2-Minute Neuroscience: DMT

DMT is naturally produced in a variety of plants and animals (including humans) and is also a potent psychoactive drug known for its ability to cause intense hallucinations and psychedelic experiences. In this video, I discuss how DMT might act in the brain to produce its unique effects.
TRANSCRIPT:
DMT is a substance that’s produced naturally in a variety of plants and animals, including humans. The functions of naturally-produced DMT are unclear, but DMT is also a potent psychoactive drug known for its ability to produce intense but relatively short-lived hallucinations and psychedelic experiences. When used recreationally, DMT is typically smoked, but it’s also the main psychoactive ingredient in ayahuasca, a brewed drink that produces longer-lasting psychedelic effects. Although orally administered DMT is rapidly degraded by an enzyme called monoamine oxidase, ayahuasca is brewed with plants that contain inhibitors of this enzyme, enabling the DMT in ayahuasca to remain active even though it’s administered orally.
The pharmacology of DMT is not well understood. The drug has actions at a variety of receptors in the nervous system, but its best characterized effects are its ability to stimulate a wide range of serotonin receptor subtypes. Studies suggest that DMT’s action at the 5-HT2A serotonin receptor is especially important for producing its characteristically intense visual hallucinations. At the same time, stimulation of the 5-HT2A receptor alone does not seem to be sufficient to cause the hallucinations experienced by DMT users. Thus, it’s thought that other serotonin receptor subtypes might be involved in these effects, and some evidence suggests that receptors for the neurotransmitter glutamate may play a role as well. It’s also possible that DMT’s actions at other receptors, such as sigma-1 receptors and trace amine-associated receptors, may contribute to the drug’s effects, but more research is needed to elucidate DMT’s full mechanism of action.
DMT, like many other psychedelic drugs, is now gaining attention for its therapeutic potential. Studies with ayahuasca have found the drink to have beneficial effects in the treatment of depression, anxiety, and addiction, and studies are currently underway to investigate the possibility of DMT alone offering some of the same benefits.
REFERENCES:
Cameron LP, Olson DE. Dark Classics in Chemical Neuroscience: N, N-Dimethyltryptamine (DMT). ACS Chem Neurosci. 2018 Oct 17;9(10):2344-2357. doi: 10.1021/acschemneuro.8b00101. Epub 2018 Jul 23. PMID: 30036036.
Carbonaro TM, Gatch MB. Neuropharmacology of N,N-dimethyltryptamine. Brain Res Bull. 2016 Sep;126(Pt 1):74-88. doi: 10.1016/j.brainresbull.2016.04.016. Epub 2016 Apr 25. PMID: 27126737; PMCID: PMC5048497.
CREDITS:
The image of ayahuasca is a CC image courtesy of Terpsichore. The work can be seen here: commons.wikimedia.org/wiki/Fi...
The background kaleidoscope image is courtesy of Merlin Lightpainting. The work can be seen here: www.pexels.com/@merlin/gallery/

[@teehee4096]

Changa (DMT) is absolutely the most intense substance I have ever tried. Life changing. Great video.

[@Ericxnugz]

same!! breaking through is insane. had me sitting on my couch for hours so confused lol

[@blaiseandthebambina]

2-Minute Neuroscience but my dumb ass has to watch it 10 times to understand the topic! 😂 Thank you for your videos!

[@emredemir9852]

I still can't understand why DMT produce that much intense effect on humans, obviously current literature can't explain it. There are lots of immersive stories about DMT and it makes me so interested about this molecule.

[@RottieGuy1980]

It’s because most people are smoking spiritual doses when using dmt. You can get similar effects from lsd and mushrooms, you just have to take high doses.

[@neeta378]

@@RottieGuy1980this is nothing like mushrooms n other things. DMT is totally different experience, this is like death experience, You can see your body in this world while you traveling another world. I have done that experience but I have words that I can explain in a one line . So much see is different what you see every day. It not a dream, people talk to you while you’re not in body, you notice you have come back to answer & you don’t want to come back. DMT is Amazing thing

[@wtconroe879]

I personally don't believe that science is ever going to be able to adequately explain how profound DMT visions are. There are certain things in life (this included) you have to experience them in order to believe. Certain things are just too stunning to be able to put into words, You can try but they always seem to fall short.

[@Vortex_Feedz]

you release all of it from your brain, when you die

[@joseleader_]

Ayni sekilde gunbegun benimde merakim artiyor ama sosyal hayatimi yasantimi ve benzeri seyleri nasil etkileyecegini kestiremedigim icin denemiyorum. Gelecekte elbet birgun deneyicem.

[@figrollin]

I'd love to see you cover GABA; the pams, the agonists, the subunits etc

[@Neuroscientificallychallenged]

I have covered it, but couldn't get to all of that stuff in 2 minutes: kzbin.info/www/bejne/mIKshmWBedl7iqs

[@jimmiejackson8489]

Love it !

[@DontCancelMeBro]

DMT is amazing

[@morin1997]

DMT is God

[@desiredecove5815]

Again- excellent education for all

[@Nathaniel_smith189]

*Hey I'll refer you to this dude online who guided me through my first ever experience,he got all kinds of psychedelic stuffs and he also ship discreetly to any location**

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[@Nathaniel_smith189]

Hillstrips√√°°°

[@aamirrazak3467]

Thanks for posting this! I learn something new whenever I watch your videos! That’s interesting that DMT may have some health benefit

[@Goddessbrea23]

◇♡◇

[@itaygev1377]

I'M ADDICTED TO YOUR VIDDEOSSSS! Thanks for sharing information in a simplistic way. (please pin

[@jonny10493ify]

I have never tried DMT in my life, but I have been thinking about it. I'm seriously tempted to just go full send. Like as many rips as I can before I'm immobile. What's the worst that could happen? Wouldn't it be beneficial to get the worst part over with first? Plus I imagine it would be one hell of a funny story to tell.

[@InnocentAgilityPuppy-pp3es]

DMT an other psychs are easily accessible from this dude i cop from. Super reliable ship's discreetly worldwide...

[@InnocentAgilityPuppy-pp3es]

*On Instagram and telegram as*

[@InnocentAgilityPuppy-pp3es]

*@Chequefibs1__*

[@eggheadusa9900]

Sucks that bots ruin the discourse. Every comment is rampant on any video talking about psychedelics

[@Mellow_Flow]

Calling the effects of DMT “hallucinations” is an understatement

[@VerityConley]

{ *Chequefibs1__* } is a psych dispensary such as DMT, shroomz, LSD, MDMA and lots more. Ships discreetly worldwide

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*On Telegrams and Instagram*

[@aaronp1174]

I’m not a stranger of psychedelics done mushrooms about a dozen times, Acid a few times, salvia half a dozen times… Still have tried DMT though before and been thinkin i should at Least once…Is it as life changing as people Say it is?

[@Amina88888]

Salvia? You mean the seasoning?

[@Goddessbrea23]

Dmt is everything ❤

[@dennyink1158]

I’m starting to think so too….that dmt is the collections of all the existing hallucinations, and we are just one of them…nothing is real

[@oldlifter530]

At a time when science is exploring the impact of light eg.. the loss of infrared in lighting, impact of lack of exposure to sunlight and the increased use of media devices on mental health. Perhaps getting out to watch the sunrise and sunset, reintroducing infrared and ultra violet to LEDs, and putting a blue light filter on media devices. May be a lower risk positive impact on mental health ? Investigation of the properties of DMT is very important but medication is always used incorrectly by someone.

[@oldlifter530]

@@InnocentCompass-hx8cg not trying to be mean but I stick to KZbin so there is some control on my behaviour. Look up Dr Jack Kruse for info on light therapy circadian, Mitocondria, melanin. Algorithm will pop up other researchers and scientists. Dr Kruse has been researching this for about twenty plus years and is a good foundation can be annoying but he's a practicing Neuro surgeon and a Quantum Biologist so he pretty up to date with current research..

[@emilboyyy]

NOT THE SIGMA 1 RECEPTOR😭

[@emilboyyy]

@Ryan-xk2cr Did i fucking ask? And also I'm 16 so stop.

[@HT.100]

pretty sure it acts on MDMA receptors as well

[@Ori-lp2fm]

lol no

[@Lee-cj8ck]

Definitely not

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On instagram.__^^^

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Not for this girl!

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First

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Second

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Third

[@Lo-is]

Third!

[@Lo-is]

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[@fettuccinerecords]

DMT created by breathing exercises is best

[@ronnymac278]

mycotripper1

[@ronnymac278]

On instagram and telegram …..?¿

[@ronnymac278]

They have the best dmt lsd shrooms and other psychedelic edibles and ships discreetly

[@Echozero4]

lmao you fruit loops and your natural bs

[@oldlifter530]

So putting chemicals in your body you don't know all the effects of because you have 'serious depression' or other problems?

[@tioscha0]

Bro you can't even write down a legible sentence, stop trying to school people on shit you don't understand. Like wtf are u even responding to, you weirdo.

[@rohan1_]

This is a valid concern that people probably dismiss too quickly; but keep in mind that we don't understand the precise mechanisms of a whole range of drugs which have therapeutic benefits and which have been prescribed for years. Benzodiazapenes and Lithium in particular come to mind.

[@pumpkin7889]

Do you have knowledge of everything that you put into your digestive system, that is, you know all chemicals in them, and their pharmacodynamics? For example, a bread?

[@oldlifter530]

@@pumpkin7889 I don't know everything in a bottle of rat poison but I hesitate to consume it. Bread ? I find reading and listening to people who are not payed by people who profit from the sale of bread or a competing item, gives me some information to choose consume or not. But then again there are those that just eat the rat poison.

[@pumpkin7889]

@@oldlifter530 Great! Now you can use this insight to study about the substance with rich reaserch results/anecdotal reports called DMT. Enjoy.

[@markivan5324]

seemingly all ur videos have "unclear" "may" as the main theme more then anything, and really offering nothing ty tho

[@teehee4096]

The brain is complicated my friend. Deal with it.

[@Teties]

Oral?

[@Dominique901]

Breaking through on DMT was the craziest I’ve ever had.Truly an astonishing 15 minutes I can refer you to this dude I got a couple of grams of DMT he ships discreetly

[@Dominique901]

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[@Dominique901]

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