Psychiatrist Shares His Experience With GLP1 Weight Loss Drugs

GLP1 agonist weight loss medications Wegovy and Ozempic have become popular medications for overweight and obesity and are also increasingly being used in psychiatry to target symptoms of depression and anxiety. But are Wegovy and Ozempic safe to use in psychiatry? University of Toronto psychiatrist and researcher Dr. Rodrigo Mansur discusses the research supporting the use of GLP1 agonist weight loss drugs and explores his clinical considerations when discussing these medications with patients. Could they be a new treatment for psychiatric disorders? That remains to be seen as we consider the potential adverse effects. But it seems clear these drugs are becoming more popular, so the more we know about them, the better!
Expert featured in this video:
Rodrigo Mansur MD PhD
psychiatry.uto...
Dr. Mansur's publication mentioned in this video:
Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: A pilot, open-label study
pubmed.ncbi.nl...
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Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Time Stamps
0:00 Introduction to Weight loss medications in psychiatry
1:04 Introduction to Dr. Rodrigo Mansur
2:17 Interview Begins
3:30 Dr. Mansur's interest in GLP1 medications
4:57 GLP1 drug effects in the brain
6:04 Data on GLP1s and mental health
8:17 Data on GLP1s and serious mental illness
9:31 Concerns with GLP1s and mental health, increased suicide risk
13:40 Dr. Manur's clinical use of GLP1s
15:28 GLP1s are effective for weight loss in a psychiatric population
16:11 Lifestyle interventions are first line therapy
18:39 Conclusion
#MetabolicMind
#KetoForMentalHealth
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#KetogenicMetabolicTherapy
#NutritionalKetosis
#MentalIllness
#Bipolar
#GLP1
#Ozempic
#Wegovy
#Weightloss

[@CashMoneyMoore]

I'm taking it and I find it quite helpful for mood. But I think it's a secondary effect of limiting desire to eat foods that would take me away from ketosis, and eating slightly less. Keto/lowcarb + low dose glp1 seems to be the best of both worlds

[@NeseretBemient]

So fascinating! First you give a person medication that is known to cause metabolic issues, then you add more medications to address the "side effects" of the first medication. There are no "side effects", there's only the full effects of medications. And not to worry, those black box warnings of increased suicidality, it is "very rare". I guarantee, it wouldn't be comforting to a parent of a suicidal child/adolescent - if it happens to one person, it is one too many. What's the message that is given to clients when they are prescribed a medication to "lose weight"? It is similar to the message you give when you prescribe a client "sleep aides" - that they cannot manage a routine function of human beings. Sleep is a normal human function, just like breathing. You can fall and stay sleep on your own. You undermine the basic human instinct and self-confidence in their ability to function on their own. However, a holistic, comprehensive approach requires some thinking, time, patience, planning, and consistency. (Did you notice how fast he went back to talking about medications after Bret kindly asked "what about lifestyle" approaches?) Well, It also takes patience, discipline, effort, self-awareness, self-restraint, and self-mastery to implement lifestyle interventions, such as the ketogenic diet. This is both on the part of the patient and the clinician. There are no quick fixes. Medication is the one trick pony of the medical and psychiatric system. In my 17 years as a Psychiatric RN, I have seen so many people put on medications, that not only, DO NOT address their core distressing mental health symptoms, but now they have to contend with the "side effects"/full effects of those medications. Why do we have so much treatment non-compliance in psychiatry? Not because those medications are so effective! Definitely not and for some the lethal doses of their prescribed medications are what they end up using in an attempt to end their own life. I've witnessed way too many people, after experiencing years, even decades of unrelenting pain and suffering with zero relief, lose hope, and give up completely. Human beings shouldn't be experimented on! We're not dealing with "a population", we're dealing with complex individual human beings. Someone's child, someone's partner, someone's brother or sister, neighbor, and many a times - someone's whole world! Exploring lifestyle factors shouldn't be providing lip service - that they should "eat right", "exercise", and practice "sleep hygiene" etc. Everyone knows those things. And how long were those explored before they were handed medications? Not too long! Not very long! I'm blown away at the speed at which family physicians and psychiatrist diagnose and medicated a person, even with children and adolescents. Typically, after the first session or two at most. You meet a client during acute crisis, you get a snapshot of where they are currently, and there is no time to explore what really happened? How did this person get to this point and how do we reverse engineer this condition, get them back to health and wellness? You make a decision largely based on what's happening now. Lifestyle interventions need to be an ongoing effort, not a single isolated conversation. Medications can be life saving measures in acute crisis, but no one for sure knows their long terms effects. "Open Dialogue" in Finland follows this approach (medications in acute crisis only), and their patient population that suffers from schizophrenia fairs so much better than their North American counterparts who are left on antipsychotic medications long term. Clinicians have become so desensitized to human suffering caused by medications. Serious side effects such as suicidal/homicidal ideation, irreversible effects, and toxic effects are glossed over. What's the worth of one human being who dies by suicide because they were prescribed the wrong medication, and at the wrong time?

[@drirene57]

When big pharma donates to the training of medical students, nurses and dieticians, pays for most of the “research” and therefore sets “the standard of care”, is the main advertiser in medical journals and mainstream media, donates to every medical association, and is the #1 lobby group in the US, the answer to every problem is a big pharma pill. The medical system is under the control of big pharma. Luckily the grassroots efforts of the low carb community is working and the word is getting out that there’s a better solution. God bless you for your testimony here.

[@kenziejoslin-peter1243]

mounjaro seem to trigger some pretty hefty anxiety and depression issues for me. my last injection date was 10/16 and it’s now been week 6 off and still struggling also i know it was the mounjaro because this happened to me one other time.. i didn’t realize it was the monjauro until after i started it back up again in september.. it’s everytime i hit the third week of the 7.5 mg. This time i’m sure of what the cause is and i’m done for good.

[@drirene57]

Lawsuits are already occurring in the US. This drug will be eventually pulled from the market.

[@kaelaliscious]

I’ve been on saxenda and works from a weight loss perspective but my depression is the worst it’s ever been to the point where I can’t function and have now stopped saxenda

[@lezliesecunda843]

I must be on a true keto diet avoiding vital wheat gluten “keto” products and taking a glp-1 or tirzepatide to get the mental health piece. If I am on a glp with a regular American diet that’s only when I get anxiety and digestion problems. Weird how the pendulum swings to the other end. Note: I’ve had a gastric sleeve 3 years ago and was taking Prozac.

[@vickimartin7601]

Thanks

[@AtulHanda-dl7ih]

Education which makes healthy mind whether mitochondria of brain has genetic preepsition