Von Willebrand Disease (VWD) Subtypes: Type 1, 2A, 2B, 2M, 2N, and 3

Von Willebrand Disease (VWD) Subtypes: Type 1, 2A, 2B, 2M, 2N, and Type 3 VWD.
Von-Willebrand factor (vWF) comes from the meagakaryocytes (bone marrow) as well as the Weibel-Palade bodies (endothelial cells). Von Willebrand factor (vWF) helps the platelets adhere to the sub endothelial collagen via GP1b receptor on the platelet.
Von Willebrand disease (vWD) is the most common inherited bleeding disorder worldwide.
Primary hemostasis involves forming a platelet plug (thrombocytes) whereas secondary hemostasis involves making a fibrin thrombus (coagulation factors).
Ionized calcium helps blood coagulate.
We test for primary hemostasis via platelet count, bleeding time, and platelet aggregometry.
We test secondary Hemostasis via prothrombin time (PT), activated partial thromboplastin time (aPTT), and the old coagulation time (or clotting time, or thrombin time).
Von Willebrand Dusease (vWD) affects primary as well as secondary Hemostasis.
Hemolytic Uremic Syndrome (HUS), atypical Hemolytic Uremic Syndrome (aHUS), and Thrombotic Thrombocytopenic Syndrome (TTP).
Atypical hemolytic uremic syndrome (aHUS) is similar to thrombotic thrombocytopenic Purpura (TTP).
Typical Hemolytic Uremic Syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.
Thrombotic thrombocytopenic purpura (TTP) is a pentad of microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, fever, and neurological abnormalities.
💊 Get my Anti-Cancer Pharmacology Course: www.medicosisp...
Use the Promo Code: 35OFFCANCER to get a 35% discount on any product (only 6 left).
💊 Cardiac Pharmacology Lectures:
www.medicosisp... ...
- 💊Antibiotics Lectures: www.medicosisp...
Bernard-Soulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).
Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.
Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of Bernard-Soulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).
😍🖼Animated Mnemonics (Picmonic): www.picmonic.c...
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Picmonic has hundreds of animated medical mnemonics...These are very interactive Picmonics that help you memorize and retain tons of medical topics.
They also have a mobile app so that you can learn and have fun on the run.
Disclaimer: I use affiliate links...
Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
► Get my Leukemia Notebook:
www.medicosisp...
► Watch my hematology videos: • Hematology/ Oncology
► Support me on Patreon: / medicosis
► Support me on PayPal: www.paypal.me/...
► Join my Channel on KZbin: / @medicosisperfectionalis
► All of my premium courses are ON SALE: www.medicosisp...
► Watch my Cardiac Pharmacology Playlist on KZbin: • Cardiac Pharmacology
► Watch my Rheumatology Playlist: • Rheumatology
► If you have any questions, please email me at: [e-mail]
► Watch the entire playlist of Rheumatology • Rheumatology
--If you have joined my channel on youtube (the join button that's next to the subscribe button), then go to the "community tab" and you will find some member-only posts.
Thank you so much for supporting my channel! Love ❤️
Happy studying!!
😍🖼Animated Mnemonics (Picmonic): www.picmonic.c... My Favorite Productivity App: airtable.com/i...
📊 My favorite Productivity App: airtable.com/i... 📱Save on your mobile phone bill: fbuy.me/q6bMj 🏦 Qbank (TrueLearn): truelearn.refe...

[@dvf4550]

This guy teaches a technical, dry topic with wisdom and hilarity! :-D

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@jimmypk1353]

Yeah! Like, "We gotta keep the blood stream PG-13." How can you forget an analogy like that? 😁

[@kollywogs3342]

Great video. Thanks! I have VWD Type 2M with severe symptoms. The standard of care for this type is Humate-P as this type is only variably responsive to DDAVP. I even keep Humate-P at home and take it with me when I travel because hospitals don't always have it on hand. Surgeries are particularly difficult because DDAVP requires a strict fluid intake which is often impossible to adhere to when you have to get IV fluids and/or blood transfusions during and after the procedure. Everyone who has VWD should work closely with a benign hematologist who specializes in bleeding disorders because surgeons and anesthesiologists often don't understand the nuances and you need to have a plan going into the surgery. Oncologist/hematologists are often focused on cancer and they don't have a lot of experience with the VWD subtypes. Also, fun fact... type 2M gets misdiagnosed more often as Type 1 than it gets correctly diagnosed as Type 2M. This type doesn't necessarily have missing multimers, just abnormal ones. There is a large variabilty in bleeding patterns and laboratory phenotypes. Genetic testing can help.

[@Yippieyiyo]

I'm not a med student but I have type 2b and I love learning about my condition

[@MedicosisPerfectionalis]

Thank you so much for watching! I wish you all the best!

[@shahabuddin6149]

You are the best teacher in KZbin as well as in globe,we are only depending on you're lovely and precise notes,not college professors,keep it up be happy and healthy forever

[@MedicosisPerfectionalis]

Thank you so much, brother! I appreciate you!

[@shahabuddin6149]

@@MedicosisPerfectionalis most welcome Sir,,I note you're 2 lectures daily base thanks,achieve first position from day first up to 4th years MBBS

[@theafricanesther5795]

I'm still a med student but I thoroughly enjoyed this video. You made it so easy, thank you

[@MedicosisPerfectionalis]

Glad it was helpful!

[@fatimarezai5644]

Sir thumbs up for you The best ever explaination All videos of you are a great gift for all the poor knowledged medical students for life Big fan of you❤❤❤❤👍👍👍👌👌👏👏👏 The one n only authentic source for me out of many others

[@MedicosisPerfectionalis]

Thank you so much 😊

[@emanabdelghaffar1923]

Words can’t expess how much I’m grateful for you , you have made medical school much easier (: Much of love from your home country

[@cherrrriii]

i can never stop admiring your work, thank you so much

[@MedicosisPerfectionalis]

I am honored!

[@Pathology92]

Thank you!❤❤,,,,,best explanation of subtypes,,,,,most abundant platelet surface receptor is Gp2b/3a complex(40,000-90,000 copies per cell with an additional pool that can be recruited by agonist-induced platelet activation) and qualitative or quantitative deficiency of it leads to a coagulopathy named glanzmann's thrombasthenia,,,,,,,

[@MedicosisPerfectionalis]

Thank you so much for your kind words! You’re absolutely correct

[@flaviusmiron9171]

Can't believe that you used "The Good, the Bad and the Ugly" movie reference. Love your videos, they are great :D

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@DasEsa]

Ur style for lecturing are Amazing. Allah blessing u. From Kurdistan/iraq

[@MedicosisPerfectionalis]

Thank you so much! I appreciate you! Would you please help me by sharing?

[@sissilguitare7919]

Thank you so Much man best explanation ever love this playlist

[@MedicosisPerfectionalis]

My pleasure 😇

[@jacksparrow-wq1pb]

Never skip the ads ❤ that's how I show my gratitude ❤

[@MedicosisPerfectionalis]

I appreciate you so much!

[@MohamedMohamed-uq7bn]

Really exellent vedio .... bleeding disorders were always a nightmare for me... not any more

[@MedicosisPerfectionalis]

I am so delighted!

[@manarmahmoud9872]

12:26 subtypes ❤️ Thanks for your efforts ❤️❤️

[@MedicosisPerfectionalis]

Thank you!

[@nesmaessam9115]

I love you, 😭😭❤️❤️❤️ I stady to my exam from here.. and I'm sure I'll passsssss 😭😭😭❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you so much 😊 Good luck to you!

[@leptoquark6278]

The best ever......and u don’t need to retire...lol...

[@MedicosisPerfectionalis]

Haha 😂 Thank you so much 😊

[@rathodnehal2869]

i am nursing student but after i watch your so many video iam happy and i have confidence tq so much 😘😊👍 and clap 🖐️🖐️🖐️tq again

[@dominikabajguz1221]

Nice video! Just one correction: Type 2N is also autosomal recessive. Carriers do not have symptoms

[@Truth_Seeker1]

I have Von Willebrand’s disease type 3.

[@MedicosisPerfectionalis]

I am so sorry 😐

[@Truth_Seeker1]

@@MedicosisPerfectionalis Thanks, so much but it’s not your fault. I don’t get bleeds too often so I’m fine. I did get injections everyday after surgery.

[@madhureddy6483]

Plz Send me your mobile no I have type 2

[@dvf4550]

I and most of my family have type 2N. Our doctors have us use Wilate, not Desmopressin.

[@ravitejasamudrala4]

Hi my family history all members have Von Willebrand disease factor 8. We can take Covid-19 vaccine or not.lot of confusion please help me

[@abelsaju5155]

the most abundant receptor on the surface of PLT is Gp2b/3a receptor

[@knblaster5448]

Thanks prof! Really enjoyed the video.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@itssomeone4407]

Thanks alooooooooooot

[@MedicosisPerfectionalis]

You’re very welcome! Would you please help me by sharing my videos with others?

[@ayecii]

You are amazing.

[@kaptankancik9816]

2N is autosomal recessive

[@alraheemt47bc12]

i watch your videos whenever i feel low.....

[@MedicosisPerfectionalis]

:)

[@LEW_Aleha]

You are the best!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mahmed5021]

U made it all so easy! Thank u 💌 just one request, can u please explain the vwf:Rco/vwf:Ag ratio a bit more please? Why its increased in type 1 and type 2N and decreased in type 2A , 2B, 2M? thanks!

[@MedicosisPerfectionalis]

Just divide vWf: Rco by vWF: Ag, and you get the answer. There is no scientific explanation here, it's just a mathematical ratio

[@mahmed5021]

Medicosis Perfectionalis thanku ! Didnt notice it before ☺

[@orbetayedamarie6213]

Hii, i really love your videos :)) can i ask what books is your references for this? I am a medtech student and we have a case study concerning this. Thank you so much!

[@ayaaljarrah6359]

What's is the answer

[@patrickmwai6514]

On the type 2N, why did you not mention about the effect of abnormal vwf on platelet adhesion?

[@mohammedalshubbar5273]

But since type 1 is a quantitative defect, why will there be decrease in vwf activity, should it be only in antigen?

[@rathodnehal2869]

hey. 🖐️🖐️ doctor do you please make video of DIC please 🙏🙏

[@MedicosisPerfectionalis]

Coming soon

[@rathodnehal2869]

@@MedicosisPerfectionalis thank you doctor🙏🙏 i wait 🙏🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@beequinn5204]

Why would you have low factor eight and factor seven lacking in vWD, I always end up having to get plasma & blood transitions??? What happens when you can't have DDAVP

[@yalda3339]

amazing sir!thank you👏💖

[@MedicosisPerfectionalis]

My pleasure 😇

[@meredith1581]

How about if you VWB factor is super high (over 500) and factor VIII is normal. Which type would that be?

[@dominique573n9]

i have been diagnosed with VWD type 3 it is very severe and need to get humate p infusions for the 7-10 days I get my menstrual cycle. My parents have had genetic testing and only my mother has the gene for VWD. My dad does not. My question is, don’t both parents need to pass this in order for their child to have VWD type 3? How does it work? Thank you!

[@ifrahakbar2878]

please make videos on cancers of all the systems!

[@TorieEzernack-s2w]

Stanton Haven

[@hannahlutz2382]

Why does it say to give desmopressin with type three???

[@hannahlutz2382]

This is stated in the table. It is wrong and should be corrected. Does repression should never be given in type three.

[@MargaretSosa-v5z]

Wilson Jose Lopez Linda Hernandez Maria

[@sarahlaila4379]

Which tests should be done to distinguish vWD 2b from pseudo vWD?

[@AbbottAdam-b5i]

Ubaldo Circles

[@IvethFonsecaop]

Waylon Shores

[@rezvanmehr1990]

Pefect

[@CyndiPallares-z4j]

Hettinger Shoals

[@MaxwellMartha-f3n]

Graciela Ports

[@LetaWallace-i2m]

Stark Road

[@NoddinArmy-g8e]

Lopez Shirley Rodriguez Helen Gonzalez Ronald

[@NehemiahEdwina-y4r]

Erica Forge

[@HooverJane-g1t]

Damaris Vista

[@KeynesBarrie-j9z]

Porter Expressway

[@BradleyNeal-p5i]

Kassulke Avenue

[@ConradHerman-t4l]

Bergstrom Trafficway

[@RichardDouglas-h4q]

Norberto Dale

[@SassoonBlake-u2k]

Jenkins Road

[@BachHugo-k3o]

Alejandra Stravenue

[@RayleignJocelyn-n3i]

Nicholaus Springs

[@TaylorDave-r3l]

Kristina Road

[@RaglanChanning-g3e]

Bergnaum Garden

[@IsabelElsie-b8n]

Alba Alley

[@AnnaMiller-p8x]

2M has normal multimers

[@EvelynPhillips-h7l]

Hartmann Track

[@LoisGrant-m2s]

Martinez Melissa Garcia Sandra Lopez Mary

[@ArmstrongBurke-j1g]

Conor Expressway

[@FloydWalker-x2d]

Sporer Plaza

[@SandraBenoit-q3s]

Effertz Turnpike

[@MariaDean-d1l]

Ramon Tunnel

[@HobertDukas-d9x]

Dach Squares

[@JeanMiles-d1t]

Gottlieb Canyon

[@LeightonBrady-x3b]

Willis Glens

[@JeromeSebastian-s1o]

Jacobi Dam

[@LoisGrant-m2s]

Moore Anthony Garcia Sandra Lopez Melissa

[@БожидарБожидарЙОРДАНОВ]

Perez Susan Clark Brenda Martinez William

[@JohnJenkins-v9l]

Eulah Manors

[@JamieLaroche-s6n]

Benton Ranch

[@RoyanaKhatun-c8n]

Clark Scott Garcia William Walker Jose

[@JudyStockton-c1n]

Julius Bridge

[@LucasHulda-c6x]

Gene Road

[@JimChepiga-d6d]

Braden Inlet

[@JoeyThissen-q3b]

Cartwright Landing

[@NannetteChapoton-y4t]

Littel Avenue

[@StanfordSchlesier-r4r]

O'Reilly Place

[@ChaucerBing-u4g]

Luna Shores

[@FeltonRoe-r3v]

Halvorson Island

[@randytracey7714]

Gonzalez Gary Martinez Gary Thomas Daniel

[@FinnMicheal-y3h]

Kathryne Dam

[@GusEdison-m8m]

Seamus Mills

[@jennawalkman9466]

Lopez Ruth Harris Kenneth Gonzalez Thomas

[@adaezejanet4020]

Adeline Isle

[@PaulaNguyen-d9w]

Schneider Fall

[@FredMcGinley-w7o]

Rath Via

[@MargeryPamela-z3d]

Hammes Plaza

[@VitaMosakowski-v6r]

Finn Flats

[@MackintoshAdair-p4r]

Ratke Forge

[@LeroyHarrison-w8r]

Russ Cliffs

[@EirikSolheim-jq3km]

Davis Carol Gonzalez Robert Lewis Frank

[@SonmerfieldWendell-e4q]

Schneider Islands