Metabolism | Fatty Acid Synthesis: Part 2 (Updated)

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this guy is a doctor synthase.

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Genius

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Nobel price is at least $100k. I agree.

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honestly bng!

[@ruthmusonda5544]

I don't know how I would survive med school without you ,love how you explain in detail and make high yield videos

[@jg9227]

It seems you made a mistake. In 19:44 you said that 3 C atoms come from malonyl and 1 C atom from acetyl. According to Lippincott's 'Biochemistry' (2017) the atom in CO2 comes from malonyl, not acetyl, so eventually you get 2 C from malonyl and 2 C from acetyl. Cheers!

[@arnabdas5883]

Yess that 2 Cs from Acetyl stay in the ultimate fatty acid chain at the terminal end.

[@yosoysoya7944]

Makes sense if then every time another malonyl is added, it is decarboxylated. Thanks!

[@monikaantonyan2272]

When I noticed, i was like, okay let’s read the comments 😄

[@skylordgamesreviewth453]

@@arnabdas5883 you mean the side that isn't -COOH right?

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You are correct. The teacher is teaching something that is WRONG. He should replace the tutorial video and reupload it correctly. 🤦‍♂️

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[@oliverkleim5152]

3:58 pyruvate has 3 carbons, not 2... I've been doctor for 23 years and studying again all of these issues. Thanks a lot for your help in this process

[@fernandoagz1973marzo]

Excelent explanation! Just a small obsrvation at 2:18 Citrate is transformed to Isocitrate by the catalysis of Aconitase enzyme, but this is not the enzyme that is regulated. When there ATP concentration is high, Citrate Synthase is inhibited and Isocitrate accumulates, and since that the reaction from Citrate to Isocitrate is reversible, Citrate starts to accumulate as well.

[@moonlight7993]

he said and explained it in part one

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I love how its so clearly taught. 37 mins and I understand everything.

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Your videos are very detailed, easy to understand and informative. You make the pathways easier to understand. Thank you your videos are saving my grade in Macronutrients!!

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I am a university student in Sri Lanka. I couldn't get any idea about FA synthesis before but now I have a perfect understanding about this. Thank you very much

[@HajongLee]

I have been grappling with this all week, just trying to understand FA synthase. This is just gold. Plus it's been recently updated! How perfect! All the powerpoint slides I have been given at med school was just useless... Thank you and congratulations on your website launch!

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Professor Zach is truly a diamond in our lifes

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This man is every medic's joy and salvation.... if I finish med, would love to someday repay all these videos somehow.

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no words, just emotions. I finally understood this topic, of course with the help of the greatest professor on our Planet- professor Zack Murphy. Infinite Love and Respect from me to Ninja Nerd channel

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تعبت وانا اقول اسطورة، توفير وقت وجهد، الطب صار سهل

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His passion and enthusiasm is fabulous 😀

[@suiyru_san8692]

this is the first time i smile while i study, doesn't mean i don't like the material but i am just focused. but his enthusiasm and smiling laughing. i like how he mention when the NADPH are used in the 5th step of FA synthesis, he's like "they're comin in baby"

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the best teacher ever!!!!

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OMG! that's really cool you are being more and more organized, keep going, love it :)

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[@alandfarhadmahmud751]

I just covered a whole lec in just 37 minutes man you are awesome❤❤ and i just wanted to mention it's actually 3-hydroxy ACP dehydratase rather than what you wrote on the board and i think you even corrected it in the end mid-explaining

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This is really amazing. I hate watching videos that are more than 5mins but I really love this explanation and watched both videos. Thanks a lot for these explanations.

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I am out of words to appreciate and thank 😊🙏 you Ninja Nerd!

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Thank you Ninja Nerd. You're the real OG

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Yeah ninja nerd it makes perfect sense and we enjoyed it❤😊❤

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Thankyou professor for making our med journey easier

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Everything becomes easier after watching these videos. God bless you, legend

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This guy made biochemistry really interesting and easy to understand and remember.

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came here from ur website just to comment and say- the way you get excited about biochem (those nadphs) is like a kid in a candy store! thank you and ur team for putting in so much effort for all of us out here!

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It's simply Amazing and mind-boggling of how you simplify the concepts for the learners.....hats off for the Nobel endeavour 👏👏👏👌🙌

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You deserve Noble prize 👏👏

[@arjunbhardwaj7526]

hey Zach, in the reaction catalyzed by Condensing enzyme, the CO2 is released from malonyl bound to ACP domain and not the acetyl group ..it is the same CO2 added to acetyl coA by ACC previously . so there should be 2 red and 2 blue carbons in step 3

[@joud72]

YESS exactly i was going to comment this!

[@aliemrebodur9664]

I just thought the same thing and came to check the comments to see if there is anyone else who thinks like me :)

[@juditaanthi9284]

Thank you, I was about to comment this too - the extra CO2 (acetyl to malonyl) is there in the first place to make the pathway, specifically the condensation step, thermodynamically viable. The CO2 that "leaves" the cycle each turn during condensation is ALWAYS from an incoming malonyl-CoA because of this specific reason :) The resulting palmitate (the product after its hydrolysis from FAS I) therefore has C15 and C16 from the original ACETYL-CoA, the rest comes from these "temporarily carboxylated" building blocks, malonyl-CoAs :) Hope that made sense! Anyways, I absolutely love these videos. I'm in the final stages of cramming for my very last exam for my PhD in biochemistry and these videos always give me an immense motivational boost... and I can listen to them anywhere, too! Good thing I have discovered this channel before it's too late. NinjaNerd, prof. Zach, you are a lifesaver :)

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Just saying, your videos are really helping me understand stuff for my metabolism class in university

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Consistent, detailed, and comprehensive...thank you so, so much!

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this man is the reason i love biochemistry

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Thanks man. What I do Without your Lectures ! Stay Blessed.

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Love this guy. Favorite professor.

[@ran5984]

Thanks alot! Pyruvate has 3 carbons tho, not 2 (3:55).

[@1Dann123]

I thought pyruvate was a 1-carbon molecule?????

[@annajoyoregan4744]

@@1Dann123 glucose is a six carbon molecule which is split into two pyruvate so each pyruvate is 3 carbons. No CO2 is removed during glycolysis

[@1Dann123]

@@annajoyoregan4744 Anna… I thought the multiple question marks would have tipped you off… maybe ninja has some videos on sarcasm you can watch!

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am a first year med student ,i have been studying this thing on biochem book but i havent be understanding it bt after i have watched this videos .everything looks easier,i thank you prof zach together with your team

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When it all clicks ✨ This gotta be the perfect time that you uploaded this just a couple weeks ago thank you proff

[@Generalblack818]

This process is hella cool! Had fun learning it!!!

[@yosoysoya7944]

As a kinetic-visual learner, this form of gradually adding to a picture is ideal for me!

[@hmone]

Thanks for the great video! Small notice: ATP is negatively regulating Isocitrate Dehydrogenase, not the Aconitase. You explained it correctly in part 1. Cheers.

[@hmone]

At step 10: IMO the leaving CO2 should be the one from the Malonyl, the Acyl group does not have oxidized carbons to release as CO2.

[@narutouzumakix9201]

@@hmone yea I was just about to comment this lol

[@jinx2873]

@@hmone yeah. in the next step too. to retain the OG 4Cs, the CO2 should evolve from the new malonyl group on ACP

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You deserve all the support professor ❤️❤️ I can understand biochemistry because of you Thank u so much❤❤

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currently learning fatty acid synthesis and this is a life saver

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Best video sir u r so hard working u explained even small points too

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You are a life saviour for many of us 💕 lots of love for you professor. Thanks alot for such conceptual videos. May God bless you

[@abdullah84290]

Thank you so much! it would be extra excellent if u could show the Chemical structure of the reaction species of addition of old Malonyl chain with new Malonyl residue of ACP. But when I see that step 2nd time and draw the chemical structure by myself and thought of it ,,I just understood that!!! U r such a Nicer Human!!!

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Saviour…understood n learned every bit ….all credit to my report card goes to you😭thank u sm❤️🥺😭❤️❤️

[@abdulahmohamed3655]

Thank you sir. Two idea different from my book 1. The four carbons of acyl group , two from aceyl coa and two from malonyl coa, while the carbon removed is the one added by acetyl carboxylase enzyme. 2. The condensing enzyme is called ketoacyl synthetase Thank you sir

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yall are fantastic!

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Glad you corrected part 2 because it had some errors on the old video. God Bless you

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Mind blowing lecture🤯

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This video is GOATED!