Mechanisms of Autoimmunity ( Immunology / Pathology / Microbiology / Medicine ) ( NEET PG )

All 10 of the mechanisms of development of Autoimmunity are explained here in a simple and descriptive manner
Even though the video runs on for a while, bear with me XD
Subscribe for more content on Study tips , Concepts , MCQs . :D
Comment on what you would want to see next
Facebook NEET PG Study / Preparation group : / 238027616934102
|Add me on Facebook at : / right.pg.71
Follow me on Instagram : / dr__right
Subscribe to channel at / @dr.rightspg790
Thanks for watching!!!
EDUCATION DISCLAIMER
While the channel and its associated personnel take great care to sceen and make every attempt to review the contents, Dr. Right's PG (DRP) MAKES NO WARRANTY , EXPRESSED OR IMPLIED, as to the accuracy of the content contained in the educational materials, in this video or on this website. The reader of these materials uses these materials at his or her own risk and DRP shall not be responsible for any errors, omissions,or inaccuracies in these materials, whether arising through negligence, oversight, or otherwise.
RELIANCE ON ANY INFORMATION APPEARING ON THIS SITE IS STRICTLY AT YOUR OWN RISK
The information and educational material contained herein is meant to promote the general understanding of the topics. Such infromation is not meant or intented to serve as a substitute for healthcare professional's clinical training, exper ience, or judgement. For patients and individuals, such infromation is not to be a substitute for professional medical, therapeutic, or healthcare advice or counselling. For medical issues or concerns, including decisions about medication and other treatments, readers should always consult their physician or , in serious cases, seek immediate assistance from emergency personnel. SELF MEDICATION IS HAZARDOUS.
DRP MAKES NO WARRANTY THAT THE INFORMATION CONTAINED HEREIN WILL BE ERROR FREE, AND THE READERS OF SUCH INFORMATION USE SUCH AT THEIR OWN RISK

[@elsa8555]

I searched for numerous videos on autoimmunity , none was satisfactory....but then I came across your video ...thank you so much....sir ! ....

[@dr.rightspg790]

Dear Chowtisha Dutta, Thank you for your kind feedback. It brings me joy to hear such kind words. I have always tried hard to provide students with knowledge which is simple to understand and which will provide them with the maximum benefit. - AR

[@elsa8555]

@@dr.rightspg790 yes , tomorrow my pathology exam , I hope whatever I studied just retains in my brain...

[@dr.rightspg790]

​@@elsa8555 fear is the enemy of memory. I have seen students who dont even answer simple questions because they get scared. be confident and relax before opening the question paper. ALL THE BEST . if you have studied it , it will be with you

[@furnacerun]

Same situation for me! Thank you so much, AR. I searched but was not satisfied, until this lecture. I will nail immunity section due to this. Thank you! :)

[@dr.rightspg790]

Dear Eileen, Glad to be off help. For me medicine should be understood and not memorised. Once you understand the heart, the rest is easy. - AR

[@dominic2446]

10 mechanisms of autoimmunity: 1. T cell anergy breakdown 5:23 2. failure of AICD 6:15 3. loss of T reg cell / function 7:05 4. B cell helped by T cell 7:38 5. sequestered antigen 9:06 6. molecular mimicry? 11:40 7. bystanding antigen? 12:43 8. polyclonal immunity 13:57 9 and 10. epitopes and sequestration 14:36

[@apoorvaetikala1861]

Thankyou

[@harishchenna2486]

Thank you

[@dirtrtls]

Doing god s work

[@iyalaakaviyal7291]

Well explained 👌 really best video for auto immunity....keep doing more videos....I am now confident about this lesson... thankyou so much❤️

[@andhrapradesh3648]

I just fallen in love with your voice 😍😍💕

[@mayuridiwase7521]

One of the most informative and best explained videos

[@Remedy1629]

Much much appreciated Thank you Finally got concept of autoimmunity

[@comet8361]

Best explanation nd Your voice is very attractive !❤

[@nimraehsan8965]

Excellent way of teaching..u made it very simple.. thank you

[@funkhor6070]

Sastry ❤.. but you've cleared my confusions 🎉

[@sampritagangavathi7411]

Well explained sir ...it helped me a lot

[@snehasne6278]

In this lockdown situation your lecture made it easy to understand than Online classes ....

[@supriyomitra4027]

humble request to you sir, pls complete the whole mechanisms until its very hard to understand the process.

[@durreziya3644]

Very well explained 👏I understood it for the 1st time 🙂 Thankyou so much sir 🙏

[@aniyakhan500]

You have a beautiful handwriting

[@thilagavathi7459]

Your explanation is awesome.... Can u pls make a video on antigen processing and presentation

[@mysterioussoul5668]

Helped me understand the concepts perfectly 🤩..Thnks alot🥰

[@mrunalmore2302]

Very well explanation sir! Thank you so much. Btw i like your voice and sense of humor too.

[@dipikabhinsara1460]

A very very nice and easy understandable mechanism of autoimmunity is explained....

[@anindyasonar9360]

Too good handwriting to be a doctor 🤣🤣🤣❤️❤️ Btw well understood by the video... thanks

[@dr.rightspg790]

Thank you

[@PranamyaNayak-et2dv]

Thank you sir🙏

[@annapureddysuvarna1528]

as normal lens is not exposed to antibody due to absence of blood supply, even though antibodies against one eye is formed due to trauma ,why does the other eye get blinded ? please explain sir

[@dr.rightspg790]

Dear Annapureddy, This is an excellent question. 1.Though the lens itself is an avascular structure devoid of blood supply and hence antibodies, the uveal tissue in the eye ( iris, choroid and ciliary body ) are highly vascular. 2. Antibodies are found in the aqueous humor which is formed by the ciliary body. the injury to the first eye stimulates the body to form the antibodies which are normally absent in the blood. these antibodies which are formed then travel to the adjacent eye where they enter the aqueous . From here, the antibodies can enter the lens and cause various problems . please feel free to clarify if the explanation was not clear. -AR

[@kamalchavan9457]

@@dr.rightspg790 hello doctor, how can I contact you,need your suggestion regarding auto immune diseases post covid

[@hira4126]

Hi sir i have a confusion is it Anergy or energy?

[@dr.rightspg790]

Anergy - absence of the normal immune response to a particular antigen or allergen.

[@hira4126]

@@dr.rightspg790 thank you so much sir main ne bs abhi abhi lecture complete kiya and i enjoyed alot♥️

[@josephineravenclaw6262]

Finally... Found the one🥰.. Thank you so much

[@visalharikumar9996]

Made it so simple.... Loved it .... Thanks a lot sir....

[@ashwiniasare4183]

quite explainatory n satisfactory and simple very nice

[@dishithapyla3107]

Hello Sir, Can you explain about Antigen-Antibody Reaction and about their types,process.

[@113_ravitejastolinavar6]

Crystal clear concept,, thank you,)

[@ShriJanakiNayakam]

environment and genetic effect on autoimmune diseases pe please sir

[@dishithapyla3107]

Your way of explanation was very nice sir

[@UNKNOWN-tp9oi]

The best video infact..thanks ...🌼✨❤️

[@ramkumar-wb1wl]

Nice lectures sir.. do more videos like this..

[@concepttrigger6517]

It is very well explained sir !❤

[@jemsheenachinju9995]

Ur voice is just so wow. ❤.

[@abishekpidugu129]

Nice explanation sir .......thank you sir👏👏👌

[@Vishnu-bg2kp]

Thank u sir it is soo simplified 😁

[@mofeokoromadu2962]

Great video. Thank you sir

[@user-bv1qg9jm9z]

Excellent tutorial bohot achhein

[@rahuldagur5689]

this is the best explanation

[@sk5869]

Please make more videos.. ur videos are very helpful

[@linkage183]

Sir is this sufficient for bsc 3rd year exam

[@drrajeevdahiwal1856]

Great video sir. Plz can you make video on pathophysiology of ankylosing spondylitis? Thanks in advance

[@chaithanyav7470]

Nice lecture

[@MolecularMedicine327]

You are so good

[@dr.rightspg790]

Thank you

[@suraiyaanwar3111]

You explain it soo well thanks alot doc😍

[@kunalkumarmishra9105]

Well explained sir...thanks a lot 👏

[@bapu78]

Awesome teaching

[@ahir9599]

Excellent explained autoimmunity 🔥🔥🔥

[@ShriJanakiNayakam]

sir autoimmunity pe videos daliey please

[@anandnair3066]

Bestt✌️

[@hira4126]

Sir meri presentation hai 45 min ki aur 6 group members hain toh time divide ho ga aur ye boht lengthy hai kiya ap mujhe in main se 5 most important mechenisms bta sakhte plz k in main se 5 most important konse hain.

[@vershapanda9300]

Awesome

[@roshinikudurmalla5850]

Sir u r amazing

[@kirankumar5011]

Sir u r telling, Inside the woomb antibodies are produced.... But an infant will ptoduce antibodies after 20 weeks..... If IgM antibodies are present during fetal life it is congenital infection.... How to justify it sir??

[@dr.rightspg790]

Hi, Fetus is capable of producing IgM antibodies after 20 weeks of gestation as you said. And specific antibodies to some viruses after 20 weeks indicates congenital infection due to that virus. Other than that IgG antibodies pass through the placenta to the fetus to provide passive immunity. According to clonal deletion theory mentioned in the video, it hypotheses the presence of all antibodies in fetus and subsequent deletion. This is just a theory used to explain the antibody response to non self antigens and external antigens and so on. Hope this helps

[@GG-bv1ns]

Well explained Sir 🔥🔥

[@dikayatama3777]

Would you please tell us Which software do you use to write notes as in this video?

[@vismayak8297]

Liked laughing in between ,it make me awake 🤩

[@alexthottakara4790]

Is this 10 mechanisms which is the one involved in Systematic erythematous Lupus condition.

[@dr.rightspg790]

Most autoimmune disorders are a mixture of various types of mechanism. In general immunity develops to an antigen that should never be detected by immunity in the first place or even if detected should be ignored. If you need the more specific explaination, I have linked an article to help you better than I could in an KZbin comment section. "Both innate and adaptive immune systems play a role in the pathogenesis of SLE. The innate immune system activation is either Toll-like receptor (TLR) dependent or independent. The cell membrane-bound TLRs (TLR 2, 4, 6) are activated on exposure to the extracellular DNA and RNA from dying cells, which leads to downstream activation of the interferon regulatory family (IRF-3), NF-κB, and MAP-kinases, which serve as transcription factors for the production of proinflammatory mediators such as IFN-b." - www.ncbi.nlm.nih.gov/books/NBK535405/#_article-24526_s5_ Hope this helps

[@adityakadu9252]

Well explained

[@sumeethsoman3554]

Great job

[@aartipillai6536]

Excellent 👌👌😊

[@docstrange4152]

Sir how the HLA assisiated autoimmune diseases occur ...I don't know whether HLA DR3 is present in everyone r it's present predispose the person to DM

[@dr.rightspg790]

HLA are involved with antigen processing and immunity to that antigen Autoimmunity is basically immunity production against self antigen which occurs due to improper processing or self vs non self antigen HLA D3 and D4 are variants of HLA in which this type of defective antigen processing takes places in DM

[@docstrange4152]

@@dr.rightspg790 I was asking that if a person has HLA DR2 and one has HlA dr3 How diabetes takes place 🤔

[@dr.rightspg790]

@@docstrange4152 The exact pathological mechanism that occurs for IDDM ( insulin dependant DM ) to occur due to various HLA types is unclear but statistically it has been found that certain HLA types are seen more commonly in certain diseases. HLA DR2 has been found to have negative association with Type 1 DM that means that it is actually protective against IDDM. A person with DR2 is less likely to develop IDDM when compared to general population. Not clear on the exact mechanism HLA DR3 has been found to have positive association with IDDM. Meaning if a person has DR3 Haplotype then he has an increased chance of developing IDDM when compared to the normal population. Hypothesis - Normally the islets cells are not immunogenic in our body but in people with DR3 and DR4 ( which are responsible to immunity and antigen presentation ) they are considered as exogenous antigens and are presented and subsequent immunity against them develops.

[@docstrange4152]

Mean ... Immune cells doesn't attack HLADR2 but if HLA DR3 is present ... Immune headquarters recognize it as foreign antigen and attack ...

[@dr.rightspg790]

In a simple way what you have said is correct. But keep in mind 2 things 1) hla is expressed on all cells but only some cells are presented. Autoimmunity is developing against only few types of cells and not all cells of the body. 2) not everyone having dr3 / 4 will develop IDDM One study found that in a population with DR3 and 4 1 in 20 developed IDDM before age of 15 yrs So environment, diet and other factors also play a role.

[@karanpoudel8240]

You explained it so so so well sir ❤️..but a query is why were you laughing in the video?😂

[@pramitisarma4401]

Excellent

[@ramaraochenchu1775]

Sir my daughter age13years suffering from auto immune diseases like neuro mylities optica from one year she is not walking properly is it curable or not plz reply

[@AdnanKhan-dg8qt]

Sir why did u stop making videos?

[@AbuBakar-or2rs]

Excellent explanations..

[@dr.rightspg790]

Thank you dear Abu Bakar for your feedback. Please feel free to ask for any topic to be added into further videos. -AR

[@anjushree3239]

Why does a adult mother's womb show tolerance to zygote although it is foreign body? Does clonal deletion occur at this time as well. Mother's body is not in foetal stage.

[@dr.rightspg790]

Dear anju shree, This is great doubt. Thank you for asking. The main defense from the mother's immune system is provided by the trophoblast and placenta. they both act at keeping the maternal immunity from acting up and reacting against the fetus. They are many mechanism by which maternal immune tolerance occurs and that can be separate video by itself but here are the list of the main ones 1- maternal circulation never comes in contact with the fetal circulation due to the placenta. mother's antigen presenting cells are not exposed to the fetal cells. 2- the placenta expresses atypical MHC 1 due to which APCs leave it alone 3- presence of Regulatory T cells which decrease the immune reactions though there are many more, this i believe are the main ones please feel to ask for any further clarification if required and for any topic you would like to see a video on. -AR

[@NehaRajput-kc9yz]

Your voice is good 👍👍👍

[@nandinichaudhary2962]

Thank you

[@srinivasaraosirasapalli5104]

very nice sir.please post videos on local anaesthetics useful for neet pg

[@nikhilasreegasikanti1173]

Nice sirr

[@safdaralinandoliya5330]

Are B7 Molecule present on each cell?

[@dr.rightspg790]

Dear Nandoliya, B7 molecules are NOT found on all cells. They are only found on specific activated immune cells

[@isaacchiwowa5186]

avoid laughing in yo presentation

[@bishalchand2178]

If one eye is traumatized and body start producing antibody against it.. how does it reaches other lens if that lens don't have any blood supply?

[@dr.rightspg790]

The lens is isolated from the blood stream and hence there is no antibodies against it. Our body doesn't know such antigen exists. When one lens is exposed to blood, antibodies will b formed against it through antibody producing cells after antigen presentation and processing all take place. These antibodies start circulation in blood and can also come to be in the aqueous humour which is in direct contact with the lens apparatus. Hence, even without blood , antibodies can reach the lens through aqueous humour.

[@vnatresources551]

Very nice

[@calmdown766]

Thanku sir

[@MolecularMedicine327]

Please make more video in autoimmunity

[@dr.rightspg790]

dear Sadiya Samir, I would love to make more video on autoimmunity but the only drawback being that immunology is a very vast subject and selecting specific topics from this is difficult. If you could provide me with a list of topics on which you would like the video to be made, then rest assured i will upload them. -AR

[@Information-00000]

Sir please this vedio make in hinglish language for better understanding

[@hpchannel3307]

what is the topic of tenth mechanism sir?

[@dr.rightspg790]

Both 9th and 10th mechanism are molecular sequestrations occurring at different stages of life. in 9th , the antigen is hidden and thus, anergy is not developed against it in 10th, the hidden antigen is released cause autoimmunity. ( Both can thought to be part of the same theory, but some authors mention them as separate.)

[@haarshitchaudhary8635]

You skipped genetic reasons

[@dr.rightspg790]

Dear Haarshit, Though genes do play a role in autoimmune diseases, it is mainly by the production of abnormal molecules / antigens or via production of dysfunctional immune cells. So those diseases will eventually work via one of the ways which has been mentioned. Hope it could clarify. -AR

[@vaishnavianilgopal1209]

❤❤❤❤❤❤❤

[@fathimaabdul3716]

I dont know y , resembled sharuk khans Voice

[@thilagavathi7459]

The way you explain things is gud...but pls don't talk in hindi in the middle...coz I am not able to understand

[@priyamanoj3896]

This notes are from apurba satri😁😁

[@prajwalareddy2603]

Thank u so much Sir