Multiple Sclerosis Overview

[@EvenSoItIsWell]

Sharing my story. 😉 My first discernible relapse was in 2006 (main symptom was foot drop). I was not diagnosed at that time but I did make some significant diet and lifestyle changes. The foot drop resolved after several months - I credit the steroids, my amazing body healing, and the diet and lifestyle changes (hooray for yoga!). In 2016 I started experiencing more symptoms and in 2017 I received my diagnosis. I am now on a DMT and do 5 things to help with managing my symptoms and possible progression; I eat a whole food plant based diet, exercise regularly, try to get good sleep, practice mindfulness, and take supplements under the guidance of my neurologist and naturopathic doctor. I believe all of these are key to my health and well-being. 😊

[@DrBrandonBeaber]

Thanks for sharing Vickie. What treatments do you do through your naturopathic doctor?

[@EvenSoItIsWell]

@@DrBrandonBeaber My naturopathic doctor specializes in nutrition and functional medicine approaches to neurodegenerative conditions. She helps me manage my symptoms with guidance on diet and lifestyle. We also do regular bloodwork to check hormone and nutrients, from those we adjust supplements as needed.

[@RobdeKlerk-qg6lc]

Hallo , 1 question..is central apnea common in ms ? Thank you...​@DrBrandonBeaber

[@mishooofficial]

@DrBrandnonBeaber omg Doc that looks like a lot of work to make this video for us thank you very much!

[@eileenazar7595]

can someone have MS without any lesions showing on MRI brain and cervical spine?

[@garyrooksby]

This is a goldmine. Thank you so much, sir. I was diagnosed RRMS in 1999 (1st symptoms 1993) and now EDSS 4.5 so I've done well. I've just retired due to the cognitive symptoms but I've loving life. Keep up the excellent work!

[@DrBrandonBeaber]

I'm glad you liked the video.

[@sassygirl6407]

I was diagnosed with MS (RRM) December 2014 at 31 years old. Started getting my first symptoms of numbing in the legs and awfull lower back pain in March 2014. Went to my GP back then, he brushed it off as a pinched nerve without even looking me over. A week later I still had those symptoms and went to another GP. She looked me over and immediately referred me to a neurologist who did bloodtests, scans, neurological testing and all that. One day I had lost the feeling in the left side of my face that lasted for a week. My neurologist immediately booked me an appointment for another brain scan. That scan was so obvious that she said I didn't even need a spinal tap, it was very obviously MS. Started medication (Gilenya) January 2015 while monitored in hospital and I've been stable ever since 🤗

[@paulaburke8136]

Very informative video on Ms would like to see what the brain images look like showing ms

[@AaronBosterMD]

Excellent video!

[@DrBrandonBeaber]

Thanks! I actually originally had this idea from your videos. This current video is a remake of a prior video (a self-plagiarism if you will): kzbin.info/www/bejne/qICsqIKVj9FshZY

[@jamesflange]

Wow, I just had to comment. What an honour it is to be in the same conversation with you guys! Love from Ireland. ❤️🇮🇪 Keep up the great work both.

[@heathertomazin5556]

Thank you for this video Dr. Beaber! I am an infusion nurse who administers ocrevus, Tysabri, and rituxan for MS and this video was very helpful in my education of the disease process. I also work in integrative medicine so I was glad to see you mentioned Dr Wahls work as well as ALA, Vit D, and Low dose naltrexone.

[@cnt2495]

I'll share my story as well. I was diagnosed in August 2015. The incident that caused me to go to the hospital was vertigo and nystagmus. Thankfully, I was recommended to see my current neurologist. I was on copaxone for about 6 years and had no relapses. During one MRI session, my neurologist found a new lesion and recommended that I go on Ocrevus. I've been talking Ocrevus ever since then. My EDSS was never officially taken but i can still walk and run but over the years, the distance I can go has declined to a little under a mile. I can't thank my neurologist enough for providing me the best care. Going 9 years strong with no new relapses since my diagnosis in 2015, I can say that I'm very happy with my neurologist and all the new research in making sure I'm living my best life!

[@DrBrandonBeaber]

Awesome. I'm glad you are doing well.

[@dn-pp5ny]

Great video. Wish you mentioned the fact Dr. Wahls’ was diagnosed with cancer and received chemotherapy, I think her story is a testament for HSCT more than her diet.

[@__Wanderer]

exactly - I actually find Dr Wahls to be a charlatan profiting on her "diet" recommendations. She had a dose of good luck that her chemo somewhat cured her rather than her diet..

[@ph7346]

I've never once bought in on her story. She's never once showed before and after of her MRIs to prove her Diet program reversed her systems while she makes thousands of dollars selling her book. HSCT FOR REAL RESULTS

[@nb7166]

This is false

[@__Wanderer]

@@nb7166 she did take heavy chemo drugs... google it

[@dn-pp5ny]

@@nb7166 she didn't have cancer and receive chemo?

[@EvenSoItIsWell]

Thanks Dr. Beaber. Excellent video! I will be sharing it. I loved the MRI overtime. It is fascinating that the lesions can come and go like that without outward showing signs.

[@DrBrandonBeaber]

That is quite an extraordinary study. We see this in real life all time, and I have seen quite dramatic radiologic improvement many times.

[@finneyfer]

These videos are great! I’ve had MS for at least 20 yrs, dx at 30. This is the best explanation I’ve ever seen. Thank you and please keep it up!!!

[@DrBrandonBeaber]

Thanks!

[@erinnicolefranco6807]

AMAZING! Thank you. First symptom in 2001 at age 16. Diagnosed at 35. Wheelchair user with bilateral optic neuritis. No brain atrophy and almost no brain lesions. My brain stem and spinal cord have taken the brunt of the damage. Many neurologist have evaluated me. It’s not NMO or MOG

[@Mack_Memphis]

Hi @drbrandonbeaber I was diagnosed with MS on July 26th, 2024. It all started with severe lft shoulder pain in 2020, then moved up the left side of my neck in 2021. After several physical therapy classes, and dr appts., I finally got an mri this year. I have one frontal lesion, one large one on the rt and seven small ones. Dr says. I have arthropathy and Multilevel Cervical Spondylosis with uncovertebral hypertrophy. I also have syncope / vertigo . I know i dont require a spinal tap, but I do have to have infusions every six months now, several blood test, test for sexual diseases and vaccines. Im new to this. P.S. I lived down south most of my life and then moved back to Michigan to find this out. I am also a fit 56 yr old african american male who looks 30. To me, this disease has no prejudices. I am subscring to your channel. You were very informative and acceptable to listen to ( calm & easy going ).

[@vj8406]

Less sun in Michigan

[@mattz5275]

ON was my first symptom. Ty for doing this video very well done as always.

[@roberture5903]

Excellent video Dr Brandon, my vitamin d level was 50 when I was diagnosed and now after supplementing for several years I'm now at 100 which has really had no significant affect on my ms.

[@trescccc]

Happy birthday?

[@bhlom4135]

I had a vitamin D count in October (2023) in the single digits. I immediately started taking 5,000 iu/day. Fast forward to the past few weeks, I am feeling waaaay better. My energy level is increased, bowel &bladder issues are a little better as is body strength (borderline bed ridden ppms'r). I hope your journey with this bs improves for you also. Just thought I'd share my experience , every ones individually unique with this shtuff especially. ✌️

[@RickoColby]

Excellent summary and comments section.

[@jsykes04111954]

I was diagnosed with MS due to optic neuritis in my left eye. My diagnosis was quick. October 1992. Only had one exacerbation since that time. Was treated with steroids intravenously. I am now 70 years old and recently experiencing a lot of fatigue. I also had a mild stroke in October 2023.

[@elizabethmurphy3931]

I am going to share this with my family. This is such an informative video covering so many aspects and answers so many questions. Thank you for this.

[@DrBrandonBeaber]

Thanks. I tried to make it accessible to someone first learning about MS.

[@lemonpeelangelfish]

Thank you Dr Beaber this is a fantastic summary! My story: April 2021 numbness developed in my back and progressed down my arm was on holiday (in country of residence). Numbness spread was admitted to hospital. MRI next day diagnosed with MS confirmed by neurologist in May. 5 days from symptom onset to diagnosis! Was put on dimethyl fumerate but advocated for a higher efficiency treatment (partly due to your video on a research study showing starting higher efficiency early on was more effective) and now on Natalizumab. Eat less diary, been a vegetarian (but eat fish) for over 20 years. I think EDSS is not a reliable measure of the impact of MS it focuses heavily on mobility. After all most pwMS leave the workplace due to fatigue so it doesn’t really reflect the impact of MS on people.

[@__Wanderer]

Fantastic overview - thank you Dr Brandon for taking the time to put this presentation together :)

[@DrBrandonBeaber]

No problem

[@vanessavaidya7135]

Ladies, It’s not easy when your physical exhaustion is signaling a bodily issue, but the saying goes “if you don’t use it, you lose it.” Take a deep breath, ask a close relative/friend with effective communication skills to advocate during an appointment. There are virtual forums or social media groups to help navigate towards more answers. Accepting the fact of this new reality is crucial for one’s mental stability to motivate health towards a baseline. Dr. Brandon, what about the effects of MS on menses, pre-menopausal, process of menopause, then post. Does it cause MS flares?? Thank you!

[@Ryukachoo]

30:45 Keep an eye on mrna based treatments. Based on that treatment for peanut allergies currently in trials, its possible a similar technique could apply to MS, essentially turning off the immune system code that causes it to attack the sheaths

[@SunBex]

Thanks for the video Doc, I’ve had MS for 15 years, got it at 19, have an amazing doc who gave me the right meds at the right time, the first attack was bad, had double vision, lost taste, couldn’t stand or walk. Had a couple of relapses since, on medication for RRMS now, I’m feeling much better, have trouble walking for more than 1km at a stretch though. 😊

[@DrBrandonBeaber]

I'm glad you are doing well :) Things have certainly changed in the field, even over 15 years. Perhaps I'll do an update on this video in 2025 or 2026.

[@nodeofranviere7638]

Thank you for this Dr Beaber.

[@DrBrandonBeaber]

You're welcome

[@hector-3089]

fantastic video! Thank you for sharing your knowledge and time with us

[@DrBrandonBeaber]

:)

[@belmakanlic1113]

Great video for newly diagnosed!

[@AQtoo]

Keep it up, it’s going to be a new chapter in your life, it is going to be a different experience. Take care of yourself.

[@DrBrandonBeaber]

I hope it was helpful

[@s.jatighetchi9021]

Thank you for sharing this overview video Dr. Beaber. I've recently been diagnosed with MS through an initial MRI scan. My family and I are plant based and super active. I'm a cyclist and runner and compete in both amateaur cycling and running events. As far as I know I don't have a history of MS in my family but have had a poor immune system ever since I was born. I'm 46 yrs old and feel I'm in the best athletic shape of my life until the MS disease weakened my left leg about three weeks ago. I'm still learning about the disease as I wait for a neurologist to make further assessments of my condition. Thank you again and I look forward to watching more of your videos and learning about MS.

[@ABskywalker]

Thanks for all the great information, Dr. Beaber! I'm wondering if there is any research regarding adaptogens such as Lion's Mane mushroom tinctures affecting fatigue or pain.

[@katsato3118]

Last june '23 i had a stroke like episode while showering. I had been seeing neurology for 6 years with non specific lesions and yold they were just bad headaches and ayay in therapy. This episode had me feeling flippy and unable to coordinate movement and speak. The hospital did a ct, admitted me, did an mri and gound a mid falcine (maybe meningioma, maybe not) and a right oins lesion that wasnt there 2 weeks before when a similar episode occurred. I was sent to Cleveland clinics brain tumor center where they said i "didnt want them to mess with the tumor, waych wait because treatment could make worse", told i had ms but csf lp only came back very high gamma globulins. I have been sent all over Ohio and now that they see the lesions and tumor theyve stopped calling me crazy but also say "sorry" that they cant diagnose to help me? Im now day 3 coming a bit out of another "stuck episode" where i feel as if im in and out of comatose state, speech is still confusing and my thoughts are slow. I dont even go to the er anymore to be billed and told they dont know what to do. To boot i also have systemic scleroderma and the meds for that make me sick as is. I hate the medical field. I appreciate professionals like yourself though because at least you take time to explain what is happening. I iften wonder if medical is like this in every state in regards to no understanding of scleroderma and crappy neurologists. Im 42 years ild and have spent 8 years being told im just stressed and i thought having a diagnosis would mean care. So wrong when you cant access knowledgeable decent drs. Anyway, thank you. This video is very informative in regards to the nature of lesions. I wish neurologists would stay up in these things as well. Too many people having their lives wasted because of ego.

[@NYashkovsky]

Thank you for the video, great overview! And thank you for all the information you share on this channel, it’s very helpful. I am newly diagnosed and your channel helped me enormously. It would be interesting to know more about pregnancy and MS: the latest findings and recommendations. I watched your older videos on that topic, but maybe there is something new we know now. Especially interesting to know about strategies for newly diagnosed women who were planning pregnancy before diagnosis, but didn’t become pregnant before first relapse. Because it seems like the earlier you get the stronger medication the better, but most strong medication is not safe during pregnancy. So is it safe to use copaxone or interferons for couple of years (pregnancy + breastfeeding) or it could be potentially harmful in the long term and it’s better to postpone pregnancy and use stronger medication and then trying to conceive (and for how long in this case). Because it seems like more aggressive treatment is important in the first years of MS. Or maybe there are other strategies that we have now. This is a question I faced with and maybe the answer would be helpful to other women. Thank you 🙏

[@MohammedNomer]

Thank you so much dear doctor for this wonderful summary 🌹

[@Georgia_transplant]

Thank you very much for doing these videos! Will echo others saying tremendously helpful for newly diagnosed!

[@j2j_5675]

This is my go to Dr. for MS information from now on. Amazing video

[@DrBrandonBeaber]

Thanks

[@majesticblue92]

Thank you Dr. Beaber for the informative videos. You didnt mention anything about clemastine and its possible activation of remyelination. I heard trial results are coming out this year. Are you hopeful this will have a meaningful impact on reversing the damage? Or are the results not that promising?

[@DrBrandonBeaber]

Here is a video on clemastine: kzbin.info/www/bejne/imfTZphoiciFb7M There are still ongoing trials such as this one: Clemastine Fumarate as Remyelinating Treatment in Internuclear Ophthalmoparesis and Multiple Sclerosis (RESTORE): clinicaltrials.gov/study/NCT05338450

[@numbr6]

While on Copaxone one day I had an onset of a clonic shoulder twitch which "sometimes" made picking up a cup of tea without spilling difficult. The whole gambit of drugs you mention for spasticity were tried. All failed. More than a decade later, "yet a new neurologist" asked "would you be open to trying Valium?" "Sure, if you think it might help". Well that was my magic bullet for that more rare than common twitch. Fortunately, I do not find 10mg Valium as needed sedating at all, and it knocks down the twitch within 20 minutes after feeling a twitch starting. I've never had a full-on seizure, so there is no correlation there. I graduated to Tysabri therapy for about 9 years, which made my neurologist increasingly nervous, over time as I'm in the higher JC Virus antibody group. I'm currently on Ocrevus, and I'm doing even better than the obvious improvement I had while on Tysabri. Loving the 6mos infusion schedule, vs every 28 days, plus MRIs every 6mos looking for PML. Geez, I felt like I was always at the doctor back in the Tysabri days.

[@MrKoshnica]

perfect for newly diagnosed! Thanks!

[@DrBrandonBeaber]

That was my hope

[@vladc.8852]

Very useful overview. Is there a topic for CRISPR-Cas9 gene editing for multiple sclerosis?

[@zoranagavrilovic9403]

+1 for brain atrophy (someone else mentioned it in the comments), it would be great if you could talk about that and how to potentially slow it down :3

[@DrBrandonBeaber]

I show some data on brain atrophy in this video: kzbin.info/www/bejne/pp6rp5Std6t2aK8

[@__Wanderer]

only research I could find about this is alpha lipoic acid (article title: Lipoic acid in secondary progressive MS - PMC). The study showed a 70% reduction in annual brain volume loss.

[@mary-vy3mo]

see "normal brain atrophy after hsct for ms"

[@__Wanderer]

@@mary-vy3mo hsct seems to accelerate brain volume loss from what I can see due to the toxicity of the treatment :O Lipoic acid is a basic supplement available cheaply ^ personally am surprised all neurologists don't suggest taking this, there is literally nothing to lose and no adverse effects at medium-low doses.

[@alancoss]

Thanks Brandon. Very helpful information.

[@VernaMarie]

This was so wonderful! I learned so much. Thank you so much!

[@ralfvok]

Thanks for all your very informative videos, if not for mself ( 66 yr PMS EDSS 9 ) then for my daughter who has just been diagnosed with optic neuritis and ms. I have had my dx 33 yrs ago and have tried copaxone and rebif among others, but mostly I was too late and beyond repair. Now I just hope save as much of my cognetive functions as possible.Any suggestions on that would be welcome

[@Holly_Allanach]

Thank you, i have my mri scan on Wednesday i am showing a lot of the symptoms so i am just trying to prepare myself

[@thedroneguy6914]

Hello Dr.Beaber ! Great video as always! I believe that the new generation of DMTS such as B-cell / BTKI are going to be a great help in the future. I had a few questions though, is there any studies of mixing DMTs that work in different ways ? It is to my understanding that BTKIs are able to penetrate the CNS and act on B-cells within it, where as ofatumumab/ocrelizumab do not have that high of a CNS penetration. Would it be plausible to expect future trials of two of the drugs taken at once or do you think the side effects would outweigh the positives ? I also read a interesting clinical trial by the name of "Efficacy of transcranial direct current stimulation in people with multiple sclerosis" it reviewed TDCS devices affect on MS patients and gave some interesting results. I believe these devices are used in stroke patients, do you think devices like that could potentially bring symptomatic treatment like that in the future ? This one goes primarily for spinal lesions, do you believe new revolutionary medicines such as NVG-291 or the dancing molecules could potentially help resolving existing damage within MS ? Thanks for reading ! Your videos always make me think about what the future brings !

[@stonz42]

Thanks Dr. Beaber - lots of good info to unpack in this video. I'm now 38, diagnosed at 35, but had my first symptom at age 19 (Left arm weakness). However, my vision started to decline in my right eye at age 29 and went misdiagnosed during multiple annual eye exams until I was unable to read the chart and got my diagnosis after a grueling battery of blood tests, MRIs, and a spinal tap. I now have permanent 20/200 vision in my right eye with optic nerve atrophy. I sometimes have problems with fatigue, balance, and cog fog, but all have since improved since starting Ocrevus 2 years ago. Although, lately I've noticed some minor issues with hand dexterity at times. A healthy diet and active lifestyle have always been part of my adult life, but I've become more strict since my diagnosis. I generally eat a mediterranean style diet very low in sat fat, dairy, and processed foods with inflammatory oils. I remain active regularly, but in a less strenuous manner than my younger years (as expected by most folks). Looking forward to seeing the sun and getting outdoors again soon - it's been a wet and dreary winter here in the NY metro area.

[@DrBrandonBeaber]

It's unfortunate that you weren't diagnosed for many years, but hopefully you will do well going forward.

[@stonz42]

@@DrBrandonBeaber Thanks Dr. B, I'm doing well now and hoping to maintain stability going forward as well. During my eye exams, I explained that I would get cloudy and blurry vision while exercising and it was misdiagnosed as allergies all those years because I would recover and was still able to read the chart at those visits (albeit not as clearly). A year or so before diagnosis I had significant problems with contrast vision in both eyes, which still happens sometimes today, especially during Unthoff episodes. I wish I had known about optic neuritis symptoms earlier, but I didn't have any other significant symptoms to suggest MS so it never crossed my mind. That also made diagnosing quite the endeavor for me. Looking back, I can now identify multiple periods of likely relapses between ages 19 and 35. Fortunately, I fully recovered from most of them.

[@MrFreeride1113]

I had a similar story. I was 29. Now 60. An older eye doctor told me years ago he could diagnose MS in seconds.

[@danielhernandez-fo3mj]

Deff a grate video really good data in here ty for doing these videos

[@andrewreisinger6860]

Very good overview of MS in 2024! My story: Dxd in 1993 at age 22 while serving in the USN. Relapsing/remitting with only a few relapses until 1998. Started my first DMT (Betaseron) that same year. Symptoms included increasing gait problems and MASSIVE fatigue. Stopped working in 2005. EDSS continued to worsen. Started ocrelizumab in 2018 when I hit EDSS of 6.5. I am currently still at 6.5, although memory, cognition, and processing seem to be worsening. MRIs show very significant atrophy with many lesions in brain that seem to be morphing into one another, also black holes. Lesions throughout cervical and thoracic spine. Upper body seems to be relatively ok, and I go to the gym to weight train at least 5x a week. Current age is 53. Trying to stay out of the chair.

[@Py16777216]

I'm 31 male, doing really well with MS. I used Lemtrada last year after avoiding DMTs for 16 years. I'll get the second and perhaps final course of it soon. It was definitely the best option for me. Since it was FREE with the right program and income limmits in the US and there's an infusion center a mile from my house that got trained for the administration just for me. Insurance pays for all the infusion related costs and monthly sample follow up is cheap or covered if I used a different site. I have some thinking and memory issues and slowed reaction time and damage to nerves that assist with smooth eye movements. Extensive persistent lesions but no physical disability. I'm thinking about anti depressants and stimulants after my next neurocog test to see if it's warranted. Maybe just 140mg of caffeine is sufficient. Definitely helps bring me almost up to my highly skilled peers level in video games.

[@lucianademelo6557]

Thank you Dr. Beaber.

[@DrBrandonBeaber]

You're very welcome

[@sarakhaldi5085]

Ampyra saved my life and I can actually walk half way decent now, I still have a gait but that is PHENOMENAL!

[@DrBrandonBeaber]

Glad to hear it.

[@dacesetten5748]

Thank you, Doctor!

[@jurriaanmomberg1711]

Hi Dr Brandon, I just found out that I have MS. I am 51 and I am diagnosed 2 times and the last in the VUMC in Amsterdam. Tough I dont have heavy symptoms, some tingeling. They offered me this Medicine: Tecfidera and they want to start in February. I never took medication and don't know what benefits it's bringing. Should I go for a healthy lifestyle or have this pill 2 times a day with side effects. I would rather choose for a wholefood plantbased diet, yoga and sport. Or do a stamcell in Mexico. Do I really need a DMT?

[@jerodewert8334]

Start a DMT while you wait to understand this more, I suggest Ocrevus. (I am so mad that we still waste time with Copaxone.)

[@lararose9106]

Dr. Brandon can u please explain to me why i was prescribed amantidine for chronic dizziness of unknown origin? And what options would u recommend other than amantidine? I read about it and the side effects are not ok for me. I already suffer from dizziness and i wasnt told it had withdrawel.

[@acs5928]

Very clearly explained. Thank you

[@DrBrandonBeaber]

:)

[@RazyMon]

I (now 38M) was diagnosed back in 2016 (had first attack in 2012) with RRMS. At that time not one doctor told me to check my D3 levels, and instead it was my brother who later suggested it. Done the test, and it was somewhere around 5nmol/L. Immediately started taking 10000 IU daily, along with some flax seed oil. Ever since then, I haven't had any major symptoms, aside from random muscle twitching. In 2023 (can't remember when exactly) I stopped taking the D3 and the oil, and, coincidence or not, last week I entered a relapse episode (random bursts of dizziness and left leg weakness).

[@DrBrandonBeaber]

This is interesting, but my personal opinion is that that the overall evidence suggests vitamin D supplementation is ineffective in treating MS. One relevant study is described in this video: kzbin.info/www/bejne/ip3dkJuwgdecpMU

[@MrFreeride1113]

Noted, thanks, I'll take some right now.

[@Peter-o6w8g]

What a great video. Thank you. I do have a question about brain atrophy, and where we stand with that going into 2024? Many thanks.

[@DrBrandonBeaber]

@DrBrandonBeaber Here is a video on brain atrophy in MS: kzbin.info/www/bejne/pp6rp5Std6t2aK8

[@AhmedMohammed-mi6ru]

@@DrBrandonBeaberplease doctor i want to contact you its urgent. please please

[@tawny-fw7cc9iy6k]

This is a fantastic explanation. Thank you

[@SpiritWood-ki8nk]

Thank you 🙏. Very helpful in my journey!

[@davidarmstrong7549]

Fabulous video 👌 thank you. I am 58 and was diagnosed with RRMS at 37. However, my first relapse, optic neaurits, occurred age 33. Disease onset was age 13 with spasms in my left leg, which continue to the present day. It is possible that I am transferring to SPMS and may therefore be prescribed Siponimod.

[@carsonwhitney4100]

Plant consumption actually doesn’t have a high impact on MTorC1 or Wnt/β-Catenin cruciferous veggies-decreases mTOR activation and provides natural mTOR inhibition

[@annmariemoreno3904]

I had MS for 24 years have secondary MS on mavenclad 10 mg having some memory and mood swings March taking second dose of mavacald

[@jp7357]

As I get older I try to understand what may “get me” next …. Dementia, Alzheimer’s, heart disease, cancer … so I went to your channel to see how to mitigate Parkinson’s … I was SHOCKED to hear that mono is a fundamental prerequisite for MS … I caught a really bad case of mono when I was 16 … 50 years ago … guess I’d better stay healthy.

[@greatexp59]

Thank you for this great explanation!

[@DrBrandonBeaber]

Thanks

[@sebastianstanko8685]

Good work, keep it up

[@DrBrandonBeaber]

Thanks

[@lararose9106]

Dr. Brandon have you had MS patients who have had long COVID and it had affected there symptoms chronically? Do u use amantidine and are there other natural alternatives like supplements?... another q plz😊 if a patient like myself has been in a wheelchair for months and cant walk who would assess muscle strength a neuro or physiotherapist?.. i dont want heavy medications like baclofen and muscle relaxants. I already have severe vertigo.

[@pmarcum7146]

Excellent overview, Dr. Brandon. Thank you! Two related question for you: In the chart presented around the 6:30 timestamp (the plots of disability vs time), how would you categorize the following situations: (1) Suppose that there is a single but non-negligible "bump" at the far left side of the bottom plot (the plot for Primary Progressive MS). In other words, one distinct attack at very early time. Would that one bump, by definition, eliminate the primary progressive label? (2) Let's now talk about the slope of that line. How relevant is the slope to the category in which the diagnosis is placed? Suppose, for example, that the slope is significantly shallower than what is shown in that bottommost plot (Let's say that the line is definitely sloped, but just not nearly as steeply as shown). Still considered to be "primary progressive" ? Thanks!

[@DrBrandonBeaber]

1) Some people use the term "single attack progressive multiple sclerosis" to describe a form of PPMS which starts with a relapse. My personal opinion is this is irrelevant as SPMS and PPMS are the same disease as explained here: kzbin.info/www/bejne/hZPSgKCOf7qXmdU (2) The slope is not relevant to the subtype, and progressive MS can progress extremely slowly sometimes.

[@pmarcum7146]

@@DrBrandonBeaber Thank you for the succinct but complete reply, and also for introducing that term, single attack PMS, that I've not heard of previously. (Which also suggests that my confusing MS presentation might not be as unique as I thought it to be!). Thanks also for the video link -- I have also questioned the scientific relevance of distinguishing between SPMS and PPMS!

[@taralovell5055]

Thx for the great info!

[@DrBrandonBeaber]

No problem.

[@alexandreturgeon465]

Great video, as usual, doctor Beaber ! Looking forward to your other videos in 2024 ! One question that keeps bothering me is, typically, how long does a lesion should appear on the brain before one feels the symptoms related to that said lesion ? Thank you so much for your precious time. 🤞

[@shahlaZafari]

Dear Dr Brandon Thank you for sharing this video. I would like to share my experience. in Jun 2023,last year I got very bad pains in my eyes and more in left one. I visited one neurologist and I had MRI brain with lesions. but he said because I do not have any other symptoms ,this is migraine. In November 2023 I started more symptoms in my left and right foot and weakness of my leg left. I had MRI from spinal cord and it was two lesions , one at c3 and another at T6. but they did not prescribed medication as they were not sure it is MS. In January 2024 I got influenzas and after that many other symptoms came up such as burning and sensation, no sense in my legs , after 4 months now they said I have active MS and progressive MS and I have to take cladribine treatment. I rejected this treatment and I spoke to them to start Kesmpta injection and I am waiting for their reply by next week. I am not under any medication and every night I have burning and pain in my both legs. Please advise me at this stage which treatment would be the best. Many Thanks

[@briandaniel6354]

I would like you to do a video on the stem cell treatment that was done in a hospital in San Giovani Retunda Italy. I looked at some information but it was all way over my head. It was a treatment were they drilled a whole in the skull and injected stem cells directly in to the brain. It seems like it could work but I have a lot of qeustion about it such as safety and efficacy and frequency of injections (I did see that it said that the initial treatment lasted for about a year but does that mean this would be a yearly injection or just require multiple injections based on how you respond and thus requiring a port that would alow for mulitple injections). Thank you.

[@pattischmitz2680]

Could you please link the study? Thanks!!

[@Jerusalem_Warrior]

STAY AWAY FROM "TOURIST TREATMENTS"! NEVER heard of a treatment involving "drilling a hole in your brain"! 😱😱😱

[@DrBrandonBeaber]

Thank you for the suggestion. Do you have a link to any of their research which is in English in MS which interests you? I would have to look into it.

[@briandaniel6354]

@@DrBrandonBeaber I have tried to post about it several times but it keeps on getting deleted by KZbin the last one I just listed the name of the article in question and were to find it =/

[@aleksandraczumaowska2922]

Hi, thank you for the video :) The BTK inhibitors study didn't show good enough results :< Are TYK2 inhibitors the same thing? I've heard a drug company is looking into these, could you please explain a bit about this type of drugs?

[@danmccartan6614]

Great video. I had a question on any new news on the drugs that would repair our myelin sheath?

[@DrBrandonBeaber]

There is no new data on clemastine to my knowledge

[@GigglemonsterXD]

I have a question: for numbness associated with MS, if its in a limb, is it the "whole" limb (or a whole "section" of a limb, e.g. "from the knee down") or can it just be "patches" of numbness in certain places?

[@jensenjames3874]

According to some other videos you can have just patches.

[@GigglemonsterXD]

@@jensenjames3874 I appreciate you taking the time to answer- thanks!

[@lararose9106]

Can we treat spasticity with physiotherapy? Ive been in a wheelchair for months from dizziness so i cant tolerate strong meds like baclofen.

[@LucBoudreau-c9r]

Hi Mr. Beaber, I was diagnosed with MS (RRM) in 2012. I started really young to play the guitar for living and did it till 2018, but i play now like a beginner because of MS... I had Avonex, Aubagio, Teriflunomide and now Ocrevus... I tried Fampyra to see if it can help me to play the guitar again but it didn't work... I'm in Québec, Canada and i'm really interested in testing the Pipe-307, could you please help me with that? Thank you.

[@DrBrandonBeaber]

I can't help you, but if you go to the clinicaltrials.gov site, you can try e-mailing the study contact: www.clinicaltrials.gov/study/NCT06083753?term=PIPE-307&rank=3 Good luck.

[@Rene-uz3eb]

1:27 imo focal lesions are a sign of infection. 15:02 'areas of the world where they have more parasites they have less MS': That's because they (correctly) assume it's parasites, not MS.

[@__Wanderer]

@23:12 I wish researchers would split this data based on demographics. Say only taking people diagnosed within a 10 year time window for instance rather than lumping everyone together. A 30 year old with MS may be far less likely than a 60 year old to need a cane 10 years later post diagnosis for example. It muddies the water in my opinion. The age chart at @24:10 is a good example of this :)

[@ernietollar407]

UBO's were discovered at Roswell

[@ahmeterwinog6295]

Hi Dr. Beaber Excellent video! I learned more about my condition (RRMS). I have a question regarding OCB since you mentioned it on the video: I got on my spinal tap 6 OCB, but zero on the blood serum. What is the prognosis? Thank you and have a great weekend!

[@DrBrandonBeaber]

There may be a slight association between the number of bands and prognosis (with more bands being worse), but it is not a strong correlation. I show some studies in this video: kzbin.info/www/bejne/oqeZh6KvoKaDmMk

[@BaBaYaga1999-p7u]

Didn’t BTK recently fail one of the clinical trials?

[@mary-vy3mo]

yes...some have posted online that they have progressed on btki and stoppped. see "biogen bails on btk"

[@MsChiguita]

Hello Dr. Beaber. I have a question for you 🙏 Your patient comes in with numbness and tingling across the stomach, crotch and back, both hands and in the left leg. In addition, there have subsequently been a number of fluctuating symptoms, such as nerve pain in the left hand, buzzing down the spine, and a spastic calf in the right leg. After 1.5 months, almost all symptoms are gone. What remains is a sleeping arm during sleep. Often left. And the buzzing in arms and legs, especially during exertion. 6 months ago, the patient developed pain under the right foot. The pain has never gone away. Feels like walking on bones. CSF shows 2 oligoglonic bands and a cell count of 6. What do you do from here?

[@leaveittolefty]

interesting connection with Jean Martin-Charcot. i have Charcot-Marie-Tooth 2CC

[@DrBrandonBeaber]

Yes he was quite prolific.

[@Alex-sv5ic]

Dr. Beaber! Hope you're doing well. Quick rundown - I'm 33, got MRI results showing these white lesions a month ago. Talked to a bunch of neurologists; two say it's MS, others disagree. Any chance you can help me figure out if it's really MS or not? I can't understand is it MS or not. If you do online consults it will be great? I've got my MRI scan and all ready to share. Would really appreciate your insights. Thanks a bunch! 🙏

[@rosered3919]

I was given a lumber puncture .

[@jessicasuddreth7619]

The next step is a lumbar puncture/spinal tap. My suggestion is request it is done under fluoroscopy (xray guided). It looks for many different diseases along with signs of MS.

[@pmarcum7146]

(I am re-writing this question, after having watched your video published about a year ago on the difference between MS and vascular disease lesions appearing in an MRI). In the list of alternative diagnoses in MS misdiagnosis (around timestamp 8:54), which (if any) in that list would share the more nuanced features of MS lesions. Specifically, in addition to being located in the regions typical of MS brain lesions (periventricular and/or juxicortical), which of these diseases, if any, would also be commonly associated with a central vein sign, and/or have a Dawson Finger's morphology, and or persist on the MRI for several years and evolve into a "black hole" as seen on an MRI image?

[@DrBrandonBeaber]

This is a difficult question to answer, and there is some degree of gestalt involved in interpreting MRI scans. The central vein sign is present in some benign lesions and in conditions such as Behcet's disease and primary central nervous system vasculitis. Many forms of injury to the nervous system are dark on T1 sequences. The term "Dawson's Finger" would generally be used if the suspected diagnosis is MS, but lesions which touch the ventricles can occur in other diseases which could mimic MS. The video you watched focuses on benign "unidentified bright objects" but you may appreciate this video on MRI multiple sclerosis mimics: kzbin.info/www/bejne/qYu5eKZmmdl_a6s

[@AQtoo]

Thank you!

[@brandeneubanks2295]

Thoughts on IGF-1 treatment for MS?

[@peterhutchinson2805]

Pins and needles hands legs arms fingers constantly hurting anyone going through it knows exactly what I’m on about. Your back will hurt you aswel. Going urine frequently also aswel.

[@BJM1134]

Well. I was pregnant with my son at 24/25... before that I was a pretty healthy person. I had a very tough pregnancy (for me... my son was a big healthy baby, but I was so sick I lost weight in the first trimester, horrible migraines, a kidney infection, interstitial cystitis, and carpal tunnel towards the end when I was high risk, wound up with low fluid and had a csection)... the carpal tunnel was awful but ob/gyn sent me to get fitted with braces and said it should go away after birth. Same with interstitial cystitis and migraines. None went away just became intermittent. Then electric shock pains down my neck. Then drop foot in left leg. Between ob/gyn, pcp, and ER they all prescribed pain medication. ER wanted to do surgery on my spine for pinched nerve but I said no. Weeks later drop foot went away. Exhaustion, heavy tired legs, swelling, bloating, bladder problems, numbness, weird skin sensations (burning itching tingling etc)... horrible heartburn but feels almost like my insides are numb and I can't burp. Anxiety, squeezing chest/torso... but no dr listens. Once they gave me all those pain meds and I had a hard time getting off them, they wouldn't take me seriously. Even told me I'm too young to be having these issues. Now though, at 41, I'm exhausted, my right thigh is numb and burning, my feet are so swollen... where do I turn??? When working every day is a monumental task I don't have the energy for another dr to blow me off.

[@vanessavaidya7135]

It’s not easy when your physical exhaustion is signaling a bodily issue, but the saying goes “you don’t use it, you lose it.” Take a deep breath, ask a close relative/friend with effective communication skills to advocate during an appointment. There are virtual forums or social media groups to help navigate towards more answers. Accepting the fact of this new reality is crucial for one’s mental stability to motivate health towards a baseline.

[@MariDelSordi]

Thank you Dr. Brandon! What can you tell us about Nervgen Phase 1b/2a clinical trial of NVG-291? Do you see any potential for MS?

[@DrBrandonBeaber]

Thanks for the suggestion. I would have to look into this.

[@freethinkeralways]

Thank you, Dr. Beaber! Question: why fraternal twins have higher risk of MS than just siblings? May that indicate strong environmental causation?

[@cherubfoxx]

Requesting an Opinion: I have had most physical symptoms of MS. However, my doctors (I'm a vet and my VA docs always changing) never review my MRIs for MS. One mentioned that my symptoms were synonymous with MS in passing once but never followed up. I was diagnosed with neuropathy and radiculopathy years ago and have chronic issues with recurring back and leg pain, stiffness, face, and neck tingling, even talking clearly at one time. But it comes and goes. I'm in my 40s, and this started in my 20s. Scheduled for surgery next month to relieve nerve pain. Should I be concerned about MS, or would it have been evident on my MRIs and addressed? Could some nerve pain be MS related? Thanks Blessings of good health to all!

[@freethinkeralways]

Sorry to hear...I've heard that MS diagnosed within 7 years of service is considered service related by VA. May b that's why your dr.s r hesitant with diagnosis?

[@jerodewert8334]

MS patient here: sounds pretty typical to my amature brain: get a copy of your brain and spine MRI and send it to a private doctor for confirmation. If they haven't done one yet, get both done in one session with Contrast (they will know what this means.) send it to a Neuro for confirmation. IMHO

[@cherubfoxx]

@jerodewert8334 Thanks so much for your suggestion. I do have contrast MRIs, so I have reached out to a private office requesting an appointment with their MS research department. Thank you kindly for responding.

[@jude4896]

Even if alcohol is ok - mostly.... there are known complications with some cyeactric medications. Thank you for sharing

[@Dantfermo]

First off... great video! I was diagnosed with relapsing remitting when I was 36, I'm now 57. Of interest, a few years before, my older brother was diagnosed. It took about a month of having double-vision before the the MRI was done to get the diagnosis. To make the vision corrected, I had to to take steroids with IV of several days,. I then took Rebif and then Aubagio. Honestly, it didn't make a difference. Rebif got me used to giving myself needles About a decade ago, I stopped the pills. I actually felt better after. But last year year, it got worse. I was diagnosed with Secondary Progressive. The issue was that my mobility (legs, feet, still get bad cramps) were challenging (got a cane), the short-term memory is like an open window. Oddly enough, I was not prescribed specific MS meds. I was given Trintellix, which actually makes a difference. Lifestyle changes have made no difference

[@uduakdan6209]

Thanks a lot. My question is, how do they get an improvement of symptoms when the nerve damage had already occurred?

[@DrBrandonBeaber]

The nervous system does have some capability of repair. There is some evidence exercise, a healthy diet, and stress management may promote neurogenesis and neural repair. There are also some medical treatment to improve symptoms such as ampyra for walking, treatments for spasticity, etc.

[@uduakdan6209]

Thanks a lot for the prompt response.

[@aliceroth3017]

I havve a question no one can seem to answer. Could ocular histoplasmosis and ms set one another off bc i presented with (permanate central vision loss in one eye overnight, which was diagnosed by my opt. as histo, then after he sent me to a specialist for that it lead to my chart being shared with his neurologist colleague who specializes in ms.

[@DrBrandonBeaber]

To my knowledge, there is no known association between these two conditions (except in the case of someone with multiple sclerosis taking immunosuppressants who would be at increased risk of infections in general).

[@barbaramisenti3941]

My first symptom over 30 years ago was insomnia. I have never fallen asleep naturally since then; I always need a medication to help me sleep and I also never sleep more than 5 or 6 hours. No one ever believes this is caused by MS. Can lesions cause this?

[@SpAzZzZz_]

0:52 2:59 5:03 7:14 7:50 9:04 10:08 11:12 13:28 15:43 17:19 18:02 18:46 21:05

[@olgsi]

Hello, can you make a video about Octopus trial for progressive MS?

[@DrBrandonBeaber]

Thanks for the suggestion but I may wait for the results for this one

[@lararose9106]

Hi Dr. Beaber can you please tell me is amantidine used for dizziness and what are alternatives for fatigue like vits and supplements

[@DrBrandonBeaber]

Amantadine has been used for multiple sclerosis fatigue, but I have not heard of it being used for dizziness. There are alternative treatments for fatigue such as b12 shots, certain diets (whole foods plant based diet, terry wahls diet), and stimulant medications.

[@lararose9106]

@@DrBrandonBeaber do you use it often Dr. Beaber ive heard its not much help and it actually causes dizziness whch i already have and it affects mental health as side effects and withdrawels too

[@cherylnavarrete4198]

Going to gp now and will ask for vitamin D & b12 blood work I am also curious on how you think chiropractors would help with spasticity?

[@nikocasual5126]

Terry Wahls has had chemotherapy, but she doesn't talk about it ☹️

[@bekalugetenet5683]

Hi Dr i have one question how do see cooled thermal? I live Ethiopia Africa (tropical)

[@DrBrandonBeaber]

I'm not sure what you mean Is this a cooling device?

[@Boris1250S]

thank you sir