Pharmacokinetics | Drug Metabolism

[@onesmuskennedy3400]

Should pay my tuition fee here

[@wanahmadamsyarzafrie8080]

Man I love the new quiz-types questions at the end of the video, they really test your memory, the videos/notes and illustrations are super great as well, thanks Ninja Nerds

[@NinjaNerdOfficial]

Glad you like them!

[@naderahmed7938]

Please keep adding more quiz questions they really help solidify the lecture also thank you @@NinjaNerdOfficial

[@marquisdesade6156]

The thing that I absolutely love most about your phenomenal teaching is THE REPITITION, it does incomparable WONDERS for students MEMORY and so many teachers just pass through a term once and stroll on,, making it easy to forget

[@khalilahd.]

I don’t know how you do it but you make complex processes so much easier to understand! Definitely saving this for my watch list! 🙏🏽💜

[@gotenks81]

I've unfortunately pursued a career path completely different from Medicine and now, at 43 yo, I feel an insane frustration, every single day, because I'm not happy at all with my job. I love so much Medicine, Pharmacology, Biology that every time I get into this topic people around me always say that my eyes start sparkling. In my spare time I'm studying on my own since that's the only way I can find a tiny bit of happiness. Your videos are such a refreshening, delightful caresses for my mind that I'm devouring them one by one. Thanks for this great work!

[@AbuhurairaJamil]

Never have I ever listened to pharmacology lecture for 40 minutes straight until now😂. Hats off man ❤

[@automntl]

The fact that these got uploaded just in time for my pharm course is excellent. Im not religious, but I know Jesus loves you. I met him shortly after watching this.

[@Ronaldo71543]

Wtf 😒😅

[@FadumaAbdullahi-o4m]

R u serious? 🙄

[@automntl]

@@FadumaAbdullahi-o4m wallahi

[@alimenhem3348]

Sure... its getting overused now

[@איתיעובדיה-ו4ל]

By far, you are my best prof. in med school!

[@MichaelBrown-sf6py]

Mr professor taught this today and had me completely lost and I didn't think I would ever understand this. But the way you break it down makes sooooooooo much sense so thank you.

[@iyayii]

I have my pharm midterm exam in four hours and was confused on the topic. My notes and lecture slides didn’t help. Your video really helped break it down and make me understand the topic more. Will start watching your vids from now on!

[@lydiakaoudjt9369]

Thank you is never enough for your efforts dr ninja nerd. May Allah bless u and all your beloved ones u are making our life easier thanks a lot

[@shaikabdulrafey4981]

Bless with the greatest blessing Aameen

[@jaygala9420]

I never got general pharmacology right until I watched your videos. My 2nd year final exams are going on and your videos are saving me and helping me to write something in exams! Thank youu Ninja Nerd Team and special thanks to you Dr. Zach.

[@riogrl324]

These videos have opened my eyes! FINALLY someone explaining it without confusing the masses 😂

[@marianamelo9672]

these classes are GOLD! your teaching makes us excited about learning, thank you!

[@camillepage208]

Omg THANK YOU THANK YOU THANK YOU!!! I am studying to be a therapist & am struggling with my psychopharmacology class. You have helped me understand way way better than the book could. Thank you so much for breaking this down so it’s understandable to people who have 0 foundational knowledge like me!

[@ssburrus]

grateful you are single-handedly teaching me my first few weeks of PA school :')

[@AliRahat-u2w]

You are just a life saver for medical student, who find these concepts complex to understand. You are just amazing to memorize this huge sum of knowledge and delivering it with such smooth flow. May God bless you❤

[@rashmijagadeesh5753]

You made such a complicated topic into simpler job that I never forget the concepts which you taught . I admire your efforts and thank you so much 👍

[@anulikaizuchukwu7198]

I have struggled for so long to understand this phase 1 and 2 reaction. This video made it so easy. Thanks alot!

[@brazuca14]

I’m Acing CRNA school thanks to you!!! Thank youuuuuuuu.

[@nnajilight8008]

Ninja nerd you don't know how popular you are among Nigerian university students...bless you brother

[@taliarabelo4034]

Hello! This class helped me a lot, I'm Brazilian and I was having a lot of difficulty understanding this subject, but with your incredible didactics it's impossible not to learn. Thank you very much!

[@coconut2262]

I was actually terrorised in med school when my teacher taught us this..couldn’t understand a bit and when asked about 1st pass metabolism in my test it moved me to tears to write what I had in my mind.. Thank you so much for this..🙏

[@tinkerfae1977]

Zachary your amazing I have turned my uni colleagues onto your channel and they are all so grateful , I have even been given all clear to use your website in my references xx ❤

[@calvinklein6903]

This dude right here is the GOAT!

[@anouckvanes]

You are really the best teacher I never had! Please keep up the good work

[@peaceomada9488]

I like the fact that you try to make everything simple and make everyone follow up

[@ngumkapapi7222]

Ninja Nerds a godsend to the medical profession

[@muhammadusama1347]

Am addicted to Ninja

[@Jaycar1997]

@ninjanerd First off I wanted to say that I love your videos. They've been keeping me afloat through med school. I usually don't comment at all but at 11:50 in the video you talk about codeine in slow metabolizers and in those cases I think it would actually be more beneficial for the children with low metabolism because codeine is a prodrug with the active metabolite causing respiratory depression. So it would actually be ultrametabolizers who are at risk for respiratory depression since they're turnover rate into the active metabolite is increased.

[@mamalyfarahmand592]

thanks to you and the team that is supporting you

[@22.Satty.]

Sir you are my favorite teacher for rest of my life thanks a lot 🙏

[@darlingrunnerpt3342]

This makes sense as to why I have so many side effects with medications. Must be a very slow metabolizer. Had horrible side effects on 3 different DOACs. Hematologist had no idea why.

[@JJadx]

apparently some people think doctors shouldn't google stuff. i'm so glad my doctor does haha. ain't no human remembering every drug interaction. great bg asmr for drawing once again b.t.w. mr ninjaman.

[@mhammedsuiman6493]

Thank you so much 💓 💗 I have an exam in pharma next week ..... i can't answer the cases questions but you help me...... thank you again ❤ Great explanation 👌

[@saffaayub4570]

Grateful that I found them right before exam!!

[@manalemad1589]

clear and informative that's what a med student needs endless thanks for the ninja nerd staff we do appreciate your hard work ❣❣❣❣

[@ummkulthumabdussalam6726]

Hi, Omeprazole is an inducer not an inhibitor, thanks for the amazing class ❤️

[@fearlessgamershubandroidga9305]

Hats off man. You're the best

[@tahaalameri4832]

I think that the codiene become toxic when you metabolize it more, because codien metabolite is morphine, 11:50

[@doc_matox]

Just though of commenting on the wonderful videos i have watched recently. Thank you so much for making my Pharmacology journey going smooth❤❤

[@ashu9178]

Jazakallah khairan kasiran kasira 💝✨️

[@fatimah-2]

I followed you since 3y from iraq , keep going i respect you so much

[@Ronaldo71543]

May Allah heal the Iraqis whom suffered of cruel bush

[@fatimah-2]

@@Ronaldo71543 Amen

[@minutemovienight9094]

Thankyou so much Ninja Nerd! Your are doing great work. I will repay you one day

[@dominicbarandica6717]

Add more questions going forward that was super helpful for a check of understanding. Keep up the great work. 😊

[@Taemna7]

I have no word to cheer up this angle😇😇😇😇😇

[@juanmartinvillamea378]

the explanation is on point, as always

[@noahelia1579]

Allways a fan of these pharmacology videos! Such great content. I'd love to see one on pharmacogenetics and some in depth content on polymorphism of drug metabolizing enzymes.

[@Jay-lq8ly]

Best explanations!! You simplify all topics❤

[@mirror9lifer]

I have a question regarding 18:48 - when turning a pro-drug into an active drug the effect is vice-versa. So an inhibitor such as Omeprazole would become an inducer, no? But then at 24:24 in case of a pro-drug activating we still have Omeprazole being an inhibitor. Not getting my hopes up that someone will see this comment and help out :)

[@sabaiqbal8873]

Super great videos. I understand every bit of your lesson. Thanks are not enough for your efforts. Superhero, an ideal teacher.

[@karmagaming7112]

Love u 3000 ❤️ We are Ninja Nerds 🥷

[@PeaceOffmate]

May Allah bless you and the entire team with immense success

[@linaaa2535]

Please make more pharm videos! These are amazing, thank you so much!

[@rebekahparris2425]

Thanks once again, you make learning so exciting and this isn't even necessary for my studies, just out of curiosity I wanted to know about this. I also love the Q&A at the end. ✌🏽🇹🇹

[@sharminbala]

Very nice! Clearing concepts

[@crespomwakapande6299]

Thanks very much u make concepts easier

[@coconut2262]

😭😭😭😭😭😭 I can’t thank you enough sir..

[@ShahMehrunnisa]

Oh! how much I love this man and his expressions🤌🏻😉

[@CloudBluesky-g7r]

Thank You ❤

[@AboobiadaAlmohager]

I love your science prof. Zach ❤❤

[@Lusungumsimuko5816]

Thank you very much This very helpful and unforgettable 😊

[@samhasanpour1628]

Love love loved it! Much appreciated🎉

[@MatimbaHope]

Yhooo this guy is something else❤️‍🔥❤️‍🔥❤️‍🔥

[@sr689]

Very well explained. Thanks

[@RobotChitti-j7g]

Thank you sir, may god bless you ❤❤

[@alexmukisa]

I appreciate you so much doctor 👍

[@hamlilasma5434]

thank you infinitely

[@carolinaruiz6227]

eternal gratefulness

[@eljubourii]

Great explanation 👏🏻👏🏻👏🏻❤️

[@BaoTran-ls7oy]

Thank you for great explanation and visually appealing board content! In phase II biotransformation, there are additional two substrate which are Glycine and Ribonucleoside/nucleotide synthesis. Can someone clarify this? 😕. Thank you

[@PETEYBOY954]

This is so interesting.

[@doctortobe7345]

Thnk u 🙌🙌🙌🙌 u're the best ever

[@118_mirunaliniprem8]

Nee nalla irupa ya manusha ❤ love from Tamil Nadu India ❤❤

[@Shahzadraza333]

Good explanation 👍 Just to notice, for CYP 450 inducers you mentioned the exls of CYP inhibitors and for cyp450 inhibitors the exls of CYP inducers are mentioned in haste. It is overlooked!

[@AMDALReviews]

Thank you so so so so much sir 🌷

[@حذيفةأحمدسعيد-ح2ر]

Thank you, you are great.❤

[@urmilakumari6328]

Amazing lacture!! Make lacture on pharmacodynamics plzzz

[@tabatakalhelo3993]

Thank you doctor

[@biybimaryamjoldasbaeva506]

THANK YOU SO MUCH

[@niyadeo7970]

Amazing!!

[@PerfusionPrime]

Thank you ninja nerd

[@bobj9923]

Dr zach, what's your specialty? Cause you make videos about everything medical and it's mind blowing!

[@LoluOres-r3k]

Truth is, all this is regarded as basic knowledge in the medical sciences! Specialists go even further but in a narrower scope.

[@tilwedie23]

Do one on umbilical hernias or all the different type of hernias that can happen in the abdominal region. 👍

[@zizojaezekeom3565]

Amazing video ❤ i have a question please : in case of activation of drug, it passes through the two phases too or it doesn't?

[@ChesnaT-u8t]

Thank you so much 😢😢😢❤❤❤❤❤

[@prashanth-py9jc]

Superbb sir always awesome

[@mohammedabdulrehan6643]

Thanks a lot sir

[@саньокшевчук-щ1й]

Hi Bro, I am very thankful for your superunderstandable explanations and I may seem abrupt, but can you make a video about all fossa( infratemporal, temporal, pterygopalatine and so on). Please!

[@husseinsaied6061]

U R amazing ❤

[@ranakronfol]

i have an exam tomorrow and if it wasnt for u id get an F i swear, thanks alotttttt

[@rakeshshah1074]

U r amazing sir

[@akinwonmioluwaseun6925]

I doff my cap Prof!!!

[@wonderful-wafwaf]

I knew mark Kerr the smashing machine was smart but wow. this is what he's doing now!

[@Miah-jd1si]

fantastic

[@noorfalak6341]

26:26 in lippioncot pharmacology illustrated reviews 10th edition, it iswritrn that phase 2 reaction also involves addition of amino acid .i.e., amination.... So, what will b the right answer if both sulfation and amination are involved?

[@fatimaverse7892]

Thank youuuu

[@kabouch]

3:02 I would think about another probability of metabolism that is when a nontoxic drug like paracetamol is sometimes converted into the toxic compound NAPQI.

[@shryf742]

Thanks alot Professor Zac Murphy😊

[@joyasia2752]

Good job