Metabolism | Triglyceride Synthesis

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Ninja Nerds!
In this lecture Professor Zach Murphy will present on the process of triglyceride synthesis and all of the associated enzymes involved. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #FattyAcidSynthesis #Metabolism

[@annaskakic4642]

I think you might just be the reason I'll pass my Biochemistry exam. I will forever be thankful.

[@mandychin7346]

I shall never attend lecture ever again

[@shanzakhan3602]

Im a medical student and ur videos have really helped me alot thank you for these awesome videos now i really understand biochemistry cuz of you :) Also i will appreciate if can make videos on proteins metabolism as soon as possible thanks :))

[@hannahgoldstein8760]

Currently prepping for my biochem final in grad school and just wanted to say this channel has helped me so much this semester! I think I will frame all of the drawings I made from these videos. Thank you thank you thank you!

[@biswaamanpatra]

Ur the foundation of my Knowledge....thanks sir for making medschool interesting

[@richanarayan5166]

I wish there was no attendance necessary in my college!! This channel is enough to learn biochemistry!! ❣️🙏 Lots of love from india 🇮🇳🇮🇳

[@vanshikavikramsingh3953]

You don’t know what your existence means to us….. we love you thank you….

[@safiullahkhan9472]

sir please zoom out the camera in the end so that we could take a screenshot of the lectures. thanks

[@ahmadsahil2157]

Agreed

[@ishaanchandorkar]

@@saeeda4517 How do you know he is an Indian?

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@@ishaanchandorkar becuz only Indians and Pakistans call people sir and speak to them as if they are superior then themselve.

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@@saeeda4517 Wow... it's amazing how you have such stupid stereotypes... Grow up ffs

[@hihowareyouiamfinethanku7102]

@@saeeda4517 moron

[@SoulReviving786]

Zach you have helped millions of students in making MBBS easy ❤

[@mitochondria6254]

It’s really satisfying to take nap in biochem lectures after attending ninja….

[@miriamwilliams9603]

I honestly stopped going to classes. I just watch your videos! God bless you!!!!

[@1Mrstrike]

I'm first year medical student in Brazil, thanks a lot for this biochem playlist!! We both are visual learners so it's easy to understand your explanations! :)

[@moonlight8854]

Yo showed the beautiful side of biochemistry, it makes me love it, and it is unforgettable from my memory after understanding it. Thank you🌸. I pray to God to comfort your heart and make you happy as you do with us 🤲💕

[@sharafina97liner]

you are honestly the reason why i love biochemistry! i actually hate and despise chemistry all my life but all your videos are so great in explaining every process in our body and right now my favourite and top scored subject in medschool is biochemistry! T_T Thank you so much you're a life changer really

[@NinjaNerdOfficial]

+cupcakechip So happy to help! Glad we were able to make you enjoy it!

[@kamalabdulrazak6449]

I am medicine student and I am preparing for my exam by your videos I had watched the 30vvideos of biochemistry and until now I didn’t found any one better than you in explaining biochemistry

[@riakgarangjok1064]

One of the best doctors I have ever seen, Your videos have really helped me sir and keep it up

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As a medical student your videos really help me a lot. Biochemistry is so complicated and I learn it more easier than lectures because of your videos.

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Ur like osm and ur lectures literally helping me alot can't imagine my biochemistry with ur channel Thank you sooo much😊

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i really like how you explaining the things which i can understand it clearly. thank you for the great videos!!!

[@fawazal-abdullah4039]

Thank you for making me pass my biochemistry exams with your lectures , i love you man 💜🙏

[@shaniewright3509]

Loved this video! You explained this process very well and I was able to make sense of it all. Thank you :D

[@mm_me]

I swear this guy saved me, I'm extremely grateful for this channel 🙏

[@jasperjoshuavaldez2956]

Thank you very much! It is a great help as I prepare for my comprehensive examination.

[@chillyzibra7836]

I still cant believe that this is free.. thank you sooo much

[@juandrayo]

So happy I watched the fatty acid synthesis and oxidation videos you advised!

[@alirezaahmadi1777]

Best ever , love your concepts and how u make it easy ! Great job ✅❤

[@seren1104]

This video made it so so clear thank you !

[@nennoucheikram906]

You make it so simple ❤ thats awsome 🐼 thank you it really helped 💙

[@pq2552]

Awesome videos! I felt like I'd never get metabolism. Thank God I found you💕. Please male vid. About nucleotide metabolism and phospholipids.

[@user-qt4zq1fc3b]

OMG THANK YOU, you have made a subject I dread easy to learn and enjoyable

[@drvonyt8897]

What an excellent video, just like all others!

[@urbangustavsson525]

Many thanks to you! You are great! Keep up your good job!

[@malirax354]

thank you very much Zack it was so helpful as everytime

[@AAABBB-oq3rk]

that was absolutely fantastic explanation for that process thank you so much 🧡🧡🌹

[@varnika3140]

You are a literal life saver amazing video!!

[@jena_r8178]

Thank you 🙏🏼 great explanation 🧡

[@user-oe9nc9ex1w]

thank you, best explanation of the situation !!!

[@davidtagauri2034]

Great work, thanks for every video

[@chhavirawat5500]

Thankyou sir. This vedio is very easy to understand .Very nice explanation. 👍

[@msmakuack6064]

thanks so much, this is very helpful. may God bless u

[@tashachiks2663]

Omw this is so understandable ...please please please do a protein metabolism video series

[@peachyjeffrey2392]

you're literally a Harper's Heroes as your shirt says...I can't understand the book hahaha thanks alot man! i dont skip ads because i love this channel and I want you to keep growing this channel!

[@SeptimusCreed]

Great video as always. There are a few things I wish you'd mentioned. First of all I only learned later that Glycerol 3-phosphate is made directly from DHAP via Glycerol 3-phosphate dehydrogenase. I don't believe you mentioned that. Also a mention about glyceroneogenesis would have been great. Anyway. Thanks for the video. Maybe I'll actually survive Biochem with this.

[@NinjaNerdOfficial]

+SeptimusCreed thank you very much I hope the video was able to help. Best of luck in your future endeavors

[@yahyaqais3761]

I almost waste 4 hours looking for someone I can understand on and finally the legend reveals itself 👑

[@Hvaniceday]

Thanks alot from nigeria 🇳🇬

[@nileshbiswas1403]

Thank you sir for helping us

[@caleb6709]

Questions: Is the second fatty acid in a TAG always an unsaturated fatty acid? Does this mean that fatty acids 1 and 2 will always be saturated? Furthermore, are the answers important in the context of nutritional ketosis?

[@shailendrajadhav4686]

Very nice explained .useful to me👍

[@RepublikSivizien]

The ⁻O-CO-(CH₂)ₙ-CH₃-CoA notation is a bit weird, I guess you mean H₃C-(CH₂)ₙ-CO-S-CoA or something like this? Usually, there is no 5-bond-carbon and the FA-synthesis should result in something like R-CO-S-CoA.

[@maheshbhatt8422]

Yes.. the notation is not weird. I would call it wrong. It misleads. H₃C-(CH₂)ₙ-CO-S-CoA this one is correct.

[@donnaezhukattil6310]

such a good video!! maybe you can explain also one for unsaturated FA or unodd FA :) thank you so much!!

[@christianramos9006]

Another great video as always!!

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Biochemistry become my favorite subject after watching your videos 😃❤️

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Same here

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Preparing for CSIR... This person is great..!!

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you're amazing! thank you so much!

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I have my Biochemistry exam on monday and i've been studying it since February :(, your videos helped me to love and learn this subject, thank you so much!

[@theaizere]

how did it go?

[@camillamicucci1155]

@@theaizere really well! 27/30💕

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@@camillamicucci1155 that’s wonderful! Great job. aspirational

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Thank you. It really helped a lot!!!

[@geniuspeng]

You are amazing, thank you so much!!

[@sidharthit-it2gz]

Toooo good explanation.... Thanks a lot brother👦

[@Khudiya-diet]

great lecture u made everything clear thanks sir

[@NinjaNerdOfficial]

+zena said You’re welcome!

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we really love u, thank u

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Most thankful from Jordan

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Really we owe you a lot sir

[@viratkohli5367]

Thanx sir for ur best explanation

[@shahnamshams1051]

Hello, thank you for making this useful videos for us, I have a question about this lesson: at the beginning we added a phosphate to the Glycerol using Glycerol kinase then before adding fatty acid number 3, by means of Phosphatidic phosphatase we got rid out of that phosphate, so what is the function of that phosphate group?

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I'm in lovee with biochemistry bcs of ur vidéos broo

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IT WAS REALLY HELPFULL

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We love you thanks a million just keep going

[@arvindvignesh4184]

Thank you👍

[@PeterBilberg]

Very lovely video, thank you so much for you content Ninja Nerd. However I do think the 3 fatty acyl-CoA you have made in the beginning is a little bit misleading, since it should be CoA-SH bound to the carbonyl group with a thioester bond right? The CoA should be drawn in the other end and the Oxygen shouldn't be present right? Please correct me if I'm wrong.

[@arunkumars6257]

Thank you!

[@user-up9xl5ny8m]

You’re the king of biochem

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Thank you !!!

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Thank you 🙏

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Thank you so much !!!!

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Man,you're better than my lecturers, what am i paying my money for when i can study online with you

[@omermohammedomer4017]

firstly thanks a lot for your great explanation you and the team works with you to create such an amazing stuff like this I have a question 🙋 can adipose tissue contain a glycerol or not. I know it only get the glycerol 3- phosphate from the glycolysis because it's doesn't have glycerol kinase but I think you said in this videos the glycerol come from the adipose tissue when it breakdown or something like that ....... explain it to me please. thanks a lot

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This man is a real doctor..

[@Dr.Abisha]

Love from tamil nadu 😍thank you sir

[@user-wi3nu3cp7z]

Thank you so much

[@realitylover5749]

Good job Sir ❤️

[@aylin5615]

I’m watching this after five years and thaaanks❤ just a question.. you told the fatty acid chain that is gonna attach to carbon No. 2 in glycerol should be unsaturated but how simple saturated triglycerides are made? Or we don’t have simple saturated triglycerides naturally?

[@shohruhbekmirabijonov]

Thank you

[@kojacknet]

hi, your video is so awesome. I have question. Where does our body can get the Fatty acid CoA? Can our body synthesizes it ? or should we take it externally?

[@depressedcockroach4045]

Fatty acid synthesis + acetyl coa (could be from pyruvate, from carbohydrates, lipids, amino acids)

[@TheViktorkaZ]

Where does the O from fatty acyl coa and H from glycerol-3-P go when they form the bond?

[@alsetabwsin3443]

Speechless!!!😮😍😍😍❤❤❤❤❤❤❤❤

[@onsguirat2596]

Thanks a lot ❤

[@rishovdas2756]

@ninjanerdscience We cannot call MAG (Monoacylglycerol) and DAG (Diacylglycerol) without removing the phosphate group attached to the respective compounds. and in Step #3 conversion of Phosphatidic acid to DAG should take place first using phosphatase enzyme and in the next step we add the last Fatty acyl CoA to make it TAG. Anyways, Thank you for this amazing video. Love to revise through this.

[@estherruth2781]

It can be called a DAG phosphate or a MAG phosphate

[@hosseinabedinifard539]

Thanks a lot

[@sitarasubboh2765]

U r the best ❤️

[@amiryoucef1220]

thank you

[@salmafadlallah611]

You saved my life

[@ibrahimfurkankaya5572]

When a phosphate group linked to a glycerol molecule its formula become C3H7O3PO3-2, you guys add an additional oxygen atom and a negative charge. The rest is awesome thank you :DD

[@johnpowell9174]

pKa1=1.0, pKa2=8.0 for phosphatidic acids, so at physiological pH, almost all are singly-protonated, that is -HP04-1

[@seanluong6064]

@@johnpowell9174 I think the main issue he is pointing out is that it should be PO3 linked to the glycerol backbone (resulting in O-PO3), instead of the O-PO4 that is shown

[@johnpowell9174]

@@seanluong6064 Agreed.. There a structural formula issue