RANK and RANK-Ligand | How Your Bone Is Broken Down!

[@MedicosisPerfectionalis]

🦠Antibiotics Lectures: www.medicosisperfectionalis.com/ 📝 Download Notes: www.medicosisperfectionalis.com/

[@farfarhad1283]

One Correction for Whoever watching after me. ● Steroid = inhibits Osteoblast, whose function is bone formation. So, Steroid causes osteoporosis. How Steroid causes Osteoporosis ? By inhibiting bone formation by:- 1. Apoptosis of Osteoblasts & Osteocytes. 2.Inhibit intestinal Ca++ absorption. 3.Increase Renal excretion of Ca++. 4.Causes Secondary Hyperparathyroidism (Ref:- Devidson's Principles and Practices of Medicine, 23rd edition) Thank you 😍 for this Excellent video.

[@yanbingzhu2550]

Thank you so much. You just saved my life. I was biting my nails, pulling my hair....... I was like "steroids inhibitors osteoclast, then why does steroids cause osteoporosis......." Does this mean overall, steroid both inhibit osteoblast and osteoclast? By the way, do you know why can PTH analog be used for osteoporosis? As I know PTH stimulate osteoclast, so high PTH can cause osteoporosis. Shouldn't PTH analog make osteoporosis worse?

[@Me.super.nerdyy]

@@yanbingzhu2550omg sameeee they saved me with that comment

[@ubongumoren1856]

Guy for the first time ever I fully grasped the RANKL-RANK pathway as well as the basis of elevated ALP! Thank you very much!!

[@MedicosisPerfectionalis]

You're very welcome!

[@munakhalil8448]

I gotta admit I'm a total nerd but I've never enjoyed learning more than I do when watching your videos. This is awesome!! Hats off and thank you!

[@kimt1214]

You are amazing Sir! What the book wrote in one chapter was succinctly summarized in 10 minutes, well-explained and easily understood. Every time I watch your videos, I try to keep my stupidity buried somewhere far away lol!

[@MedicosisPerfectionalis]

Haha 😂 You’re awesome, Kimberly! Thank you so much 😊

[@nicolekarmo]

Can you explain the effects of estrogen on bone? Specifically on the levels of OC/ OB/ RANK/ RANK-L/ ALP/ Ca/ PTH/ hydroxyproline? I had an up/down arrow question on this topic. Great video by the way!

[@WhyNot-si4pj]

Estrogen results in low levels of OC / RANK / RANK-L / Ca . High levels of OB / ALP / hydroxyproline / PTH .

[@quagmireglen7497]

you sir, just gaved me a 2hour lecture in 10 min thank you !

[@MedicosisPerfectionalis]

My pleasure 😇

[@rodeselgac]

I adoooore this channel. It's just amazing. Thank you so much Medicosis! :)

[@MedicosisPerfectionalis]

My pleasure 😇 Thank you so much for watching!

[@rodeselgac]

@@MedicosisPerfectionalis 🤍🤍🤍🤍

[@tanyasharma990]

Hello Sir U said that steroids inhibits osteoclasts . But one of the adverse effects of corticosteroid is Osteoporosis ... Please explain .

[@pujapatel7236]

prolonged steroid creates imbalance in cytokines, thus there is a decrease in OPG production, therefore promoting the RANK to RANKL binding which produces more osteoclasts. While the steroid prolonged longevity of osteoclasts, their bone-degrading capacity was suppressed. The inhibitory effect of DEX on bone resorption reflects failure of osteoclasts to organize their cytoskeleton in response to M-CSF

[@WhyNot-si4pj]

Actually cortisol inhibits OSTEOBLASTS not OSTEOCLASTS ===> osteoporosis !

[@hariskhan-xj4wk]

steroids MOA=1.causes apoptosis of both osteoblasts and osteoclasts 2.decrease absorbtion of calcium 3.inc excretion of calcium 4.decrease cytokines e.g opg 5.causes hypnogonadism.decrease testosterone more bone loss 6.secondary activation of parathyroid hormone when calcium is low and more bone resorbtion

[@WhyNot-si4pj]

@@hariskhan-xj4wk Let's conclude that cortisol has an anti- vitamin D effect & a suppressor effect on bone stem cells known as OSTEOPROGENITOR CELLS limiting bone cell division & differentiation !

[@jeminkukadiya13]

What?

[@ItsMe-jr6kd]

I was stupid and I hated 😁RANK and RANKL till i watch this awesome video 🌹

[@MedicosisPerfectionalis]

Thank you 😊

[@lindadahlen7407]

I really learned a lot from this video. Thank you. I am trying to have a dialogue with my endocrinologist to determine why I have a senile case of osteoporosis. i have high ca in blood and urine and very high inflammation in my body. I will discuss these cytokines that activate the osteoclast with my doctor and other pertinent information from this video.

[@MedicosisPerfectionalis]

Awesome 👏 Please follow up with your doctor, and never give up!

[@mernaelnosiry9672]

Very helpful. Thank you.

[@MedicosisPerfectionalis]

My pleasure 😇

[@amandarossell5167]

Thank you!

[@MedicosisPerfectionalis]

My pleasure 😇

[@yanbingzhu2550]

Medicosis, does stimulate osteoblastic stromal cells also increases osteoblast activity and increases bone formation?

[@cagrbelli2561]

You are perfect !

[@MedicosisPerfectionalis]

Thank you 🙏

[@gracecabungcal4392]

How about publishing your videos into paper? Some still prefer to study on paper version .. I would be excited to purchase one! 🎉

[@MedicosisPerfectionalis]

Thank you, Grace! I have these notes in PDF forms on my website. You can download and print: www.medicosisperfectionalis.com/

[@nha8909]

Thank you !!! Q: how come steroid cause osteoporosis then??

[@pujapatel7236]

prolonged steroid creates imbalance in cytokines, thus there is a decrease in OPG production, therefore promoting the RANK to RANKL binding which produces more osteoclasts.

[@nha8909]

@@pujapatel7236 thank you !!!! makes sense

[@loubnadr7407]

My prayers are with you

[@MedicosisPerfectionalis]

🙏🙏🙏

[@AnindyaDasAdhikary]

Thank you, very helpful

[@MedicosisPerfectionalis]

My pleasure... Thanks for watching!

[@Friendsseries1]

Thank you so much 🤓

[@MedicosisPerfectionalis]

My pleasure 😇

[@tola123100]

thank u for your effort

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@batoolqassim9715]

YOU ARE AWESOME

[@MedicosisPerfectionalis]

Thanks 🙏

[@abdulhyealmonsur1000]

Excellent

[@MedicosisPerfectionalis]

Thank you 🙏

[@niss2nice]

If i understand correctly, whenever an osteoblast is activated it will also activate an osteoclast through the rank-land rank pathway. is that correct?

[@MedicosisPerfectionalis]

Yes

[@niss2nice]

@@MedicosisPerfectionalis thank you

[@Mohammedbenmizraim]

Thank you ..

[@MedicosisPerfectionalis]

My pleasure 😇

[@pao154]

Thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@drpepper7801]

Why is ALP level normal in osteoporosis while it is high in osteomalacia

[@dsun_blue183]

How does a steroid cause osteoporosis .. please explain

[@MedicosisPerfectionalis]

They inhibit osteoblasts while stimulating RANK-L to stimulate osteoclasts and increase bone breakdown.

[@abkarmarkar]

Which video recording software u use?

[@MedicosisPerfectionalis]

Kindly send me an email: [e-mail]

[@kaztazable]

You are doing the Lord's work with this channel....saving one medical student at a time. We're simply not deserving of your excellence

[@MedicosisPerfectionalis]

Thank you so much 😊

[@jerrypotter9070]

Can you please explain heterophile antibody in detail? No good video on KZbin.

[@MedicosisPerfectionalis]

Coming soon

[@loyaltyesmaeel5656]

the only relaxing thing in this video is the musical intro 😔😔

[@MedicosisPerfectionalis]

😂😂

[@Vxneji]

I thought vitamin D was good for bones? but here it shows vit D encourages bone reabsorption ? is this true?

[@MedicosisPerfectionalis]

Vitamin D wants to optimize the level calcium in the blood...If blood calcium is low, vitamin D may break down bones to get the calcium out. So, it really depends on the situation!

[@yanbingzhu2550]

@@MedicosisPerfectionalis Is that why we alway give vitamin D together with Calcium?

[@mammad3345]

Amaaaazing:))

[@zasaltik]

OPG inhibits RANK-L, not RANK

[@nicolekarmo]

OPG is a soluble decor receptor for RANKL. It binds RANKL and thereby inhibits osteoclastogenesis. It's ultimately needed to regulate bone mass homeostasis by preventing excessive resorption by osteoclasts. Someone who is OPG-deficient would exhibit excessive bone resorption and severe osteoporosis due to an unchecked OPG-RANKL axis.

[@Tamunolabofori]

I still dont understand

[@ezatkhalil4879]

estrogen inhibit RANK-L

[@clementmasai7487]

For this single slide ....😂😂😂😂😂

[@MedicosisPerfectionalis]

:)

[@Soul-Edge]

Not pro ,its pre osteoclast, i guess

[@dhruvibhavsar3872]

Steroids + osteoclast = osteoporosis. Correction

[@User-to7nb]

can you stop going on and on uselessly and teach? "but with medicosis its going to be prefeectinalis" HA-ha no one thinks its funny -.-

[@user-oh7fz6nr3h]

No one forced you to watch!

[@milicao28]

THANK YOU!

[@MedicosisPerfectionalis]

My pleasure!