Immunology | T- Cell Development

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
Join Professor Zach Murphy for our lecture about the thymus gland and T-cell development. We go into detail on positive and negative selection, and the movement to secondary lymphatic organs. We hope you enjoy this lecture and be sure to support us below!
References:
● Steve Ford. 2020. [Digital photo] The lymphatic system 2: structure and function of the lymphoid organs www.nursingtimes.net/clinical...
● Vector Shock Lymph node structure medical educational vector image. [Digital photo ] www.vectorstock.com/royalty-f...
● Indiana University. Histology of Spleen [Digital image] vmicro.iusm.iu.edu/hs_vm/docs...
● Teach Me Anatomy. Tonsils [Digital Image] teachmeanatomy.info/neck/misc...
● Varsity Tutors. MCAT Biology [Quiz] www.varsitytutors.com/mcat_bi...
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● lberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P . Molecular Biology of the Cell. New York, NY: Garland Science; 2002
● Murphy K, Weaver C. Janeway's Immunobiology. Garland Science; 2016
● Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
● Levinson W. Review of Medical Microbiology and Immunology. Lange; 2012
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#ninjanerd #TcellDevelopment #Immunology

[@ahmedelhenawy1998]

This was more informative than a 2 hour university lecture from a phd that has written his own textbook on immunology.

[@AestheticMEDICO]

Lmao yessss

[@namitachanda2124]

Exactly

[@nbme-answers]

Good research and good teaching are two separate, highly specialized and unrelated skills. Don't let anyone tell ya different!

[@Jabreup.]

💯!!! This guy is the best!!

[@gulanzafar7636]

Yup indeed!

[@katerbrig]

There's a big difference between an expert and an expert who can teach. Thank you for being the latter.

[@Almog6k]

This is how education should look like. Thank you!

[@sayalidukare135]

Plz make a whole series of an immunology leacture, it's very beneficial to us

[@DrZoonotics]

Actually, I have counted 8 Ninja Nerd videos concerning inflammation.

[@carolinerivera108]

I have been teaching this stuff for close to 20 years and yours is the best explanation I have ever seen!

[@princessjazz5767]

I really hope u r a good Professor because... most of the Professors just assume we know all of this. What ZACK did is TEACHING, what Professors in Uni's do is not TEACHING at all, i dnt care what anyone says.

[@abdoulazizdabo9064]

I like your humbleness and honestly, I wouldn’t surprise if yours also is the best.

[@TheFarahzz]

I know that you guys hear this a lot, but I am truly thankful for these videos. It has been 3 days now in which I haven't been able to grasp this concept when my teacher has explained it and you guys were able to do it in just 20 min. Much appreciated and keep them videos coming

[@elenasultan3627]

Good teacher. Shame that we can only see and learn from KZbin nowadays when the course has been paid thousands of pounds and no one there to teach, so I end up listening this guy here.

[@zuluzero4659]

Simpily amazing! My university lectures explain this in such a difficult way with 100s of slides and i almost gave up but watching your video motivated me that I CAN DO THIS!!!

[@lilchiliflake]

Thank you so much for this Immunology playlist as well as the videos on COPD and asthma pathophysiology! You helped a desperate biology master student to dive into therapy research on chronic lung diseases and to pass her oral exam with flying colors :D The Janeway was giving me a hard time to get myself oriented! You are my hero

[@leeannstorms3239]

I am a retired high school biology teacher and I enjoy watching your videos so much. You truly have a gift.

[@hamzenouh4911]

you guys are helping humanity. you deserve the highest award possible for education

[@yuqingcai3447]

I had been struggling with this part for many hours, and now everything is clear. Thank you so much, sir!

[@amdgarcia17]

Please please make more on the immune system 🙏🏽 your videos are very detailed and explained well for someone with no medical backgrounds. Mom has had auto immune disorder/RBCAPLASIA (acquired). And when we found out we were so lost and confused because her doctors would explain it in medical terms, we didn’t understand anything until we started searching and watching videos like yours. Truly appreciate you, I feel like I better understand her situation and feel confident explaining it to others as well

[@DrZoonotics]

Actually, there are 8 Ninja Nerd videos concerning inflammation.

[@amdgarcia17]

@@DrZoonotics Actually when I posted my original comment which was a year ago, there weren’t all the videos that are up now. Of course now there’s been more uploads since then.

[@xSEALs2007x]

Teaching cannot get any better than this. This is the best I’ve seen by far.

[@abdullahibrahim531]

no one in thizs world can b better than this guy.....thanks alot

[@patponggullayanon3075]

พ

[@joanapires8883]

A minha vida

[@paromitasarker151]

It is exactly what i was looking for. It synchronizes perfectly with the main text book. Thanks a lot. You saved me

[@humanitytribe1111]

Thank youuuuu! I spent hours trying to understand this in my text and you literally helped me completely understand it in a short period with zero confusion.

[@Welshwildthing]

So thankful for your videos! I struggle with my reading sometimes but you explain things so well, I wouldn’t get through some of it without you!

[@chandlereyre8792]

Thank you for the video! I did want to add/ask one thing, however. Current medical student, and we were taught that the downregulation of CD4 or CD8 on the thymocyte is due to the interaction between TCRs and the MHC 1/2. If the TCR (by chance) interacts with MHC1, then the corresponding CD8 will also interact alongside it, and CD4 is downregulated. If the TCR on a thymocyte interacts with MHC2, then CD4 will persist, and CD8 is downregulated. I guess this differs from your explanation in that you imply the CD's are what determines this varability and choice. But I believe the chance originates from RAG recombiation to the TCR earlier on. Thank you for such a helpful video!

[@uqunerds1180]

I love the way that you explain , oh god thank you sooo much for every things you saved my medical life❤❤☹

[@xclvrfip]

Thank you! I couldn't get this topic for the past hour trying to skim and read my textbook over and over again. I'm glad I found this video. Thank you a thousand times!

[@SpoonieSensei]

i have always been a little shaky on my t-cell development and this is honestly the most straightforward and comprehensive information i have ever come across. thank you!

[@MK-ih6wp]

Same. I have decent memory of what we learned back in school but never felt very confident about t-cells, until now!

[@KG-pt2sr]

Dude! You are a flat out BEAST/BOSS!!!! I'm an engineer and can't help but appreciate your mastery of what you're talking about. You're a natural!! Keep up the GREAT work!! Love this site - best site out there.

[@user-gg2ne4mm8c]

I just wanted to come back to these videos and thank you so much for single handedly helping me achieve my goals in my immunology course! I just finished my first year as a pharmacy student and your videos really helped me, thank you!

[@ftyuiokmn]

Been looking for a proper explanation of the T-cell development for quite some time now and I'm glad I came across this video! Goodluck to me analysing and memorizing all this to report in front of the whole class and our teacher. 😬 Aiming for that high score for the evaluation!

[@sliderulelover]

Excellent description of how T cells differentiate via the thymous and various chemical signals.

[@sashaschtein2690]

I can't express how thankful I am for this.

[@stellawu1768]

Bro, that was awesome. I can't understand jack in my immunology lecture and you just made it so clear and simple (well, it's never simple), but definitely manageable especially during these times where my exams are online I can't understand any of my e-learning lectures!

[@nightlythoughts4701]

I've been staring at my pathophysiology book trying to understand this for hours. thank you!!

[@sannahshah1115]

honestly, you are an angel sent down to us depressed and tiredlookingforanswers students. may God bless you :)

[@princessjazz5767]

GOD BLESS U MAN.... I dont know why we go to universities at this point when we learn more from KZbin than our Professors.

[@raynehentges5414]

I have been working on learning this information for a while and watching this video, everything finally clicked. Thank you so much!

[@dra.acosta7397]

I'm so amazed in the scrumptious way he explaine everything. Thank u sooooo much 😍😍😍😍

[@AGrant-eb5mr]

Thank you so much -- you cleared up my confusions! Your teaching is the absolute BEST!

[@madhavdhakal1715]

Wow you are expressing so nicely. I am doing PhD Biotechnology and I learned so many things from this video. Thank you for this video

[@MK-ih6wp]

I know we are all marveling at this guy's incredible teaching skills... but do you guys ever get blown away by the complexity of the human body? I just can't get over how intelligently our bodies are designed.

[@yaklub]

Dude, you keep amazing me. This r cell development video is outstanding. Humbled by both you, Ninja Nerd, and evolution.

[@tranll1]

Love it!!! This is the best demonstration for T Cell development so far!! Thank you 😊

[@SilenceInTheBliss]

Oh my goodness I want to cry this is so good. Thank you!

[@lilygyu6080]

You guys are life saviors thank you so much for every course you upload❤

[@dev-ir7ox]

This downright has to be the best way of teaching anatomy and physiology there is

[@shahiramohammadi7284]

Because of professor Zach immunology playlist I got 100 marks in immunology 😁Thanks to Zach and his wonderful team🥰

[@walebelayneh2892]

how you can keep all these things in your mind? is so amazing you deserve so much respect

[@mouhamedcherfi8202]

The video already relisted before 5 years ago but this is the best explanation I have seen thank you teacher you are amazing 💯💯💯

[@CarnivoreAnesthetist]

Who are the 48 people didn’t like this video? Probably immunologist somewhere thinking this physician assistant knows more about this stuff than I do ha ha. Nicely done great video. I practice clinical anesthesia. but, I have been addicted to the immune system the last 6-7months. Most of what I washed on other videos I have learned nothing from. Probably very basic for the casual watcher. I learned a bunch watching this video. Very good job do you have a true gift

[@sbtsbt4224]

Ohhh...thank u so much sir Zach.... U are just perfect....! I really enjoying learning by you and never get tired or bore... Thank u 🤗 Love from Pakistan...

[@layalitamesh2125]

It’s the last night before my immunology exam. You simply explained me 90 slides ❤

[@joudizawet7573]

Very helpful ❤❤❤ thanks a million.. I know that I'm watching this video after 3 years after uploading it but it really helped me a lot.. much love 🔥❤

[@latonaakaworkaholic_rn3502]

Dang I needed this lecture more than words can say. Thank you!! For real - THANK YOU! 💜🙏🏼

[@system3008]

This is insane. Wow so much respect understanding all this.

[@ameliajohson4329]

You've explained it so well, I was really confused.

[@darshinimalukar3246]

Perfection in teaching's every aspect. Thankyou sir. awesome video

[@user-yh4ky1cb9o]

OMG, I'm speechless. Thank you.

[@lucyforeman9950]

Thank you, thank you, thank you!! This was incredibly helpful!

[@hawraawhite]

I have a final coming and this video definitely saved me. THANK YOU.

[@suzanneanderson3193]

You have helped me so much in A and P 1&2! Thanks for making these videos! Sadhu!

[@mitochondria7554]

You're a great teacher After Dr Najeeb I follow your lectures..💓

[@user-dx1jr9es3m]

Great thanks for you Mr. Ninja we hope to complete immunology course with autoimmune diseases, hypersensitivity, tolerance and other important topics which related with immunity. Thank you again 👊🏻❤

[@kathb1683]

Glad to catch this vid! I’m a newbie. I’d be interested in learning how t-cells become exhausted!

[@mokukim7205]

Omg thank you so much for making this video, you helped me understand this concept much better!

[@aditijoshi4959]

Finallyy !! I got the concept !! Thanks a lot for this video :)

[@jacquim5134]

I'm a first year med student and I just finished watching your series of videos on immunology. Wow, you explained it all so well! As someone with myasthenia gravis I'd be interested to see your explanation of MG's effect on the thymus, t cells and what implications thymectomy to remove a thymus with hyperplasia would have on an adult.

[@bionium6976]

Mg is so painful i beleive

[@soumiasalhi1220]

Thank you sir for ur time and ur amazing explanation ! U helped a lot

[@ivanhdz503]

love the passion and love for medicine! great Job explaining this!

[@digitiminimi5730]

it's almost 2022 and i love you man, you made my life wayyy easier

[@dr.ayolizer8778]

Thank you so much ❤️ It's short and direct to the point To more of this💪

[@elfreixo]

Thank you so much mate! great videos and explanations!!! Keep up the good work!

[@AbdulWahab-eh3sq]

Fav KZbin teacher ❤️❤️ you're faaaaaaaaar better than all of my physiology teachers

[@vence84]

The whole thing is, there is no hard lesson there is bad teaching. Thank you soooo much, actually this issue was very simple i know that now because of you❤

[@jk..7707]

Helped me super a lot! Got me through it finally

[@mariammusri5640]

You are amazing! This was literally the best thing ever. Thank you so so much!

[@emmazblewski7837]

Thank you so much!! This was so helpful for me as a medical student :)

[@aayushbatra1147]

IMMUNOLOGY WAS VERY HARD TO ME BUT THANK'S TO YOU FOR MAKING IT SO MUCH EASY TO UNDERSTAND. CAN'T THANKYOU ENOUGH❤❤❤❤❤❤❤

[@marinara2596]

I could watch you for hours

[@maram5102]

Masterpiece! Perfect explanation!

[@hossamsaeed7088]

this is a pretty good and satisfying explanation ❤ thank you so much ❤

[@priscilamarcondes7635]

Thank you!!! You are reeeally good explaining!!! congrats for the talent!!

[@zacharygomes1843]

The marker capping and uncapping is soothing to my brain

[@gamelaalrohaidy3779]

Thank you so much you are a great teacher With great way to explain information

[@shaguftamalik649]

your way of teaching is amazing.

[@mohitk325]

Thanks for the videos. Hope to see more. Keep up the good work. Thanks once again

[@saeedsahebdel855]

I really wished you were our teacher each semester and each course! Keep going!

[@oscarortega1136]

This was seriously well made. Thank you

[@user-qc3uv8bu8b]

thank u, sending much love from Egypt

[@mateuslacerda284]

This was very helpful. Thank you, Sire.

[@aib7592]

You are the best seriously, you deserve much more.Thank you a lot. -Love from Turkey

[@TheEbuitrago]

I love your videos. Thanks for your time, greetings from Panama.

[@gulanzafar7636]

Yes it helped bro! I really needed to get this mechanism cleared,and it worked😇

[@sabrinademello2036]

Just perfect! Thanks, guys!

[@aimyclapano1933]

wow! Ninja Nerd Science..this is my favorite. thank you!

[@aqsa968]

very wonderfully explained THANKS ALOT

[@wolfie5470]

I dont know what I would do without your lectures! You are so great, guys! Thank you a lot!

[@TheAmmarKeylani]

perfectly explained. The only missing info you missed is the fact that it is NOT RANDOM where the stage of T cells become either T helper cells or T cytotoxic cells but according to a regulatory hormone from the liver reflecting the status of the body at the time of formation of T cells and its demands to which kind of cells it needs such as in yellow fever or Malaria or Dengue etc .. Thank you for an extremely simple and elaborate lecture! :)

[@elenemchedlishvili303]

Could you please provide reference? I have been searching for paper that describes the process.

[@aaratibhusal6486]

thank youu so much sir . but we need complete playlist on immunity . forever ninja nerd

[@rkndovianney1203]

Your have explained well sir . Thank your for sharing with us

[@bilalsafi1090]

Really helpful and easy to understand video, thanks a lot.

[@ThatConspiracy-Indeed]

I F love this guy, your teaching method is amazing bruh, kinda easy to snatch your knowlege in a kinda cartoon way

[@starfaith721]

You make it so easy literally. Usually i hate this subject cuz it's so hard to understand. But damn. Never stop making videos😭👍

[@morsz6829]

Omg love your videos so much, thank you and it’s so far the best one

[@davidteaster3953]

You are an awesome teacher!!!! Amazing stuff:) Thanks