Mitochondrial Transplantation to Reverse Aging & Aiming To Reach 130 | Tom Benson Interview

[@ModernHealthspan]

If you like our content please consider joining our patreon group patreon.com/ModernHealthspan Pendulum Akkermansia pendulumtherapeutics.sjv.io/baoQVg Metabolic Daily pendulumtherapeutics.sjv.io/NkqE0q Stemregen 15% discount Code MODERN tinyurl.com/45z968yr (Only available in the US) Renue By Science 10% discount code MHS: tinyurl.com/bdew4bfs NMN Powder tinyurl.com/syc7rwkh n1o1 Nitric Oxide 10% discount with code Modern tinyurl.com/3esakm4s Nitric Oxide Lozenges tinyurl.com/yh4rrtht DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 NMN tinyurl.com/wyzj2f3d Bulletproof 15% off coupon code: HEALTHSPAN15: tinyurl.com/4npjk5vp Omega-3 Krill Oil bulletproof.fdf2.net/xkdxmy OmegaQuant 5% discount Code MODERN omegaquant.com/shop/ Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN Wellness Extract 10% discount Code MODERNWE Geranylgeraniol Essential wellnessextract.com/RICHARDWE Delta Gold Vit E TruDiagnostics 12% Discount Code MODERN TruAGE PACE trudiagnostic.pxf.io/oqYVMY Neurohacker Qualia Senolytic tinyurl.com/22t9thrn BiOptimizers 10% Discount Code MODERN bioptimizers.com/modern Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS tinyurl.com/28admfxr If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan NM

[@marknasia5293]

thank you for your dedication to this channel, I have learned a lot and it has helped increase my quality of life

[@ModernHealthspan]

Hi Mark, thanks! That is very encouraging and great to hear!

[@JESS-CH]

Great interview! Sounds super promising.

[@ModernHealthspan]

Hi Jess, thanks! I hope that you found it helpful.

[@peterz53]

Thanks. On platelets, you might want to interview researcher Dena Dubal. I've heard her comment on how exercise can promote a burst of platelets and that one platelet factor, PF4, seems to have a profound positive effect on the brain. She can also speak on alpha Klotho expression and how it is related to lifespan and health. Exercise, again, is implicated in profound health effects.

[@ModernHealthspan]

Hi Peter, thanks for the comment and the suggestion. I had a quick look at Dr Dubal's profile. She does look interesting.

[@evilman]

Very interesting interview and as always Richard did a good job conducting the interview. He asked all the right questions we all were dying to know. Congrats!

[@mrsbj322]

Dying to know!

[@ModernHealthspan]

Hi thanks for your kind words!

[@audreybennati2618]

Dr Adeel Kahn should be interviewed. He has scientists and funding and is working with Stem cells, exosomes, and peptides. Loads of info on longevity and wellness

[@hamidaabdenour9092]

Con artist

[@audreybennati2618]

@@hamidaabdenour9092 and why do you say that?

[@macrystalclear8026]

Relevant and very important interview-thx for sharing Richard

[@ModernHealthspan]

Hi thanks!

[@KenOtwell]

Question: How many cells does a single mitochondria visit in its lifespan? How long is its lifespan anyway? What percent of mitochondria in a cell are immigrants? Microsoft Copilot: Mitochondria are fascinating organelles with a lot of unique characteristics. Here’s what I found regarding your questions: Lifespan of Mitochondria: The lifespan of mitochondria can vary depending on the cell type and the organism. On average, mitochondria can live for about 10 to 25 days1. They are constantly being renewed through a process called mitochondrial biogenesis, and old or damaged mitochondria are removed by mitophagy. Cell Visitation: The exact number of cells a single mitochondrion visits during its lifespan isn’t well-documented. However, mitochondrial transfer between cells is a relatively rare event and usually occurs under specific conditions, such as during tissue repair or in response to cellular stress. Immigrant Mitochondria: The percentage of mitochondria in a cell that are “immigrants” (i.e., transferred from other cells) is not precisely quantified. This phenomenon is still being studied, and while mitochondrial transfer does occur, it is not the norm for most cells under typical conditions.

[@ModernHealthspan]

Hi Ken, thanks for sharing. Interesting. Tom mentioned that it was cutting edge research and some of it was his team's understanding from limited data. One key point that I only understood after talking to Tom was that although the mitochondria are constantly being refreshed the mtDNA is not. Once a transcription error gets into the mtDNA it will not be cleaned up. So the errors could accumulate over time.

[@oryol1]

It’s call mitochondrial heteroplasmy.

[@barryth]

Eye opening interview. Tx alot. is there any crowd funding site for Dr Benson.? Guess he answered that ? in the last few seconds

[@ModernHealthspan]

Hi Barry, thanks for the question. Not that I am aware of, if you want to connect with Tom there is a contact page on Mitrix Bio's page. I did not discuss any specifics of funding with him.

[@GodsWordDailyMessageofficial12]

Please invite Dr. michael levin and have a discussion with him about aging

[@militiamc]

I became disappointed when he said it's been done in mice for years. Longest lived mouse is from calorie restriction, not mitochondria transplantation. So he's essentially saying this treatment won't get us any better than calorie restriction

[@scottsiegfried6436]

Thanks!

[@ModernHealthspan]

Hi Scott, thanks for the support!

[@atitslan4776]

Come to our Healing center in Guatemala where you will not be regulated and do your mitochondrial studies there 🙏

[@robertdaymouse3784]

Mito Transplantation, Senolytics, and Klotho supplementation seem to me to be the 3 most promising age mitigation intervention strategies currently being researched. Of course regular exercise and not poisoning yourself are prerequisites to said interventions.

[@ModernHealthspan]

Hi Robert, thanks for sharing. Yes lifestyle comes first. I would add secretome from stem cells, (Dr Hans Keirstead) or factors from young blood (Dr Harold Katcher) which both work the same way as being promising.

[@rogerreich2721]

Can we get the therapy somewhere? another country? this seems like a no brainer if supplied by a reputable company.

[@tombenson5957]

It's very new and not yet approved by any regulators. We have a lot of research still to do. thanks for your comment!

[@audreybennati2618]

Look up Dr Adeel Kahn. He does treatments in Japan, Mexico and Dubai. It's very expensive thus far.. but his results seem incredible

We finally have the technology to delay retirement for up to 100 years. The country that implements it first will have a great technological advantage over the others. :-)

[@ModernHealthspan]

Hi thanks for the comment. There are certainly implications for work and retirement. The current set up works for the last 100 years but is not effective now. But there are so many conflicting themes, lower birthrate, people living longer, AI that it is not clear what the outcome will be. Personally I am in no hurry to stop working!

[@ConfirmedCynic]

So damage accumulates to the mitochondrial DNA. What protects the mitochondrial DNA in egg cells?

[@tombenson5957]

Great question. We think it's 2 things: First, the female reproductive system is constantly cleaning and mainttaining the mitochondria in the egg cells. This is a very energetically-demanding process, but the egg cells are small. Also, those mito DNA aren't replicating...they are sitting calmly waiting to be called upon to replicate. Second, some people have reported that the mitochondria in the egg cell have their Complex I systems "deactivated". That's the equivalent of "turning off the burners" on a powerplant, while it's not being used, so that there is less wear and tear during downtime. Note that the mitochondria in the egg cell don't even start dividing until several weeks into gestation of the baby. 500K copies of the mitochondrial DNA is more than enough to supply mitochondria for those early weeks WITHOUT replication. So again, Nature seems to have these strategies for reducing mitochondrial DNA degeneration. We seem to be evolutionarily optimized for long life.

[@ConfirmedCynic]

@@tombenson5957 Thanks for the reply. > Note that the mitochondria in the egg cell don't even start dividing until several weeks into gestation of the baby. 500K copies of the mitochondrial DNA is more than enough to supply mitochondria for those early weeks WITHOUT replication. Could there be a selective process at work here? Namely, the cells that receive the best mitochondria during this process have the best energy budgets and so are most likely to divide and contribute to the largest portions of the soma (and new eggs cells for that matter)?

[@MrDjhealth]

Who is this CEO Tom Benson? What is his educational background?

[@natashasmyk8778]

What happens when we get a blood donation or an organ transplant?

[@ModernHealthspan]

Hi Natasha, thanks for the question. Both of these would come with their own mitochondria. This is also true if you have exosome therapy. Tom mentioned that there did not appear to be rejection or incompatibility issues with mitochondria, though different ethnic groups would have different DNA. His concern was that there may be an issue with large scale replacement of the type he is planning (no evidence of this as far as I am aware but something that needs to be tested). I don't think that either blood transfusion or organ donation would include sufficient mitochondria to be an issue.

[@davidgifford8112]

If you get a blood donation it’s red cells in albumin, the platelets have been spun off. Bank blood is normally stored for up to 4-months. Platelets degrade quickly and must be transfused separately in cases of sustained blood loss where low platelet counts have been identified.

[@jamesjonnes]

Therapeutic cloning is the way.

[@ModernHealthspan]

Hi James, thanks for sharing. Do you mean whole body cloning? Just seems like it would take too long to grow the clones.

[@jamesjonnes]

@@ModernHealthspan Create a cloned fetus, take the cells from each part and add to the original. Such as, the cells from the joints to the joints of the older self, the cells of the brain to the brain, etc. This has been done to mice with great success even 15 years ago. It could be done to pets right now without issues to extend their lives.

[@ritascolaro4059]

You said you can rejuvenate RIGHT NOW…….SHOW US!

[@militiamc]

Lol @ falling down on the Moon and getting a cut. You'd be dead instantly with decompression of the suit, loss of oxygen out the suit and also freezing temperatures

[@tomprovan50]

what about PQQ?

[@ModernHealthspan]

Hi Tom, thanks for the question. It looks like PQQ may help with mitochondrial biogenesis and activity. I think it would have the same issue as the other supplements which support biogenesis which is that it does not protect the mtDNA. So you will have more mitochondria but over time their quality will degrade.

[@GM4ThePeople]

"Tom Benson" is an anagram for "No Entombs". o/

[@newdata]

sounds like higher mito burning end up shorter lifespan.

[@ModernHealthspan]

Hi thanks for your comment. It would make sense that excess ROS would lead to accelerated damage to the mtDNA.

[@nightmisterio]

Aren't Exosomes just pieces of celular trash so it would have all kinds of celular parts in them.

[@selsoft]

It is not a big deal to reach 130, if I am not feeling 40 when I am 90. Tom looks old.

[@Montie-Adkins]

Please hurry. I'm 53 this year.

[@Larsonaut]

Sorry you have to accept the fate of all your ancestors. Don’t be selfish. It’s for multimillionaires and future generations 😂

[@MelB868]

I don't want to live to 130 that's way too long I want to live but I don't want to be here that long

[@Montie-Adkins]

@@MelB868 Good for you. And no one is going to try and make you take any treatments. And of course I will choose to partake.

[@KenOtwell]

I'm 68. Get in line!

[@RomanPetrenko-y9j]

Ahaaa!!!) great!!!)

[@MelB868]

130 seriously yeah no one wants to be on earth that long

[@trojanthedog]

Speak for yourself. I'll take 130 healthy years at the drop of a hot. So will millions of others.

[@povijestpovijest9569]

Not everyone is suicidal.

[@MelB868]

@@povijestpovijest9569 I want to live but I want God to take me to heaven before 130 that's too long

[@MelB868]

@@trojanthedog no one lives that long especially healthy

[@ModernHealthspan]

Hi thanks for your comment. It depends on how healthy you are, which is why the name and the focus of the channel is healthspan.

[@Wizard19977]

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