Von Willebrand Disease | Pathophysiology, Types, Symptoms and Treatment

[@zakialyamani2648]

I am pretty sure VWF binds unto the GP1B, not the GPIIB/IIIa, as that is a Fibrinogen receptor.

[@mariiakasianchyk3768]

Yes, you are right! It seems that this guy confuses an adhesion and aggregation.

[@adrianpop4427]

Von Willebrand factor does act as bridge between platelets by binding two GP IIb/IIIa receptor on diferent platelets. Sources: kzbin.info/www/bejne/d3-7n2amishseaM, and articles www.ncbi.nlm.nih.gov/pmc/articles/PMC424474/, ashpublications.org/blood/article/105/3/1078/19658/Von-Willebrand-factor-accelerates-platelet. BUT that is aggregation, most sources agree that the platelet plug starts with adhesion which involves the platelet binding to the vWF (which is tied to collagen) via the GP Ib receptor. After that it rolls on the collagen and binds to it with GP VI and GP Ia/IIa strengthtening the bond. After this follow the GP IIb/IIIa story.

[@shvonned.burkemsncrnpagpcn619]

Yes, I believe it can bind both domains although 1b seems to be more heavily studied.

[@thislifeisagame9540]

"VWF mediates adhesion of platelet to subendothelium by binding to platelet glycoprotein 1b, Gp2b/3a when activated and to subendothelium" Source -class slides

[@abhinavmahajan3569]

Also missing most important concept in labs, like increased BT, PTT. Normal platelets and ristocetin test decrease agglutination.

[@McMedLife]

Great video. Just as a quick side note in case it helps someone, Desmopressin (DDAVP) is generally *avoided* in vWD type 2B due to risk of causing thrombocytopenia (due to gain of function defect - i.e. increased affinity for platelet binding and aggregation - this is also evident in an *increased* RIPA [Ristocetin-induced platelet aggregation] at low doses, as opposed to all other types which are all typically normal or decreased).

[@traceysmith4963]

Very interesting and helpful video. I think i may have Von Willebron disease. Recently had 2 teeth extracted and ended up in the hospital due to excessive bleeding from the extraction sites. First they tried topical meds and then DDAVP. I was admitted for observation and ultimately send home later the next day. Will be following up with Hematologist.

[@angelavrobinson4127]

I had a similar experience. I was sent home after dentist was able to stop bleeding. Two days later I was feeling extremely fatigued went to doctor was told that I was in shock. Sent to hospital by ambulance. Received a transfusion. I had a history of dysfunctional menstrual bleeding, and nosebleeds with heavy clotting and frequent gum bleeds. I was not diagnosed until a retired army doctor referred me for testing. He had once treated a man with Von Willebrands. My fortune was being misdiagnosed with a sarcoma in my gluteus muscle. I had to return to the hematologist that had sent me to get the blood work with the National Hemophilia Foundation. I had a very expensive battery of tests was told that I had Factor VII. I was treated with Amicar. I was told sometimes stress can trigger episodes. Good Luck.

[@aishwaryatamil8560]

Very helpful video.Crisp and many concepts covered.Thank you so much

[@dansemacabre1773]

When I was 12 they did a clotting test before I got my tonsils out. It took 25 minutes for me to stop bleeding. Tonsils weren't taken out and I got admitted to Vanderbilt's Children Hospital. I spent a month there due to the uncontrolled bleeding.

[@DrStewartGibsonPortElizabeth]

Excellent lecture. Thanks. DDAVP is costly. Cyclokapron is effective. It is often prescribed for menorrhagia, possibly managing undiagnosed VWD, with great success.

[@ericamaquilang9795]

I think vWF binds to GP1b receptor of platelets

[@hakanozduran3973]

tıp 2 b

[@claudeanurudha7907]

Excellent presentation.Thank you so much .

[@sabrinastratton1991]

They are testing me for it because ive had recurrent miscarriages, hemorraghed during childbirth and bled badly with dental and abdominal surgery. My menstrual cycles are awful. I do carry the Hemophilia B gene but my OB thinks VWD is the mkre likely culprit tho you can show symptoms as a hemophilia carrier.

[@avishkarmaney3638]

Vwf binds to GP1b on platelets

[@picfunmedicosis1187]

Excellent sir

[@KimBarchok]

Thank you!

[@ravitejasamudrala4]

Hi my family history all members have Von Willebrand disease factor 8. We can take Covid-19 vaccine or not.lot of confusion please help me

[@CarlosCanepa41]

There is a chance i have this according to my doctors because my VWF is low, should i be worried? Is it deadly?

[@competitiveconcepts7006]

Are you fine?

[@competitiveconcepts7006]

What are your symptoms? Please tell me?

[@riverogue13]

It is not deadly, and it's very easily treatable lol.

[@CarlosCanepa41]

@riverogue13 ok thank you, the doctor said i have a minor case and it shouldnt affect me, some things are that.i cant take some medications such as aspirin, ibuprofen etc

[@CarlosCanepa41]

@@competitiveconcepts7006 well i get frequent nosebleeds thats the main symptom

[@rehababdelbagi]

thank u so much

[@1Itsyasr]

Great ❤!

[@AdyanKhan-jb1cl]

Hi sir what is the treatment of VWD my kid's have VWD kindly help me to show me the right way 🙏

[@randomwalkonstreet]

What symptoms does he have?

[@competitiveconcepts7006]

Please tell me the symptoms?

[@prachiparikh8738]

It's GP1B for vWF

[@barsonfamily8545]

When you have VWD, can you undergo major surgery?

[@Candy_labra1111]

Yeah they give you drugs to counter

[@AprilLeech-x8h]

Aylin Green

[@WhiteheadLeona-g6e]

Clifton Road

[@BulahQuinci-p1v]

Rippin Drive

[@jafarsaif182]

Can we give minirin tab

[@ElinorIris-v3i]

Colby Hill

[@CristinaStonge-v2k]

O'Keefe Corner

[@SharonGonzalez-c7t]

Greenfelder Cliffs

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Catharine Ridges

[@AlickRayleign-j2p]

Isabelle Crest

[@TinaJones-c9r]

Hayes Port

[@StephenLena-i4l]

Jeffrey Point

[@EdenMirabelle-v4o]

Everette Glen

[@HughJessica-h9q]

Schmeler Hills

[@LincolnChristian-m7p]

Kautzer Circles

[@BernardCash-s5v]

Charlotte Union

[@HerbertFrank-r6b]

Kasey Prairie

[@JeromeLew-y2w]

Pfannerstill Square

[@StanfordKleinpeter-q9k]

Paolo Points

[@CharlesJohnson-s8w]

Delpha Vista

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Syble Trail

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Jasper Pine

[@ShenitaTryon-f3d]

Schumm Ports

[@MathildaMaxwell-q2b]

Allie Ways

[@TolandVicky-w7y]

Stark Motorway

[@samphonnetgamgee5625]

Wrong - VWF binds to gpIb.

[@GeraldoPetty-y4p]

Bashirian Ports

[@PalmerZora-e1s]

Erwin Burg

[@SonmerfieldWendell-e4q]

Martinez Deborah Lee Robert Perez Jason

[@ChresRusedn-f1e]

Lonny Passage

[@CaesarFrances-i5i]

Nakia Inlet

[@CookeHermosa-l2h]

Sydnie Valley

[@LorenzoSharples-u6l]

Durgan Loop

[@ClydeOrville]

Hall Jose Garcia Margaret Martinez Brenda

[@марияагафоник]

Rodriguez George Davis Matthew Moore Paul

[@SonmerfieldWendell-e4q]

Walker Margaret Thomas Linda Garcia John

[@YvetteCelso-p2g]

Anais Radial

[@ChapmanLuther]

Lewis Angela Robinson Anthony Davis Cynthia

[@MackCervera-i3p]

Johnson James White Elizabeth Martin Donna

[@zigmeebhutia2780]

Can vwd people put covid vaccine?

[@ceecee3339]

I took it then profusely bled .. for 8 months .

[@JoeyojHolmsop]

Williams Angela Thomas Kevin Taylor William

[@dfdfdf-x9j]

Lydia Village

[@LuciusIngemar-b1v]

Davis Edward Taylor Dorothy Wilson Deborah

[@MK-bi8xl]

its gp1b complex for vwf !!!!!

[@MaryHinkson-s4j]

Bert Views

[@PADMAVATHISURA]

Thank you 💕

[@dimakim-n6c]

Lewis Scott Lopez Timothy Rodriguez Jessica