New Oral COVID-19 Drug From Japan (S-217622)

S-217622 - Japan's COVID-19 Oral Drug Under Review for Approval
Shionogi's Ensitrelvir (S-217622) is an oral pill with 3CL/Mpro inhibitor mechanism. It is under review in Japan for COVID-19 management. Let's review its trial results/reports.
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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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URL list from Wednesday, Apr. 27 2022
DrBeen: Medical Education Online
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Coronavirus biology and replication: implications for SARS-CoV-2 - PMC
www.ncbi.nlm.n...
(A) Molecular surface representation of SARS-CoV-2 3CL pro with the... | Download Scientific Diagram
www.researchga...
SARS-CoV-2 / COVID-19 Antibodies, Proteins, Kits | www.antibodies-online.com
www.antibodies...
Shionogi Presents Phase 2/3 Clinical Trial Results (Phase 2a Part) for the COVID-19 Therapeutic Drug S-217622 ｜Shionogi & Co., Ltd.
www.shionogi.c...
Shionogi Files for Approval of S-217622, a Therapeutic Drug for COVID-19, in Japan | Shionogi & Co., Ltd.
www.shionogi.c...
Notice Regarding the Media Coverage about S-217622, a Therapeutic Drug for COVID-19｜News｜Shionogi Co., Ltd.
www.shionogi.c...
Ensitrelvir | C22H17ClF3N9O2 - PubChem
pubchem.ncbi.n...
Ensitrelvir, An Oral Antiviral Drug For COVID-19 Treatment | MolecularCloud
www.molecularc...
Japan's Shionogi Says COVID Pill Shows Rapid Clearance of Virus
www.voanews.co...
Japan's Shionogi says COVID-19 pill shows rapid clearance of virus
news.yahoo.com...
Ensitrelvir - Wikipedia
en.wikipedia.o...
Coronavirus biology and replication: implications for SARS-CoV-2 - PubMed
pubmed.ncbi.nl...
Huateng Pharma Supplies Ensitrelvir Intermeidates Against COVID-19 - Contract Pharma
www.contractph...
shionogi « New Drug Approvals
newdrugapprova...

[@Christian-jx3nx]

We have ivm and a whole list of treatments already that work

[@complicatedmind1151]

Ivermectin does not work.

[@complicatedmind1151]

Because ivm is not effective against Covid.

[@kamranrowshandel6395]

Covid isn't so unique that we can't do anything about it. It's not the uniqueness of COVID which is "bullying us". We have had antivirals for a long time. We are probably not training doctors correctly, and this is why there's no one left for our global village to blame COVID on, other than the US. Is there any doubt that we should be training doctors who can accept responsibility for not being able to save us when we have gotten a new virus (just like all other viruses, all of which were new at one point)? Mankind has faced new viruses before, so why are we all so focused on the genetic sequence of COVID and all the other things which make COVID harder to kill?

[@andhewonders]

There are 3comments hidden in reply to you.

[@Christian-jx3nx]

@@andhewonders what does that mean?

[@tatianasilva7133]

Congratulations to the channel and the Japanese scientists! That's precisely what we need: clear and transparent accessible information so that people can make a conscious decision as to which treatment is more preferable!

[@kamranrowshandel6395]

Covid isn't so unique that we can't do anything about it. It's not the uniqueness of COVID which is "bullying us". We have had antivirals for a long time. We are probably not training doctors correctly, and this is why there's no one left for our global village to blame COVID on, other than the US. Is there any doubt that we should be training doctors who can accept responsibility for not being able to save us when we have gotten a new virus (just like all other viruses, all of which were new at one point)? Mankind has faced new viruses before, so why are we all so focused on the genetic sequence of COVID and all the other things which make COVID harder to kill?

[@rishiacharya640]

Kindly discuss the new hepatitis which is making children seriously ill

[@marlenea.6465]

Yes please !

[@marleeg5263]

Pretty sure he already did a video on that.

[@jonjones6235]

They said they discovered those children had covid a few months back. This is just one of likely thousands of different medical catastrophes that this novel virus that we know nothing about will do, and will have the potential to end humanity as we know it and cause chaos. That is why I don't want to get infected with this novel virus with its disgusting spike protein. How do we know thousands of more medical catastrophes, or premature death en masse will not happen over the next few years. It is a huge question mark. Yet they are literally choosing to gamble and give everybody this virus, neglecting research, and pretending that the V alone is sufficient.

[@charudattakasbe1534]

Thank you very much DR. Been, it is because of only you we come across this studies.

[@Surfsaus]

We already have IVM which has been proven to work.

[@complicatedmind1151]

Ivermectin has not been proven to work. In fact, it's been proven that Ivermectin does not work.

[@complicatedmind1151]

IVM has been proven ineffective against Covid.

[@kamranrowshandel6395]

Covid isn't so unique that we can't do anything about it. It's not the uniqueness of COVID which is "bullying us". We have had antivirals for a long time. We are probably not training doctors correctly, and this is why there's no one left for our global village to blame COVID on, other than the US. Is there any doubt that we should be training doctors who can accept responsibility for not being able to save us when we have gotten a new virus (just like all other viruses, all of which were new at one point)? Mankind has faced new viruses before, so why are we all so focused on the genetic sequence of COVID and all the other things which make COVID harder to kill?

[@andhewonders]

There are 3comments hidden in reply to you.

[@DespaceMan]

@@andhewonders pootube censor bot doing it's job, everyone will again move over to Twitter where free speech is again allowed.

[@marloes8726]

I liked the Paxlovid lecture (discussed 3 months ago), primarily because of the interesting mechanisms, so well explained and supported by the Dr's fascinating, enjoyable drawings! I think it's worth watching again.

[@danbanfan9524]

I didn’t watch this. I will check it out. Can you tell me though what if any concerns he has with paxlovid? One question I have is if it would prevent the immune system from creating antibodies to Covid.

[@marloes8726]

@@danbanfan9524 very interesting question and worth looking into. Would be great if he did a talk on this. I don't think I'll ever take the drug, I'm just interested in the science. 😁

[@danbanfan9524]

@@marloes8726 thank you, I don’t like the idea of drugs either. But long Covid can really suck and I want to avoid that. So it’s a consideration if get Covid take paxlovid that I’m still debating. I had the original version of covid with no problems but who knows what happens the next time. 🙄

[@joym8047]

I haven't had time to watch Dr Been's presentation on Paxlovid (though I'm sure it was excellent and thorough--and hope to once I've watched several other videos I have in my queue). If anyone can summarize what he said, I'd appreciate it. A troubling thing I've seen about Paxlovid is that there have been recent reports that some people who have been treated with it test negative for Covid and think they have cleared it, then have a relapse. This is concerning because they (thinking they are temporarily safe from infecting others) might visit immunocompromised patients, and I think it's unknown how rare this phenomena is. Another problem with Paxlovid is that it can have serious interactions with common over-the-counter and prescription drugs, so people who are on medication need to be extra careful.

[@sumeriansumer1622]

Drbeen Medical Lectures, Please do a video response video, to a video on the Peak Prosperity KZbin channel, titled: 40% Surge in Working Age Deaths

[@MsBchoice]

doesn't change a fact that's something new that hasn't been tested over longer period

[@williamtyndale1402]

Just give us Ivermectin! !!

[@deeb3077]

Love your art work. Thank you for the information . 😊 💖

[@evildan524]

Why are we bothering with this drug when we already have Ivermectin ?

[@complicatedmind1151]

Because Ivermectin is not effective against Covid.

[@complicatedmind1151]

Ivermectin does not work for Covid.

[@damianpos8832]

Big pharma has to make money somehow..

[@adonnaprice9676]

Hydrochloroquine better for omicron

[@shirlene767]

Those don't have enough side effects to keep the medical community busy and they have a track record or success. America apparently likes "New" instead of tried and true.

[@MariettaFarley]

Such an encouraging Gift for Humanity!

[@asiagrabowska5092]

"I trust the science" in Japan

[@carolinepaquette7068]

Internet my immune system. 😉

[@garybennett5231]

I have lived in Japan for 18 years. They have the “big pharma “ and liberal media problems in Japan too. They don’t have mandates like America but there is strong social pressure to all wear masks, etc. Hope this drug helps people.

[@rajwanteerobinson1761]

Thank for the medicine 💉 and side effects Bless Dr Been

[@TheShree468]

Good morning sir..nice discussion..thank you sir..🙏

[@lmwlmw4468]

Great video.

[@marlenea.6465]

I would opt to not take this med. Seems risky.

[@DespaceMan]

I believe it's still early days they need to do more testing.

[@danbanfan9524]

What about paxlovid instead ?

[@andhewonders]

Does this mean they've cured the common cold?

[@DespaceMan]

Common cold vanished during COVID

[@evanpnz]

No. I've had two colds so far this year. Strangely enough I also had two in a row, Dec 2019 & Feb 2020, but none during the pandemic. So all the covid precautions did something to slow down colds. For reference I usually have one cold a year, but do occasionally skip a year.

[@andhewonders]

@@evanpnzSo you've used Ensitrelver?

[@evanpnz]

No. I have used HCQ and Ivermectin as a precaution when I caught cold since the pandemic period began though, just in case it was COVID-19.

[@ib9511]

Paxlovid was reprting liver damage as a possible side effect

[@guytelfer1353]

Live, Vejon Health

[@brentcowan8077]

just like ivermectin or HQC

[@bmeissn3]

Not bad content but I’d much rather see coverage on long Covid. The medical industry has spent 2 years on the acute phase and hardly focused on long Covid and meanwhile countless people are getting gaslight by doctors. That’s not to say there are not good doctors out there but finding them is difficult. Luckily I’m working with some pretty good doctors

[@bynoebynoe9677]

Probably there isn't such a thing, the Amish were asked how they treat covid, they said we don't watch TV or listen to the radio, we don't have covid.

[@danbanfan9524]

It’s very possible that these protease inhibitor drugs antivirals etc may prevent long Covid I would assume because they lessen the duration of disease would lesson chance of long Covid. Have you heard anything on this?

[@bmeissn3]

@@danbanfan9524 I have not but it would probably be as effective as h1 and h2 combination therapy

[@jonjones6235]

Silence. Get the V then get infected and get permanent damage from long covid. As long as you don't make the politicians look bad by having hospital system collapse at any one point due to immediate respiratory symptoms, it is fine, nothing else matters, if you get permanent brain and heart damage then they can just replace you with a cheap foreign worker.

[@danbanfan9524]

@@bmeissn3 not sure what you mean. Can you elaborate ?

[@goodquestion8064]

Said it from the start and I’ll say it again , they can stick it where the sun don’t shine

[@ambientweets8408]

I wish you were my grandpa 😊

[@adonnaprice9676]

Paxlovid you can't take a blood thinner..

[@anthroariel]

That means no anti inflammatory meds! They all thin the blood.

[@jonnes__4657]

Ivermectin 2.0... 😂🤣😂

[@donnazukadley7300]

I am SOOOOOOO ANGRY that my whole life was DESTROYED as a nurse because of my 2nd MODERNA!

[@louiejay1246]

sorry to hear that. why?because of allergy?

[@davep7456]

I am in the same boat. But even having company is rough. If you haven’t tried low dose naltrexone I would recommend. The only thing that has helped me sleep since I got it

[@v2kfiles829]

How about hybrid synthetic/human fibers? Dr. B.... can you investigate Morgellen's disease? Im sorry if you have already, I should check......

[@danbanfan9524]

What about evushield? Nobody seems to talk about it but Would that be even better then this or paxlovid? I heard it actually prevents infection or atleast symptoms.

[@frankmcg1234]

ok, its a year now. where can i buy the ensitrelvir drug. i need it to get back my taste and smell, thats been gone for over 2 and half years.

[@BC-rq5jl]

Doctor, is there any data about Novavax and how cancer patients react on it? An unvaccinated person has been recently diagnosed with colon cancer and is waiting for surgery in a month or less. Can he get Novavax now?

[@MrMickteen]

Im no scientist but im sure the government will say it is fine. If your concerned try mRna they will say. Its best not to ask Doctors.

[@renaderba1111]

What is your chat channel? How can I get there ? Is it something new ? Thank you !!

[@markridgemr]

Can pregnant men take it? We have those in the US now.

[@raghadalsuhail9464]

Plz would you explain what’s going on in China?!!

[@Adriana-f1x]

Estão querendo render esse vírus e provocar mais uma onda de medo na população e no mundo.

[@edward9862]

LOLOLOL 😂😂😂

[@PeterDMayr]

Side effects could be virus related (ie: taste,...).

[@zobinkhan8130]

All.....all.....alll

[@thanosisback2754]

Driving variants 😂 this will culminate in virulence.

[@Sonia76373]

Should just be ivermectin.

[@380.motorsports]

In terms of the number of days that symptoms were relieved per their testing, I got the same results taking current over the counter flu medicines. Many but not all symptoms were relieved and the virus was defeated by my body in about 4-6 days. Pretty sure I had either the alpha or beta virus type given the time frame I was sick. So, I don’t see any miracle need for yet another drug that does not completely work better and may cause serious effects on pregnant women. If it becomes over the counter how do you insure that a pregnant woman will not take it? Just another way for a drug company to try and make profit. No thanks.

[@alhaddi]

I am from Yemen and I want to buy a subscription but I don't have a credit card nor a bank account. Any help on that?

[@trishashaw1688]

Send a check

[@jonnes__4657]

Chinese health experts.... 😂🤣😂 Xi is ALWAYS right. He is the new god. 👎👎

[@StartHere281]

Jesus savesㅤㅤㅤ Jesus loves like no other loveㅤㅤㅤㅤ