Modafinil benefits for depression | Dr Muzaffer Kaser

Dr Kaser presents his research into using the drug modafinil to help improve decision-making in patients with depression.
Depression is typically associated with issues such as low mood, sleep disturbances and appetite problems. But some of the most persistent and long-lasting issues facing patients with depression are cognitive problems involving concentration, memory and decision-making. These cognitive problems do not respond to traditional anti-depressant treatment, leaving patients with a clear unmet need.
Originally licensed for use in narcolepsy, the drug modafinil modulates dopamine and norepinephrine levels areas of the brain involved in learning and decision making. In this study, Dr Kaser used a reinforcement learning task to show that modafinil improved patients' ability to explore options when making a decision - and so leads to improved decision-making outcomes. This suggests that modafinil could be a valuable tool for improving cognition in patients with depression.
Dr Muzaffer Kaser is an NIHR Clinical Lecturer at the Department of Psychiatry, University of Cambridge.
Our Clinical Academics in Training Annual Conference, or CATAC, offers early career researchers the chance to present work and receive feedback from senior panelists in a truly interdisciplinary setting. The conference gives clinical academics the chance to meet people from all areas of biomedical science, and share ideas from many different perspectives.
This presentation, 'Computational approach to reinforcement learning in patients with remitted depression: results from a double-blind, randomised, placebo-controlled study' was runner-up in the Post-Doctoral Plenary Competition at CATAC 2018.
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[@ViralKiller]

Modafinil is the best anti-depressant I ever took...wasnt even supposed to be one..Also gets rid of all anxiety...amazing stuff

[@rafaels8017]

Start with 100mg, you can always adjust the dose.

[@ViralKiller]

@George P Im not a doctor this is not medical advice but 100 first day, you will not sleep, but 1 week later u will build mental tolerance and want to naturally goto 200...beyond 400 diminishing returns

[@rafaels8017]

George P 100mg is fine for me, but I also read that doctors prescribe 400-600 mg. It’s all trial and error, you’ll have to find the right dose for you. I also noticed, that it works better when ingested with food.

[@markm137]

@George P try artivigil

[@elsagrace3893]

George P also could be that it’s not the drug for you. It doesn’t work for everyone and some people get toxic liver problems from it

[@CobraHigh]

I've suffered from chronic depression for years. I started taking this drug to help me to study and get more work done, but shockingly I began to become happier. Granted I still have ups and downs but I second guess myself a lot less, and resolve conflict a lot faster. The major draw back is when it wears off. I don't exactly experience a crash, but I basically go back to normal and suddenly realize just how miserable I am, it's pretty horrible, it's like working at a mansion, and then having to go home to a card board box

[@trafficjon400]

won't last you will want more and be come frustrated and denpending on it.

[@trafficjon400]

ya it sucks. its not working any more. have to stop it for at least 2 day's. i took 600mg and still have no effect. getting sick of it. been on it for years. its better than nuvigil

[@trafficjon400]

@@samadtamboli7394 never herd of hair loss taking modafinil. should not effect any one like that.

[@brunotorres4160]

Try psilocibin mushrooms, a fairly high dose (3 - 4 grams of dried mushrooms). They are awesome for depression.

[@trafficjon400]

@חומס צ'יפס סלט don't work for it does not cover the problem. many people have the amount of vitamines nature

[@earthredalert]

I use it from time to time when in a depressive phase/lacking in motivation. I find 200mg gets me kick-started and productive, increasing my self-worth as a result and I'll not need to redose on a daily basis thereafter.

[@oldjeremyx]

Mi hermano, me alegra ver canales de habla hispana con esta calidad de edición. Hace una combinación perfecta con tu forma de expresarte. Tienes un nuevo seguidor de contenido

[@The.Player]

Wow. This video is totally in time for me. Such valuable information! A million thanks for the Channell and Mr Kaser!

[@Jericho642]

Haven't taken any modafanil for a while, but my depression and anxieyhas been getting worse. Tried lots of things to get me out of the slump; no more weed, early morning treadmill sessions, etc but no improvement Took one modafanil today and I'm back to my normal self; I feel great. Anxiety completely gone as the day progressed 🎉

[@80neptune]

Are you still doing okay?

[@Jericho642]

@@80neptune still some ups and downs but generally much better

[@holokolo4449]

I've been taking anti depressants for like 6 months now with some changes in meds as well as going to therapy I got prescribed modafinil because I thought I had ADHD and couldn't focus fuck all if my life depended on it I did my first dose yesterday of 100mg Felt like 10 percent better I think I did 200 mg today and it does feel different I think I might stick to 200mg for a couple of days to see if it works I hope this med will work out Has there been any side effect for you?

[@silence5707]

Thanks for the video. I am genuinely grateful.

[@astaroth0316]

During university I had lots of trouble getting focused and motivated, the last year I needed to work while still studying so I started taking Modafinil for dealing with sleep deprivation syntoms; then I started to notice how my performance increased as I was capable of getting focused much more often and easily than before, even with sleep deprivation. Now I suspect I had some level of depression and modafinil aided me a lot.

[@mrcosmic1234]

How much were you taking? At once?

[@notme7310]

Did you take it everyday? Did you build a tolerance from it?

[@astaroth0316]

@@mrcosmic1234 1 200mg pill per day which I hadn't sleep well

[@astaroth0316]

@@notme7310 At some time I indeed took a 200mg pill every day, but that is a bad idea, not because of tolerance which I didn't notice, but because of sleep deprivation accumulation. If you're so much tired you can fall asleep even if you just had taken a pill. I took one pill early at morning and tried to sleep at least a few hours testing whenever possible. Sleep deprivation really fuck up your health, lowering your defenses and triggering some syntomatology similar to immune deficiency like some kinds of dermatitis and opportunistic infections. Also sleep deprivation really affect your mood. Use with moderation because of sleep deprivation consequences

[@notme7310]

@@astaroth0316 I see. So do you no longer take modafinil now?

[@wvmoraes]

That's video is so amazing.

[@Frag_Star]

Modafinil for sure helps me to make quick decisions and stick to them until completion.

[@vegabanderbilt1778]

Modafinil cured my extreme anxiety and depression, I completely hacked my brain back.

[@KhaledBu23]

Dosage please! I'm seriously considering as my last hope! Is it a prescription drug ?

[@vegabanderbilt1778]

@@KhaledBu23 The right dosage varies from person to person for what I read in the comments but my experience is that if I take less than 200 mg it kind of backfires and it worsens your anxiety, in the other hand if I take more than 200 mg it just works as well as if I took 200 mgs. To me its been a blessing I've being taking it for years and I have no side effects at all other than being thirsty which at the end is really good because at least in my case don't get hungry and lost Weight to a healthy level. I order them from a website MODAF mod.af/ -- I don't know if it is a prescription drug but if it is they wouldn't give it to me, because they prescribe it for other disorders I think. At least here in the states I don't know how is it where you are at. You will find them from different manufacturers in the website I tried all of them and they work slightly different some you need a bigger dosage and on others a bit less and it does the work, but try them you might like one more than the other. All the freaking nonsense that the brain loops on and on just disappears. It works in minutes if you dissolve the pill under your tong that if you want instant results, the flavor is awful but works better at least for me. Here is other that works really well its called DARK ENERGY its a pre-workout powder I would say it's at the same level as modafinil it just makes you way happier but last less longer.

[@AryanSharma-qj4eu]

@@vegabanderbilt1778 you wrote this after taking modafinil right? 😂

[@ishan107]

@@KhaledBu23 100 mg in early morning ain starting,

[@poor_impulsive]

@@AryanSharma-qj4eu 🙉

[@sartainja]

I have been taking it for a few years now. It is great to increase your energy level and pulls you of the depressed cycles.

[@THEDReamER347]

Is the tab named modalert a good one?

[@jinxblaze]

@@THEDReamER347 yes it is, i started taking it for for adhd last week, 100mg dose, does help me.focus

[@travv88]

No side effects or diminishing returns?

[@Existentialcrisisaf]

​@@jinxblazehow often is taking it safe?

[@jinxblaze]

@@Existentialcrisisaf daily was my dose of 100-200mg, beware ur body builds tolerance to it after a while so nowadays it's not effective

[@carolinesafara4011]

I suffer from light depression and study law. I started using modafinil to study longer and more focused, but started to realize, how it helps my depression. I can enjoy day to day activities and the pressure in my mind slips away. It works 5-12 hours for me, but I feel kinda anxious and weird when it wores off.

[@servantofallah2004]

thanks for sharing, i will start modafinil for my chronic depression, but i am reluctant on it causing anxiety. Can you please elaborate more what kind of anxiousness do you get from this?

[@trafficjon400]

sounds wrong. it works 2- 4 hours and only short term. how is it working now.

[@9879SigmundS]

Happy for you. Depression and law do not mix. Success in law, esp long term success, has much to do with one’s psychology. Because you are constantly being attacked from all sides, being bulletproof is helpful. Good luck.

[@17tomtomtom]

Many lawyers are Better lawyers because they are depressed, depressed people often analyze too much. Not every depression looks the same , so a statement like that is not very accurate Some people with depression are okay with been attacked and might even attack back better :). I think my depression would make been in front of a computer without people more challenging than arguing law

[@9879SigmundS]

@@17tomtomtom I suppose it depends on whether one's type of depression causes them to be less functional as a lawyer. I would imagine that most types do.

[@missadventuresmotorcycledi2773]

My Mother suffered Dementia and was prescribed modafinal, the difference in mood was remarkable.

[@missadventuresmotorcycledi2773]

I am here to honestly say it made her better not to promote sales, ok thank you.

[@thedativecase9733]

@Christiana Gorge Does he sell in the UK?

[@highcurrent1125]

I took modaf for a while and here's my take... While taking it, life is good, nice anti-depressant effect, albeit with added anxiety levels though. The day after taking modaf however, I felt hung-over from it. I always thought this was do to a rebound effect in my brain chemistry. Loved the effects and benefits while taking it.... I worked varying shifts at work so it was super helpful.

[@Mel-os3ld]

With any up, there’ll always be a down sadly!! I feel it too!! 🙄😊😊💜💜💜

[@SomeGuy-cq3yv]

All Eeyore needed was some mod

[@Therealdrewdober]

Truuuu

[@MrSingh-pq4qk]

Great qustion at minute nine. The guy had to ask it three times becuase the answered it incorrectly the first time. I think the study is lacking data. Awesome job who ever asked that.

[@jhonperegrino5636]

There appeared to be a language barrier. I do not think this otherwise knowledgeable presenter is totally fluent in English especially his ability understanding lacks. But he made a good presentation.

[@dansmith9724]

Also be interesting to see the testosterone levels of the males in the group that responded to modafinil. Testosterone is known to interact with dopamine pathways. Its possible that male responders could be misdiagnosed with depression but instead be hypogonodal, especially if over 40. It should be a standard test for men over 40yo experiencing depression. It would be better to treat closer to the source then to treat symptoms when possible.

[@trafficjon400]

works in same area any way. its all a drug

[@hyperdomina7296]

I've done Steroids, and even then I promise you adding Modafinil on top makes it better. if Anything higher testosterone seems to make me a bit lazy and unbothered

[@trafficjon400]

impossible to find this way. many just do as perscribed with out the age deffect or any possible deffect happens no matter what condiction.

[@spencer1980]

Its also shown compelling results for ADHD off label as well. It still has some addictive properties, but SUBSTANTIALLY less than conventional stimulants. (Seriously, I know it sounds like a joke, but I think short acting stimulants like coke are a better option for adhd. Give a patient 10 or 12 doses per month, it shouldn't be a daily medication)

[@dansmith9724]

Although it wouldnt effect the immune dysfunction seen in cfsme, it could be a helpful drug for brain fog and cognitive issues they get. Although post exertional malaise could be an issue with these types of meds and maybe lower doses would be more effective. Many are also more sensitive to medications so a low dose woukd be a good starting point.

[@trafficjon400]

Adrenal glands may not tolerate it . not sure.

[@gts447]

I recently was prescribed this and I was surprised by how little it did for me. Basically felt really awake but with no mood enhancement whatsoever and very little positive energy.

[@annbarclay3825]

I am Bipolar 11 and suffer more with Depression. I have been depressed now for three Months. Completely disfunctional. I started Modafinil two weeks ago and it was like a Miracle. Although still a bit Depressed. i am completely functional. However i have only been taking 50mgs as i was afraid i could i switch to Mania. I am thinking of going up to 100mgs. Bearing in mind i take other Meds.

[@hellonykate3105]

Get shroomz from this psychstore it helps a lot..

[@hellonykate3105]

They are on instagram as ¿¿

[@hellonykate3105]

Drepsychz

[@Wittgepedia]

The one potential bad side effect of modafinil is irritability. But this is true for a lot of stimulants for a lot of people.... Taking low dosages and not every day can help with this.

[@desertstar7664]

I took generic modafinil. No irritability issues

[@Wittgepedia]

@unscripted I had to stop taking modafinil. I get super agitated if I take them a bunch. It depletes something. not for continuous use in my case or at all.

[@SupaHoon]

I've really had rage episodes on modafinil. It definitely depletes something from you over time that makes you more and more agitated

[@forestduffe5576]

I take it to get through my work week .

[@andriusandriuskevicius]

2 days ago started taking modafinil, got the 200mg pills, splitted into 4 parts, first day took 1/4 and after few hours another, so 100mg felt maybe too much for me? Because had a bit of a headache, one moment even got sleepy or similar to need of a after meal nap. Today took only 50mg or 1/4 of pill in the morning n no complains. Noticed the antidepresive effects, pleasantly surprised, some say it makes you less social, well I became more social, meaning- talking more, not as shy, less awkward, not as hard to have a conversation and even wanting to talk with people, i guess that's the antidepressant affect

[@raodilip]

How did it effect your hunger ?

[@andriusandriuskevicius]

@@raodilip for now it feels like it has no affects on hunger, no difference

@@andriusandriuskevicius he died

[@andriusandriuskevicius]

@ may he RIP 🙏

[@andriusandriuskevicius]

@wise guy nope, it's definetly not addictive, at least for me, I don't feel like taking it. But u do get shit done with it, workouts are great

[@Jay2pay]

How about Right Bundle Branch Block and the use of Modafinal.

[@bilalmalla2199]

Doctor sir can i take Modafinil 100 mg along with my daily routine medicines ,tab nexito plus and mirtazapine 7 .5 ,as im suffering from chronic OCD issue and i have extremely mood swings problems

[@tassiad.9137]

in my experience, micro-dose is the best. Make a "to-do" list before..take 1/4 ...get the reward feeling..build your discipline and save your tolerance for when you really need it. Then, in odd times take half . I only took a full dose once but gave me strong headaches.

[@davorniksic9288]

Same experience here, less is better with Moda.

[@kite6864]

interesting, i've been taking it off and on for about 10 years. originally tired it for adhd since I can't take traditional stimulants. although i don't think it helps much with adhd it does help me to get out of depressive slumps. it's been hard finding a doctor on board with prescribing it though... why prescribe something that works.

[@weinhauser7215]

i FEEL GREAT ON MADAFINIL I AM ONLY TAKING 5OMG 5 DAYS A WEEK

[@stevenkyle2313]

My Dr won’t prescribe it :( but he’ll write vyvanse and adderall which are horrible for me. I got my hands on modaf and it’s perfect but I can’t get a script :(

[@missk1942]

Modafinil works so well .

[@DecentraTalks]

I've talked about my experience with modafinil on my channel. As someone who suffers from depression and ADHD I've noticed that the only thing it helps with is allowing me to wake up earlier. It was good for keeping me awake but idk if I'd say it helps my depression

[@Mel-os3ld]

Works differently for everyone!! I’ve read mainly good testimonials on this med!

[@Mel-os3ld]

I just checked your channel out.. looks interesting.. il watch whilst I do some house work 💪🏼👍😊

[@NanamiNishijou]

Where is it?

[@jaspalsinghahluwalia2721]

You guys are making fun of others ,you should consider yourself lucky that it's not happening to you. If it does not happen to you ,does not mean the guy is lying. If you guys cannot give a good advice then at least don't make joke on others and call them weak. People suffering , are looking for help not insult.

[@mayanksaxena6273]

Who's making fun of who?

[@taemeister9302]

My first time taking mods yesterday afternoon. 100mg. It made me focus better but i still feel the shadow of my fatigue throughout my body. I stayed well hydrated yesterday but all i ate yesterday was a tiny bit of soup and rice at around 9pm. Was i feeling drowsiness because i didn't eat all day?

[@Mel-os3ld]

From what I hear from many, the depression doesn’t lift immediately.. although the energy can come.. how’s it worked out for you ?? 😊😊😊

[@travv88]

you need food bro

[@bobmason1361]

Have any studies taken place for dementia. It is said it helps with short-term memory.

[@therach7841]

I use the following regimen: 1. 3 g of Kratom twice daily, 2. 100 mg of modafinil twice daily 3. 50 mg of ground and dried psilocybin mushrooms once every other day. I've been doing this for about 4 years with nearly complete resolution of depression which I had for about 15 years prior. To be accurate, my depression was most severe in my late teens and early 20's and I was even suicidal at many points. The largest relief I got was from forcing myself to be social which alleviated my social anxiety (my main depressive trigger). I still had a great deal of depression though which would affect my work and relationships. The SSRIs, SNRIs, and DNRIs worked a bit but not for long. I'm a pretty experienced and safe psychonaut so I did my own research and set upon finding a regimen. This one has worked for me for a long time and I have no intention of changing it anytime soon.

[@sutardjosutardjo7317]

You're pretty resourceful for a depressed person to get all of those. To get one of those things, is very excruciating for a depressed. Especially the last one. Just my opinion

[@armr6937]

@@sutardjosutardjo7317 Grow kits are available online. Takes a bit of work but it'll sort you out.

[@ricardolopezbirlain262]

Do you still doing that. I have all the combo available. For now i just take 3.7 grams of kratom twice a day

[@craigallday1236]

Kratom and modafanil have led to seizures

[@tomasranta6154]

I have been on tricyclics for 50 years. When I try adding modafinil I feel great for 2 days. After that, depression worsens.

[@Gerry_Davies]

I looked up Dr Kaser's paper - the dosage used was 200mg which seems very high to me. That's the prescribed dose for narcolepsy. Most people who use it for improved concentration/cognition etc. seem to use about half that dose.

[@samirstanton86]

It really depends on the individual. Personally 100mg doesn't do much for me. 200mg and I can feel that focus really kick in

[@trafficjon400]

low. 600mg does nothing any more. people with sleep problems take 800mgs.

[@17tomtomtom]

I like taking 300mg 100 mg might be good after a day when I took 200 or 300 as there is residual 50 in afternoon me more tired than none at all

[@surjeetsingh-wz1uj]

@@marksamson1837 u know some nootropic abt depression ocd

[@unhallowed45]

I don’t have narcolepsy so I can’t get a prescription. I plea to my doctors about my lethargy and ADHD and it’s like they don’t care.

[@marksamson1837]

Hey Where can I buy modafinil?

[@Jaydelrey]

Modafinil can be bought online and for far cheaper than prescriptions in the US. (last I checked $20-$30 per pill in the US with a prescription vs $0.89-$2 per pill depending on the online vendor)

[@17tomtomtom]

My doctor has been very happy to prescribe it but he is a psychiatrist.he likes it for add I don’t have add or narcolepsy

[@marichristian1072]

My doctor was horrified I even asked to try . No problem.... I bought some at a reputable pharmacy on- line and I only use it when I have a challenging task ahead - like making a presentation at conference. Believe me. It makes all the difference to cognitive focus and energy level.

[@adu1991]

For now, use this binaural beat.... It has the same effects as Armodafinil. However, the difference is that it'll only last 6-8 hours(whereas actual Armodafinil has a half-life of 12-15 hours). The channel is Binaural Nutrition. You can thank that person. I didn't make it :) LINK: kzbin.info/www/bejne/bnzblnqrj72tndk

[@slimbrady6004]

I’m on day 2 of modafinil (200mg) and don’t feel any different yet, but I want to give it a chance. How long does it take for this medication to start working?

[@iamthefiremanjj]

It should work the same day 😊

[@feyzam.8691]

Aga biri seri Türkçe çevirsin lütfen

[@PavanMS87]

I've been taking modafinil since may years and it no longer works for me due to tolerance.

[@emilioramirez5648]

when i started to take modafinil I love men. But suddenly, I realized how gross that is! LOVE IT

[@jessicakelley0]

I wonder why the placebo responses are commonly so high in people with depression....? Any ideas?

[@heralddobre8114]

Attention makes people happy. Does this answer your Question :)

[@KCM25NJL]

Because being involved in something that can potentially help them...... gives hope. Hope gives rise to positivity. Positivity gives rise to placebo results.

[@RAFITAESTRADITA]

You get what You expect.

[@thedativecase9733]

A lot of people who have mild to moderate "depression" don't really have Depression. Speaking as a woman who has lived with severe Depression for decades I find it insulting that the two states are regarded the same by the medical profession. "Feeling quite sad for a few weeks after your boyfriend dumped you? Oh you must have serious Depression!"

[@Kid_Ikaris]

Man 50p has a lot more weight in science than two quarters would have in America.

[@amedeocristiano4181]

I have dysthymia (chronic low depression) . I am on some thyroid hormones and I am going to start modafinil. no antidepressant anymore for me, they are basically useless for this condition.

[@millstreetteut7835]

I also suffer from dysthimia. Did you get any relieve from Modafanil?

[@amedeocristiano4181]

some relief. like a 5% of it. nothing miraculous. we are very far from the real solution of chronic depression. I am coming up with a video about it soon . for me it's a metabolic problem involving oxygen in the brain and sleep disorder. chemical imbalance is bullshit and so it is genetic. and I am sick of it.

[@millstreetteut7835]

That sounds right what you are saying! Thats what it feels like for me . I just tried modafinol. Not much of an effect, a bit more awake for maybe an hour .

[@commentscopyrightattorney5543]

I'd swallow a rock over any anti-depressant any day

[@staceywinters4964]

How are you? Did you try modafinil?

[@ExtremeZ8]

Modafinil is good to battle the loss of drive and motivation. But it can cause psychosis if you are unlucky, i.e. genetically susceptible to it. I got psychosis from modafinil

[@black_Spiders]

im a little weak when take it

[@lidialidia4150]

I took medafinil (100mg) together with me medication ( amitriptilin 25mg) , and It did help significantly improving me day to day life, I’m just afraid to have to be dependent on yet another drug to make me function normally.

[@hilarymunene7794]

How are you feeling now? Are you still on modafinil and amitriptyline?

[@filipstruhar8048]

@@hilarymunene7794 good question

[@eyemovie824]

Take it 50 mg 2-3 days then gap 1-2 days. It will not build tolerance

[@filipstruhar8048]

@@eyemovie824 i tryed moda and i had extreme headaches and illnes

[@eyemovie824]

@@filipstruhar8048 for some it will do some side effects. You can try other brands. Try modelart 100mg. And break it to 2 part and take 1 part. Its really good quality modafinil. If you buy from India it will cost 2-3 dollar

[@robertmax1316]

I was wondering if this also beneficial for migraine sufferer , or use for anticonvulsant medication?

[@marksamson1837]

Hi

[@bigfood2001]

I dont think that it will help you with your migraine, cause the primary side effect is headache. try caffeine for migraine, modafinil good for concentration and mood

[@17tomtomtom]

I think it might give more headaches

[@HighStakesDanny]

I can’t get it but it works for depression. They have it scheduled like a narc. Strict.

[@aviationmadness4236]

So it sounds like by reading the comments that people know more about modafinil Express that there's a rebound effect so it's kind of like a hangover you take something high caffeine let's say

[@80neptune]

Modafinil actually calms me down, lifts my depression and makes me feel normal. However, I cannot take it more than once or twice a week, several days apart. I think I have issues with ADHD and dopamine but I've never found a doctor who would bother to test me for these things. Rather, they put me through a course of every single anti-depressant that ever existed with no result. So... I found Modafinil out there on the web and self administer it.

[@dingding4898]

Have been taking 200mg modafinil for 4 days straight now. I think I have been having less sleep for past few days, but still awake during day, obviously because of modafinil.

[@arafatafroz1047]

Hey, i have generalised anxiety disorder can I take modafinil? Can anyone tell.

[@feyzam.8691]

No ..

[@evan3272]

Not a good idea, I'll recommend trying psilocybin mushroom for the treatment of anxiety

[@evan3272]

I can also recommend where to get them for

[@kingEbs2023]

@@evan3272 where can anyone get that. I'm based in the uk.

[@scottpreston5074]

@ARAFAT AFROZ. It seems to work well in low doses. Of course, one should always start out slowly and pay attention to the subjective effects.

[@dangad5393]

It is on my prescription since 3 years, 100mg in summer is amazing, in winter 200mg does the job, but higher doses no good, I would say 100mg is good combo with oxiracetam, neepept aniracetam and rodiola 1000mg a day

[@HMQiNVM]

Wow. Dmn, how can you afford of all it? I just stated in monafidil today, after my first appointment with psychiatrist.. I live in Central America and this all aint cheap or affordable, I bet it's much more pricier in the USA.

[@zaynumar0]

Just took 200mg tablet of "Signature Modvigil-200"

[@N-A762]

Same here brother

[@zaynumar0]

@@N-A762modafinil shouldn't be abused

[@N-A762]

I agree there is a right and wrong way. I didnt say I was using it in a negative context did I?

[@zaynumar0]

@@N-A762 I experienced weird side effects. Long term effects of modafinil use seems uncertain. Recent study shows modafinil use by pregnant women can affect foetul development

[@N-A762]

@@zaynumar0 Interesting what side effects?

[@euphoricrealm1503]

What about effects on libido?

[@user-qp7oi4xw5s]

От армодафинила либидо повышается.

[@MrBlackMarvel]

none. its like a long coffee. usually take 100-200mg

[@mooncakes9950]

Where can I buy this??

[@evan3272]

Bought mine from an online drug store

[@evan3272]

He's on Instagram and Telegram as,

[@evan3272]

-Mycojared7-.....

[@amirhosseinheidary2020]

What are the differences between Modafinil's effects on inhibition of reuptake of Dopamine and the procedure through which Adderall does it? Please explain how could a substance which increases norepinephrine and as a result could cause Adrenal fatigue in many individuals is therapeutic for treatment of depressive symptoms? I presume, you lack ssufficient practical knowledge on Modafinil's full mechanism. Please don't erase this comment and just enlighten others.

[@aakashyadav2711]

200mg makes me feels it's effect but I'm shitting all day. But then 100 mg doesn't make me feel anything. So Im stopping from today

[@bakingsoda9769]

If modafinil helps you then go ahead and try it, but in my case I became manic, agressive, restless and from time to time even more depressed. The 1st 4 days were a nice boost in concentration and alertness but after i ran out of modafinil (had a 10 x 200mg blister) I noticed how psychotic I was on that pill, throwing punches at the air and crying 2 hours later in the shower for no reason while feeling like I was in a dreamlike state - i took a pill daily but even at 50mg I was showing such symptoms. Modafinil was a hell for me, but maybe it might be an opportunity for you. I'm better served by psychedelics in small doses every 2-3 days.

[@bakingsoda9769]

@Neil Blööm You're not the brightest person, aren't you? www.webmd.com/drugs/2/drug-16962/modafinil-oral/details/list-sideeffects

[@medusasaurus1447]

@Neil Blööm modafinil can definitely do this. It’s in the official warnings, dumb-dumb

[@eyemovie824]

I really laghted on your comment. You need a psycritist first.then take modafinil. If you take moderately its just awesome

[@bakingsoda9769]

@@eyemovie824 i took it moderately, once per day and even at 1/4th of the pill i had severe side effects but thanks. The depression community is kind and supportive, laughing at people who struggle with their psyche because a medication does show RARE side effects in him. www.webmd.com/drugs/2/drug-16962/modafinil-oral/details/list-sideeffects

[@medusasaurus1447]

@@eyemovie824 you don’t get modafinil from a psychiatrist, it’s for narcolepsy and sleep disorders 😂😂😂

[@annbarclay3825]

anyone had any positive results for depression

[@robertmax1316]

No one had ever tried yet

[@lennyb1969]

I have certainly, take 100mg dailly

[@trafficjon400]

yes first but later it got worse. modafinol and any other man make mood drug is not natural.

[@lennyb1969]

@@trafficjon400 How much later

[@9879SigmundS]

It helped me get through my father’s death after caring for him for 3 - 4 years. I have a tendency for depression.

[@dheepratimdas260]

I have severe anxiety after modafilin

[@streetcrypto1218]

Explain please

[@dheepratimdas260]

@@streetcrypto1218 see I already have anxiety and I have taken modafilin 7 times and everytime I took my anxiety increased

[@streetcrypto1218]

@@dheepratimdas260 did you take it with coffee? Or caffeine? That will increase anxiety exponentially

[@dheepratimdas260]

@@streetcrypto1218 I don't drink coffee

[@1TheWhiteKnight1]

Take less. I’m down to just 5-10mg when I wake and it’s perfect. Can’t believe some take 100-200mg a day.

[@matfry2310]

Eat with the dose. It can make your isseus worse if not 🤘👌 now ya know

[@joshuaharrington5994]

I’m sorry in my opinion concerta is far superior

[@fraxizztv6433]

also more addictive and more side effects, generally speaking

[@-destroyingyouverbally7614]

But is it really true does this medication modafinil- does it cause hair loss?? Does anybody notice this? If u take the med can u please let me know if u have notice hair loss

[@adu1991]

It will not make you go bald. However, if someone is already losing their hair or prone to male pattern baldness, it may speed up the process.

[@frmlm6112]

yes it does apparently. Depending of the dosage you take

[@adu1991]

Natalie P It doesn't cause hairloss, but if someone is already predisposed to balding(theough male pattern baldness or alocepia), then it can possibly speed up the process.

[@asitroysaha8254]

Agartala

[@sutardjosutardjo7317]

@@adu1991 do you know how to counter it?

[@mianshahzadiqbal]

How can buy in pakistan?

[@criticalthinker72]

Get a prescription or research companies that you can buy from in India.

[@TheEverydayManChannel]

It's produced in India. So you can order it from an online Indian company if you have a prescription.

[@ashramdhan1582]

Sun pharma makes the modalert.

[@Aftabalam-on4ux]

​@@criticalthinker72hello sir hope doing well. How i can order it from انڈیا to pakistan

[@bukansiapasiapa5867]

Itu obat asli g sih ya guys?

[@TheEclipse5]

asli, bisa di beli di tokopedia, harga sekitar 200k rp untuk 10 biji.

[@17tomtomtom]

A person taking modafinil will feel is not placeboo unless they give him some stimulant. I wonder how such studies look after the person becomes sleep deprived from the insomnia side effect Modafinil restricts certain type of thinking ( creative). There is now an antidepressant labeled for cognitive improvements : trintellix I love modafinil but I’m yet to discover how to take daily in a successful way I only feel it’s magic if I don’t take it for a few days I also recently noticed a higher dose does better for me A low dose actually makes me more tired With modafinil after not sleeping you feel Tired mentally but can’t sleep

[@17tomtomtom]

My experience has been that 200 mg makes me less drowsy that 400 and 300 is were I get the most energy but then can sleep . You can play with it until you find your dose and best time of day to take. Recently has some success using it later rather than first thing in am .. most people even have if it doesn’t energize them all day will feel that is not placebo I would think .. Also I’m not sure if antidepressants don’t affect how modafinil works I’m sure each antidepressant and person is different . Good but I think if 400 mg doesn’t work try 300 ,200 , 100 before giving up on it

[@17tomtomtom]

*then can’t sleep I meant

[@mandelaaffected5059]

n3ur0 h4ck3r I actually had nonissue sleeping since I took the meds so early in the morning. I lowered the dose this morning and will gradually increase it until I find the best amount for me.

[@Riffeeee]

How does modafilin restrict creative thinking?

[@mandelaaffected5059]

I no longer feel the “anxiety” caused by Modafinil that was very similar to how I felt after taking Adderall. I was on edge until my body adjusted.

[@amrmoneer5881]

Lol ironically this drug caused me a lot of depression and anxiety. It did help with concentration but the side effects are counterproductive so i had to stop it

[@rahulkeshri6476]

Who came here after rhea's interview

[@shrisharma7355]

Me 🙋

[@rahulkeshri6476]

@@shrisharma7355 everybody is fighting for , Sushant he will get justice for sure

[@shrisharma7355]

@@rahulkeshri6476 I hope he does.

[@rahulkeshri6476]

@@shrisharma7355 yes, he was from Bihar and me too so I am supporting his fight for justice till death

[@rounakagrawal3701]

@@shrisharma7355 have u taken modeafinil

[@tjb9105]

Is modafinil use for low sex drive

[@user-qp7oi4xw5s]

Нет.

[@pierre4856]

Modafinil cured my gay addiction

[@rickybradley6177]

That’s gay.

[@dahsk7872]

I had a friend who took this and it ruined his life and motivation. Just beware. Maybe he got a bad batch, but please be careful with these things...

[@sreno66]

In what way did it ruin his life?

[@streetcrypto1218]

Explain

[@iamthefiremanjj]

Lol ruined his life

[@garyflint5824]

How does it compare to Kratom I wonder ?

[@azizamehdizadeh1164]

It's a whole different energy and focus. I've tried both and prefer modafinil

[@SA-yp3xh]

@@azizamehdizadeh1164 what/how did you get a script?

[@raimundorogerio9812]

Teria que ser traduzido😂

[@paweltracz1061]

Strange. I heard if you have depression or psychosis to stay away from the drug. Side note , watch out for a rash which is listed as a potentialy fatal side effect

[@dekonfrost7]

What happens when you have a 164 iq old scale what would that look like? When you are already on the genius spectrum?

[@generalingwer4341]

Just really makes me mad when i see stuff like this.i dont care how severe ur depression is ull never get anyone to prescribe stuff like this.its a joke really.suffering needlessly.

[@needheartranken]

Where you from? You can buy it from legitimate websites.

[@generalingwer4341]

@@needheartranken pa.

[@trafficjon400]

don't take it long it does not work. you made want more. pay more.

[@trafficjon400]

Stoping for a period and hoping it might kick in again.

[@zameerpactyan]

I will burn a book inside the class room to get my self dropped from the University even if i see you giving a lecture in my dream!! the subject is good but this guy has remain silence or should practice public speaking :)

[@Brainstorms77]

Give your speech and lecture and will compare

[@michelekisly2535]

Comments are better than this Presenter

[@tenancingogarcia]

I don't like this medicine at all

[@beckyweaver5981]

Why?