30. Nitrogen/Amino Acid Metabolism I

MIT 7.05 General Biochemistry, Spring 2020
Instructor: Matthew Vander Heiden
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Professor Vander Heiden introduces nitrogen metabolism, describes the role of glutamate, discusses the transamination reactions and PLP, and goes through the urea cycle.
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The first half of this course, taught by Prof. Yaffe, is available on the MITx platform as 7.05x Biochemistry: Biomolecules, Methods, and Mechanisms. The videos below are from the second half of the course with Prof. Vander Heiden, which focuses on metabolism. The exception is Lecture 12, which is in the first half of the course and was taught by Prof. Vander Heiden. See ocw.mit.edu/7-05S20 for more information.

[@SalesforceUSA]

I don't know why KZbin recommended this to me, but I stayed for the whole lecture...

[@woloabel]

(On Friday of March 17, 2023). On the Matter of Nitrogen And Amino Acid Metabolism by PhD Matthew Vander Heiden on Overall Topic of General Biochemistry From MIT OpenCourseWare (Online Outstanding Resources Endowment Grant of National Security Class): 1) Nitrogen Metabolism as Source of Amino Acid Biosynthesis Via DeNovo Modality as well as Salvaging whereby Nitrogen Fixation (The Reduction of Nitrous Gases in Atmosphere to Metabolites) is Primary, and Biosynthesized only by Certain Prokaryotic Bacteria (Essentiality of Ecologic Awareness). In Humans, Nitrogen from Purine (Nitrogenous Bases of Nucleic Acid) And Amino Acids themselves are Disposed by Transformation to Ammonia (NH3) and Ammonium (NH4+) By-Products and Part of Excreta (Urine a Product of Urea). However, Nitrogen Inputs should equal to Outputs Thereof otherwise Pathology of Metabolism Ensues (Metabolic Acidosis) to Cachexia (A Negative Nitrogen Balance); 2) Essential Amino Acids (Nutrition Provision Only): Leucine (L), Isoleucine (I), Valine (V), Histidine (H), Lysine (K), Methionine (M), Phenylalanine (F), Threonine(T), and Tryptophan (W); 3) Semi-Essential (or Conditionally) AAs: Tyrosine and Cysteine; 4) Non-Essential Alpha Amino Acids (Human Biosynthesis Possible): 1) Alanine, Arginine, Asparagine, Aspartic Acid, Cysteine (if EA is Available), Glutamic Acid, Glutamine, Glycine, Proline (P), Serine (S) and Tyrosine (If W is Available); 4) Transamination Reactions via Pyridoxyl Phosphate (PLP) and Pyridoxine (Vitamin B6) are Cofactor in such Reactions with Enzymes of Transamination and Glutamate Dehydrogenase (GDH); 5) Urea Cycle (Hans Kerb's First Biochemistry Contribution [Tricarboxylic Cycle is the Other]) is the Excretion of Nitrogen of Transamination via Cytosolic Reactions (A One in Mitochondrial Locus) Arginine AA to Urea (Urine Essentially); Citrulline (Amino Acid) and Ornithine (Amino Acids) not Found in the Protein Chains (Polymers of Amino Acids) with Arginosuccinate Synthase (ASS)----Well, I'm in this for Life and "ass" is not part of Such Grandiosity. Carbamoyl Phosphate (Carbon Dioxide and Ammonia) combines with Ornithine to Form Citrulline which Interlinks Cycles of Urea and TCA Cycles. And the Cycle of Life abounds through a Sound and Interconnectivity beyond even Philosophical Rational Assessment. PhD Heiden. es geht sehr gut mit Deiner Wissenschaft Der Biochemie aber meine Ding uber Geschlechtsoffnung ist. Heil!

[@pilotavery]

Holy s*** I found someone with the same exact picture as me!

[@wickymonvil9080]

Wicky enjoyed this lecture

[@umartemiraliev6561]

Umar did as well)

[@МихаилД-ч4з]

A funny joke at the and is ))))))