10-minute Rounds: The Serum Anion Gap

[@7andala95]

i just wasted 30 minutes reading stuff on google and didnot understand a thing and you sir explained it in 10 minutes ! Thank you so much !

[@ijanaahhh]

I had this explained by my teacher for one and half hour, which was a waste of time, because I couldn't understand. But now, because of your video and the amazing explanation i got it! and in 10 minutes! thanks a lot!!!

[@gtmacd]

I'm a 3rd yr med student who has struggled with this. You've cleared it all up for me in a short 10 min. Thanks!

[@Giatros89]

Finally a well explained SAG video. Now if we can find a ....ondemand 10 min round for all the other specialties medical school would almost seem too easy. Those who can --> do, and those can't --> cause confusion, those are awesome --> teach well! Thanks again

[@nephondemand]

You're most welcome. Please let us know if there are other concepts that you want us to discuss.

[@nephondemand]

No problem. Glad we could help out. Please let us know what more we can do to make your nephrology learning experience better.

[@anaoreskovic4279]

Great video!!!

[@markulinos]

thx mate...ua-uc was the key to understand everything!!!you saved me

[@nephondemand]

You're very welcome! Glad we could help.

[@nephondemand]

You're welcome. Glad we could help.

[@nephondemand]

Actually, we've never heard of this position before. To our knowledge, protein size (molecular weight) should not have any bearing on its electrical charge. If you could point us to a reference please send it to us (just comment here). Thanks.

[@nephondemand]

@JeffBertolotti Can you give me some more patient information? Perhaps the clinical context or additional lab values? Thanks.

[@NK-jt2zw]

When we say that anion gap is less than 0 why is it due to increased unmeasured Cations but not due to low levels of sodium?because when we will calculate anion gap from sodium,chloride and bicarbonate even their levels would have changed then only we will get anion gap less than 0. So why do we not interpret that as hyponatremia ?why do we interpret that as increased unmeasured cations?

[@bookeaterintube]

Very nicely explained. thank you!

[@adamaitalioulahcen5438]

why we call it anion gap however its also include cations as well

[@Guest8293]

simple and clear!!!!! thank

[@291ayl]

OMG THANK YOU... So the UA-UC, duh... makes so much sense mathematically. Literally, the way other people explained it the math made 0 sense lol!!

[@nephondemand]

Alissa Liburkina it’s my pleasure.

[@JeffBertolotti]

I was wondering how these values look to you? anion gap 4.. (lab norm 5-15)... RBC 4.57 (lab norm 4.70-6.10)

[@the_nerdy_np]

This was incredibly helpful, thank you SO MUCH.

[@chriswebb3285]

Could the anion gap be more positive, for instance, not just due to increased anions, but due to decreased cations? Along those same lines, could it be more negative due to decreased anions instead of increased cations? I'm just starting a renal course in med school and I was just wondering if any pathological processes could cause this to happen. Thanks!

[@nephondemand]

Great question. Theoretically, the answer is yes to both your questions. However, I'm not aware of any pathophysiologic conditions in which: 1. the AG is very positive because of extremely low cation concentrations. I suppose you could have a situation where a patient is severely hypocalcemic or hypmagnesemic, but we generally don't calculate the anion gap because these cations, while considered "unmeasured cations (UC)" in the AG equation, are easily measurable in clinical practice. 2. an AG that is more negative because of very low anions -- again, I've not seen this but it should be theoretically true. In patients who are extremely hypoalbuminemic, you will see an AG closer to zero (0) but I don't think I've ever seen a case where the anion gap is actually < 0 because of very few anions.

[@amnamehmood7659]

Thanks a ton! that was really helpful.

[@tikhara123]

extremely helpful! thank u so much

[@tra12345iscool]

Albumin, proteins generally are too big to be an anion

[@hh-zq9io]

U r super...thank u

[@drgurpreetrandhawa]

Awesum!!

[@jadattia6723]

this video is great

[@alexandradieffenderfer7789]

Thanks bro!

[@MohamedAli-bk6vk]

marvellous.

[@swatiM722]

Thanku sir ♥️

[@waedghassan1037]

thank you