NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide

[@FoundMyFitness]

*00:00:00* - Intro. *00:00:48* - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. *00:02:47* - Overview of NAD+ *00:05:12* - NAD+ plays an important role in mitigating DNA damage. *00:05:30* - Excessive DNA damage can decrease NAD+ levels by 20-30%. *00:05:42* - Lymphoblastoid cells from centenarians show increased PARP-1 activity. *00:05:55* - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. *00:06:36* - *Lower organism evidence:* A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. *00:06:43* - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. *00:07:03* - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. *00:07:37* - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. *00:08:13* - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. *00:08:48* - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. *00:09:48* - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. *00:11:56* - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. *00:12:30* - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. *00:12:50* - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. *00:13:10* - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. *00:13:47* - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. *00:15:57* - Plausibility of dosing: comparing animal and human doses. *00:18:05* - Tissue-specific metabolism and bioavailability of NR and NMN. *00:24:32* - Oral administration of NAD produces NR and NMN in the intestine. *00:24:19* - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. *00:26:15* - *Human study #1:* 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). *00:27:12* - *Human study #2:* 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. *00:29:08* - Concluding thoughts and recap.

[@dg7438]

00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. Yikes..that's scary

[@vinster9165]

Such research developments, give all of us hope, for more youthful longevity on the horizon. I hope scientists like you and others who are similarly dedicating their lives to the study of anti-aging medicine, will discover the Human immortality reality holy grail within the next decade or two. I don’t wanna leave this plane of existence, just yet. With all my heart I would love to live beyond 120 years, not as a crusty old fart, but as someone Trapped in their 30s. Time is running out for all of us who are long past half a century in age. Our hopes and dreams are in you, and your colleagues. We wait in great anticipation for your latest developments and understandings in these regards.

[@glennmiller9768]

Scary for mice, yes.

[@vinster9165]

Suzanne Ito scary for humans too. We use mice to help predict outcomes or give insight into medical research possibilities for humans. We share sixty percent of our genetics with mice.

[@Re3iRtH]

Not raining on anyone's parade here. Let's stop for a second and think. They have been searching for a single molecule in a pill that could extend life for going on 60+ years now. Nothing has been found to be effective yet. NOTHING. What makes us think the next 60 years will be different? The only think that works is plain hard work and sacrifice - eating healthy, sleep more, exercise, fasting (still debatable), and caloric restriction (prohibitively hard for most people). Where is the pill in that. Do you see one? I don't. I am above average optimistic person precisely for the reason that life has a definite start and endpoint.

[@bahb00]

Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos!

[@amperage8032]

Chuck A or saying NR or NMN. I don’t think she’s abbreviated once. The more you say it out loud the easier it becomes. I’m certain it helps with warding off cognitive decline also.

[@Entheogenical]

I have a stutter issue sometimes... hope its from anxiety

[@ChannelSRL1]

@@amperage8032 Yes, the video would have been about 15 minutes shorter with some abbreviation. Ribo and Mono would work for me...great info though.

[@s0cializedpsych0path]

Did you mean qudos? Kudos was a snack bar in the 90s.

[@jossfangirl]

@@amperage8032 🤣🤣

[@Spicydoc1]

How Lucky we are to have Dr. Patrick in our lives. She is amazing. Knowledge just oozes out of her..

[@pablopolski1228]

Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done.

[@swisstrader]

pablopolski cuz she’s one of few on YT that speaks pretty quickly which I appreciate

[@KaneCiticani]

David Lloyd-Jones spoiler alert. You probably divorced more than twice and you never let anyone else talk. I’m joking

[@TheDavidlloydjones]

@@KaneCiticani Nope.

[@KaneCiticani]

David Lloyd-Jones Yep

[@KaneCiticani]

David Lloyd-Jones Cause it’s a joke, you can’t say nope 🤪🤪

[@peterdavila3045]

I'm 66 years old. I started taking 1g a day of Apigenin a few months ago. Apigenin is one of the ways to raise NAD+. It is amazing how much energy I have now. It feels like the energy that I remember having in my 30s. In addition, in conversation with my neighbors, they have commented that I seem to look younger every year, instead of older. I also take Metformin, even though I do not have diabetes. I also do a lot of intermittent, 3 day water fasts. I'm planning to start on 1g of Fisetin a day for 5 straight days every month in the next few weeks. My diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (Walnuts, Cashews), seeds (Flax, Hemp, Chia). Dark Chocolate (80% cocoa). I do drink lots of coffee. I don't drink cow milk but almond milk instead. I don't drink alcohol. Live Long Enough to Live Foreever.

[@ownpetard8379]

@Peter Davila I take Metformin, too. Cleared liver enzyme and liver glucose issues almost immediately. Lost a few pounds too. I'm on a "low dose" of 500 mg. I'll look into the Aligenin. And the Fisetin. Thanks. Not to "sharp-shoot" your comment, but the best nuts (common) are pecans and almonds. Lowest in polyunsaturated fat, more like animal fat. Cashews are legumes, not nuts, I think. Walnuts have value in other ways. Thanks again.

[@peterdavila3045]

@@ownpetard8379 Pretty cool. Good luck. I just ordered CaAKG. I start taking that as well next week. I still take Metformin, Apigenin and Fisetin. I just turned 67 and I feel great.

[@ownpetard8379]

@@peterdavila3045 I'll look into that CaAKG. If I take a typical calcium supplement, it makes me feel relaxed, but it also shuts down my bowels. Whatever else it does, if it avoids the shutdown, it would be a plus.

[@Pat206]

@@ownpetard8379 Almonds are [I think]. the only alkaline nut. Good thing.

[@Pat206]

@@ownpetard8379 Cashews are not legumes. Either called nuts or seeds! They form at the bottom of the cashew fruit. Have to Google it because it's a strange process to end up with the edible cashew.

[@DDFaye74]

This is just about the most thorough and intelligent PP presentation I've ever seen. She is one smart lady! Wow.

[@keng7758]

I simply love your style of presenting with the latest facts. You speak fast, which I like! The data you provide and the research you do prior to presenting makes you one of the best health span advocates on KZbin. Thank you Rhonda! ♥️

[@Cryptosifu]

Holy crap, this was amazing. This 30 minute video took me 2 hours to get through. Had to pause and read and then pause and research. Thank you!!!

[@mvrao29]

It appears that Dr Rhonda does a lot of preparation and compilation of subject matter for making each video. Her tone and presentation skills are excellent. She seems to be interested in sharing her in depth knowledge for the good of the people. God Bless Dr Rhonda Patrick 🙏

[@paulniziol5055]

When you finally find someone that you can understand, just love this lady. She's passionate about this and it shows. Look no further for any other teacher. Great respect. I found her after watching a video where 2 sisters, one lost all of her hair so the other one grew out her hair quickly, then cut it off and gave her sister the hair in wig form for her wedding day. Awesome. All kinds of products showing up for enhancing us folks who are looking for anti aging products that are natural and have studies to show. Love it. Trying to decide what to do. Think I know now. Thanks.

[@scott.joshua]

What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda.

[@jhumm007]

I've been taking 1g of NR daily for 2 years. I find that I don't get jet lag or hangovers anymore. My contribution to this fascinating science.

[@drewp1974]

Jason Humm What Brand are you taking?? I’m using TruNiagen by Chromadex.. but only 300mg a day. 3x that would get kinda expensive, no??

[@jhumm007]

@@drewp1974 I have a triple subscription to TruNiagen. Can't put a price on life extension 😎

[@swimbait1]

Have you noticed other benefits? Changes to endurance, recovery, overall health?

[@jhumm007]

@@swimbait1 I was already healthy but joint pains after heavy workouts have stopped.

[@gustavomartinez9810]

There's no risk of getting cancer? I'm taking the same too tru niagen

[@squamish4244]

NAD+ is a miracle drug and no mistake. The hype is real. It has had a profound effect on my mental and physical health at the age of 41, after many years of drug abuse, persistent old injuries, and the general exhaustion brought on by 25 years of OCD and sky-high anxiety.

[@lifeisforlivinghereandnow877]

How.many mg do you take?

[@squamish4244]

@@lifeisforlivinghereandnow877 I actually get it intravenously, at a clinic, 3 times a year to keep my blood levels high. In between I take it nasally, 15 mg at a time, twice a day, so 30 mg total, $120 for a three-month supply. Intravenous NAD is ~$700-$1,000 a session, 5-8 hours a day (the higher cost is for treating serious disorders, for longer), but if you can afford it, it is WAY more powerful than if taken orally, sublingually or nasally. WAY more powerful. They should be doing studies on IV NAD, not oral, because it is there that they will find the effect.

[@vclocals5536]

​@squamish4244 where do you get the nasal spray?

[@jenna9690]

Here for the nasal spray! I had my first 200mg NAD IV. Was one of the worst 60 minutes of my life 😂😂😂 But the benefits by far outweigh the risk!!! I also love the 200mg shots. Want to start the injections myself to save some $$$

[@alexlyee]

@@jenna9690 I'm interested in doing the injections myself since I cannot afford it right now, any suggestions?

[@ALulzyApprentice]

This is the most comprehensive video I have seen on this topic. You are a gem. Thank you.

[@chrisbenton5335]

Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique.

[@sleepsmartsmashstress740]

Perfect presentation

[@bobrags1976]

@@sleepsmartsmashstress740 I coq10

[@sumyabolormaa8601]

​@@sleepsmartsmashstress740⁰

[@turinhorse]

few notifications on youtube get me as excited as a video from Dr. Rhonda Patrick.

[@nolimit1152]

A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you.

[@WhalesWilly]

I could look and listen to her all day.

[@Noveleffect]

I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough

[@MicroUrb]

Not so rare Dr. Gary Null was teaching us this material for over a decade on WBAI and now on PRN.fm, not to mention the many books he has written, the AIDS patients he cured including one famous basketball star and the diabetics he cured. You can look up old episodes of the Tony Brown Journal for some documentation.

[@lightinthedark33]

What a great video doc. I saw you in person once but did not want to bother (Fashion Valley). I would consider you to be one of my hero’s in the health field… I’ve been greatly inspired by you and Dr.Sinclair to understand health from a scientific basis in hopes that I can pass this knowledge onto my mother who has MS and the rest of my loved ones. Thank you for what you do.

[@richrozmarn3817]

Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60.

[@capgains]

What brand of each are you liking ?

[@ravivermaverma5573]

kzbin.info/www/bejne/iofMiqaXirJrq80

[@lifeisforlivinghereandnow877]

How many mg Nad do you take?

[@Tar791]

@@lifeisforlivinghereandnow877 I'm about

[@cuentadeyoutube5903]

Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed!

[@18KarlaG]

5 months later and I'm still coming back to relisten to this video. Very informative and so well put together.

[@Healitnow]

Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰

[@davidevans1420]

Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health...

[@tomjones2348]

I like to watch informational videos like this while doing my hour of piano warm ups. Nope....can't do it on this one. Need to give this video my 100% attention. Thanks Dr. Patrick.

[@optimizewithscience8883]

It is a fascinating topic and I love how scientific Dr. Patrick approaches it!

[@JunoBeach1944]

She's the most articulate legitimate research scientist I've ever come across. I filled a pool full of NAD+ boosters and I take 10 laps every morning, sipping as I swim.

[@optimizewithscience8883]

@@JunoBeach1944 I am finishing my PhD soon. Maybe she is looking for young PostDocs in her lab :D

[@KekeeBlack]

Love your channel man, good to see you here :)

[@optimizewithscience8883]

@@KekeeBlack Always very happy to hear that. Thanks :) Dr. Patrick is just a great source of information!

[@optimizewithscience8883]

@Zeek Banistor Nice to meet you, George.

[@johnhunt3759]

Thank you . Please do not stop helping people the way you do.

[@BD-xf7yn]

Excellent!! Conclusion: Fasting, less calories, regular exercise increases NAD level👍 We all need to wait for using supplement at this point till more data available!

[@vibhaspalding6457]

I have nmn and nad both in capsule form. Vitamin d, k2, quercetin, berberine, creatinine, alpha lipoic acid and some other supplements. After hip operation last year and sciatica, I found my recovery was a slow progress. Starting on the various supplements means faster walks with my dog. Manage strength training, aerobics very easily. Lost inches. I am atleast one size smaller than 4 months ago. Clothes are very loose. I am continuously getting complements in the gym, about how shapely I am, and someone called me best pilates bum in the class, including the pilates instructor. I have never felt this good. Reminiscent of my 30's and 40's age, when I was doing 3 hours of workout. I feel very good at 68. Thanks to Rhonda Patrick for bringing so much information to us to decide about our health. In my family, people wish to believe what the GP's say. If these doctors says, no vit d or k2, they stick by that. They do not wish to know about these supplements. Time will tell. My siblings are younger than me.

[@juneallison7052]

Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤

[@AL_THOMAS_777]

Yep ! Nobel prize candidate !!

[@echomanechoman78]

The best all-in-one-video on KZbin that explains NAD+

[@equsnarnd]

I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+

[@gururajbsavakar7154]

Congratulations! Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!! Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities . With a final recap!! Thanks for this useful educative share! Many regards!

[@heroicalx786]

Dr. Rhonda, the people's champion! 😁

[@wolframluchner5316]

Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content!

[@mookywilson1054]

DOC!!!! your the best! I wish there were more docs like you.

[@tprmd]

Superb presentation!Thank you for making a potentially difficult discussion very manageable.

[@JosetteBadger]

You remind me of my favorite med school professor- one of my favorite instructors of all time Thanks for the clear and concise video!

[@roblovegreen]

Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦

[@gatesroyale]

Why? Is their benefits?

[@DrMichaelMoeller]

I personally get NAD IVs@24:30 and use them with my patients and notice an increase in energy and improved cognition.

[@viorelg9499]

Weren't those banned by the fda?

[@danashannon8234]

Do you know if it helps with depersonalization/derealization....or is it being sold as snake oil for that?

[@danashannon8234]

@@viorelg9499 has it been banned?

[@sirt1353]

Can you supplement with NADH directly? If so, how much mg is considered safe and effective?

[@theancientsancients1769]

@@sirt1353 NADH Birkmayer is an expert he is from Austria and i know it works! Check him on KZbin for normal health 40mg is ok. For Alzheimer up to 80mg a day mostly take in the day. It helps with alertness and jetlag too

[@catman4471]

I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years. I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing. I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off. The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing.

[@Yazzie101]

I also started NAD plus at night .. bad idea I had too much energy 😂 I’m very sensitive so I find out pretty quick.. let’s hope 🙏

[@Pat206]

WOW! I'm so happy for you. Life can turn out okay. Yay! from Oz

[@Joe_Robinson]

Thank-you Rhonda!

[@a2audrey]

I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too.

[@sirt1353]

If you don't have acsess to NMN or NR, is it still a good idea to supplement directly with NADH? It says it should be taken on an empty stomack in the morning, and perhaps I can fast as well for a few hours after consuming it.. And then break fast with a little meal, and add reservatrol and quercetin etc. to enhance the effects? Will that still be good? (Using NAD supplement, instead of NMN or NR, is basically what im asking). And if so, how can I best enhance the effects?

[@tomymelon6293]

@@Shaylas please be careful. Even the highest dose study was barely absorbed...there is no long term clinical data. Even in IV form data is very limited ...almost all good news was fr animal studies

[@tomymelon6293]

@@sirt1353 I would say make an appointment with a naturopathic doctor. Self medicating with supplements can provide good symptoms, but may have insidious effects. in the video at the end, she mentioned she is not ready to jump the gun on the efficacy of NAD boosters

[@a2audrey]

Tom y Melon thanks for the advice. I have direct, personal evidence of its benefits and effectiveness. I’ve lost 15% of my body mass and had pretty severe inflammation related to a leg and ankle injury that is gone since starting the regimen. I haven’t felt this healthy in 15 years, so I’m going to keep going thank you very much...

[@selene7134]

Which brand do you take? Thank you

[@scottwilliams2136]

For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.

[@scottwilliams2136]

I decided to add some links for support into the need of discussion about NAD and certain Cancers. After yen years cancer free, I was diagnosed with Lymphoma. Just finishing my six months of Chemo. The Cancer reappeared just after 5 month of NAD. Brand was TRU NIAGEN.. THEY HAVE FAILED TO RETURN MY CALLS.. ANYWAY, HERE ARE THE LINKS I WISH I HAD READ BEFORE STARTING NAD www.scientificamerican.com/article/cancer-research-points-to-key-unknowns-about-popular-antiaging-supplements/ www.frontiersin.org/articles/10.3389/fonc.2018.00622/full www.ncbi.nlm.nih.gov/pmc/articles/PMC6315198/ www.mayo.edu/research/centers-programs/cancer-research/research-programs/gastrointestinal-cancer-program/mayo-clinic-pancreatic-cancer-spore/research-projects/targeting-nad-catabolism-pancreatic-cancer-cells My only wish is that they put into the selling of their products, " the possibility of Cancer.

[@realtriumph]

Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again.

[@Agapy8888]

Sometimes the damage to your body takes longer to repair.

[@MotoDocADV]

Damn. I need an IV of this channel straight into my brain. Oh, and that other stuff you were talking about, as well.

[@robertjopling9217]

i think they do niacin on a IV and the results are pretty good! they do a quick iv push that takes like 5 mins but its pretty uncomfortable on the subject. However the results again are very good

[@PinataOblongata]

@@robertjopling9217 Is this above the sorts of levels you would find in a healthy diet?

[@robertjopling9217]

Piñata Oblongata totally much higher , it’s not cheap either , for a regular b12 Iv it’s about £600 not sure on the 5 minute push Iv ?

[@PinataOblongata]

@@robertjopling9217 So what evidence supports such doses? How long does last in the system? What are the effects?

[@mikajendreas]

Me too😂💯

[@markodenda]

Would be cool to have an update on this topic at the present time.

[@xotaic]

The year is 2063, Dr Rhonda Patric still looks 23 and now posseses levitation has awakened her 3rd eye.

[@gatorkea]

I would love to awaken her 3rd eye ;)

[@Ahov]

My buddy and I always make similar jokes

[@sleepsmartsmashstress740]

Do you her real age is 73?

[@DANA-pp4cg]

Your crazy

[@swim610]

😂

[@profitfever]

So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research.

[@Hgulix62]

I think you can't make more concise and comprehensible than this

[@Libertas_P77]

Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail.

[@richardwheeler1387]

Best presentation on the NAD/NMN potential and current status I have seen anywhere.

[@MrJamesdryable]

I weigh exactly 180 pounds... this is great.

[@thor4164]

Not if you're 4' 11"

[@justinajones3000]

That's funny. Are you taking NR or resveratrol?

[@MrJamesdryable]

@@justinajones3000 Both.

[@justinajones3000]

@@MrJamesdryable Thank you.

[@ownpetard8379]

@@MrJamesdryable Well, you're you auditing this course, then. 😄

[@dukecityrecords]

Thank you Dr. Patrick I appreciate the honest review as someone who was just looking into this I really appreciate the data and information you've brought forward. Please continue to be an Amazing Doctor! ❤

[@mr.reberdo6141]

Best video I’ve seen on the subject. Thank you!!

[@unclejoe3397]

Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks!

[@moonoom764]

Please Rhonda, the Floxing community needs you to make a video about Fluoroquinolone Toxicity!

[@phreedomphile]

FYI : Mercola has some good articles on that topic. His most recent one >> articles.mercola.com/sites/articles/archive/2019/01/09/antibiotics-trigger-heart-disease.aspx and those listed in a search >> search.mercola.com/results.aspx?q=Fluoroquinolone#stq=Fluoroquinolone

[@davlmt]

I keep waiting for a major public figure to come out with floxing and bring this major public health issue to light but it never happens. I'm 8 years out and now at 41 years old I have no more friends, and family just look at me like I have simply been a weak unambitious whiney loser all my life whereas I used to be strong, athletic, passionate about many subjects, a polyglot, a musician, a dancer, a traveler... You just learn that our existence is insignificant and we should never expect people to care about anything but their own problems. It's extremely humbling but hey we gain a perspective on life most people never get until maybe their last breath.

[@moonoom764]

@@davlmt i feel you :( I can relate to a degree. All the best❤✊🏻

[@watchutalknboutwillis1874]

its bonkers to conceive that this is free. ty Dr Patrick

[@creightonfreeman8059]

It sounds like senolytics should be taken with NAD+ boosters to mitigate the potential for renegade senescent pancreatic cells. David Sinclair also mentioned that Niacinamide inhibits Sirtuins, but since it is also converted to NAD+ that didn't make sense to me. The saturated conversion pathway may explain that, but then the question becomes at what dosage of Niacinamide does the pathway reach saturation? At least one publication by Hwang and Song, ("Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells." Cell Mol Life Sci. 2017 Sep;74(18) ) suggests that since Niacinamide is rapidly converted to NAD+ in cells it only temporarily inhibits Sirtuins followed by an increase in NAD+ and increase in Sirtuin activity. If this interpretation is correct it opens the possibility of using a much less expensive compound as an NAD+ booster and Sirtuin activator. Do you have any additional information or thoughts on the potential of Niacinamide as an NAD+ booster?

[@redberries8039]

I'm also interested in this line of reasoning [I take NAM 2x per day most days, it works well] We need an honest broker like Rhonda to look at this since there is no money is NAM. [I'm re-posting your comment in part].

[@Frogman214]

For us layman, you're talking Nician correct? I too heard Dr. Sinclair say that Nician may inhibit this longevity process. Thank you!

[@redberries8039]

@@Frogman214 I'm unsure about niacin (NA). I'm pretty sure about niacinamide (NAM) re: whether NAM ' inhibits Sirtuins,' in a test tube which they say it does, and that is not encouraging. But in a body maybe NAM does not ' inhibit Sirtuins,' not according to the paper, and that would be great.

[@creightonfreeman8059]

@@Frogman214 No. I was talking about Niacinamide (NAM). Niacin is nicotinic acid. Niacinamide has an amine functional group (NH2) on the molecule rather than a hydroxyl (OH) as Niacin does. Niacinamide is also called Nicotinamide. I have only heard Dr. Sinclair say that Niacinamide (NAM) inhibits Sirtuins, but you could have heard him say something at another time.

[@redberries8039]

@@creightonfreeman8059 off-topic but i've been reading about AKG and wondering how likely it is OAKG or AAKG might substitute. Any thoughts?

[@ngallure]

So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process.

[@viorelg9499]

10:48 - at a certain concentration of NAD+ conversion halts. So where exactly is that sweetspot?

[@slimturnpike]

150mg/day

[@davlmt]

@@slimturnpike Where do you get this number from?

[@slimturnpike]

@@davlmt From a study that measured NAD + 8-9! _-3

[@viorelg9499]

@@davlmt she uploaded a newer video. If you watch it, it clearly suggests, that there's room for way more than 150mg a day. You should watch that.

[@stephenhurst1348]

Thank you so much for the thorough long-form video, all of this information is very important.

[@michelleguerrero2848]

Dr. talks to us like we could really get it....I do!!!

[@lucmarcoux2144]

Wow, thank you for that full explanation. I have cut sugars, am into intermittent fasting, with 4 prolong 5day fast a year, and now looking into Mr Sinclair's research. I don't look anywhere my age, I'm told. Exercise and eating right is crucial. I am a nut at getting my DNA and any acetylation or methylation repairs done. Doing the autophagy route for this right now. I was thinking of these surpluses, but I think, I'll stick with my diet and exercise routine. Thank again, great explanation, backed with studies. I'm loving you already!

[@dominysynclair]

Luc, can you go into detail on what you mean by "getting my DNA and any acetylation or methylation repairs done."?

[@lucmarcoux2144]

@@dominysynclair DNA damage is caused by Acetylation and/or Methylation(environment markers) which increases over time, from what I understand. Well, at least, when they occur in the wrong place with time... In other words, aging! To slow this down, I fast 5Days, 4x/year or every 3 months. I know that on day 5 or towards the end of my fast, my body is looking hard for amino acids to use for protein synthesis. It therefor, unspools the whole chromosome in the nucleus looking for damage DNA to recuperate those strands for amino acids, while replacing them with a newly constructed one. To my knowledge this is where Methylation and Acethylation repair can be done too. If it's going in for a DNA check, chances are, it will be fixing this small carbon problem as well. Once you feed a new, the stem cells produced from the fresh/or repaired DNA provide a fresher or more youthful figure. I can't say I'm getting any younger, but it stopped my grey hair in its tracks, returned some elasticity to my chinney chin chin, and you couldn't tell that I am 60yrs old. Trust me, I work at an airport ticket counter, I open passport and occasionally fall on that guy who is the same age I am. Ouch! I use the occasional NMN too, but only for 2 weeks in every 3 month session. I like to research this kind of stuff, so yeah, look it up! Have a great evening!

[@metricmoo]

Every time she says "enzyme" you have to pop an NR capsule

[@joey4481]

Bet

[@metricmoo]

Cheaper than a bottle of alcohol 🍷

[@metricmoo]

$50 a bottle. Meanwhile people pay hundreds or more for a bottle of cancer 😳

[@tomprovan6817]

This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video

[@noemiromero4729]

You are amazing!!! This material is so useful!

[@robo265]

Wow talk about informative video thank you , I’ve been taking a product which contains Nicotinamide 250 mg twice a day with botanical mix alpha lipoic acid vitamin c and zinc which apparently works on the salvage pathway you have described. The company claim that Despite all the hype surrounding the use of precursors such as NR and NMN to boost NAD+, our cells actually make nearly all of the NAD+ they need using NAM ,as you described in your presentation. They go on to say That “as we get older, levels of the NAMPT enzyme are known to decline and the salvage pathway becomes inefficient at converting NAM into NAD+. In fact this is known to be one of the main reasons that cellular NAD+ declines as we get older. This means that if we want to make sure that NAM doesn’t build up in the cell, then we must make sure that NAMPT and the salvage pathway are working optimally, like they were in young cells. Rather than simply trying to fix falling NAD+ levels by putting more raw material into the cell (using precursors) the product is designed to fix the underlying reasons why NAD+ is actually declining, namely the failing salvage pathway. I am however concerned of the effect of Nicotinamide on sirt2, they claim however that Nicotinamide does not effect sirtuins if it doesn’t hang around for a long time when the salvage pathway is working properly . I just wondered what your thoughts are on this. Again many thanks for your very detailed video

[@proTRUMPproREALMADRID]

I'm exactly 180lb, thank you for this vid!

[@LaunchMedicalMedia]

This is a wonderful video. We will probably be sending our patients this video when they ask about NAD+ from now on!

[@John-hj6ed]

I think I will stick with exercise and fasting to increase my NAD+ ... NR and NMR dosages are too high for comfort...

[@KenOtwell]

Do you know of any study showing how much exercise increases NAD+?

[@dg7438]

The creator of NMN says exercise doesn't raise NAD+ .. it does nothing.

[@KenOtwell]

@@dg7438 That sounds wrong. Do you have a link? Edit: Your claim is directly contradicted in the video at 7:03. Sorry.

[@dg7438]

@@KenOtwell From David Sinclair himself..kzbin.info/www/bejne/g5eZk4SQncR6j9U

[@jasonhendrickson2289]

@@dg7438 "In mice"

[@2kosio]

Congratulations 🎊 - It's pretty rare to be able to see such good quality presentation for so complex topic and compressed in so condensed time

[@spockboy]

Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful.

[@clsatc]

Dr. Rhonda - you are such an amazing speaker and i have learned so much from you. I just want to respectfully remind you that the word "associated" does not have the "sh" sound in it. So many people make that same mistake so probably most don't notice it.

[@rioverde123]

Seems Fasting, calorie restriction and exercising is about the only thing that works for the moment. No magic pill. Great information 👍

[@chrisbrown2211]

Also NR and NMN

[@vinster9165]

Chris Brown how much to take of each of those together per pound of human weight? And I got the impression iv was more effective than pill form.

[@dexterlacroy4132]

@@vinster9165 But oral is still effective enough to make an impact

[@dmana3172]

Diet and fitness are important, but it won't increase NAD. We need to take NR or NMN to raise NAD.

[@Re3iRtH]

@@dmana3172 No evidence that taking precursors to raise NAD will do anything that you think it will.

[@dr.stevehrubyd.c.3666]

Thank you Dr Patrick this is above and beyond anything that is out there.

[@firehorse_44alpha-omega]

Excellent lecture. Thank you for this presentation Dr. Cheers

[@firehorse_44alpha-omega]

@Zeek Banistor can we both agree that her title allows her to be addressed as "Doctor" ? LoL Cheers

[@andrewmooreone]

Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you!

[@KenOtwell]

Great data - but leaves me with one big question - how much does exercise increase NAD+ and how does that compare with supplementation? Also - is there any synergy between exercise and supplementation?

[@truvelocity]

Every study in the past shows that there is no replacement for exercise and a healthy diet combined. Some regulated supplements have been studied to show some benefit, but nothing compares so drastically to a healthy life style. The bottom line, is that supplementation is good, but you have to combine that with a life style like good diet and exercise.

[@KenOtwell]

@@truvelocity Perhaps - I'd just like to see researchers like Rhonda talk about those comparisons. We get detailed numbers on the supplements, but platitudes on the lifestyle impact.

[@charlespatrick8650]

Ken Otwell I think there is with my recent experience taking NR

[@PinataOblongata]

@@charlespatrick8650 You have any bloodwork or other quantitative measure behind that, or just how you feel/performance? Are you comparing periods of just one or the other to periods of both?

[@ronyan]

@@truvelocity Sure but your ability to exercise can be restricted by certain health conditions so there is always value in looking into ways to achieve benefits without exercise.

[@lookmomitsthatboy1869]

I found out about dr ronda a few months ago! I’m 26 and haven’t became 27 yet! I owe it all to her and my broccoli sprouts

[@lookmomitsthatboy1869]

Do you consult People’s diets ronda? I wish you could go over what I eat and tell me how I’m doing hahah

[@KenOtwell]

So what's causing the nicotinamide feedback loop and how do we increase the NAD+ setpoint so that more nicotinamide is converted? That seems to be the key to increased usable NAD+ in the body.

[@pravoslavn]

Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work !

[@christinalawhorn2627]

** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you!

[@neylsonmoreirabraga]

Best NAD research on KZbin!

[@johncurtis920]

Looks like more studies on humans are needed since the animal studies seem so promising. I've been taking nicotinamide riboside (250mg) and pterostbene (50mg) for over 5 years now. It's the only supplement I take. I'm 66 years of age, 5'10" tall and weigh ~155lbs. I feel in perfect health despite a few creaks and hiccups in my giddy-up (heh). I'd also like to think my diet, while moderate, is well-rounded in a healthy sense. Lots of fruits, vegetables and a modicum of meat. I'm not much into junk foods and the like. I sleep well at night, averaging ~8hrs, and function well all day long. My energy levels remain constant pretty much all day, though I'm not going to claim I have the same level of endurance I had at 18-20 years of age. I bike and walk for exercise and pleasure. I suffer none of the maladies I see beginning to manifest in friends and colleagues in my age cohort. And I still have my marbles. Or.....at least I think I do. Friends may disagree. ;-) Now is this due to the supplement? Possibly. Physically I feel like my body is functioning at a nice "steady state" level though the vicissitudes of time do appear when I look in the mirror. There's nothing to be done, overall, about the ever constant, albeit slow, aging that it shows. Gray hair, wrinkles and the like. That's just life. That said I feel like I'm motoring along nicely. But in the interest of full disclosure I'm unclear if this is entirely due to the supplement I'm taking. A portion of this might be due to it; but I've a 90 year old father who still runs +20 miles a week, every week. As he has done since I was a toddler. And my mother is still alive and kicking, though a bit more frail. Both still have their minds, too. So the supplement might be noteworthy, but I suspect so, too, is my genetic coding. So that needs to be considered when evaluating the merits of my health. In any case I see nothing wrong with supplementing the diet with it. I take no vitamins and eat a moderate, rounded diet. It would be nice to see the results of more human-oriented studies of nicotinamide and the like. I think there's merit to it keeping one healthy for as long as one lives. And regardless of how long you live staying healthy is the whole point, isn't it? John~ American Net'Zen

[@posturebalanceandfitness8429]

Thanks!

[@Pat206]

Hi John. Yes, genetics [your father is wonderful] play a big part, but not if you abuse yourself by bad lifestyle. You seem just fine. Love your humour especially in the 'giddy-up' department! I'm 66, 155cm, 55kg but have not taken great care of myself, possibly because I have a great gene pool too, which I obviously took for granted. [Idiot!]. I'm still in great health, but over the last 3 years [a bit late, I know!] have totally changed my lifestyle, except for wine! I swim and walk. Take curcumin[+pepper] and today started Nicotinamide. I only found this/and other channels today whilst looking for info re Ribo and Mono nicotinamide. Glad I did. Gleaned a lot. Sorry for raving on. Hope life is treating you with an abundance of health & happiness. from Qld, Oz.🦘

[@johncurtis920]

@@Pat206 I'm now at the 68 level and still motoring along just fine. But don't misconstrue my earlier note. As you might expect from my age, being a Boomer on the tail end of that cohort, while I adhere to a mostly healthy diet these days, moderation in all things being my mantra, in my younger years I did abuse myself in all the ways you might imagine. Drugs, alcohol and just generally not great, more American, dietary habits of junk. But I've come to understand something about myself. Whenever I'd reach too far into any particular abusive "well," I always recoiled back to a middle way of doing things. Unlike some of my friends and associates bad habits like that never captured me. They, unfortunately, are suffering the vicissitudes of Time and bad habits a lot more forcefully than me. And baby, are their travails nasty and seem only going to get moreso. Why not me? I dunno. Maybe it's a pain tolerance thing? I'm not big on pain, and whenever a habit would attempt to ratchet itself upwards, invoking more pain than pleasure, I'd revert to the things I at least subconsciously knew were better for me. Any damage done genetics would patch, and along I'd go. My "adventure" with NAD+ might be another example of following my subconscious since in no way, shape or form am I a medical professional. By career path I'm a techno-geek who followed a computer systems and telecom network design path. All just a guess, of course. So how much long do I have in this plane of existence? Who knows, but the parents are now at 90 and still rolling along. It looks like they'll do one hundred easily. Umm...barring absentmindedly stepping off a curb and getting hit by a crosstown bus. So, since I can see the road ahead at least that far I suppose I'd better keep to the healthy habits. Besides, I'll be damned if the parents outlive me (which is probably what my kids are thinking about me, too). Heh! Stay safe and well out there.

[@Pat206]

@@johncurtis920 Me too. I've got to stay on track. All the best.

[@cs-cg9wl]

Wow, your speech is so much better. Speed, clarity, cadence, all resulting in you being much more pleasant to listen to while keeping all that detail intact. I remember googling you a lot after joe rogan and being a bit disappointed back then.. Time to check out Rhonda Rousey again. (althought this stuff is a bit above my head keep at it!)

[@MarmaladeINFP]

She used to sound extremely awkward or even robotic. It gave me the impression of her being someone who didn't really know what she was talking about, as if she was just repeating what she read. Her presentation has improved, but I still don't observe much in the way of original thought from her. It still sounds like her repeating info, rather than offering her own personal observations, insights, and thoughts. Take someone like Paul Saladino who is equally conversant with scientific research but regularly offers his own original thoughts and alternative theories about what it means.

[@devinlauwerier404]

I just hope she appreciates me keeping this comment classy. -Thank You, Rogan again soon?

[@CompSource]

Wow amazing job and the best, most concise source of information I've ever seen for NAD oh, great job!

[@jcrc65]

QUESTION if worried about niacinamide high content... 500mg available commercially ...I was told to take niacinamide along with BETAINE ANHYDROUS to avoid liver damage due to the high mg 500 of niacinamide ...can you explain a little more deeply into this subject. thank you.

[@revilodraw88]

A lot of clinical trials have patients taking A LOT more niacinamide than 500mg. Some I've seen have up to 3g/day. So I wouldn't worry too much about 500mg being bad for your liver. But I would worry a little bit about niacinamide inhibiting SIRT1. For that reason, I'm only taking 100mg of niacinamide, 3 times a day.

[@VladimirMinkin]

You can find a lot of information about B3 in Dr. Abram Hoffer books, he said - "The only side effect of taking niacin is that people live longer". I'm personally taking from 2-3g of niacin or niacin hexanicotinate each day and feel good.

[@g.e.boroush5176]

Go directly to Dr. David Sinclair videos from which Rhonda takes this information. He cautions against taking large amounts of niacinamide because his research shows that a large amount inhibits the Sirt enzymes (which are the longevity enzymes).

[@redberries8039]

@@g.e.boroush5176 Have you a link for those vids? cheers.

[@lawnmower11]

jcrc65 Chris masterjohn has discussed this topic on his channel and I believe he mentioned TMG supplementation

[@davidg.johnson7208]

Loved your interview with Dr. Daivid Sinclair! The meeting of two great doctors! Hope you have another with him! Maybe get a pre-copy of his new book to come out soon for an interview?!

[@rogerm3708]

I fast every day for 20 hours. From what you said I may already be replenishing my NAD

[@iandalrymple7255]

Roger M same here

[@naiitabolsen819]

dont u become skinny?

[@mura0]

@@naiitabolsen819 that is my problem. I would like to fast every day but I become a broom stick. I started fasting again after months last month and I already lost weight. Now, I will try 3 times a week only.

[@1LIFEtoWIN]

Roger M Fasting, Exercising, & Keto boost NAD levels

[@1LIFEtoWIN]

Galpha male If you don’t reduce your caloric in-take you should maintain your weight while Intermittent Fasting just eat what you normally would eat in a smaller eating window per day.

[@billyjoehuggins]

Thank you, Dr. Rhonda Patrick! Great information!

[@Leoji67]

Are there any studies that look at pre and post fasting levels? Is this the key factor in the relationship between fasting and longevity?

[@gstlynx]

We know that being in ketosis increases NAD/NADH ratio. Infer away.

[@DavidSchwartzjr]

Been looking into this a bit recently. Thanks for the new upload, Rhonda! 👍

[@dplsurve]

You’re so smart it’s scary!!!!!

[@MrVeteranhawk]

I did 10 push ups for every time she said NR or NMN, I don't have to workout until the year 2023 now..lol. But great presentation, very helpful for my age at 52. I've been doing a lot of research on taking supplements to increase NAD+

[@ownpetard8379]

Same here, except I put an "If" at the start of what you said. 😃

[@andrewclancy2511]

So you're "not ready to jump in with both feet". I'm curious what that means. Do you personally not supplement with NMN or NR at all? Just a little?

[@FoundMyFitness]

Yeah, so to clarify - I am cautious and that means I am not taking any NAD+ precursors right now. We’ll see where things go in the future.

[@japrogramer]

@@FoundMyFitness do you take resveratrol?

[@cwstars]

@@FoundMyFitness as is Mike Mutzel

[@johnny7808]

@@japrogramer after reading the link below I'm guessing she is not yet jumping in with both feet on resveratrol either. www.foundmyfitness.com/topics/resveratrol

[@nolaenglish659]

She's a scientist. She needs absolute science. Also she cautions about mega dosing which nothing is good in mega dose. There are many other studies that she does not know about.

[@karenandreabrown7621]

I started taking NMN and trans-resveratrol because of David Sinclair on Rhonda Patrick's podcast! All my health markers have gone up since! I didn't notice those effects when I was taking elysium's NR.

[@simpleman7203]

I wonder if exercise in fasting state would boost more NAD?

[@FS-gl9cg]

probably

[@stephenhurst1348]

I wish these were put on the podcast app so I could listen while I drive or work.

[@beautifulrose8619]

I'm pretty sure she has a podcast app.