NAD: Structure and Reduction of NAD to NADH

[@user-vw5pl8lj9p]

When I search for help on concepts or details, I seem to always end up on yours to find exactly what I need. Thank you so much for taking your time to make them

[@official.rajarshidutta]

Can't thank you enough sir. Now the concept is crystal clear to me. Teaching is an art and you sure have it in abundance.

[@devencatalano6488]

Awesome video! Gives enough o-chem background to make me feel that I actually understand the biochemistry rather than having simply to do rote memorization

[@jackyjack9660]

Who does just memorization?... How will you apply the biochemistry in practical without understanding anything... Weird why people say they do memorization... Very strange...

[@sowmyakrishnan240]

Thanks a lot for this amazing video. These concepts really saved my day today. I was looking for a video where pi-electron rearrangement during NAD+ to NADH conversion was clearly explained and this did it for me. Sincere thanks for the examples with isopropyl alcohol and the amine too!

[@scottwilliams2136]

For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.”

[@meeboX2]

This is a fantastic video! Thank you so much! so glad i found your channel!

[@shwetahanmantmane5794]

My dream is got a PhD in this chemistry topic 😃😃😃😃 your language I can understand.. better...sir you're great Person you doing this task very well for the students..very thankfully

[@shiv9206]

One of the best explainations

[@Aml587]

Really great video. You explained it so well. Thank you!

[@CatalystUniversity]

Thank you!

[@olenapo4895]

On 2:00 when you speak about pyrophosphate linkage, you're still writing P-P instead of P-O-P, is it just a small mistake?

[@jdonmusix2014]

so the electron transfer occur on the nicotinamide side of the NAD???

[@harshsinghal4342]

nice video. got exactly what i needed.

[@shwetahanmantmane5794]

So nice explain about tuff Topic....

[@nadhunter3650]

my name is nadh i dont even know about this..i think it soo sososo hard

[@adamborg1]

Thank you! Is there a simple explenation to why NADH often is written as NADH + H+? Are there in fact two hydrogen atoms at play, or is this a way of simplifying in some way?

[@leonbuol6470]

Adam Borg I have the same question as you!

[@shiv9206]

That H+ is what the base took off

[@shiv9206]

And it reamins in the medium so it's called NADH + H+

[@cmhardin37]

Where exactly did the electrons from the hydride anion go to? I know that one electron from the hydride bonded to the carbon when it attacked, But where did the other electron go?

[@KhangNguyen-lu8fu]

Where can we find the video on the reverse reaction when we use NADH to reduce molecules ?

[@bobu5213]

But if NAD+ (Positive charge meaning it can gain an electron) is reduced by just adding an H, and when oxidising NADH becomes NAD+ and H+, then where did the electrons go? I'm so confused about this. It seems that H shares it's electron with NAD+ therefore oxidising it? Aaah help. I don't know if NAD+ is reduced or oxidised and I don't understand where the electrons go in either of these steps. Could you explain this in a reaction?

[@farzanehkarampour6772]

Thank you so much

[@alaaalnshar6234]

Really you are great ❤️❤️

[@albertomolano]

Where does the + charge in nitrogen in NAD+ come from? I just can't figure it out. Nitrogen is 1s2, 2s2, 2p3, so it can accept 3 electrons in its outer shell. In NAD+ it appears to form 2 single bonds and 1 double bond...

[@woozworldsuperfan]

It has a 4th bond with the 1st carbon of the ribose moiety.

[@albertomolano]

@@woozworldsuperfan nope. I figured it out: Nitrogen can generate Sp3 or Sp2 molecular orbitals. In sp2 mode it leaves an intact p orbital which delocalizes over the ring, creating a paucity of negative charge over it

[@kapila1997]

Thank you SIR

[@mambigaaa6413]

It is oxidation or reduction reaction ,please clearmy doubt sir

[@Dazzletoad]

Hello, first thank you for the video. It seems like a great piece of education, but I am new to chemistry and my current college is useless and frustrating. I am trying desperately to understand the formation of hydride ions, and in particular a step in glycolysis wherein glyderaldehyde-3 phosphate dehydrogenase takes NAD+ and forms NADH with H+. I am struggling to understand what's happening in terms of the hydride and formation of etra hydrogen. Can you (or anyone in the comments) help? I would be very grateful, also if anyone wishes to contribute and can leave links that would be great :D

[@bodywise007]

Still confusing. NADH is a net electron donor which is critical in the ETC or OxPhos. That is what generates ATP. Not NAD+

[@CatalystUniversity]

Every time NADH gives up it electron to the ETC, it is converted back to NAD (the electron-devoid form). The generation of ATP occurs "down the line" , but it is part of the net equation: n NADH + n FADH2 + 2 O2 + n ADP -> n NAD + n FAD + 4 H2O + n ATP.

[@bodywise007]

thank you. But ... this is vital. It is NADH and not NAD+ that drives the ETC. There is too much emphasis on NAD+ today which is commercially driven. NADH is a higher energy state. The ETC is a biochemical marvel. It is electrical. It is similar to a photon photomultiplier. Or similar to a old fashioned radio "tube" with an anode and cathode.

[@dimaal8477]

Thank you :)

[@CatalystUniversity]

No problem; glad this could help.

[@sciencenerd7639]

cool

[@victordasilva5255]

Jesus....I just want to know if imshould take some ....

[@shwetahanmantmane5794]

Live in the small village I ..

[@shwetahanmantmane5794]

Hi I am from India

[@chel1967]

Thanks a lot