Heparin-Induced Thrombocytopenia (HIT) | A Comprehensive Explanation

[@MedicosisPerfectionalis]

❤️ 💊 Cardiac Phrmacology: www.medicosisperfectionalis.com/products/cardiac-pharmacology-course/

[@mirnas.1692]

I never EVER thought I'd say this but... I'm actually having fun watching these videos lol

[@MedicosisPerfectionalis]

Wow 🤩 Thank you so much 😊 I am honored!

[@littleblue7487]

This is literally the best thing that has happened to me the whole week 😅. Can't believe it's taken me so long to find this channel

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@rosaexcelsa]

@@MedicosisPerfectionalis me too. You are AMAZING!!! 🌟🌟🌟🌟🌟

[@tamanna9221]

You're the reason for my survival in medical school.❤️

[@MedicosisPerfectionalis]

Thank you 😊

[@waytoallah9977]

Underrated Channel.... Great work.You deserve million subscribes 👍🏻

[@MedicosisPerfectionalis]

Thank you so much 😊

[@scarecrowzero84]

this helps me understand HIT I and HIT II way better.

[@MedicosisPerfectionalis]

Awesome 👏

[@nora5230]

This is amazing! I wish I found this channel years ago. Very educational and entertaining Thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@yanbingzhu2550]

Me, too. I hope I found this channel when I was in nursing school. My stupid textbook did not explain anything. My professors read PPT (don't get me wrong. they are nice, but they read PPT.) Everything was needed to be remembered. My brain was getting burned. I kept asking why. Nobody had a freaking answer.

[@jacobcolombo3158]

I wish i found this channel in 1st year instead of 4th year. Fantastic stuff and love your personality that you inject into the video to make it fun!

[@MedicosisPerfectionalis]

Thank you so much,Jacob! I appreciate you! Would you please help me by sharing?

[@sumayyarehman99]

It is the first video of this channel that I've watched and God do I love these! I am taking the oath to watch most of its content if not all. God, so smart!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@yanbingzhu2550]

Medicosis, I just had a patient this weekend. She came in at the end of Oct, with acute severe abdominal pain and was diagnosed with superior mesenteric artery thrombosis. She has abd surgery right after. They could not find the blood clot. However, there was no s/s of necrosis of her bowel. When I saw her this weekend, she was lying in bed with heparin drip at the rate of 1600U/hr, NPO and with PPN and lipids running. Her platelet level was within normal range. Her PTT was 67(WNL). However, since the day before yesterday, her urine became dark black tea color and there was brown sediment in her foley tubing. And her surgical site started seeping minimal amount of bright red blood. There was no more s/s of active bleeding. She was hemodynamically stable. However, her WBC spiked up to 60. We reported the hematuria to the doctor and also the WBC. She was already on multiple antibiotics. And we could not stop the heparin, because her bowel would die. But I was really concerned about the hematuria. It was very difficult. Can you imagine she had 4 IVs running?

[@MedicosisPerfectionalis]

Oh my!

[@eil9663]

I dont know why i found you channel JUST NOW. can’t believe it, my academic life would be so much easier if i found it earlier. Anyways, thank you so much!!!! This was very helpful

[@MedicosisPerfectionalis]

My pleasure 😇 Welcome to the family!

[@oderadee169]

Your voice and humor. Thank you Dr.

[@MedicosisPerfectionalis]

My pleasure 😇

[@sagar5267]

No words"..immense hardwork n made insanely easy for us...stay forever

[@MedicosisPerfectionalis]

Thank you so much 😊

[@Rickytikkitavi]

That well drawn out Messi in the cascade 🙌

[@MedicosisPerfectionalis]

☺️😊😊

[@underxk8640]

اسأل الله في هذا الشهر الكريم انه يفرج همك ويرزقك من حيث لاتحتسب ياارب والله يادكتور بسطت اشياء دكتوري معقدها ومخليها مملة. مصر مفروض تكون فخوووورة فيك 😔❤️❤️❤️❤️❤️❤️🇪🇬🇸🇦

[@MedicosisPerfectionalis]

Thank you so much 😊

[@Maryam2825]

This author is hilarious, I love his teaching approach!

[@MedicosisPerfectionalis]

Thank you 🙏

[@rishidas2479]

Watching this with Robbins pathology just cleared my whole concept Thanks bro Love from india

[@MedicosisPerfectionalis]

Thank you 🙏

[@leviathaen]

Thank you! I had HIT type 2 years back and my doctors did a poor job explaining its effects and cause. Thankful to finally have a better understanding of what happened to me.

[@MedicosisPerfectionalis]

Thank you 🙏 How is your health today?

[@leviathaen]

@@MedicosisPerfectionalis I am much better, thank you! It took quite some time to fully recover from the PEs, but I am doing well.

[@kathmandunepal9547]

Thank you soo much for your videos!! Have MRCP in 1 month, your videos are soo helpful! You make studying fun! Laughing in humour white studying at 11 pm in my bedroom, something I had never imagined!

[@MedicosisPerfectionalis]

I am honored! Thank you so much for watching my videos! Would you please help me by sharing my videos with others?

[@Music-xp5wg]

Warfarin can be given for HIT according to my textbook that's a copy Warfarin (goal INR 2-3) for all patients with confirmed HIT diagnosis once the platelet count is above 150,000/mm3 a.Duration depends on the presence of thrombus. i.No detected thrombus - 30 days ii.Thrombus - Continue for appropriate duration depending on thrombus type (typically 3-6 months). b.Start with doses of 5 mg/day or less, and overlap with injectable anticoagulant for at least 5 days. c.Will need to account for elevation in INR caused by both argatroban and bivalirudin during transition

[@theresia115]

Thanks!

[@MedicosisPerfectionalis]

My pleasure 😇

[@peregrimus]

Dude you’re awesome greetings from cardiology resident

[@MedicosisPerfectionalis]

Thank you 🙏

[@dailydoseofmedicinee]

What are the signs and symptoms of HIT? Pain, redness, and swelling of an arm or leg. Bruise-like discoloration of your skin. A rash or sore where a heparin shot was given. Weakness, numbness, or problems moving your arms or legs.

[@keyurr_27]

Thank u for your superb teaching master accept my salute 🙌 le second year mbbs student from India 😅

[@MedicosisPerfectionalis]

Thank you!

[@abduls.h4385]

Sir your tutorial is excellent and I couldn't stop laughing at your sense of humour too, made the tutorial more interesting, stay blessed and hope to see more 🙏 😊 ❤

[@MedicosisPerfectionalis]

Thank you so much 😊

[@DrRkd101]

What A superb methodology, Mind blowing felt Immense pleasure 😊 to watch.....May God give me strength to learn it for thousands years 😀🙏🏻😊

[@MedicosisPerfectionalis]

Thank you so much!

[@zjengle6878]

As a lab tech who works with a Sysmex XN CBC instrument on a regular basis, I can confirm that it is, in fact, a stupid-butt machine.😆 Thanks for these videos! They're helping me a lot while I'm studying for my hematology final this week.

[@MedicosisPerfectionalis]

You’re very welcome 😊 Good luck 🍀

[@chiranthiem.k.h.1597]

As a medical student, I'm living for the undisguised medical student hate ♥ Thanks for the clear lecture doc

[@MedicosisPerfectionalis]

My pleasure 😇

[@pavanbevoor8636]

Ur angel in disguise. Tq doc.

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@alpr1864]

Dear Medicosis Thank you so much for your lectures. It has helped me a lot with my study. I can only wish that no medical student would live in restricted-resources areas (like middle eastern countries) to not afford your brilliant lectures. Best regards.

[@omar-iv9xi]

A complex theme made very simple and in nice presentation

[@MedicosisPerfectionalis]

Thank you so much 😊

[@deyandimov9589]

I think im not dropping out after all.. thanks dude

[@MedicosisPerfectionalis]

My pleasure 😇

[@hkohlanyy]

awesome explanation, and great sense of humor gentle doctor. those 3 dislikes must be from the aforementioned medical students

[@MedicosisPerfectionalis]

Haha 😂

[@TooMuchTigerero]

Favorite videos thank you! I have a topic discussion on the topic and your lectures really help make things click! Keep it up!

[@MedicosisPerfectionalis]

Thank you 😊

[@abukhalidrussian9561]

Great lecturer Amazing lecture ☺️

[@MedicosisPerfectionalis]

Thank you 🙏

[@challotteawasum2375]

love your videos, you really deserved million follows. just one request if you will slow down when explaining, it will help a lot

[@MedicosisPerfectionalis]

Thank you so much 😊

[@zachsbabe2013]

what a great video, loved the commentary but very helpful, information was presented in a great way!

[@MedicosisPerfectionalis]

Thank you 😊

[@yanbingzhu2550]

Hi Medicosis, can you talk a little bit more about HIT type I. In you video, you said type I is clinically insignificant. Does that mean it will not cause severe thrombosis and bleeding symptoms as type II? How do I distinguish type I and type II?

[@anastasiaaa4094]

I was studying from Harrison and understood nothing and came here . Thankyou 🌟

[@muneeraabushukur3498]

Best tutorial ever 👏👏thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@lydao8292]

You explained HIT very well. Thank you very very much!

[@MedicosisPerfectionalis]

Thank you 🙏

[@hannahrosa5485]

Kermit was right. It's the greet top. Thank you for yet another valuable lesson.

[@MedicosisPerfectionalis]

Haha 😂 You’re very welcome 😊 I remember your comment on the last video...You’re so smart!

[@hannahrosa5485]

@@MedicosisPerfectionalis But you are so much smarter than I lol

[@MedicosisPerfectionalis]

Nope...You’re smarter!

[@shaikyasmeenbegum7295]

Wow believe me I had fun watching this💝

[@MedicosisPerfectionalis]

Thank you so much 😊

[@MrNetyzen]

Fantastic work. Thanks!

[@Saisowmyashree_Iyengar]

You're simply amazing!!!! Loved it!!! ❤️❤️

[@MedicosisPerfectionalis]

Thank you 🙏

[@toniencheff4046]

Thank you for your amazing video. A lot for me, and a bit above my head, but I will listen several times. You could have a second career as a stand-up comic. Maybe at a destressinv conference for medical people? ❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you 😊

[@abensteve132]

Great video as usual.Life saver!!

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@dr_marwabekheet7387]

Good job👍👍

[@MedicosisPerfectionalis]

Thank you 🙏

[@Lerolero_candelero]

Thank you so much for that explanation, that was really awesome

[@MedicosisPerfectionalis]

My pleasure 😇 Thank you so much for watching!

[@evankim2158]

Just, just superb

[@MedicosisPerfectionalis]

Thank you so much 😊

[@kelseyecho]

I’m studying for a critical care exam right now and I can’t stop laughing.

[@MedicosisPerfectionalis]

Haha 😂 Laughter is a cheap medicine…Even cheaper than Heparin 😉

[@ΟΓιώργοςοΜπουκας]

great work, keep going!

[@MedicosisPerfectionalis]

Thank you 🙏

[@yanbingzhu2550]

@MedicosisPerfectionalis, in HIT type II, does the immune system destroy the involved platelets? When you say the platelets level increase after the incident, do you mean the bone marrow produces new platelets?

[@luna.kashyap1313]

Just loved it

[@MedicosisPerfectionalis]

Thank you 😊

[@linkkraft]

Are you fucking kidding me? 1 min into the video and i already learned some amazing things

[@MedicosisPerfectionalis]

Happy to hear that! Thank you 😊

[@WhyNot-si4pj]

02:43 You mentioned that LMWH inhibits factor X alone & NOT the rest of the upstream clotting factors of the intrinsic pathway ; that's why the aPTT is NOT prolonged !!!!! As you know ; both intrinsic & extrinsic coagulation pathways converge towards factor X to activate it in order to proceed down the coagulation cascade ! So how comes an inhibited factor X alone does NOT prolong the aPTT ?

[@IMResident_IMG_Indian]

Lmao. I’m dyin at “your woke professor might care”. Very well made brother. Thank you and God bless you

[@MedicosisPerfectionalis]

God bless you too!

[@lianallado1616]

you are hilarious! love your videos, thanks so much for making them!

[@MedicosisPerfectionalis]

My pleasure 😇

[@leenrawashdeh585]

You are Amazing!! 🙌🏻

[@MedicosisPerfectionalis]

Thank you 🙏

[@amuletangelamuletangel6229]

Sir, Instead of using direct thrombin inhibitors, can we use fondaparinux in HIT2 after stopping heparin?

[@mourisarker6872]

Wow this is so cool. So funny. "Who named these things?" Really I also think so...why so difficult to remember drug names

[@MedicosisPerfectionalis]

Thank you 😊

[@Apratim98]

Why would we use ELISA and not Coombs test?

[@MedicosisPerfectionalis]

Coombs is for RBCs, not the best for platelets!

[@narandetagenblirtillluft1419]

Cool as usual 🌷

[@MedicosisPerfectionalis]

Thank you so much 😊

[@tanvirizaz8665]

Hi Doc... Can I get VITT after get vaccinated by Astrazeneca vaccine... After getting the vaccine, I'm having persistent abdominal pain from last 5 days...

[@arunmehta8234]

You are awesome !

[@MedicosisPerfectionalis]

Thank you 😊

[@saralissali1090]

Please make us a video about antiphospholipid syndrome dr

[@MedicosisPerfectionalis]

OK 👍

[@saralissali1090]

@@MedicosisPerfectionalis thank u u r the best

[@trickster1030]

why does the thrombocytopenia cause clotting? Shouldnt it bleed more?

[@trickster1030]

ah i think you explained it at around the 12 minute mark

[@AbidKhan-qn7wt]

that '' SHUTUP'' was personal hehehe

[@MedicosisPerfectionalis]

:)

[@maryangelicaj624]

😂😂😂😂😂😂😂😂😂 love the comedy that you add to your videos

[@MedicosisPerfectionalis]

I am grateful! Thank you!

[@dexterdexter402]

My brother has developed hit type 2. Platelets is down 60 and now 45. Hematoma in glutes (12-17 centimeter). Dr is now giving him platelets and fondaparinux. But not argitroban. What should they be doing? Administer platelets or not? Thanks

[@asmaalamin6245]

Amazing

[@elizabethjaco8144]

What other anticoagulants could you use other than argatroban?

[@MedicosisPerfectionalis]

Have you watched the video?

[@noonijo1997]

Thank you so much!

[@MedicosisPerfectionalis]

My pleasure 😇

[@nagatsatti8426]

Thank you so much sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@himanshuambilkar4160]

Argatroban Lepirudin IgG Platelet factor4

[@MedicosisPerfectionalis]

I don’t understand

[@himanshuambilkar4160]

Sir I have written important key words so that when I come again I know the overview

[@lynjohnson2778]

I have a blast watching your videos! But why does the doctor sprinkle dust on his head when type II HIT is confirmed? You are a smart funny and confusing man

[@MedicosisPerfectionalis]

I was just joking 🙃 I meant to say: “it’s a tragedy.”

[@WIN-c2y]

Me working into my exam hall knowing Hit is Thrombosis 💪🏻

[@MedicosisPerfectionalis]

I wish you success!

[@k4kingkiran]

You are awesome.

[@MedicosisPerfectionalis]

Thank you 🙏

[@aboutfarvardin]

Thank youuuu sooo much...

[@MedicosisPerfectionalis]

My pleasure 😇

[@poojapujari2502]

Plzz make a video menustrl cycrcls

[@MedicosisPerfectionalis]

Ok

[@poojapujari2502]

@@MedicosisPerfectionalis tunku soooooo much sir

[@ahmedalhafid9272]

"shut up, If a student says that in real life I will kick him in the nuts" xD

[@MedicosisPerfectionalis]

Just joking 🙃

[@rayanefilali934]

awesome!

[@MedicosisPerfectionalis]

Thank you 🙏

[@davidwu3247]

So funny!! thank you!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@momo2211-zzz]

ما تبطل بضان يسطا واشرح زي الناس وبطل تشد في بضاني انا تعبت بس شرح جامد الله ينور

[@esraaabdel_shakoor6609]

رهيييييب 😂😂😂😂😂😂😂😂😂

[@MedicosisPerfectionalis]

Thank you 🙏

[@rimshasiddique1255]

Fity munh!

[@sadiyaafreen1308]

This vdo🥰♥♥

[@MedicosisPerfectionalis]

Thank you 😊

[@AmandaJPChin]

Proves smart people can be funny too

[@MedicosisPerfectionalis]

Haha 😂

[@jimazing1]

As a lab tech I take offense at you calling our machines stupid LOL. Most platelet problems come from preanalytical errors!!

[@MedicosisPerfectionalis]

I was joking 🙃 I can only imagine how much stress lab techs have to work under! I appreciate you 😊

[@thiagodinizcoelho]

WOW!

[@MedicosisPerfectionalis]

Thank you 🙏

[@zangetsu949]

All i wanted to know was HOW But we are soo stressed on just mugging up that when asked how it happens we tell them well those who can cause coagulation can also cause anti coagulation It would have taken just extra 1-3 min to tell how the fuck is it causing thrombosis BUT NOoooo.

[@matthewreddick9334]

The platelets go crazy? That’s the explanation?

[@MedicosisPerfectionalis]

Yup 🤪

[@Black-mj3yz]

This not clear ???!!! 🤨🤨 What mean ( anything that makes you clot, make bleed) ? This is not clear explanation. Unclear point, please explain it in another way..

[@drfadumaibrahim9402]

HIT tpye1 medical student😁😁😁 doctor dancing

[@MedicosisPerfectionalis]

Haha 😂

[@hanifyousuf5880]

dudeeee i love u ,,,, hahahahhah

[@MedicosisPerfectionalis]

Thank you 😊

[@amaardoc8148]

You filipino 😮

[@Black-mj3yz]

❤️❤️❤️❤️💡💡💡

[@Pedro-hk9ng]

Horrible presentation but good information.

[@MedicosisPerfectionalis]

Ok

[@dorantebrutus5188]

LOL….

[@MedicosisPerfectionalis]

😊😊

[@noamikhan7771]

Slow down. You're talking too fast. Someone who doesn't have much knowledge of the subject will find it difficult to follow u.

[@MedicosisPerfectionalis]

Thank you for letting me know!