Metabolism | Ketone Metabolism

[@tanika2614]

I usually never leave comments because I'm too shy but I just have to say that your videos have helped me so much in understanding biochemistry and being able to appreciate the beauty in metabolism. Its so incredibly fascinating for me to see and understand how everything in our bodies is so closely linked. Thank you so much!!!

[@jaykaria6031]

This is some really good content Just one suggestion At the end of your videos if you could leave the board as it is for 2seconds so we could get a clear screen shot. That would help us revise whatever has been done in 30 mins very quickly. Thanks for doing what you're doing, it's brilliant

[@harshhoughton1750]

That's one of the things u get on becoming a patreon member

[@gwho]

This

[@nutritiontrader]

just 5 dollar and you get everything worth the money

[@fadhladel247]

You are genius. Your content is extremely useful.

[@DemoderDen2027]

@@harshhoughton1750i always wondered why he didn't do this turns out they're making people pay for a schreenshoot? No thanks i'd rather wait for the right moment and do it myself

[@petergrace7356]

I studied exercise science as a grad student twenty something years ago and had to memorise the krebs cycle for an exam. Not long after that I could no longer recount these steps from memory. I've encountered human biologists who've said, like me, they understand the krebs cycle but probably couldn't recite all the steps without some revision first. This guy recounts all the steps in the kreb cycle, gluconeogenesis, and ketosis on the fly while illustrating relationships and processes and doing an A+ job of it. Phenomenal!

[@swooosh3145]

When you got an exam and wach 2x speed xD

[@igj3224]

Still very damn understandable! 😍

[@juuni1503]

record the video at 2x speed and then watch it at 2x speed in your video editor :)

[@neurolife77]

I always watch lectures or every videos of this type in 2x speed, otherwise my ADHD brain can't stand the slow pace and I have a hard time following what is taught. (In 2x speed he is still very clear and easy to follow, which is not always the case for other resources. I'm so glad I found this channel!)

[@ilmj9]

@@neurolife77 Shit, I also can't watch in normal speed cuz i have a hard time following what is taught (same reason why I can't follow most lecturers, as they are normal-paced). I also couldn't follow the teachers at school, so I've basically taught myself everything since then and my grades were good, but this is getting hard to do with medical school. Based on your experience, does that mean I should check this (medically)?

[@mahirabdi5532]

Me😀😀

[@bashirshuaibu6040]

Words alone can't express out gratitude... We are very very grateful Sir, indeed you are rising doctors to a greatest hill of understanding.

[@kanishksharma6954]

A suggestion from my side. After the completion of video please give a view of whole board so that we can take screenshots for future references. Thank u very much for this video.

[@Trucker_2_doctor]

Indeed!

[@xmahanah]

Or you can just take notes 🤨

[@SuperBitCat]

If you swupport his patreon you get the screenshots :)

[@alih6953]

support patreon and get them

[@meriems9920]

take notes it helps to memorize it

[@renukatewari9143]

I love the colours and simplicity.Very student friendly.

[@NinjaNerdOfficial]

+Renuka Tewari awesome I'm so happy that we were able to help

[@achalabhardwaj7449]

Ya it appears too approching that every concept u teach becomes simple and easy

[@HungGarEarthBender]

It is INCREDIBLE that you did all this from memory. NO cut scenes or anything. I am blown away.

[@investwithstuph5887]

next time i will be fasting, I will understand all the processus thanks to you. big up!

[@azinsarhaddi119]

You realllyyy made biochemistry sooooo much easier for me. Before watching your videos I didn’t know what I was doing with biochemistry. Thanks sooo much❤❤❤

[@majoro7251]

+Ninja Nerd Science 1st video for me here. Holy ****!! You're a science beast!!! Not only are you helping us by simplifying and illustrationg all of this in a brilliant way, but also you're fortifying those concepts in your head. Thanks a lot dude... I wish you'd do more on this. For example, people on a ketogenic metabolism are generally advised to consume vitamin C, citrate, sodium, and potassium to balance ketosis acidosis and prevent kidney stones. But again those are mere direct tips with no science and logic build-up behind them. I suppose a bright mind like yours can provide more than what others can do! I'm not a Medstudent but of an engineering major and this more or less made sense! Salute from Syria! Liked and subbed for sure.

[@HungGarEarthBender]

I second this

[@vistian]

Hands down. Best Ketogenesis + Ketolysis explanation I've seen on the internet. Thanks!

[@1m59-x6g]

I’m French and I’m so thankful for you and your video!! It helps me a lot for my first year of médecine school MERCI BEAUCOUP !!🇫🇷🇫🇷

[@amine6005]

Now you are thir medical school right

[@hhansen3240]

So so so grateful! Seriously, this helps me so much. I actually ENJOY learning these concepts when I watch your videos!

[@versatileStockInvesting_Vandit]

None of the other videos on youtube has the better explanation of the concept than your video!! Awesome man!!

[@jerryhenderson8923]

I'm on Keto diet. Its a challenge to get ketones to 2 mmol. My clarity and sense of well being have increased greatly, Nine to ten mmol is where ketoacidosis ocurrs. No where close. Great lesson as always.

[@aeternusromanus]

Jerry, I recommend you read Ray Peat

[@shawnmulberry774]

I have been Keto for about half a year. Quickly lost 40 lbs from my original weight of 240. Have been stable ever since. Had acetone breath for a while but that changed. My understanding is that the body becomes better and recycling or otherwise managing ketones, perhaps in the kidney, over time. So my ketone test strips showed higher values when I first started. But I have great clarity and my fitness has improved since I began. Probably staved off Diabetes type II which loads of people get in my family sometime after age 40.

[@davidpannell2172]

Good job. Watched you years ago and thought I'd never refer back to your content. You are a champ. Your family must be proud!

[@AisyaAmaliaBintiOmarDA]

My friends keep asking me to watch this video and this is my first time watching your video. AND OHHH MYYY GOODNESSSSSS!!!! THIS IS INCREDIBLE!! YOU ARE MAKING MY VET SCHOOL MUCH EASIERRRRRRRR!! THANK YOU AND KEEP DOING AWESOME VIDEOSSS!! LOVE FROM MALAYSIA

[@Al-mustaphaAbbaAli]

Words can't express my feelings, u make me understand what i spent almost three weeks reading without understanding anything😂, thank u very much sir.

[@島影ふじえ]

Finally i have learned electron transport chain, then ketosis. You took fear out of me of biochemistry. I am going to follow you all the way through until i pass usmle

[@jerryhenderson8923]

I second all the accolades in other comments here. However, this particular lecture raised some fear about the Keto and Intermittent fasting lifestyle I have adapted. Those fears are a contradiction to the amazing benefits I've experienced from the change in lifestyle. Before Keto, I battled with losing and maintaining weight loss with high protein low carb low-fat diets, HIIT, and weight lifting. I was going from 203-220 lbs, swings in mood, energy, and struggles with cravings and hunger. When I adapted Keto I went from 216 lbs to 178 in 6 months and a BMI of 25 which I haven't achieved since my early 20s (I'm now 73). I have maintained my nonextended fasting weight between 178 and 180 for almost 4 months. My energy level is very high. My brain fog left. My cognitive function has improved and my mood and sense of well being have improved significantly. I measure my Glucose and Blood Ketones regularly and I've only been out of Ketosis a total of about 10 days out of about 290. I try to stay objective. The concerns raised in this lecture belie the results I've achieved with Ketosis.

[@tilfliegel]

You just need to be sure not to demonize carbs and don't try to cut them completely out of your diet. And also: the low carb is not for everybody, a lot of people get perfect results dieting with carbs, including myself.

[@camillenc8878]

OMG YOU HELPED ME PASS THE GOVERNMENT EXAM TO VALIDATE MY DIETITIAN LICENSE! THANK YOU SO MUCH!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

[@raghadalomari4058]

i'm not going to talk about how amazing your teaching skills are and the way you explain things very neatly!! but i'm amazed by how passionate you are towards what you are teaching others!! when you said "how beautiful" i was like omg i want to study with this kind of passion, to actually love what i'm studying ! THANK YOU for your hard work !

[@AriePharmD]

@raghadalomari4058 I share Zach’s and your admiration of this beauty. First exposure to Krebs Cycle (Rx), I felt the same way. Here I am, years later and still amazed.

[@Rosalyahia]

Thank you for making this so simple!! This is what happened to my Boyfriend for doing Atkins for so long. Everyone was so shocked he didn't get it from sugars and carbs.

[@abdullahiqbal7685]

Thankyou. Amazing video. Question: ketones are produced due to absence of OAA. Then how bow do they enter the kerbs cycle in the end when there was no OAA in the first place?

[@KetoChristina]

It's important to differentiate between ketoacidosis and nutritional ketosis. NK - high ketones, low serum glucose. DKA - high ketones, HIGH serum glucose.

[@e.goeke_]

Thank you for realizing this.

[@sepehrdadbadei9364]

If we say in the liver due to low level of glucose we get low amount of OAA and therefore low NDPH or FADPH, how are we not having the same situation in the process of making ATP in the muscle or brain?

[@tuborgcarlsberg3208]

Because gluconeogenesis only happens in the liver. So, in the brain, OAA is not converted back into pyruvate and thus is available to make citrate together with acetyl-CoA

[@LikeDaniel]

@@tuborgcarlsberg3208 I was scouring the comment section just for this answer. Thank you!

[@mr.m22d]

@@tuborgcarlsberg3208 me too thanks 😅

[@MrBuzzyTube]

Tuborg Carlsberg Thankk you man!! I was so confused and now it makes perfect sense.

[@kimba_7095]

@@tuborgcarlsberg3208 Now they'll come together and make sense. Thank you so much!!

[@davidecallegaro444]

I am definitely gonna mention NinjaNerd on my thesis, I already know it. Thank you so much Zach

[@commander_pickle4273]

Thank you for giving me a fighting chance in passing biochem. You are helping and changing the lives of countless med students and biochem students.

[@apurvakmr]

OAA can be continuously produced from many amino acids for example, alanine can become pyruvate, which is then carboxylated to oaa, tyrosine can become fumarate eventually and enter TCA.

[@junedkhan652]

Yaar maja aa Jata h bas.... U are superb teacher lots of love from indian medical students

[@vazqamanda1]

For visual learners, this is the best! Thank you!

[@nazlcanmorkaya6104]

that's your business man !!! whenever I watch your videos,I am thinking that medicine could be understandable :D learning more good stuff from you wow! thank you beast!

[@areejamjad5033]

You are very organised and deliver information very easily. I used to hate biochemistry before i watched your videos, now its my best! Thank you!!

[@yumnahussain9014]

love the way you present it and teach it. you have been a big help

[@blackwood5851]

So well explained! I'm a med student and this is going to help me pass my exam. Also something funny, some time ago I tried to go on a keto diet which caused me to vomit, I never knew why, I just thought my body refused to give up glucose as a fuel source, now I finally know that it was caused by the ketone bodies stimulating the area postrema of my brain

[@kentuckyburbon1777]

You probably had other complications…you do eat some carbs on a keto diet, ideally from vegetables, nuts and berries

[@yaldag379]

30 min? it felt like 3 min.. keep up the good work! Thank you for the video :D

[@TheTMschannel]

commenting to help the algorithm

[@thaarunianuradha6844]

Watching this before the exam day....😆😥😥😥😥.I m very satisfied.... thank u sir

[@research1917]

U make hard material look easy and manageable and that's a huge talent! Me and my colleagues are extremely thankful sir! Lead the way!!! #greece

[@johnkristensen54]

Tak!

[@anemicgoalhop495]

How can the acetyl CoA from ketones enter the Krebs Cycle when there's a lack of OAA, the situation that produced the ketones in the first place?

[@DrFareedanjum]

From now on You are my teacher... I am student in China from Pakistan. you have made these concepts so easy... By watching your Hemostasis video i got A+ in my physiology Viva... And your personality is so amazing... Keep up the hard work... Love from Pakistan and depth of my heart♥️♥️

[@laurenolivares7547]

you truly have a gift for teaching and making everything easy to understand , 31 minutes was truly worth it and it didnt even feel that long when everything was so easy to understand

[@mbibi]

You are a super star. You can make the hardest concepts sooo simple. Even my husband who is working in finance enjoys the logical pragmatic explanation of your videos. Just a few small question. 1. Why would the body go through Gluconeogenesis to create such a thing such as ketone bodies just to have an alternative path of fat use.? If it can just go through beta-oxidation then into krebs, why not just continue??? Ie Why would the body go through the rigmoral to have outcomes such as acetone breath and acidosis??? 2. Also how common is ketosis? New age diets are arguing ketosis is the automatic way the body burns fat and what everyone should strive for. Even intermittent fasting scientists are arguing the reason fasting is good is because of the ketone bodies that are released which help with myriad of things including anti-ageing of the brain. From watching your video, it seems like ketosis has a huge negative on the body and it’s not the primary fat burning path! It’s secondary fat burning path only as a result of Gluconeogenesis. I’m sorry for all the question.

[@vandarizou6685]

You are the best! Thanks for your support... text books now make sense after your lectures!

[@Farhan-co9he]

you are the best...you are the true ninja of medicine lands...thank you very well, great man...thank you for helping us to learn deeply

[@rahelrosen2769]

You literally just saved me in the last moment before my biochem exam. Than you!

[@nsoomabdalwhab76]

Waw You are a legend, creator, and king of anything

[@abigailchristina3072]

Keep this amazing work up! its not going in vain at all! I'm using it a week before my exams for review and its really amazing!

[@princeswasedominic4931]

meh this video is wonderful this is the best video i have ever watch on youtube thanks so much sir

[@theresegalenkatttant]

After this biochemistry course i will donate to your patreon, because i think i will pass this course thanks to you! Thank you so much for your videos, i cant tell you how much easier this course is because of your videos!!

[@yaninayurchenko5261]

amazing how easy you able to explaine all this processes. Now it all make sence for me. I can't even explain how gratfull am I, thank you for what you are doing

[@dingmiguel8]

SO CLEAR AND SIMPLIFIED ... THANKS.

[@עדימרוז]

Thanks you for some really good content!!!! If it's possible, it will be amazing if at the end of your next videos you can leave the board as it is for 2seconds so we could get a clear screen shot

[@Islamic_W499]

Your vedios are too much easy to comprehend....you lectures literally helped me alot❤😊

[@queenzahro5109]

I heared brain can't Three minutes with out glucose. and this process have many minutes. I'm juking . Thanks for amazing explanation

[@abderrahmanedamiri7594]

I usually dont subscribe to random medical channels. But this one is an exception

[@سلميعسكر-د1ك]

A video after another and You never let us down ,god bless you

[@nurussyahirahhamizahhjmata7295]

Your videos have helped me so much!! I've had trouble understanding ketone metabolism (especially during the pandemic when I had to learn this online all by myself) and now I finally get it. Thank you so much

[@alejandrabriones4161]

This video helped me out so much. Thank you for the simple explanations making such a complicated topic seem so easy and simple. I might actually pass my biochemistry exam thanks to this video. I truly cannot express my gratitude for the excellent teaching. Keep doing what you're doing, incredible work!!!!!!!!!!!!!!!!!!!!!!!!!

[@yuda160493]

okay I may conclude that ketogenesis occurs mainly when 1) prolonged hypoglycemia, 2) oxalo-acetate in citrate cycle is depleted due to gluconeogenesis, 3) activated beta oxydation pathway provides abundant Acetyl CoA. so the excess of Acetyl CoA leads to HMG-CoA pathway to produce ketone bodies. keton bodies move into bloodstream as secondary fuel for brain and muscle to be broken down into Acetyl CoA again to produce ATP. but in certain situation, too high ketone bodies level leads to acidosis and other clinical signs and symptoms. thank you!!

[@joemann4643]

Man you know your stuff. What I particularly I like about the way you teach is you pause, then reminding the viewers.... What is this. Quite unusal in my opinion you what the guys to understand not just to know it. Big. Big difference 👍. When One understands it lead to more understandings not only in the subject, bit accoss the board so to speak. Knowing is used to pass exams understanding​ is used to increase what one is. Well down man

[@mercyomini9256]

Thanks for this video it had helped me to understand biochemistry and ease my reading. Thank alot

[@safieaalkhider6621]

It's funny that your videos travel across the continunts all the way to help me do better with my exams thank you from heart ❤️

[@AliHassan-l6g]

You are a legend .God bless you I am happy and blessed that I found you on KZbin love you man (from pakistan)❤

[@Steve46567]

Not just for building up basics, but even for revision your videos are extremely helpful. Helped me a ton for my entrance examinations.

[@giftchisanga7788]

You have really been helpful in my medical life

[@ashanagiri5114]

why do people dislike your videos??? you are truly inspiring…

[@manlikepac]

You're such a good teacher! 👏🏽👏🏽 Thank you for what you do🙏🏾

[@som956]

I can't thank Ninja Nerd teams enough! thank you ❤️❤️

[@carbonproduceroxygeninhaler]

Thank you for your videos! You have a very clear and concise way of speaking and your articulation is very precise, usually I have trouble learning from videos but they way you convey information was very straightforward and helpful!

[@sanabanokawthery]

انت كائن بشري كفووو .. thank you honestly 💓

[@Gameplayery]

i just started Keto, and this video is just amazing, easy info to digest(pun intended), thanks dude, subscribed

[@aeternusromanus]

read Ray Peat

[@xoxoxoxoxo4856]

you are superb i do understand better from you're videos then else where amazing.

[@amaann8080]

you are just the best, you really see to it that the point is understood and driven right home , thank u sooooo much

[@silentnight8346]

i m really happy of having great teacher like u ... love u so much bcz u made my study easy then i was expected... thanks alot 😊

[@NinjaNerdOfficial]

+S jamil wow, thank you so much for your kind words I'm so happy that we were able to help!

[@ghjj66]

Literally OUTSTANDING!!

[@madihanawaz4256]

You're simply the best teacher!! 👌👌

[@vinnieferreira1548]

First time on your channel and i am in love with it!!! fantastic work indeed!! made me want to go back on my notes from uni and study all over again :) thx

[@salmakhaled1364]

Thank you so much for your videos you save me every time I have an exam PS, I am a pharmacy major💜

[@ahmeddarwish6820]

Brooo, your ways of explanation and content is dopeeeee

[@adiarbiv4613]

i was curious. this is beautiful. amazing. honestly like the fact we know exactly how this happens is actually beautiful

[@irenam5574]

I learn so much from your videos, and not just what's required for me to learn. You're actually amazing! I hope to be as knowledgeable as you one day.

[@ayshadaliyeva5140]

Blessings to you. Because it is written whoever helps one of my little ones will not lack the his reward!

[@RafaelGarciaYito_7131]

Brilliant!. I finally got this ketone bodies explained at a detailed level that I could understand. Thanks a lot , what a great content!❤️

[@assiabns1433]

Your work is amazing Sir we can't thank you enough

[@MonopolyMoney247]

Thank you, these make it so much easier to understand

[@bangojoreat-uz4dl]

That is my guy . ONE LOVE MAN

[@mahlatsemolepo3807]

Wow you are the best man. Continue the good work. I thank you very much...

[@chikeagbo3531]

Fantastic teacher..Great guy..I just have to point something out, the decarboxylation of Acetoacete is spontaneous..It doesn't require any enzyme...Other than that, lecture was great!!!!

[@imanearaar7428]

Biochemistry became much more easier for me now , thanks !

[@OrdinaryImmortal]

This guy is a saviour for over a few million med students

[@monicavelazquez3652]

you've become my new science hero. thank you for your passion and clear teaching

[@millicentjohns5967]

YOU SAVE ME HECK LOT OF TIME GETTING THE CONCEPT IN 30 MINS

[@baranilim7003]

You are an avasome tecaher . I discover your channel to late but i love it very very much .

[@architasaha8917]

Salute your patience and depth of knowledge.

[@melissalogan8953]

Wow thank you SO MUCH for going over the hypovolemia part!!

[@hasinsami601]

thank uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭

[@mythstapes]

again, pinky promise: i have my biochemistry exam in three days. if i pass it, i'm subscribing to your patreon for my entire life