Anticoagulant Drugs

[@christophertom1311]

A couple incorrect statements were mentioned. Factor II was not circled, but Factor I was circled when mentioning procoagulant factors affected by Vitamin K epoxide reductase. UFH can be used IV in addition to SQ.

[@gayathrijinesh3004]

Infact, iv is the conventional method.

[@TheJtoben]

And anticoagulants don’t treat VT they prevent them

[@damjanvranjkovic]

on point!

[@desertsun9008]

you're wrong. Enoxaparin does bind to antithrombin, and inhibits factor Xa and IIa, however it has much greater anti-factor Xa activity than IIa activity.

[@zillo376]

LMWH does bind ATIII which then complexes with Xa.

[@chmith27]

thanks for sharing. corrections: your warfarin slide incorrectly circles fibrinogen and not prothrombin. also at 6:25, it says heparin is subcutaneous- that should be SC or IV.

[@emmittkeaton1348]

pro trick : watch series on flixzone. I've been using it for watching lots of of movies recently.

[@callumedward405]

@Emmitt Keaton Yup, I've been watching on Flixzone} for years myself :)

[@mrscrambled3162]

over all top class....thanks doc...

[@anfalziar507]

i don't get why warfarin requires bridging with another coagulant , shouldn't be an ANTI-coagulant ? since we dont want excessive coagulation to begin with ! and i thought heparin binds to antithrombin no matter how long the polysccharide heparin chain is , it just doesn't form a hug with the thrombin when it's less than 18 sugar long

[@MedLecturesMadeEasy]

+Anfal Ziar You're right on both points -- sorry about the mistakes, and I'll have it fixed in the video (as annotations) soon. Thanks for pointing that out! Warfarin is bridged with a shorter-acting ANTIcoagulent: "Bridging anticoagulation refers to giving a short-acting blood thinner, usually low-molecular-weight heparin..., when warfarin is interrupted and its anticoagulant effect is outside a therapeutic range." circ.ahajournals.org/content/125/12/e496.full Heparin binding to AT: "Molecules of heparin with fewer than 18 saccharides lack the chain length to bridge between thrombin and AT and therefore are unable to inhibit thrombin." atvb.ahajournals.org/content/21/7/1094.full

[@anfalziar507]

other than this the video's been very instructive thanks

[@KungFuKid4]

+Anfal Ziar Warfarin is initially pro-coagulant because it depletes Protein C first, which is its self an anti-coagulant. After a few days Warfarin will start to work fully and act as an anti-coagulant. These first few days need to be bridged with another drug like Clexane in order to 'bridge' this period.

[@anfalziar507]

it also takes time to inhibit the formation of new coagulation factors when stopping the formation of potassium , the few coagulation factors in the blood before the administration are always effective nd so the anticoagulation isn't obsereved untill 4 to 5 days after the administration when the coagulation factors in the blood have ran out

[@ohcrapitsmrG]

heparin is also used in IV drip. mostly correct but very generic info

[@jameshayward3842]

On one slide you say fonda can be used with HIT and on the next you say it can't

[@mathewhorodner2000]

How does Jane Fonda factor into this? :)

[@TheJtoben]

Yea he said it doesn’t induce HIT and then says it’s does when he was talking about Argatroban...

[@lbryanmillanl]

3:00 wouldn´t it be "another anticoagulant"? not "another coagulant"... , thanks.

[@hamzaertugrulmd4865]

thanks

[@alemon22]

Please let me know: does the blood clot injections hurt? I'm 75 kg pregnant at 9 months, this Friday I have cesarean still I get these injections? Thank u indeed!

[@bonita3867]

yes they hurt! I've been injecting lovenox since Feb twice a day..I ice before n after but it still hurts n I get huge hematomas n bruises

[@ahmedqais3282]

oh my god ,, i am in love with you MFer you damn good. f the university