux8174]

off to a Vanillin rabbit hole!

[@nonyabusiness9747]

​@@manipuluslux8174what'd you find?

[@alexpace3700]

Don't keep concentrated peroxide around for a long time and don't get it near acetone. Oh, and ice-cold acetone can be useful for cleaning up a fresh batch of fish flakes.

[@foxmulder7616]

Or at least put it in an amber colored glass container. I had some of that 30% in a glass bottle with an eye dropper, it ruined the rubber dropper, I guess from linking the cross polymer chains/vulcanization.. That stuff is dangerous, don't spill it on your skin for certain!!!! Lol

[@seraphxxkuraku9361]

guy just cured my depression

[@karlfromhighrock7158]

Amazing video, your presentation kept me watching even though I probably didn't understand 75% of what you were talking about. Keep at it and one day you're gonna be an amazing chemist. Stuff is like Chinese language to me. Thanks, looking forward to watching your other vids.

[@bradleybanks8871]

A very smart young man. Keep up the good work your very talented and an inspiration to any young study..

[@joseferlduarte]

Cool video! How come that you get all that as a present?! You are better equipped than I could get at most of my university chemistry labs😮! it seems wonderful!🤩 If someone else is giving up old labware and reactives in Colombia I would very gladly take it !

[@ethanbarnes3973]

Be carefull with the Karter si 5L beaker they can break pretty easy so if your heating it especially anything sketchy beware. I would be cautious of doing anything other than mixing at room temp. Planning for it to possibly break.

[@joewarrick6043]

Very cool stuff. I have a question. What machine should I get for suction

[@STODIpro]

now can you eat the dopamine? or smoke it or how does that work or can you injest it at all? and also what are you going to do with it ccause id be willing to try some out for you channel if you was sure its safe to consume?

[@blinkenlights]

I can totally relate to the bad yields. The tar too. At least you didn't accidentally polymerize your crystals like I did on my last project. Congrats on creating the dopamine, definitely a lot of work. Totally jealous of the big haul. Also, there's something weirdly comforting seeing others use the same cheap stir plate that I do.

[@JohnDoe-lk3oy]

Honestly, with all of the experience I have, I'm impressed with two things. One, the fact that you had the attention span beyond what is typical of your age group and, Two that you accomplished the intended result. I can only imagine how amazing you could be, with a little more discipline, and a real laboratory. Keep it up kid, we need more minds like you. Best

[@throtmorton2326]

Ok, boomer.

[@JohnDoe-lk3oy]

@@throtmorton2326 Wrong again, as usual.

[@captainmidnite93]

That a Corning PC-320 heater/stirrer I see in the cabinet? I got a lot a lot of service out of mine, had to fix it a couple times and looking up the info one comes to the conclusion that Corning treats that model like a red-headed step child.

[@christopherleubner6633]

The yeild was low because the reduction did not go well as a result of the zinc preferentially reacting to the HCl. Aluminum activated with gallium or mercury works better. The amount of either one iactivstor is stupidly small as well.

[@ShannonGrugel-cu8oo]

Not so much what you made,but how intuitive and knowledgeable you truly are. I love science,nothing like what you do. Keep up the good work. Detication pays off.

[@beckythornton6470]

Oh for real? i am wondering if "detication" would work for me. turn down your bunsen burner and grab a dictionary sweets, and stop encouraging irresponsible jerks online!

[@danceswithtallcans7694]

Dedication sweetie

[@daynosdr]

what happens if you ingest or intake that some other way?

[@pblake61]

don't quit kiddo! I thoroughly enjoyed your video. And the genuine excitement when you created the Dopamine! Subscribing NOW!

[@hunnybunnysheavymetalmusic6542]

Question is: NOW what you gunna DO with it?

[@luckyspec2274]

and finally after 20 steps we get coffee

[@williambock1821]

You probably made more dopamine in your brain from completing the process than in the beaker! But I’m sure you’re gonna be a great chemist since you’re obviously very enthusiastic about it! That’s the key to being good at anything. 🤙

[@richardmcgonigle1160]

Seratonin. Too lol

[@JoshPhoenix11]

@@richardmcgonigle1160Your body cant make Dopamine and Serotonin at the same time. The both pathways use the same rate limiting enzyme in the last step to synthesize L-DOPA > Dopamine, and 5-HTP > Serotonin. But this has a lot to do with when they're used. Dopamine is not exactly a reward neurotransmitter in how it sounds like it is. Its the anticipation of the reward. It makes you want something, to seek it out, to motivate you to get up off the couch and go do whatever needs to be done to get the reward. But its not the actual getting of the reward, only the wanting. Serotonin is the getting. So it means Dopamine levels peak the highest right at that very moment that you know you've secured the reward and when you can literally see it. The very second you get it Dopamine starts to fall. Then in order for you to feel the satisfaction from the reward Serotonin is released. Its what happens in addiction especially things that target Dopamine because it prevents satisfaction which is essential otherwise your constantly stuck in the wanting mode.

[@dread357]

Real talk

[@richardmcgonigle1160]

@@dread357 100%

[@dirtyfiendswithneedles3111]

Just like Hitler

[@DominicNJ73]

Great video buddy, thoroughly enjoyed it...btw, you are just adorable and brilliant.

[@jhonbus]

Does that Zn/HCl reduction of the nitrostyrene actually work? I could never get it to work to any degree when I was trying something similar many years ago. Although my substrate had a couple more methoxy groups on the ring, so maybe that was interfering. Never did get it to work before I was "rudely interrupted" and wasn't able to continue.

[@CyanBlackflower]

WOW!! What a super nice gift/score. It looks like it was given a good home, to the right person. I love the fascinating science/craft/philosophy that is the world of chemistry. Had I been imbued with 12 X the main sequence lifespan of a healthy human, I know I could spend that entire time pursuing the study of it and still know just a wisp of what there is to learn.. Everyone is a bit of a chemist, if they have ever cooked food 4 example... So I just use existing products of chemistry, for better living.

[@ladywolfwolf]

I'm getting ready to create Italian meringue butter cream, with vanilla, of course.

[@christopherparis1173]

Awesome haul! 😎👍 For the “one-speed” stir plate. The control knob may be oxidized inside. You may be able to spray some deoxit or similar into the control knob and twist it back and forth to work the spray in. After it’s had time to dry give it a try again, you may be able to regulate the speed afterwards. The spray is also great for amps, old Hi-Fi equipment, etc. where controls don’t work, or make a lot of static when used. Be sure to wear eye protection, gloves and use it in a well ventilated area.

[@MrDrspuddro]

or wd40?

[@432b86ed]

Power it through a ceiling fan speed control, or a variac.

[@michaelrosas6863]

This looks amazing something new to learn good video!

[@stevenclapp3330]

I enjoyed the video and even tho the yield wasn't that great that's to be expected one your first run hope to see more videos

[@joshvinson1237]

I have no idea what is happening, but its very entertaining. And i wish i understood it properly. Chemistry seems like so much fun. Unfortunately the war on drugs made a whole generations miss out on learning to love chemistry. All the rubbish classes i was forced to sit through in school, the things i would have lived to learn were never wven offered as options. The public school system really didnt offer me any real knowledge. Im trying hard to catch up in my own time, while working all day to pay the bills.

[@DylanBadillo]

From one chemist to another, the reason your yield was so low was because you did not taste the forbidden mustard.

[@JeffMcDuffie72MeridianGate]

I'm interested in making muster gas. Any suggestions ?

[@incomplete_machine]

i relish mustard gas on liquid hot dogs,

[@chirallabs226]

Yo those folgers filter papers are great for general purposes

[@jeremycrochtiere6317]

Using a PH buffer solution and NaOH would result in much less gas production. And the left over product is NaCl which is much easier to remove

[@Psyden5757]

+500 social credit for the backyard scientist!

[@whoever6458]

Well the more you do this reaction, the better it will get. Maybe a distillation or two would help to purify the product. Lots of my yields were super small too. That's the real world of chemistry. I think they get higher yields using computers and stuff for the professional manufacturers or, better yet, they probably splice the gene responsible for making human dopamine into a microorganism because no one makes it better than a cell with the gene telling it to make it.

[@DirtyApronBoy]

What a boon for your channel, Kevin seems like hes a pretty cool guy. Can't wait to see how you put that stuff to use. No back to watching this vid. cheers

[@williampeek7943]

You're awesome. Don't stop. Ever!

[@jarrodtanner1986]

Woo! Making dopamine, something that i actually need more of 😅. Got to love how impossible it is to get stimulants for ADHD in Australia due to cost

[@fss1704]

Try mucuna

[@pazsion]

Honey? Well why is your adhd a problem? It’s actually the normal state of the human brain…

[@jarrodtanner1986]

@@pazsion it makes it impossible for me to focus, to remember stuff, to be able to study, to be able to complete stuff and impossible to get a job. No one wants to hire me because I can't complete online training or keep focus

[@sulcuryaltinone4570]

​@@pazsionIf it wasn't a deficit in many ways, you'd be kind of right.

[@ashleyobrien4937]

For the Henry reaction, you could use many other lower aliphatic amines, and even some aromatic ones, potassium hydroxide in methanol works too, as does ethylene diamine, many things that are basic enough to pull of the rather acidic alpha hydrogen on the nitromethane, or nitroethane (sodium nitrite and ethyl halide)..you can make you sodium nitrite from sodium nitrate and sodium sulfate, it's a thermate reaction, not thermite...

[@PyrotechnicalScience]

I thought about using another base but the literature gave best yields with methylamine so I decided not to push my luck on it lol

[@ashleyobrien4937]

@@PyrotechnicalScience I'm assuming you are familiar with that "Elemental" site Rhodium ? sshh...my bible actually....

[@KurtisJoseph]

So, what is the crap that was cracking as you were filtering it? Zinc salt?

[@robertgutierrez1549]

What do you guys think that is good for the nerves my hands have arthritis. And when I’m holding something my hand, faints and drop things. I lose grip of it. My hand twitches too and I deal with a lot of bad is anxiety.

[@lapinlogic6267]

"I need a dopamine hit" Body - "Meh, give me 80 hours"

[@thetaintpainter5443]

“It’s cold maybe it’s evaporating” or maybe it’s endothermic lmao

[@3089io]

Great video and I look forward to more.

[@nancyallen8497]

So when you're finished what do you do snort the dopamine..?

[@chikntendie]

This guy’s like the love child of Styropyro and NileRed 😂

[@CatboyChemicalSociety]

change it up and add a bit of DCM somewhere in the steps to get dioxole structure and wadaya get some "sasafras derivative"

[@science_and_anonymous]

The de-methylation of vanillin is notoriously difficult, and almost always low yielding. That methoxy group is very stable and requires pretty significant catalysts to be removed, such as AlBr3/Pyridine. This is the first time I've seen a possible success from HBr ad reflux alone, but then again, we now no longer have that aldehyde on the ring giving stability. I would bet the ring is de-stabilized enough for halogenation and substitution if 3,4,5 substituted phenethylamines are your thing.

[@snareplug3872]

I hear sassafras and think of MD 😂

[@CatboyChemicalSociety]

@@science_and_anonymous u work with the aldehyde first then worry about the de methylation later as he done in this video

[@whoever6458]

OMG, the GLASSWARE! That IS heaven!

[@tactileslut]

8:53 Mmm, cherry slushy. With mustard. Made of cleaner and scented like fish with a hint of vanilla. Looks great.

[@user255]

Very nice! But always do purification steps before melting point tests. Impurities can change the melting point a lot. For an extreme "example" google "deep eutectic solvent".

[@johng2779]

Lets just all hope this kid never loses his mind and becomes a mad scientist

[@REALTV30]

Legend has it,it too late 😂😂😂

[@ladywolfwolf]

That's my ultimate goal. ,🧐

[@davidreynolds4684]

I gotta ask. What are you planning on doing with the dopamine? Its handy if you have low blood pressure at a critical level.

[@ChemicalEuphoria]

good work!!! 21:35 why didnt u use HCl gas or con csulfuric acid to salt out the intermediate? this way you could have prevented water to dissolve your salt

[@ashleyobrien4937]

conc sulfuric wrecks nitrostyrenes..red tar...especially ones with hydroxyl on the ring

[@ChemicalEuphoria]

​​​@@ashleyobrien4937it wasnt the nitrostyrene intermediate, that was already the phenylethylamine derivative and using anhyrous HCl or HSO4 in an acetone solution of the freebase is a common way to crush out the salt (also because u cant salt out a nitrostyrene with an acid)

[@jhhyuu_DaveIsNoProfessor]

Is this considered an amphetamine (class). I guess the more correct question is: when or does it cross the BBB (blood brain barrier) ??

[@trevorjohnson4965]

Wondering the same. I think hospitals use this or something called DOPA for surgeries or traumatic injury I'm pretty sure.

[@glasstracks7614]

This is a phenethylamines not an amphetamine. However amphetamines are a subclass of phenethylamines. If nitroethane was substituted for nitromethane the result would be the amphetamine anolouge of dopamine. Eating dopamine does not produce any effect because it cannot cross the blood brain barrier effectively. Though intravenous injection of dopamine can be used to treat some cardiovascular issues.

[@robertbernard651]

I need this for treating my Parkinson's, dang

[@gyrran]

have you thought of any specific use for the dopamine hydrobromide? as far as i'm aware, dopamine can't be used as an oral supplement, and bromide is toxic, right?

[@Technotranceism]

Exactly

[@stayingretired7906]

With all of your fancy new (to you) glassware, it would be valuable to have an old school video on repairing or fusing glass chemically, without chemical glues or epoxies.

[@justinbanks2380]

I feel like if you ever get a visit from the DEA or any other government agencies with three letter acronyms, gonna have a really interesting conversation especially given how thrown together/hacked together your setup is. (Not knocking it, it works. Just one of the situation where looks matter, at least in how likely you are gonna have to explain things, lol)

[@geargeekpdx3566]

Nah. Dude is on KZbin that is like dunking an entire meth lab in an olympic pool's worth of baking soda. They like people trying to hide not trying to educate and make some scratch by getting public attention from nerds. Ask me how i know. Or rather... don't. BUT i will add that if there is an unscheduled visit, it would be from funding sources with agendas of either moneymaking or entrapment.

[@Amateur.Chemistry]

You wouldn’t happen to have a spare kilo of this stuff? (asking for a friend)

[@suetaylor1127]

Wait so what you maid, what is used for? Please explain?

[@nikolaibond738]

man i love chemistry

[@TheCoolIllusion]

almost mdma lol

[@ultra4e]

Texas hat tip to you my good fellow, you synthesized dopamine. For what purpose?...to be consumed?

[@spookywizard4980]

A note about the green color after the HCl addition: if you have an iron impurity in your zinc that may be the cause of the color from FeCl2 forming!

[@trollied]

It is absolutely insane that the human body can just make this.

[@Embassy_of_Jupiter]

nanomachines, son

[@TheOpticalFreak]

But not the bromine part!! ☠️

[@michaelhicks8603]

@@TheOpticalFreakactually the human body requires bromine, it’s essential as a trace element for collagen IV scaffolds in tissue development and architecture, so it’s essential for human life. My favourite saying is from toxicology. “It’s the dose that makes the poison”

[@penname2064]

That stuff that smells like bubble gum might be something to give more attention to.

[@lorriecarrel9962]

Lol I'm curious what that would be

[@Imaginationscope]

Good job... I'm envious of your talents though. I wouldn't ever be able to do this.

[@mixedmediaartgirl300]

😍😍😍😍😍😍cool to see. i'd be excited too!

[@kennyKINSEY34]

Be careful about what you make . People might try and influence you, stay on the good side of chemistry.

[@tsunamisurfer7325]

So do you smoke this or what?

[@jimkimbrell4878]

Hey good work my friend, keep on keeping on

[@garettbodel3002]

Could you or anybody tell me the best way to extract LSA for morning glory seeds. Make a tea or use green alcohol

[@charlie15627]

You do need to be a little more careful about letting foreign contaminants into your solutions.

[@frogz]

i need more dopamine and seratonin, your setup is as janky as the aussie guy!

[@frogz]

the forbidden carbon rings

[@TheToemeister]

Was methylamine really necessary for the Henry reaction? Seems like a waste of a valuable reagent when other conditions are viable such as ammonium acetate in acetic acid.

[@genny_generic]

offhand, what would happen if you ate it? im imagining it would be passed through without much effect, but i cant say i remotely know for sure.

[@lesliegrayson1722]

look at all the stuff I got given.. just before he realized that two of them should not be together and that if they exploded they would mix all sorts of stuff that also should not have been mixed together for a few extra after effects clearing out all the left over buildings on his block that actually survived the first blast....

[@electiangelus]

Love it reminds me of when I was 8 years old my parents would leave and Id crawl under the kitchen counter and start mixing things. Just don't create a nuclear reactor in the shed like the Radioactive Boy scout lol!

[@dedr4m]

Nice of Backyard Scientist to give you his unused chemicals. On topic of neurotransmitters and bodily regulator chemicals, any pointers to the synthesis of Estrodoil? Should I look through the patent system instead of places like ResearchGate?

[@johangrundlingh3729]

Did you mean estradiol? Please note that estradiol is a carcinogen. IIRC, according to the older literature it was synthesized from testosterone in relatively low yield through pyrolysis at 650 degrees C.

[@whoever6458]

Now I do have a couple pairs of those safety goggles. Safety among the top three!

[@whoever6458]

Incidentally, one of my pairs is in my bike bag because the front tire of my bike has a nasty habit of spraying water over my glasses and into my eyes when it rains and that's obviously not safe so I put my chemistry goggles on whenever I'm riding in the rain. It's funny because, back when I was taking chemistry in college, I'd also use my lab coat as a regular coat. My yoga teacher asked me why I didn't have a regular coat and I told her that my lab coat would be fine since, after all, it's designed to protect a person from chemicals and water is a chemical. lol

[@jeremycrochtiere6317]

You'll want to chelate any metal ions still in the solution, you can use EDTA, sodium Citrate and many other chelators to remove Metal ion's