Metabolism | Fatty Acid Oxidation: Part 1

[@Mani-hs8dd]

I attend a fu**ing 4 hour lecture about this exact same content and I don't understand a word , but I understand it all in less than 30 minutes vid with this guy, dude this is unfair

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Monyal Knowing that these videos are free, and that I’m gonna be paying tens of thousands of dollars in loans for inferior lectures makes me angry lol

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Thats bec you attended! Each lecture is a “build up” to the next level :)

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Same here

[@hhykk]

same lol i Spent three days

[@ayushthakar691]

Might be you r dumb

[@kevo1295]

Dude, you're a genius. Metabolism actually makes sense now. Thanks.

[@NinjaNerdOfficial]

+kevo1295 That’s awesome! Glad to help!

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You are amazing man! I wish there would be professors like you in our college. Keep it up man. Waiting for new vids👍

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Thanks ninja

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Yay man!!!!

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You r awesome

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Greetings from Nigeria 🇳🇬 You’re appreciated ❤️

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Nice to meet u❤️

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🇳🇬 9ja

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I know I am watching this 6 years later, but I just want to say you are a genius. I used to hate biochem, but by watching your videos, I am now omw to become a biochem guru. Thx

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OMG. My Dr diagnosed me with non-alcoholic fatty liver disease. She said my blood work shows I am healthy but I'm not losing weight. She said I need to mobilize my fat. She recommended fasting and I didn't understand it until now. Now I know how to mobilize my fat. I thought she just meant exercise but I see what I really have to do Thank you so much

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I literally don't know why I get excited when I listen to you .... I just start walking with the excitement that I have got the core concept that I couldn't get when I listened 100 other videos. I think you are the most underrated man on utube , u deserve atleast 10M or more.... I can't appreciate you with Thankyou only .... U deserve award for all your efforts. I wish you never stop making videos please My Favrt processor in All of my life 🖤🖤🖤 Countless blessings ❤️

[@alfiemed1317]

Well done, but there’s a small mistake at the beginning of the lecture. You mentioned that atp is converted to adp in fact it’s converted to amp and the 2 inorganic phosphates and the phosphoanhydride bond is broken by inorganic pyrophosphatase otherwise perfect video

[@nancyezike7952]

Awesome!! Thank you so much!!

[@sciencenerd7639]

thank you for adding this clarification

[@teomatsa6836]

dude speak English

[@basharathussain7212]

What is atp and ADP bro?

[@roqeebatbolarinwa670]

@@basharathussain7212 ATP is Adenosine tri-phosphate. ADP is Adenosine di-phosphate.

[@bhavanakathuria3697]

You deserve more views. You easily explained something my "highly accredited" professor couldn't in 53min, while you did in less than 30. THANK YOU!!!

[@elianjoensen2756]

this is a scripted video. some would call that an advantage

[@MarieKametani]

@@elianjoensen2756 yea but he did it in one take pretty much

[@elianjoensen2756]

@@MarieKametani teachers do that too. it’s called real life, and they don’t have a script

[@MarieKametani]

@@elianjoensen2756 ohh my classes are recorded rn bc of covid lol

[@naseelmoursy]

Man you are a life saver for real!!! I would've never understood Biochemistry without your videos😭! THANK YOUUU😍

[@nickygm3429]

Thank a lot! saving me form med school. Btw I want to comment that in 20:21 the enzyme used is B-hydroxyacyl CoA dehydrogenase in order to move to B-ketoacyl CoA. Thanks a lot.

[@chitrakarcosmo]

Yes

[@questioneverymatter5851]

​@@chitrakarcosmoI was like why acyl CoA dehydrogenase responsible for convertion to Enoyl acy CoA. So B-hydroxyacyl CoA dehydrogenase responsible for the conversion to B-ketoacyl CoA. Looks like the reversed process of Fatty acid CoA synthesis.

[@esteflava]

yesss! I was like "NOOOO it's supposed to be B-hydroxyacyl CoA dh not B-ketoacyl CoA dh" while watching the vid lol

[@Hugo-no1si]

In one word: LIFESAVER. Thank you so much!

[@NinjaNerdOfficial]

You are so welcome Hugo!

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Literally ❤

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I have a PhD in endocrinology and Diabetes and I still watch your videos (Have been watching since undergrad) and they still make my heart skip a beat 😍

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My exam is in 2 weeks thankssssss you just saved meee and ur lecture notes are rlly so legit!! Keep uppp ur saving billions of medical students

[@Aleyofication]

Isn't it a Hydroxyacetyl CoA D.H and not the Ketoacyl CoA D.H in the third reaction?

[@NinjaNerdOfficial]

+Op Nutrition You are absolutely correct! I am sorry for that mistake!!

[@Aleyofication]

Np mate...great vids. btw!

[@ZainabMostafa-gk5jc]

why did not u change it or added a comment till now ??

[@baraaka5376]

Op Nutrition Why??? There is keton group😅

[@nischayjairaj]

baraa ka because the dehydrogenase is acting on the b-hydroxyacyl-coa to form your b-ketoacyl-coa

[@darshinimalukar3246]

All the praise here multiplied by 100, and that still wouldn't suffice what an amazing lecture this is.

[@moonchildc3894]

I know I'm late but honestly saying you're a LIFESAVER !!!! I understood so beautifully 💜

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no word of appreciation can entirely explain your personality SIR U ARE SUCH A GENIUS PERSONALITY ALOT OF LOVE AND RESPECT FOR YOU.U ARE JUST AMAZING SIR.

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[@Mariah-vn9lu]

I spent 3 hours in a lecture to try to understand this to no avail, but with the grace of this video I may have a chance of passing this exam.

[@VG__]

Greetings from India. You're appreciated 🙏🏻

[@afrozayaz7871]

I can't even imagine looking at my book for metabolism buhh you're awesome. The legend ninja.

[@vincentarthur8699]

Thank you very much Prof,you make Biochemistry more comprehensible,greetings from Ghana🇬🇭

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I adore your knowledge of Biochemistry and enthusiasm. How clean and pleasant an explanation this is! 💕

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Thank you from Indian state ,BIHAR ✌👍

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This guy should be a college prof. Enthusiastic, clear, concise, and speaks English.

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Brother I’m really owe u, u summarized about 2 three-hours lectures in about 30 minutes! u r incredible!!

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Genius for sure... wonder how many hours of reading Zach has put in and his team getting this type of lecture.. Congratulations to Zach and his team!!! Best! Obama should see this and endorse it.

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What

[@rinc2006]

In that 30 minutes I have referred multiple books on biochemistry, just like watching my favourite cartoon. That's Zach Murphy's magic

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You are a lifesaver for real!!!! Thank youuuu.

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Greetings from Pakistan 🇵🇰 You are great person and appreciated❤

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I spent 15 minutes watching this and I already know some badass stuff to shut everyone's mouth tomorrow Haha. You're making me the best student in the class!

[@sarahgutierrez5628]

This was the best teaching video I've ever seen, you're a great teacher ! Thank you so much!!

[@tejasvidalla2982]

Nice video sir.. but a small correction .... in the first step.... ATP is converted to AMP + PPi... which is converted to Pi by an enzyme inorganic pyrophosphatase ... this makes the first step irreversible!!!

[@GoodKnight5252]

first thing i was going to say! they should fix it....

[@guffronagung8316]

i think tejasvi is right

[@GoodKnight5252]

@@guffronagung8316 i saw it in lehninger but I'm not at home right now to confirm..

[@umarjalal397]

H

[@nidaiqbal7216]

In which step? Please mention the step

[@AjaySensei]

This is the absolute best video on fatty acid oxidation i've ever seen! I feel like I just had an epiphany.

[@questioneverymatter5851]

Just a correction at 20:22 Acyl CoA dehydrogenase is responsible for convertion to Enoyl acy CoA. So B-hydroxyacyl CoA dehydrogenase responsible for the conversion to B-ketoacyl CoA. Looks like the reversed process of Fatty acid CoA synthesis.

[@evelynjazz3706]

Thanks!

[@amenity7678]

Both my lectures and textbook (Harper) are useless and migraine-stimulating. Your videos are easy to follow, through-explained in a way that you think "It all makes sense now" multiple times halfway-through. Thank you, man.

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Normally i wouldnt even like subscribe and pay for this knowledge but you my friend explain it soooooo easy im sold.

[@momo-mn7wn]

You're a genius man!! I spent my whole day to understand this and i got it in 40mins..hats off to you

[@jokodubga6535]

Thank God, I finally understand the topic. Thank you Ninja Nerd, God bless you!

[@asserm.8047]

Great video!!!!! If only my professors were as good at teaching as u are 😂😂

[@markmuravec8624]

Amazing explanation! Thank you ninja master. I think you flipped the CoA-SH in the opposite direct. I believe it should be Acetyl-S-CoA, so that CoA is bound to acetyl with thioester bond:)

[@سلميعسكر-د1ك]

You are just a real biochemistry savior, god bless you

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[@shanicem3929]

So excited when we finally got to the acetyl CoA. Yaaay. Finally

[@gihanimanodara4264]

Thank you for your determination and the excitement in explaining the processes so well! Love from Sydney Australia

[@amynainan1157]

You are a legend thank you so much for helping me through med school... You manage to do more in half an hour than hours of professors or the textbook😁

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superb...💕💕MAY ALLAH BLESS YOU SIR💛💛

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You explain things so well I watched it twice and probably will watch it again.

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You're best teacher forever

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I wish our professors are as cool as you

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You’re saving my life with your videos

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[@hibazahid190]

Thanks sir.You cleared all my concepts.A Clap of appreciation from PAKISTAN 👌👋👋👋

[@AAUN]

Nice video about oxidation of fatty acids . Understanding Biochemistry is extremely important for all doctors including gynaecologists. Without understanding the steroid pathway we can't understand the pathophyiology of Disorders of Sex Development . I would like to add few things more here about beta Oxidation . Beta oxidation takes place in four steps: dehydrogenation, hydration, oxidation and thyolisis. Each step is catalyzed by a distinct enzyme. It is the catabolic process by which fatty acid molecules are broken down.

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Best explanation on KZbin

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You are life saver Zach 🙌

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so incredible , your lecture is life saving sir !,nursing student from Pakistan

[@MarieKametani]

when he said he's going to give us a mnemonic I was like omg thank u

[@kusocm]

Nice and concise, I really appreciate what you're doing, particularly for people that cant afford education...but bear in mind, palmitoleic acid is a monounsaturated acid, necessitating more reactions that you drew, but for palmitic acid it is perfectly correct, and the thiol group is what connects the CoA to the acyl group.

[@وائلحبوش-ك5ن]

you help us alot I'm so thankful to what you do 💙💙💙 عاششش يا كبير

[@n.c.pharmap.3436]

nice presentation Zack, clear explaining but in the 3rd step of beta oxidation the enzyme is called 3 hydroxyacyl coa dehydrogenase

[@NinjaNerdOfficial]

+N.C.pharma p.3 yes I did sorry about that!!

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Watching this from Korean medicine college, I owe you a lot. Thank you so much for the video😊😊

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You're such a gem, thank you SO much for making all these videos

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Better than my metabolism prof. I have a metabolism midterm tomorrow and you are SAVING me

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Ninja nerd is a blessing. This channel has helped me so much that a small thank you just won't do justice. I'm so grateful 💫💫

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Thank you, this is me at 4:37am trying to gather this information before my exams today Thank youuuuuu so much

[@mirembechristine3942]

thanks cause you have really simplified medical school for me

[@parvathitiruviluamala9870]

I never paid attention to this while in Medial School. What an AWESOME teacher !! God bless you !!

[@imeneamina2342]

can't find a better video sooo simple thaaank youu from north africa

[@SteLim-.-]

Grazie.

[@Tocaplayz1]

One suggestion - Don't show the thiol group on CoA just hanging off the end. The sulfur acts as a nucleophile and ends up binding to the first carbon in either acetylCoA or acylCoA.

[@bekastepanishvili11]

Donald Brown its just easy to remember like that

[@rahulprasad3310]

In medical biochemistry, it’s more important to grasp the concepts with clinical and proper disease oriented approach....rather than being so fussy about chemistry . In fact no one is here to understand chemistry, we r here to learn medical biochemistry.

[@Tocaplayz1]

​@@rahulprasad3310 I was just making a suggestion for the sake of accuracy. As an MD, I don't see how you understand medical biochemistry without understanding chemistry.

[@Nandranie-bu3pg]

It’s totally irrelevant to the process. What a waste of an MD.

[@Nandranie-bu3pg]

@@Tocaplayz1 Why see what you can't.

[@joannahpaulinecruz9830]

Hi, thanks a lot for these videos! but I just have a little correction. I think the enzyme involved in step 3 is beta hydroxyacyl coA DH

[@瀟湘-g7f]

true, you are right

[@maryb3380]

yes this is accurate

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I think you an Angel from heaven. You gonna be a reason for my academic success.

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this guy is a LIFESAVER

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man I don't have words to describe how much i'm thankful for you. You didn't just make biochem esaier, but science in all its branches. thank you very much professor Zach i love you. ❤❤🤍🤍

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Love it, i see dr najeeb effect here❤️

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You are helping me get that exemption from biochem exam and I could not be more thankful!!!

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I really enjoyed your lessons and have recommended to all my friends

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Thanks for helping me get an A in biochemistry!

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i just wish that in the other videos like glycolysis if you explain the chemical structure like here :( i had to search about it back then :( thank you for your effort :D you are really amazing

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