Each time I am watching another lecture with Ninja Nerds, my heart fills with so much gratitude. I am sharing them with anyone I know. You are definitely a gift, Professor Zach Murphy, and of course, your entire team. I graduated a while ago, and I am still coming back to these lectures over and over.
@jamiebrooke9248Ай бұрын
actually, your heart fills with blood from what I've gathered from his lectures!
@agadooska9 ай бұрын
NAFLD is now called metabolic dysfunction-associated steatotic liver disease (MASLD), I think we will need to get used to the new term soon.
@pasindusangeeth3097 ай бұрын
Is it also called MAFLD ?
@mostafael-dya49169 ай бұрын
Thank you zach and to all your team members for this great effort.
@DrBlnDB8 ай бұрын
keep up the great work, thanks so much this helped so much no doctor in my college could explain it like you. Also love the new format for the lectures
@dennispo49984 ай бұрын
Hope you can do a deep dive on the most probable cause/s of insulin resistance (IR). I've heard of too much PUFA's causing structural integrity issues on the cell membrane itself; IR is a natural reaction of the body to too much energy availability via cross-inhibition of both FA and glucose use (Randle Cycle); wrong food proportions in the context of too much carbohydrates. Impacts of sleep, stress, meal timing, intermittent fasting, extended fasting, macros in breaking of fast, exercise, etc.
@Cacophonyofvoices8 ай бұрын
YOU... YOU ARE THE GOD OF PHYSIOLOGY. I'M A FAN.
@weerakoon19764 күн бұрын
Nice presentation. Interesting. Thank you ❤
@shivangisharma9706Ай бұрын
I absolutely love love love your videos. And of course I can see the dedication to put up such nice videos. Prof you really have passion for teaching and I love it. Thank you so much for you time and videos. They are extremely helpful and easy to understand with all those drawings and stuff.
@peuppeuppeup8 ай бұрын
thanks for u dedication🎉
@shahiramohammadi72849 ай бұрын
Zach is my super ninja hero 💐💐
@aakashkamat2658Күн бұрын
Thank you so much !
@Traversquip5 ай бұрын
Thank you🙏. My daughter was dx with T1D at 6 y/o, almost 16 years ago. I never really understood insulin resistance other than our endo. telling us that insulin is unable to process carbs, now I know why! Fast forward to now, she’s graduated from HS, went to Community College, is a Pharmacy Technician, working full time, and has gained ~130 lbs. She has experienced Tachnycardia and has Sleep Apnea, Chrohn’s (currently in remission 🙏🙏). She’s currently taking a GLP1 (haven’t seen a difference ), considering bariatric surgery but she’s so young 😔. But, I don’t see a way to ultimately improving her eating habits. I just can’t get through to her!
@layanalnosani95772 ай бұрын
Thank you so much for the amazing effort, but the new guidelines state that bariatric surgery is indicated for a BMI of 30-35 when accompanied by metabolic syndrome or other comorbidities, and for a BMI of 35 or higher regardless of comorbidities.
@JTmoto9 ай бұрын
Doing a literature review related to MASLD and obviously obesity, this video helped understand the concept way better. ⚕️✨
@Fisio-BitsАй бұрын
Expected a bunch of boring biochem, thank you for such an engaging and useful approach 👏
@trinztalusan84672 ай бұрын
Please do one for diabetic nephropathy
@SusanNyambura-f7b3 ай бұрын
Hi.please return the other previous video of diabetes mellitus...plus the complications
@AhmedKhaled-zy6er7 ай бұрын
You are the best of the best, man !!! 💓
@casualonemmo-player21678 ай бұрын
Regarding the clogging up inside of the blood vessels... if you loose a lot of weight, and get into a normal bmi range... will most of the clogging get removed by itself? *or is that "damage" permanent?
@HaleenaSeller2 ай бұрын
Losing weight and achieving a normal BMI can have significant positive effects on your cardiovascular health, but it doesn't fully reverse existing plaque buildup in blood vessels. Here’s a breakdown of how weight loss affects clogged arteries: Plaque Reduction: Weight loss can help reduce the progression of atherosclerosis (the buildup of plaque in arteries), but it doesn't completely remove existing plaque. Plaques can stabilize and become less likely to rupture, which reduces the risk of heart attacks and strokes. Improved Blood Flow: Weight loss often leads to lower cholesterol levels, reduced blood pressure, and better blood sugar control, all of which help prevent further plaque buildup and improve blood flow. Partial Reversal: In some cases, lifestyle changes (like weight loss, a healthy diet, and regular exercise) can lead to a partial reduction in plaque size, especially if combined with medications that lower cholesterol (such as statins). Permanent Damage: If significant damage or hardening of the arteries (from calcification) has occurred, that part of the damage may be permanent, but the risk of further progression is reduced with healthy lifestyle choices. In conclusion, while losing weight can greatly improve your overall cardiovascular health and reduce future risks, it doesn't completely remove existing clogs in the arteries, especially if the damage is extensive.
@anjalimaurya_46799 ай бұрын
Your video are really helpful to everyone 👏👏💫💫
@valviv9 ай бұрын
Great video, thanks Ninja Nerd!
@marouane.pАй бұрын
you are just the best !
@judge16945 ай бұрын
THANK YOU SO MUCH SIR 🙏🙏🙏🙏
@jbstepke35 ай бұрын
You are incredible. How do you remember all of this information. :)
@vinayakkapatral424616 күн бұрын
Lovely!!!!!!🎉🎉🎉🎉🎉🎉
@ok61098 ай бұрын
Thanks❤❤❤
@serenitysel8 ай бұрын
Man the new sleeves look so cool!
@brofred76239 ай бұрын
Благодарю вас
@Lian42-v309 ай бұрын
This is awesome!
@subhdrasahu32734 ай бұрын
Thank u sir 💐
@finncsprivatechannel22159 ай бұрын
With regards to meds, antihistamines, especially centrally acting, are a massive cause of fat-specific weight gain and insulin resistance. Drugs like olanzapine will cause the most weight gain owing both to potent D2 and H1 antagonistic effects.
@thefallenking13 ай бұрын
Really good
@muqtarjamaegal60714 ай бұрын
If Metabolic disorder causes Insulin resistance why without exercise cause dm does it have pathophysiology
@eveberry92157 ай бұрын
thanks ninja nerd
@EvelineHendrickson5 ай бұрын
I am looking for help due to thyroid removal because of cancer, it has been years and still I am overweight, I do not eat any type of sugar includes any type of sugar and carbs, eat only 1 time daily. I just wish I could do something to help myself. I take Unithroid 112mg daily that’s all the meds I take.
@MathiasSnick3 ай бұрын
Have you consulted an endocrinologist about this? May be an obvious question, but I don't see anyone else who could help you with a treatment plan, your problem is too specific for any other health professional
@amirabbasbaharfar23283 ай бұрын
✅ Done
@TheSeahealth7 ай бұрын
I really like your explanation, Prof. Zach, especially biochemistry and metabolism, but you have to consider another concept about obesity, namely that it starts with hyperinsulinemia due to high carbohydrates...thank you
@TheSeahealth7 ай бұрын
not only just calories
@TheSeahealth7 ай бұрын
how ketogenic diet?
@kiankaveh11585 ай бұрын
This is merely a hypothesis called the carbohydrate insulin model which is of high debate in nutritional research and more often than not its been shown to be disproven through clinical trials and inpatient experimental data with metabolic wards and isocaloric diets.
@sanjith11799 ай бұрын
6 th like sir, I'm pratheesh from india( tamilnadu).big fan of you sir.say one hii sir.
@sajiruddinsk81298 ай бұрын
Allways follow to you.
@sciencesimplified38909 ай бұрын
I think this video should be re-made. There are different theories of the pathophysiology of metabolic syndrome. Many argue excess calories cause hypertrophic adipose tissue to undergo lipolysis, releasing Free fatty acids(FFA) into blood where it enters skeletal muscle (forming DAG which inhibit PKC which inhibit the insulin receptor) and also the high flux of FFA entering the liver up regulates VLDL secretion. The biochemistry defending this has been established in vivo in humans using NMR spectroscopy. Other evidence is the actos medication increases adipose tissues capacity to store FFA, reducing lipolysis and reducing these symptoms, also on the opposite spectrum the disease lipodystrophy reduces adipose tissue capacity to store fat, increasing lipolysis and FFAs entering blood and exacerbates these symptoms. I need to emphasize, im not saying the obesity and FFA theory is dogma, however to say the adipokines are definitively the cause I personally believe is inaccurate and should be emphasized is theoritcal
@sheilaherrera85849 ай бұрын
How about you make your own video
@kiankaveh11586 ай бұрын
@sheilaherrera8584 never let personal bias of liking Zach get in the way that here are huge debates in energy metabolism and nutritional research mainly the CIM vs CICO. And that there is 100% possibility that any of these theories is plausible
@chilrl7425Ай бұрын
Pretty easy fix. Animal based diet high in fats, medium protein and low in carbs. Doctors need to start looking at root cause, not just settling for "eat less, move more". Not good enough.
@Coach_Sooz8 ай бұрын
I love you
@jeaneroldi4032 ай бұрын
bro do you train? you look built
@GMU202327 күн бұрын
😊❤
@otuokwulillian90925 ай бұрын
❤❤❤
@billyhw54924 ай бұрын
Saying that obesity is caused by calories in exceeding calories out is like saying that edema is caused by water in exceeding water out.