How DNA Repairs Itself (Proofreading, Oncogenes, Tumor Suppressor Genes, Mismatch, Excision Repair)

[@MedicosisPerfectionalis]

💊 📛 Toxicology Course: www.medicosisperfectionalis.com/

[@MedicosisPerfectionalis]

My MCAT Playlists: 🚗 Physics: kzbin.info/aero/PLYcLrRDaR8_cnnwn5YP6EAfXoAYknzVI3&si=vsCtVfJHk5Upum1F 🚗 Organic Chemistry: kzbin.info/aero/PLYcLrRDaR8_f_-vdA2r_z4Ie-CFAPV2sK 🔥 General Chemistry: kzbin.info/aero/PLYcLrRDaR8_e4MrgwcOjbt3mS4nUbSs8w 🧪 Biochemistry: kzbin.info/aero/PLYcLrRDaR8_c2LBpF_OYvwijOok7ae96N 🧬 Biology: kzbin.info/aero/PLYcLrRDaR8_f10hjfgWdBzaZ9PuIut-y7 ⁉️ MCAT Questions: kzbin.info/aero/PLYcLrRDaR8_fOmzTb2f8L96D_LkLhPw0X

[@nystagmus]

Thank you as usual! I noticed you mentioned that Rb is a tumor suppressor gene but on the next slide, you put it as a oncogene

[@MedicosisPerfectionalis]

⁉️ MCAT Questions: kzbin.info/aero/PLYcLrRDaR8_fOmzTb2f8L96D_LkLhPw0X

[@anchtain6971]

when discovred your videos started enjoying studying

[@MedicosisPerfectionalis]

I am glad!

[@waelfadlallah8939]

Great to know that DNA polymerase recognize the parent strand by its extramethylation, also it's very important what you mentioned regarding how many hits required to develop cancer either in proto-oncogene or tumor suppressor gene. Thinking about it, it's very hard for any cell to develop cancer due to all checkpoints present and strikingly even when a cell senses an extra and abnormal stimulation for proliferation via Myc signaling for example, it automatically shuts down any progression to cell division!

[@MedicosisPerfectionalis]

Well phrased!

[@miqrib9596]

The best explanation. You´re simply the best. Thank you so much. The ancient egyptian Gods and The Bangles bless you, Dr. Medicosis 💜

[@MedicosisPerfectionalis]

Thank you!

[@ketolomics]

Congrats on 1m! Well earned. Except (hey, if I’m not being honest, I’m not helping you, right?) after we get into the video (at about 6:30) you encourage us to watch your Cell Cycle Checkpoints video located in your Biology playlist. That’s a great tip… but PLEASE put the link in the description of THIS video so students don’t have to poke around searching for it. Copy link, paste link, voila, Medicosis leaps up to a new superstratospheric level of user friendliness. Or, to borrow an expression, watching the right videos in the right order is so easy once you give us the links to what the flip you are talking about! 😂❤

[@MedicosisPerfectionalis]

Thank you! Here: Checkpoints of the Cell Cycle: kzbin.info/www/bejne/Z2jNiXhphrZ1p5I

[@remonsobhi6231]

ممكن تعمل سلسلة محاضرات عن ال genetic oncology موضوع معقد جدا وشكرا

[@user-xb9ub8ql4v]

this is perfection!

[@waelfadlallah8939]

Hey! I got a seat in the front row 😊

[@MedicosisPerfectionalis]

Thank you 😊

[@bolikevip-vk5cu]

NICE BRO ::::: CONTINOUS

[@nanelikahya9949]

Veeery well explained

[@MedicosisPerfectionalis]

Thank you 🙏

[@user-oe8pd4rn4b]

Does all precancer always turn to cancer????? Please answer please

[@shaziaafreen4436]

I love you and I keep loving you, you're one of the blessed soul

[@monicageller5346]

That’s an amazing explaining THANK YOU ALOT

[@MedicosisPerfectionalis]

You’re most welcome, Monica! Would you please help me by sharing?

[@monicageller5346]

@@MedicosisPerfectionalis yes👍🏻

[@user-oe8pd4rn4b]

What about leukoplakia

[@lonelyelectron5283]

I dont understand why leading strand more error prone than leading strand, doesnt ligase work on both strand, and since DNA pol of lagging strand polimerizing DNA in small chunk does that reduce error prone

[@LINGHUACHAI-us4cx]

should have watch this video 4 weeks ago

[@remonsobhi6231]

can you please make a series on cancer genetics (colon, breast, pancreas,...) it's very complex topic,, thanks.

[@MedicosisPerfectionalis]

Thank you for letting me know! Don’t forget to check my “Oncology-Cancers” playlist.

[@remonsobhi6231]

@@MedicosisPerfectionalis I’m an oncosurgeon, and I’m addict to your videos 😊

[@user-pz3gl4rx6s]

Big like 🌹

[@MedicosisPerfectionalis]

Thank you 🙏

[@Jess-wk5jo]

Will lung ever ever re grown after pneumonectomy ?