Pharmacokinetics | Drug Distribution

Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/pha...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Pharmacokinetics, specifically discussing Drug Distribution. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Drug Distribution Introduction
0:54 Factors Affecting Distribution
8:00 Protein Binding
17:05 Volume of Distribution
25:25 Drug Distribution Practice Problems
29:18 Comment, Like, SUBSCRIBE!
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health.
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#ninjanerd #pharmacology #distribution

[@hesten9648]

I bet that I am not the only pharmacy student out there who is super grateful for these videos❤😂 Thank you so much!!❤

[@reema1761]

SAME!

[@sujyotsharma]

Same! lol

[@prachetatamhane699]

Same here 😂😂

[@kulsoombizzle8553]

We r we r

[@denise9406]

Bro😂😂

[@colemanhelm6678]

These pharmacokinetics videos are coming out literally at the perfect time. Looking forward to metabolism and elimination.

[@katiebowlerRN]

I totally agree! Perfect timing.

[@yousifmohamad6161]

Literally !

[@lydiakaoudjt9369]

Thank youuuuuu so much

[@ahutamorris]

Now it's 3 years following you and I have gained a lot from you. Watching from Kenya (Nairobi).

[@mikegox2275]

All your videos are very informative. You are the only person born in this world to help medical students, doctors, and even professors too. CONGRATULATIONS!!

[@pascival6468]

Yo add nurses

[@jadec9733]

This needs to be added to the pharmacology playlist

[@NinjaNerdOfficial]

Added! Thanks for letting us know! - TG

[@humanicgenes8825]

Much love from Zambia 🇿🇲🇿🇲🇿🇲

[@mohammedisak4645]

Masha Allah I'm from Somalia🇸🇴 We proud of You Me and My friends For your Hardworking Thank you For Your Helping us With Out you I'm sure that i can't know something About Medicine. Thank you.

[@adiljb5943]

Hi bro also I'm here from somalia I'm in Mogadishu and I'm in mi 4th year of medicine without this professor I'm nothing

[@alluparantha]

You were put on this earth to teach. Honestly, thank you so much.

[@chaitrakulkarni4716]

Hi, I'm a pharm D student from India and your videos have been very helpful to understand the basics, and I'll really appreciate if you would explain a little about this pharm D course cause even though I opted this course I've been a little confused and couldn't get much info from our professors. So pls if you could consider helping me that'd be great. And thankyou for these amazing videos!

[@krishagandhi2150]

Which clg ?

[@brolistic87]

I'm studying occupational, safety and health. One of my required classes is toxicology, and this video is a lifesaver. God bless and Thank you for your contributions sir!

[@ricknimusiima6571]

Am doing pharm D, Dude you’re dissecting and simplifying every challenge I had in kinetics

[@emaderecichei3712]

I had been struggling to understand the protein binding drug until I saw your video. You are a very good teacher! Thank you and God bless you!

[@hussainahmad6457]

It was my desire to learn general pharmacology from u so now I m happy after seeing these types of lectures love from Pakistan kpk khyber❤❤

[@mahmad1273]

MashAllah, brother Zachary. May Allah bless you more.

[@charlesfavour5640]

Thank you sooo much Zach and the whole Ninja Nerd family. You are a blessing to students worldwide. From Calabar, Nigeria.

[@kryptonite654]

i am 1st year medical student and i am super grateful for your videos. It's helping me a lot to understand my course.

[@poojajollin8647]

Hi .. I have been preparing for my Pharmacy exam and all the points mentioned here is very important to remember and is also easy to understand. I have been looking at diff other videos as well, but nothing as clear and well explained as this one. Thank you very much!

[@stavhen7753]

You're a life saver! thank you so much for the effort you make in making these videos!

[@AndrewSBoston]

I am a second year dental student and these are literally a GOD SEND! Thank you so much Zach and Company!

[@priscandimila5711]

For real….Ninja nerd is out here saving our lives!

[@nouraraji1418]

I am a med1 student and its the first video of yours that I watch, definitely won't be the last .

[@elijahkurien9941]

At the end of the unit could you do a video on a case study on a drug like Tylenol or Aspirin and how its pharmacokinetics affects its distribution?

[@lindseyrhodes2739]

just started pharm in pa school... perfect timing with these videos getting released!

[@wizonceluv6377]

I literally had this lecture today!! great timing!

[@iamsufyanali]

You can be the best teacher in the world. I just love your videos. They really are helpful. Can you please make videos on the remaining topics of the LIPPONCOTT?

[@muhammadsulaiman6023]

Zach you really made it easy.

[@feliciasmith7170]

You are simply incredible! Your teaching style, your content organization, and especially your doodle of a heart. Thank you again for sharing your gift!

[@petarvukelic2091]

Can you please do a video on gaba receptors and glutaminergic receptors? Thanksss!!!

[@rileypage1109]

Thank you so much! This was incredibly helpful. This video just made my day! You are an angel sent to help me succeed in PT school. Keep up the amazing work!

[@Magnificento03]

thank you so much Ninja , its really helping. i wish you were my teacher.

[@marouanelsayed4976]

the coolest doctor in the galaxy ❤

[@bradwarr7570]

Great brother, really like the new style and podcast type questions at the end.

[@missh6773]

Thank u so much you are Amazing as always ,,please do more of pharmacokinetics videos and solve more questions ❤️❤️❤️❤️❤️💐💐💐💓💓

[@LondonBurg]

An important concept about VoD to note is the definition of VoD: The APPARENT volume of distribution is the theoretical volume of fluid into which the total drug administered would have to be diluted to produce the concentration in plasma. It is not the actual volume that the drug is distributed within the body because that would limit the volume to apprx 42L in the average human. This is why we get numbers in the thousands. (Edit to include ex.): If you needed a drug to be at 100mg/L in the blood and you know the VoD of the drug is 200L you would have to give 100mg/L x 200L = 20,000mg or 20g of that drug to achieve the desired concentration in the plasma Assuming no first pass metabolism). please correct me if I am wrong. Happy studies everyone.

[@LondonBurg]

Ps. Great video

[@jhoanrodriguez7496]

Beautiful lecture. You are saving me in PA school :D

[@soul8156]

You are the best, thank you so much 💚

[@pascalinamulu5307]

Thank you soo much, you have explained it so well, l now understand. Looking forward for you to do Metabolism and Excreretion videos because l have exams next week 🙏🏿

[@reema1761]

Man you’re a life saver !!!! THANK YOU

[@user-vu5yh4iq8o]

You, my friend, are an absolute legend.

[@evasimeonova5381]

Very useful and simply presented. Thank you🫶

[@forozanmo7520]

Please make more lectures. You explain very well

[@makemoneyonline_888]

Thank you so much for these videos❤

[@josephgrantabbam4618]

Very simplified and easy to understand. Thanks bro

[@mohamedkhalid306]

Add this one to the pharmacology playlist, looks like you forgot it

[@aaronsempa5820]

Noticed this too

[@tsabeehadel9754]

You are agift to humanity zach 🌷 Thanks

[@anikarahman5467]

He visualizes better than animation. Hats off.

[@iamsufyanali]

I just love your videos.

[@kayareii9446]

3rd year pharmacy student here u rockkkkkk!!!!!

[@sabzzz444]

What determines whether a drug wants to be bound to albumin or not? Thanks for the video, amazing as always!

[@tseyangdorji8689]

Thank you!

[@hajarb4588]

Thank you so much

[@forozanmo7520]

missed distribution part in class Thank you for explaining

[@nkechimakata3254]

Thank you very much sir

[@nena2172]

You are really really saving us ,thank U so much ❤

[@yogireddy7209]

Very understandable and easy to remember thanks 😊from Indian doctor

[@dent0osh]

Your videos are the best! I can’t thank you enough 🥺✨✨ But wish this video was in the pharmacology playlist after absorption video.. it’d make it easier for us to find it 🤍

[@negasumelaku6083]

thank you Dr.

[@lenal6342]

It was awesome! thank you so much. I have a question please: regardless of the following factors affecting the distribution, how to know whether I need the drug to be highly distributed or not into the bloodstream?

[@nikolaivikturski4557]

Thank you for another video 😊😊👌

[@Alien61747]

Thank you so much 🙌

[@molanaroomi7431]

Sir along the study we also laughing .....great sir

[@userno695]

Thank you for all these lecs they are very helpful I also really liked this shirt i want one

[@ogbeidekelvin]

Thank you leader

[@dibyasattwakarmakar]

Thank You , Sir 😊

[@hidayatullah873]

Kindly complete pharmacokinetics as well pharmacodynamics

[@angelpetersvlog2337]

Thank you

[@anwarbajwa9702]

Very helpful Thank you 😊

[@irtamalik1778]

Your "nooo" after 16 mins made my day. Stay blessed ❤😂

[@Die_Empty.]

NINJA you forgot to put this vedio on your playlist😯

[@Medperfect]

thank you

[@musharafkazmi7550]

Thank you ❤️

[@salimseleman4552]

You are super Genius 🔥✊ Thanks so much🙏

[@ladypinoy7352]

this is super helpful and engaging! thank you, you beautiful soul ❤

[@Coconinga]

Excellent

[@shafiullah8965]

Wow Zack really makes confusing topics So easy ❤❤❤❤ Gratefull To you and your team members .

[@sreejacharanya1460]

Thank youuuuuu sir

[@najyakawsar5708]

Professor pls cover all Pharmacology topics we need such explanation I mean the topics which is still not covered by u in Pharmacology.

[@ioanarotariu136]

thank you a lot

[@onejihanwasfi]

You are my hero, thank you ❤

[@user-iv8bd6ze5k]

So helpful ❤

[@dhivakardharmeswaran4020]

We are God's gifted to listen to your videos.

[@doniamohamed8132]

you're a life saver!!!

[@pascival6468]

You are a life saver

[@fatimaqueen5372]

super conceptual video

[@priyambadabejladdumotu3389]

This video was so much fun

[@harivigneshumasankar3050]

Enjoyed this!

[@sedasoon]

Another amazing video

[@asadullahkhan8727]

I didn't just give the like, You actually earned it Bro❤️

[@rawanshaker6631]

thank youuu for ur videossss

[@fatimanaveed5269]

Tysm ❤

[@rumaisariyaz4157]

Could we please have a video on Amoebiasis Love your videos!😍

[@042mohankarnati9]

If anyone sees this this I need a doubt answered albumin is a charged molecule so that also says that the drug bound to albumin is also polar so how does the albumin act as a reservoirs if the drug is ionicly bound to it?

[@user-tn2ft7zt5j]

Best clere vidos for drug distrbution thanks

[@TheLorka0]

Impressive!!

[@rawanabbas6919]

Can’t thank you enough 💕💕💕💕💕💕💕💕💕

[@letsthink2599]

2nd yr physiotherapy student here and i know i would have failed without zach

[@smithiaanmol1371]

love your style big fan of u

[@gibrilladumbuya355]

Hey Zach can you please do a video on Amniotic fluid embolism secondary to DIC More on the physiopath and management Texting from Sierra Leone 🇸🇱🇸🇱🇸🇱🇸🇱🇸🇱

[@dinaayad4891]

amazing amazing

[@alderamin1402]

THANK YOUUUUUUUU

[@jeongminchoi309]

Are solubility and permeability the same? I think the solubility you explained refers to permeability here. I've heard the solubility and permeability tend to inversely proportional, so I think it's different concept. I am little bit confused. Please explain. :)