Von Willebrand Disease (VWD) Subtypes: Type 1, 2A, 2B, 2M, 2N, and 3

[@dvf4550]

This guy teaches a technical, dry topic with wisdom and hilarity! :-D

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@jimmypk1353]

Yeah! Like, "We gotta keep the blood stream PG-13." How can you forget an analogy like that? 😁

[@kollywogs3342]

Great video. Thanks! I have VWD Type 2M with severe symptoms. The standard of care for this type is Humate-P as this type is only variably responsive to DDAVP. I even keep Humate-P at home and take it with me when I travel because hospitals don't always have it on hand. Surgeries are particularly difficult because DDAVP requires a strict fluid intake which is often impossible to adhere to when you have to get IV fluids and/or blood transfusions during and after the procedure. Everyone who has VWD should work closely with a benign hematologist who specializes in bleeding disorders because surgeons and anesthesiologists often don't understand the nuances and you need to have a plan going into the surgery. Oncologist/hematologists are often focused on cancer and they don't have a lot of experience with the VWD subtypes. Also, fun fact... type 2M gets misdiagnosed more often as Type 1 than it gets correctly diagnosed as Type 2M. This type doesn't necessarily have missing multimers, just abnormal ones. There is a large variabilty in bleeding patterns and laboratory phenotypes. Genetic testing can help.

[@shahabuddin6149]

You are the best teacher in KZbin as well as in globe,we are only depending on you're lovely and precise notes,not college professors,keep it up be happy and healthy forever

[@MedicosisPerfectionalis]

Thank you so much, brother! I appreciate you!

[@shahabuddin6149]

@@MedicosisPerfectionalis most welcome Sir,,I note you're 2 lectures daily base thanks,achieve first position from day first up to 4th years MBBS

[@theafricanesther5795]

I'm still a med student but I thoroughly enjoyed this video. You made it so easy, thank you

[@MedicosisPerfectionalis]

Glad it was helpful!

[@emanabdelghaffar1923]

Words can’t expess how much I’m grateful for you , you have made medical school much easier (: Much of love from your home country

[@Yippieyiyo]

I'm not a med student but I have type 2b and I love learning about my condition

[@MedicosisPerfectionalis]

Thank you so much for watching! I wish you all the best!

[@fatimarezai5644]

Sir thumbs up for you The best ever explaination All videos of you are a great gift for all the poor knowledged medical students for life Big fan of you❤❤❤❤👍👍👍👌👌👏👏👏 The one n only authentic source for me out of many others

[@MedicosisPerfectionalis]

Thank you so much 😊

[@DasEsa]

Ur style for lecturing are Amazing. Allah blessing u. From Kurdistan/iraq

[@MedicosisPerfectionalis]

Thank you so much! I appreciate you! Would you please help me by sharing?

[@cherrrriii]

i can never stop admiring your work, thank you so much

[@MedicosisPerfectionalis]

I am honored!

[@rathodnehal2869]

i am nursing student but after i watch your so many video iam happy and i have confidence tq so much 😘😊👍 and clap 🖐️🖐️🖐️tq again

[@manarmahmoud9872]

12:26 subtypes ❤️ Thanks for your efforts ❤️❤️

[@MedicosisPerfectionalis]

Thank you!

[@nesmaessam9115]

I love you, 😭😭❤️❤️❤️ I stady to my exam from here.. and I'm sure I'll passsssss 😭😭😭❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you so much 😊 Good luck to you!

[@Pathology92]

Thank you!❤❤,,,,,best explanation of subtypes,,,,,most abundant platelet surface receptor is Gp2b/3a complex(40,000-90,000 copies per cell with an additional pool that can be recruited by agonist-induced platelet activation) and qualitative or quantitative deficiency of it leads to a coagulopathy named glanzmann's thrombasthenia,,,,,,,

[@MedicosisPerfectionalis]

Thank you so much for your kind words! You’re absolutely correct

[@jacksparrow-wq1pb]

Never skip the ads ❤ that's how I show my gratitude ❤

[@MedicosisPerfectionalis]

I appreciate you so much!

[@MohamedMohamed-uq7bn]

Really exellent vedio .... bleeding disorders were always a nightmare for me... not any more

[@MedicosisPerfectionalis]

I am so delighted!

[@flaviusmiron9171]

Can't believe that you used "The Good, the Bad and the Ugly" movie reference. Love your videos, they are great :D

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@sissilguitare7919]

Thank you so Much man best explanation ever love this playlist

[@MedicosisPerfectionalis]

My pleasure 😇

[@leptoquark6278]

The best ever......and u don’t need to retire...lol...

[@MedicosisPerfectionalis]

Haha 😂 Thank you so much 😊

[@dominikabajguz1221]

Nice video! Just one correction: Type 2N is also autosomal recessive. Carriers do not have symptoms

[@alraheemt47bc12]

i watch your videos whenever i feel low.....

[@MedicosisPerfectionalis]

:)

[@mahmed5021]

U made it all so easy! Thank u 💌 just one request, can u please explain the vwf:Rco/vwf:Ag ratio a bit more please? Why its increased in type 1 and type 2N and decreased in type 2A , 2B, 2M? thanks!

[@MedicosisPerfectionalis]

Just divide vWf: Rco by vWF: Ag, and you get the answer. There is no scientific explanation here, it's just a mathematical ratio

[@mahmed5021]

Medicosis Perfectionalis thanku ! Didnt notice it before ☺

[@knblaster5448]

Thanks prof! Really enjoyed the video.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@orbetayedamarie6213]

Hii, i really love your videos :)) can i ask what books is your references for this? I am a medtech student and we have a case study concerning this. Thank you so much!

[@dvf4550]

I and most of my family have type 2N. Our doctors have us use Wilate, not Desmopressin.

[@LEW_Aleha]

You are the best!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@ayecii]

You are amazing.

[@abelsaju5155]

the most abundant receptor on the surface of PLT is Gp2b/3a receptor

[@Truth_Seeker1]

I have Von Willebrand’s disease type 3.

[@MedicosisPerfectionalis]

I am so sorry 😐

[@Truth_Seeker1]

@@MedicosisPerfectionalis Thanks, so much but it’s not your fault. I don’t get bleeds too often so I’m fine. I did get injections everyday after surgery.

[@madhureddy6483]

Plz Send me your mobile no I have type 2

[@kaptankancik9816]

2N is autosomal recessive

[@itssomeone4407]

Thanks alooooooooooot

[@MedicosisPerfectionalis]

You’re very welcome! Would you please help me by sharing my videos with others?

[@ifrahakbar2878]

please make videos on cancers of all the systems!

[@rathodnehal2869]

hey. 🖐️🖐️ doctor do you please make video of DIC please 🙏🙏

[@MedicosisPerfectionalis]

Coming soon

[@rathodnehal2869]

@@MedicosisPerfectionalis thank you doctor🙏🙏 i wait 🙏🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@yalda3339]

amazing sir!thank you👏💖

[@MedicosisPerfectionalis]

My pleasure 😇

[@ravitejasamudrala4]

Hi my family history all members have Von Willebrand disease factor 8. We can take Covid-19 vaccine or not.lot of confusion please help me

[@patrickmwai6514]

On the type 2N, why did you not mention about the effect of abnormal vwf on platelet adhesion?

[@meredith1581]

How about if you VWB factor is super high (over 500) and factor VIII is normal. Which type would that be?

[@mohammedalshubbar5273]

But since type 1 is a quantitative defect, why will there be decrease in vwf activity, should it be only in antigen?

[@rezvanmehr1990]

Pefect

[@DonnaPerry-s9o]

Eleanore Greens

[@beequinn5204]

Why would you have low factor eight and factor seven lacking in vWD, I always end up having to get plasma & blood transitions??? What happens when you can't have DDAVP

[@ayaaljarrah6359]

What's is the answer

[@LetaWallace-i2m]

Stark Road

[@dominique573n9]

i have been diagnosed with VWD type 3 it is very severe and need to get humate p infusions for the 7-10 days I get my menstrual cycle. My parents have had genetic testing and only my mother has the gene for VWD. My dad does not. My question is, don’t both parents need to pass this in order for their child to have VWD type 3? How does it work? Thank you!

[@IvethFonsecaop]

Waylon Shores

[@sarahlaila4379]

Which tests should be done to distinguish vWD 2b from pseudo vWD?

[@PeterRodriguez-g3m]

Kailee Spring

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Erica Forge

[@hannahlutz2382]

Why does it say to give desmopressin with type three???

[@hannahlutz2382]

This is stated in the table. It is wrong and should be corrected. Does repression should never be given in type three.

[@BrowningLarry-n7v]

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