Blood, rats and anticoagulants: The story of warfarin

The history of warfarin, one of the earliest anticoagulant drugs, is littered with the bodies of sick cows and poisoned rats. This animation tells the story of how a bloody beginning gave rise to a life-saving medication.
Find out more about the history of anticoagulant drugs in this interactive timeline: www.nature.com/collections/hb...
This Nature Video is editorially independent. It is produced with third party financial support. Read more about Supported Content here: www.nature.com/advertising/res...
13th March 2018

[@sagarrana_94]

Extremely well! I don't understand why people don't see such a brilliant stuff on KZbin. Efforts in story collection, narration and animation.

[@atacorbillel]

Thanks for the wonderful animation

[@medipuzzle]

I found this particular video very useful and have been adding this tale to my students during their class on anticoagulants, even shared it in my channel under Recommended videos

[@snipoxkillo1099]

The name WARFARIN itself was an acronym for "Wisconsin Alumni Research Foundation - arin" (the arin was taken from coumarin).

[@roidroid]

Whenever a sensationalist journalist writes "rat poison found in party drugs", they are actually talking about this medication.

[@Shloopy420]

and that's really fucking dangerous!

[@hnkjnk6710]

There actually are reports of brodifacum being added to synthetic canabinoid batches becouse of a mistaken belief that it can enchance the high so no not in all cases its not warfarin super warfarins have also been added and that is very dangerous.It is not to say adding warfarin isnt dangerous.

[@gusgalvanini]

DOSE IS EVERYTHING. Warfarrin is a life saver, as an EMT, I can say most of my elderly patients are in some form of blood Thinners, it saves them from dieing. Same w/ alcohol, a little bit, NO PROBLEM, a lot can kill. Dose is everything!

[@beezanteeum]

That's why pharmaceutical logo is venomous snake and the pestle, meaning a drug is a poison if the dosage is completely wrong

[@user-mr7uj9mu8j]

Lies it doesn't it causes severe adverse effects and also polypharamacy

[@Shloopy420]

Link was already interested in the clover disease & the blood was extremely important! "Nonetheless it would appear that Carlson had indeed come to the right place. Schofield experimented with the blood that evening and, as Duxbury and Poller comment, ‘The can of uncoagulated blood lying on the floor of Link’s laboratory was to change the course of history, and little did Link know what the long-term implications would be’ (Duxbury & Poller, 2001). Although the cause of the haemorrhagic malady had been found, in the sweet clover, the actual active compound had yet to be identified or even isolated. Link and colleagues got to work on finding the active substance from the spoiled hay" - "The story of the discovery of heparin and warfarin" Douglas Wardrop and David Keeling Oxford Haemophilia and Thrombosis Centre, Oxford Radcliffe Hospitals, Oxford, UK

[@Yamazaki339]

The best as usual! Thanks!

[@lonblauvelt7582]

Stuff like this is why I subscribe to this channel! This was really cool!

[@jjc5475]

really interesting, never heard about it.

[@TheBlackLibraryOriginal]

Excellent work!

[@DrChaitanyaPlastics]

Wonderful! Can you suggest some more stories like this one?

[@mohamdy8950]

How perfect this is... Wow

[@RitikKumar-ud3gc]

Wow this is wonderful animation and depiction

[@josuearias5434]

BEAUTIFUL ANIMATION!

[@bolourimohammadreza9614]

good thanks

[@evanzeng9828]

In Canada this drug is prescribed like common food for aged people.

[@orenkrimchansky]

wow! thanks!

[@alisoncleeton877]

Thank you that farmer!!👍😘😘😘😘

[@talithajane8155]

Great animation

[@fatm4403]

I love it!❤

[@davidgbf]

Long life to science!

[@kanesmith8271]

I find it novel that regular people would consult universities so casually back then

[@howardkurtus7069]

Fun vid

[@GabrielKnightz]

Please consider doing a video on Hemophilia (especially with Hemophilia day coming up)

[@ClimateAdam]

GabrielKnightz kzbin.info/www/bejne/nJ_FgnShbtmgsJI

[@GabrielKnightz]

ClimateAdam Thank you

[@kiloton1920]

Can cornfirm warafin works, get the brand name kaput

[@eloylie]

And what happened to the farmer?

[@sarahmina1442]

Lovely animation Nature 🥰

[@alinakaith186]

Animation 😭🤩

[@awnisavefo4381]

спасибо за видео

[@WilliamDye-willdye]

Did that poor farmer get even a small share of the royalties? A quick internet search just now was inconclusive. If the farmer was never compensated, even a little, then the closing image of the farmer and scientist hugging is a bit out place.

[@MrJerry160]

the farmer didnt work for 7 years to develop the drug

[@valuablememories5603]

Without the idea they wouldn´t even have started@@MrJerry160

[@pauldevery6173]

I believe warfarin comes from the Wisconsin Agricultural Research Foundation that found the connections.

[@Dragon-Slay3r]

Didn't we use the alien queen ram for hearsell cumon cover? The Queen narrow shield and Ram is clear

[@21willyx21]

Taking my warfarin during this video.

[@warfhistorian137]

As for what happened to the farmer: Until recently a lot people thought "Ed Carlson" wasn't a real person. We now know he was real and we've got our people working to find out more!

[@NE-BO]

So what happened to the cows though?

[@howardkurtus7069]

bobyo hovio they died

[@XiangxiMeng]

And it is linked with cancer preventive effects.

[@nicholaslandolina]

Cumadin

[@kamranadil4285]

Did Jerry die too? :(

[@valuablememories5603]

Not if you remember him

[@kamranadil4285]

@@valuablememories5603you revived me from desd nigga

[@Alex-pq2gb]

Oq é isso kkkkkkk

[@psfgtech]

Is this real news? 😃

[@followingthelight3232]

So, what happened to the farmer? Did he go out of business or what?

[@anthonypuccini4669]

Sorry folks, that "ME" between the words "TOLD" and "THAT," I typed too fast. Oh, by the way, THEY mean the DOCTORs.

[@alinebaruchi1936]

"Você é um utensílio " É a bioética chinesa. Fim.

[@rhythmicluke4555]

I thought they died of BSE when I saw them die one by one

[@zaimahbegum-diamond1660]

Yayyyyyyyy......

[@sigabra3274]

warfarin adalah obat obatan maka bomoh bomoh tak boleh gunapakai

[@diablink5]

It doesn’t kill rats just dogs or another animal that got on it….

[@alisonaddicks1584]

This is a dangerous drug and should only be used if constantly and carefully monitored.

[@Noitisnt-ns7mo]

Probably still meant to kill rats. Funny how it was first used on a guy vastly responsible for making people bleed.

[@cikif]

negzel

[@alonir101]

And now it kills dogs and cats by volumes

[@swaggking6328]

1000000000😀👍💚💛💜💕

[@swaggking6328]

.,

[@Dragon-Slay3r]

Blood thinner? By using a different spit it out? This is what I was supposed to spit out today a vertical sub double grave tablet with a jin spok fishbone tail that was hiding behind it so it could escape inside the gutter As for the believers they can hide behind me as a shield let the rest carry on getting caught because they know better Atleast we know again that the Torjet is a gaslighter to cover the toes In the meanwhile clash of the titans? 😂

[@welchkoservices4200]

Deadly for rats...use for human consumption perfectly fine. Sounds like fluoride...also killed rats, use for human consumption perfectly fine. Hmm🤔🤔

[@MrJerry160]

its all in the dosage

[@soumya9735]

then why are we alive? I wonder, or it's that most of the ppl are lucky n should thank their body for tolerating the torture.