Making Nitroaniline (And the Exploding Snake)

[@DangerousLab]

The exploding snake reaction is so comically funny that it almost seems unreal.

[@integral_chemistry]

It's such a weird one right? It's one of very few reactions where after it happened I just kinda sat and stared in disbelief. Feels like it shouldn't be possible lol

[@TheZombieSaints]

I totally laughed out loud when I saw the first exploding snake, it is funny but so cool at the same time. Well done! 👏👏👏

[@iBad527]

Don’t mind me, just keeping the fed assigned to me on their toes.

[@chemistryscuriosities]

Same 😂

[@alllove1754]

Weird how I've felt that with myself before, just the part where I feel tracked, not the part where I cause others harm, even if jest.

[@alisdairherd9501]

I like to remind people from time to time that the government doesn't give a shit what you do in your spare time. They aren't watching closely and are generally reacting rather than pre-empting.

[@alllove1754]

@@alisdairherd9501 the truth is something to be grateful for. That may very well apply the first time. But God forbid you end up on the short leash of close scrutiny.

[@wonga759]

Come from a free country?

[@richardunruh4035]

Thanks for leaving in the crystallization. I've always found crystallization to be one of the visually beautiful things in chemistry, especially with striking colors like this.

[@integral_chemistry]

No problem! I used to intentionally cut them out because I didn't think anyone would care to see crystals form. Love hearing that other people find their inclusion as cool as I do!

[@andrewjuby6339]

I just said to myself, "recrystallizations are so pretty".

[@matthewryan9283]

The exploding snake demonstration is so awesome! I don't know if I've ever seen it in slow mo but I bet it looks insane

[@Toleich]

I love the red/orange color of nitrogen compounds so much.

[@y33t23]

I love cancer personally

[@jogandsp]

Many nitrogen compounds are colorless. It's not solely the presence of nitrogen that causes the color

[@Toleich]

@@jogandsp I didn't know that. Is it the NO2 that makes the color or a little more complicated?

[@LanceMcCarthy]

Love the crystallization in methanol segment. I wish there was a backlight through the beaker.

[@integral_chemistry]

Thank you, glad you liked it! I did have a backlight under it, tried every angle and from underneath looked best, it's just a super dark solution so it's really tough to see the crystals

[@afrog2666]

9:50 totally looks like a magic trick hehe

[@integral_chemistry]

Honestly feels like a magic trick lol

[@nikolaiturcan6963]

Love the crystalliztion shot

[@alllove1754]

Yay another one❤❤❤! I really enjoy how much your education seems to have advanced- that, or you are more forthcoming with what you have known since the days of school. I also appreciate your appreciation of the crystallization. Thank you

[@integral_chemistry]

I'm glad you've hung around and continue to enjoy my projects 😁 To be honest it's some of both, I knew a lot of theory that I didn't include in my videos because I didn't think it was the kind of thing people would want to hear about on KZbin. Figured people would just wanna see cool fire and colors but I've actually found people do enjoy hearing about the science too (which has been a very pleasant surprise). However, I really didn't get much training in actual lab technique in college (especially because of covid), and because my training was in organic chemistry I came into this knowing basically no inorganic. Since I started this channel I've learned so very much on how to actually do science instead of simply learning about it, but obviously the foundational theory was necessary.. I guess the point is that it's some of both, but I love that you're enjoying the journey!

[@alllove1754]

@integral_chemistry awww! CoVID sucks for that! I don't have the excuse. I was a poorly disciplined child of a student at 19 years old, with a slew of personal conflicting identity issues and very poor patience when it came to the math, which makes me sad and truly regretful. So, yes, I drink in the education like a thirsty marlin. The only labs that lit me up back then were the nitric acid days and the acetic anhydride days. However, with time and a lot of self realization I've grown a lot and really enjoy what it is I had said I enjoyed even back then. Keep up the good work. It's actually really cool to see how much has actually changed since back then. I only remember pH scale, not pKa, for example. But that easily could be simply because of was so distracted from school. This was at the turn of the millennium, in fact just before. Btw, what would happen if you reduced the 4-nitro part to amino? To be more clear, what would the chemical be? I've not heard of aminoaniline. Sorry, I Google it and got p-phenylenediamine, which also sounds cool.

[@integral_chemistry]

@@alllove1754 I had a lot of those same issues early in school, and in my personal opinion I think that 18-22 (typical college age) is way too young for most people to have the mental discipline required to learn most of this kinda stuff. Even though I do believe pKa was already known back then, the limits of what we collectively know about chemistry has expanded so dramatically over the last couple decades that it is honestly overwhelming (especially when it comes to biochemistry). That is a big part of why my own videos are so all over the place, I just want to know it all but there is more to learn than I could ever cover in a hundred lifetimes.

[@alllove1754]

@integral_chemistry soooooo true, the 100 lifetimes comment, inarguably true true true. Having said that, and given you're speaking of biochem, I've grown very interested in enzymes, noting chiggers and how they feed. Did you know they don't chew on our skin like it may feel they do? Their enzyme LIQUEFIES the skin cells, and the cell wraps up into a little straw that they just sip our juices from! Crazy.. and I was thinking enzymes aren't acids, aren't bases (I mean, rather, I should ask, are they acids? are they bases? not stating from assumption like I do so much, apologies there). But from what I've read these really strong ones, like from chiggers, are usually very complex organic molecules, and I'm leaning towards proteins vs other known caustics. I've also been investigating acid ethers or ether acids, given how sulfuric acid seems to be a diacid, if that's even a thing.

[@shardinalwind7696]

Hell yeah, Azo dyes

[@yorkshirechemist]

nicely done! with the o-isomer, you could reduce it to o-phenylenediamine and use that to make benzotriazole with sodium nitrite or you could combine o-phenylenediamine with naphthol, resorcinol, or some other m-disubstituted species and carry out oxidative polymerisation with alkaline hydrogen peroxide to produce coloured pigments - this is the kind of chemistry used in permanent hair dyes

[@integral_chemistry]

Fascinating! Thank you so much for the idea, I'll have to give that a try and see how it goes

[@zacdubois8282]

Getting PTSD to ochem 2, but this is the stuff they never let me make in lab, so it’s worth it

[@integral_chemistry]

It gets so much cooler if you keep up with it after school, I also didn't exactly love orgo lol

[@theponk1]

What a fabulous bit of "nature" in action. Gosh, don't we live in a weird world? That's a proper cool experimental outcome huh? Like freeze frame on a volcano exploding. amazeballs

[@scienceium5233]

youre so underrated

[@integral_chemistry]

Thank you so much! I'm blown away with how many people care to watch as it is already, so I can complain, but I do very much appreciate the kind words :)

[@scienceium5233]

@@integral_chemistry you make truly amazing videos, nilered level

[@scrappydoo7887]

Excellent chemistry there 👍👍

[@integral_chemistry]

Thanks man! 😁

[@flyingshards595]

That was awesome! Thanks!

[@integral_chemistry]

No problem at all! Glad you enjoyed it

[@peter360adventures9]

Awesome

[@Neptune2109]

Id love to see start to finish synthesis of the pigments you are making

[@V8-friendly]

Cool 😎

[@experimental_chemistry]

Very nice to see this preparation, because using the components of nitrating acid is forbidden here in the EU. 🙁 Fortunately I was able to buy a few grams of p-nitroaniline from my favorite Polish seller. 😎

[@integral_chemistry]

Glad you liked it! (But I'm sorry you can't do it :/ always a shame). Who's the seller? (If you don't mind saying of course). I placed a big order recently from a Poland-based seller recently, and I also picked up 15g p-nitroaniline in the order to compare with the stuff I made here.

[@experimental_chemistry]

​​@@integral_chemistry Sorry, I can't tell you here. But if you ask me via e mail I will surely answer.

[@integral_chemistry]

@@experimental_chemistry Whats your email? is it on your profile? I've wanted to start keeping up with you via email for a while anyway

[@guytech7310]

Explosive polymerization! What the consistency of the material left, its just extremely fragile, or more like spray foam? Does it smell?

[@Moritz___]

would like to know the same thing

[@integral_chemistry]

It is extremely fragile yeah, definitely nowhere near as durable or dense as spray foam. Super lightweight so drops the way a balloon does, and it smells slightly like dead fish.. something like methylamine

[@chemnobeliumlab1520]

Awesome! PS : the last footage that surprised me about how fluffy is this thing! I was imagined it would be fragile like aerogel but it was not (maybe because it made of carbon (new allotrope?))

[@integral_chemistry]

Thank you! And yeah I also thought it would have more give to it, but it broke apart fairly easily. I don't know enough about allotropes to say for sure, but my suspicion is that it's some kind of polymer and not pure carbon. I tried dissolving it in water to see what would happen, made the water alkaline which is certainly due to the amine but I don't really have a real explanation yet.

[@matiastripaldi406]

Basic question: why does the acetamide bond not hydrolyze when doing the nitration? Conditions are very acidic just like when you do it with HCl

[@integral_chemistry]

I'm actually not 100% sure, but I do know amides are much tougher to hydrolyze than most other esters. Typically applying heat is required for hydrolysis, so keeping it cool should prevent it for the most part.. also I believe the minimal water present in the nitration mixture could play a part.

[@MTSUChemistry]

Tired this recently, thanks for the video. I didn’t film much of the synthesis but I did film the exploding snake. 4g + 2mL worked best out of a crucible. Also I did the synthesis 1/4 scale and only had enough product to try it once…. Luckily the department had some 4 nitroaniline so I didn’t have to run the synthesis again…. Keyword is HAD…. I used it all 😂😅😂😅

[@MTSUChemistry]

I did have to block some flow for the hood. I think the key is to heat slowww and cut the eat shortly after it starts smoking.

[@nakrul987]

nilered would be so jealous of how big your snake was

[@FlatBroke612]

Stopped in to say hello to my personal glow ginger.

[@timobatana6705]

You could have made up every single word in this video, i wouldnt even know. but I'm still here for it. #SigmaComplex

[@cristianoalkhabbaz3717]

Wow, I learned so much

[@janeczekdeliverservices7831]

Watching the video before commenting would teach you even more!

[@cristianoalkhabbaz3717]

@@janeczekdeliverservices7831 I watched the entire video.

[@jamiemoore1056]

Snakes and sparkles no wizz bangs🎉

[@FK-ng2gf]

is that now recrystalization asmr?

[@ryancarson3327]

Thought the thumbnail was a bowl of hash😂

[@FlatBroke612]

“Don’t tell Mr. Lahey about the hash driveway boys”

[@SeekingTheLoveThatGodMeans7648]

Ah, the forbidden cottage cheese. (4:38)

[@jimrodriguez9747]

4:40 forbidden cream cheese

[@anonomuse9094]

3:33 forbidden mint milkshake

[@memelord_699]

Any ideas what the foam is made of? I would have guessed carbon but it's awfully squishy...

[@experimental_chemistry]

It's just carbon, puffed up by sulfur dioxide.

[@Ronst0ppable1]

what is the snake made of? pure carbon or what?

[@integral_chemistry]

It's definitely mostly carbon, but also definitely not entirely pure.. it makes water alkaline when I tried to dissolve it, which is surprising given it was saturated in concentrated acid. I'm assuming the amine group is responsible somehow

[@oasntet]

What is the foam composed of?

[@integral_chemistry]

I'm pretty sure it's mostly just carbon, but definitely filled with some other messy decomposition products

[@ScienceStuff-sb2dw]

Can you do a series on the synthesis of the world's most expensive molecule, Risdiplam? It's priced at about $150,000 per gram in its pharmaceutical form used to treat Spinal Muscular Atrophy.

[@ericm381]

What is the composition of the snake?

[@ThootenTootinTabootin]

How did it crash out as crystals? Thats doesnt seem possible

[@integral_chemistry]

I've still got absolutely no idea. Never had it happen before and can't find it in literature..

[@TATPMuncher]

3:27

[@danriches7328]

8:27 forbidden curry paste mmmmm

[@wizzywod]

The para-nitroacetanilide coming out of the vacuum filter looks like cream cheese. Here's my official science question for you: What would it taste like on toast?

[@HBM_Enjoyer]

Yo you should make TATB Edit: nah, make lead azide instead 😊

[@MrYellowOffical]

I wanted to to a Vid about it a week ago and filmed it but i only got 1G yield bc i messed up the paranitroaniline crystalization!

[@integral_chemistry]

Huh.. what exactly happened? I feel you could always just reduce down the solution if you used too much solvent or something

[@MrYellowOffical]

@@integral_chemistry I used a Conz NaOH solution and dumped it in and there wasn’t rlly much precipitate than the 1G then I tought I just messed it up and I should have left it stand for some longer. But anyways I will try it again in Futrure and make a new video lol

[@lowstaar]

Subscribed on KZbin for saying TikSuc

[@seansingh4421]

Hey feds, this one isn’t as sus as other chems. You would know if yous didn’t fail gen-chem 1

[@raqibul6198]

I know a lot of people who have a sigma complex

[@pw1340]

I too have a sigma complex

[@THEBIGMEOW]

Is this Morning Wood 🪵?