NR vs NMN? I used each for 90 days & both were effective

[@Ob3yda-uc5yr]

Thanks for being our human lab rat. We love you 🙏🏽

[@RemainedAnonymous]

Aren't most people?

[@markusphenix8343]

Pretty sure brian was pissed of reading this😂

[@connorhunter9394]

This have been known since 2017 Literature shows NMN is the way to go because it converts to NAD and is able to pass the blood brain barrier but just taking NAD is not able to !

[@jalapenopoppers1753]

@@markusphenix8343is there a reaction video to this? 😂

[@vamsiramineedi6296]

What's "human lab rat"? 🤣 It's just lab human

[@walkingturtle6646]

Niacin is much cheaper and has the same effect. The gut bacteria turn nmn and nr to niacin and niacinamid anyway

[@justinpate3466]

I use tru and it clearly has helped me.

[@liamingraham7660]

Nice. Good to know

[@Gnolans_Channel]

Do microplastics affect longevity?

[@Abibabe26]

Can you please make a whole video to go in-depth about NAD boosters? @BryanJohnson

[@bastionwolf]

I'd like this too

[@ScientificSupplementReviews]

I am a Scientist at Cambridge and have recently done exactly that. A detailed review of the scientific studies on NAD boosters: Short version of the video: kzbin.info/www/bejne/hl6YZ2dro5mGd5I long/detailed version: kzbin.info/www/bejne/jF7Meqiai72DhLs

[@ScientificSupplementReviews]

@@bastionwolf I have done it: kzbin.info/www/bejne/hl6YZ2dro5mGd5I

[@neonblast7006]

@@ScientificSupplementReviews

[@dstigers6140]

​@@ScientificSupplementReviewsIs there a way to make those links clickable?

[@Mrtranquil01]

2 questions: - What dosage? - Why would you want to increase your intracellular NAD levels?

[@dominators8977]

NAD IS one of closest thing we have for Reverse aging eventually prolonging life significantly basically it fight against desiases tremendously like without NAD WE WOULD DIE IN 10 SECONDS

[@FeminismSurvivor]

I recommend the conversation between Dr David Sinclair and Andrew Huberman “The biology of slowing & reversing aging”

[@Mrtranquil01]

@@FeminismSurvivor Thank you. I will check it out.

[@farnazrostami5302]

Thanks for your dedication 🙏.

[@bock12341]

Thank you for your generous heart and spirit to share good data❤

[@kboy4120]

I do wonder if he's invested in this market - not that there's anything wrong with that but I'd love to know.

[@supaflywhiteguy7635]

​@kboy4120 Perhaps, but he already made his hundreds of millions from a tech company he sold years ago. I think he's into it more for the science at this point.

[@freespiritwithnature4384]

Thank you for testing these Brian. ❤

[@theancientsancients1769]

NR has been researched more and is slightly cheaper and more better tolerated by those who get sleep issues from NMM or palpation especially women are bit more sensitive to NMN.

[@dude861]

Both are a waste. No benefit for humans has been shown.

[@bluefootedboobie1893]

I bet you believe red meat is a carcinogen

[@never_give_up90]

NR is not researched much yet, it is still pretty new. NMN has been researched a lot. Be careful taking either one cause I read few studies that had cancer as a side affect.

[@never_give_up90]

​@@dude861There have been a lot of benefits. The most recent study in 2023 also confirmed it.

[@connorhunter9394]

This have been known since 2017 Literature shows NMN is the way to go because it converts to NAD and is able to pass the blood brain barrier but just taking NAD is not able to !

[@thomasburkhart2383]

May I ask how much was your NR dose each day for the 90 day period?

[@Amanda_Blair]

I also want to know this

[@nutech1810]

Go look at his website. Good lord people are lazy

[@Amanda_Blair]

@@nutech1810 That’s why there is a comment section, so you can ask questions and comment about what was talked about in the video. Nobody asked you 🖕

[@UnitedWeIgnite]

They have 150, 300 & 1000 mg Which one is needed

[@donson3326]

Depends on your age, 450ish if you’re 40+

[@frankasafscimone3920]

I should add that in six months the amount of deep sleep I have has increased significantly and I now dream during naps. Never had this in 70 years and it is definitely due to NMN.

[@Konicalops]

I too asked this question of Bryan a few times; really glad he took the time to look at both of them. NR and NMN are the strongest items I think for antiaging in his whole protocal (besides fiber, exercise, and reduced oxidant damage of course)

[@alexisgrace8218]

He has glycine and NAC in there also

[@stevemarshall_uk]

⁠@@alexisgrace8218 Yip, glyNAC supplement

[@dandy8308]

Theres no data out there yet that confirms the benefits of NR / NMN supplements / increasing blood plasma NAD. So why do you think this? The jury is 100% still out.

[@theancientsancients1769]

​@@alexisgrace8218He takes them separately though

[@janco333]

Would be unfortunate if all the chemicals cause issues. It is quite the experiment he is running

[@UziZero-r2k]

Bryan, thank you for all your information. I was trying to follow a lot of blue print. I have been taking NR 300 mg for about a year now. I am 42 but now I have not been able to afford the supplements for a while. I see lots of things online about people who stop taking it and feel like they have ended up worse than before. Do you know any research that shows stopping taking after so long does any damage or will actually cause your body to produce less NAD on it's own than if never had supplemented?

[@RobertLavelock]

Thanks Bryan! Real data backed decisions are the best. Keep this up, you are helping lots of us.

[@SparWiz_Khalifa]

Would be interesting to know how Niacin and Niacinamide compare to those

[@D12Min]

I don´t know man. Dude looks super unhealthy

[@leslielucci3182]

I like to see a study on how NMN, resveratrol & TMG affect women in perimenopause, menopause and post menopause.

[@nutech1810]

Some are getting cycles back

[@lisamacdonald8579]

@@nutech1810wow really?

[@lisamacdonald8579]

I would too!

[@epicvideos6227]

Very last update on Resveratrol proves it's actually harming instead of preventing aging. Now there's a huge scandal on how doctor David Sinclair tricked the pharmaceutic company GSK to sell them his patent on resveratrol 720M$... before they found out it didn't work. (He purposely made noob mistakes of incompetence in the research process that boosted his results, but also made it irrelevant, in order to back his *SS against trial).

[@AndreaMartinez-qu1be]

By menopause women, age 51, have fewer than 100 eggs. What cycle are we getting back? 🧐

[@lukasstadler8752]

Hi Bryan. You have to be careful with how you use the word ‘effective’. There are already dozens of clinical studies that have shown that taking NAD+ boosting supplements leads to increased levels of NAD+ in the body. Crucially, however, collectively these clinical trials have also shown that - over the time period tested - NAD+ supplementation has no significant health benefits in healthy humans. I am a scientist at the University of Cambridge, UK and am in the process of putting together a review of the entire scientific literature on NAD+ boosting supplements. I can share if you are interested.

[@joefosbinder6731]

I would be interested in reading that, if you would be so kind as to send me a link. Or I could give you my email. Thx!

[@lizakroberts]

I’m curious, too. Please share.

[@Parmys1]

Me too! Please do share

[@bkb04g]

I thought NAD+ and NMN supplementation to be on different playing fields with regard to its ultimate effect intracellularly, yes? NMN seemed to have the greater effeciacy regarding energy levels. Does anyone have any idea why coupling TMG with NMN could stimulate energy levels?

[@txhvc9809]

Share 😊

[@benceseger7748]

I want to buy a longevity complex supplement (based on Dr Sinclair's research) for my two grandmothers, this was really helpful.

[@Benjamin_0fficial]

If you take these NAD supplements the side effects is you will get white hair increment.. anything that is not naturally produced by your body will have side effects.. is he just promoting these brand because he gets paid?

[@stelstiak]

Yes because a sample of 1 is the scientific way to go. Just as everyone's opinion without data doesn't count as you say, so does the definition of science, which doesn't change just because you have another ignorant opinion. And if everyone has an opinion these days, mine is that you won't contribute at all to the longevity subject.

[@adityarao2134]

The worry is that these NAD boosting effects are transient in a a sense and homeostatic processes may bring these to baseline over time. This is why we need to consider more and look beyond point in time bio markers and be considering the pharmacokinetic effects. A logical next step here might be approaching the relationship between epigenetics and NAD levels. Thoughts?

[@campersruincod6134]

Good comment, you’re absolutely right.

[@truthfuturist]

Indeed....many aspects to analyze.....

[@MsPandaHime]

So are you concerned that NMN or NR supplements would behave like anaoblic steroids and permanently damage the body's ability to maintain a certain NAD level?

[@campersruincod6134]

@@MsPandaHime no. He’s worried they only offer short term benefits.

[@GrgAProduction]

No shit Sherlock. It’s like saying the worrisome if I take Vit D is that is goes back to base levels again if not taking it and not exposing myself to the sun for months😂 no shit Sherlock.. it’s not something you can take and it stays. Needs to be replenished.

[@GlorifiedGremlin]

*shows absolutely zero data*

[@ScientificSupplementReviews]

You are right. I have reviewed the data in detail and published a summary: short version: kzbin.info/www/bejne/hl6YZ2dro5mGd5I long/detailed version: kzbin.info/www/bejne/jF7Meqiai72DhLs

[@guuseh2918]

Dosage please? Thanks.

[@TheBroncosfan1993]

So I want to buy NMN and save it for when I’m 35 (currently 30) does it expire, i just want to buy while I can before big pharma cracks down

[@donson3326]

By then they’ll have genomic medicine for immortality and you can forget all about this diet stuff

[@mollasima3251]

Did you use TMG or something to help with methylation while using either of those?

[@smuet6828]

Thank you so much Bryan. I have been able to incorporate parts of Blueprint into my schedule. I will order some of this as well. Thank you so much for all of your work and sacrifice! You are really appreciated.

[@user-ki4xw2rb8q]

Now I need to know your take on molecular hydrogen!

[@kirbychamberlin8683]

I have that answer

[@user-ki4xw2rb8q]

@@kirbychamberlin8683 Tell me

[@HomeWrecknKneeKnockr]

​@@kirbychamberlin8683lol so what's the answer?😏💭

[@ezgranofsky2389]

How did you decide what brand to try? I'm worried about buying supplements that aren't manufactured the right way and have heavy metals, etc in them

[@martymcfly6411]

If you want to do it naturally just eat a lot of broccoli sprouts. Sure you won't get as much as a supplement but your body doest need as much as they put in the supplement. I actually think micro dosing ( the amount found in foods) actually better than taking large doses. We don't know the long term effects of taking such high doses found in supplements.

[@HomeWrecknKneeKnockr]

​@@martymcfly6411thank you & what else besides broccoli sprouts will do the trick my friend?🥦🤔

[@DrTomMD]

What is the best large human RCT, or RCT based meta analysis of NMN, NR or NAD for reduction in any major disease of concern?

[@lampsks433]

There is none

[@dickschwanzstein1789]

Niacin is a lot cheaper, it’s been around for a lot longer, it’s been known to be safe in low to medium doses and it also raises NAD+ levels. On top of that, it does a lot more, such as improve cholesterol markers, reduce oxidative stress and it has a positive effect on cardiovascular health.

[@Candyanthrax]

Holy shit you look good man younger every time

[@helloydl]

Thank you! Now which one of these has less side effects?

[@AngieMeadKing]

What about TMG?

[@greenb1a]

How about Niacin 50mg multiple doses per day?

[@donson3326]

Yes Go look at his website

[@galanoth17]

Hey Bryan i feel like lots of people that practice yoga look way younger than their age. You should look into it

[@connorhunter9394]

This have been known since 2017 Literature shows NMN is the way to go because it converts to NAD and is able to pass the blood brain barrier but just taking NAD is not able to !

[@MrMoeqt]

Hey Bryan - do you supplement any of the following? NAC, CoQ10, Collagen, L-Carnitine, L-Citrulline, Milk Thistle? Thanks for everything you do!

[@donson3326]

Yes… go look at his website

[@Armageist]

Tbis is where your monetary resources come into play, as you have the funds to expend to collect the data to prove or disprove while eliminating or acknowledging variables and accounting for them. I hope your work is dissemenated in the future for standardized Healthcare A.I. knowledge.

[@Atz22]

Why are your fingertips always black?

[@mathiasfrandsen5468]

once you go black you never go back

[@SilverFan21k]

Well I can guess Bryan that you have made insane progress since the start of your journey a year or two ago, of lowering your actual speed of aging. I hope you aren't stalling out of reaching your genetic peak, in that you are still able to make youth progress and gains!

[@DisciplinedLion]

Also what’s the dosage 1000mg?

[@professorJorge11]

Knock Knock

[@philipmartin3902]

Did you or would you try just taking Niacin (vitamin B3) as Dr. Brad Stanfield suggests?

[@nanohatakamachi1066]

Stanfield is half baked. He oversimplifies what he finds and makes many errors. B3 just isn't efficient. Makes no sense at all.

[@Amanda_Blair]

NR has to use less energy to become NAD but they definitely both work and Niacin is way cheaper

[@tallingates4718]

I'm curious to why you dont sleep in a hyperbaric chamber or at least utilize it and i havent heard you mention sauna or ice bath

[@neilchudgar3775]

That’s cool that’s TrueNiagen and Jinfinity are sponsors 😂

[@starshot5172]

Mate, I love what you are trying to do. But this is not scientific AT ALL. Only one person does not prove efficacy within a group. Stop spreading misinformation

[@Longevityoptimisation]

Keep up the good work !

[@paulkriegler8222]

Did you test serum levels or tissue levels? There’s a big difference.

[@Scorpio77902]

Bryan what are you providing/selling now as of 9/10/24 as a NMN supplement in your BluePrint protocol? Thank you

[@dragusanuu]

It would be best if you could try this experiment to live up to 120 with usual food not with pills and other kind of supplements only you know about them. What about the food, normal food? What s wrong with normal food ? No path way to get 120 just with normal food and no other 100.000$ devices for skin and other treatments ? I am not against what you are doing because, you are doing whatever you wish but, MOUCH TO COMPLICATED I BELIEVE THERE IS AN MORE SIMPLE AND CHEAPER WAY TO GET 100 or why not 120 LETS ASK “TAO MONK”

[@DisciplinedLion]

@bryanjohnson Whatabout NAD IV ? Don’t understand why bloat with supplements through gut when you could inject directly through IV. Appreciate if you can explain

[@tgalpha_wolf2933]

You are truly a pionner. From Montréal !!

[@MarianNadler]

I am 28 years old. Should I already start to take NMN and/or NR?

[@KatSchlitz]

No. Levels are naturally high in our twenties. Wait until after 50 or 60 depending on when you feel age related decline beginning (aches and pains, slow injury healing, easier to strain muscles and ligaments, vision begins to drop, etc)

[@CraigHocker]

It would have been better if you had then tried some of the not talked about dirt cheap options. Forms of niacin. Nicotinic acid, nicotinamide, and some form of these along with D-Ribose. These are know to boost NAD also. Based on studies, it’s very likely that ALL or almost all of the NR or NMN is broken down into nicotinamide by your gut microbiome. So taking NR or NMN end up being just expensive ways to ingest vitamin B3. All of these including what you took will raise the NAD in the blood. Measuring NAD in the blood is easy but what really matters is what the NAD levels IN cells of various tissues and that is harder to do and rarely done in studies. And when it is done there is evidence that it does not drop with age. It’s quite likely that raising NAD in the blood by oral supplementation has NO anti-aging or longevity effect in humans. So no, you really added nothing to the discussion. It was already known that these are expensive ways to boost NAD in the blood. 🙄

[@Wilfrenee]

Is taking both better ?

[@-pyaklasmaatlarm-p4072]

What you think ?

[@fiorrdaliss]

Thank you so much for this! Very useful to mention the brands and for how long you took them.

[@cathompson58]

Good ... thank you.. so next question is "does increasing blood NAD+ levels actually prolong life or increase any metabolic function?"

[@JamesBond-wg6ov]

16 year old is too old man , you need to achieve NAD level of infant

[@rubaiatsanjidhossain9855]

😂

[@KB-vx5mo]

But I still don’t understand the difference!! 😅 If they are both good, so you have to take them both-are they for two different purposes? Sounded like the both are good for nad. Also, it got blurry when you showed the nmn… I did look up the true niagen-is that the 1000 or 300, there was another one as well. Which should I order?!

[@cathyrademeyer2865]

Thank you - can you let us know your thoughts on NAD Infusions combined with NAD+ subcut. Is this something you do - is yes - why and is not, what are your thoughts and/or opinions 😊

[@karlaspoonamore5189]

Thank you for all you do for humanity. You put yourself through so much but you do not look younger nor stronger. You look like an old man. If you keep doing this to yourself you are going to hurt yourself. Every treatment has a risk and you’ve done too much to your body. I’m so afraid that one day is going to backfire you. Please be safe. Much love ❤

[@BobbySimpson]

Not enough info. Did you measure NAD levels within the blood only or within other cells? That’s the big question with these supplements. Do they actually saturate cells throughout the body, or do they just increase NAD levels within the blood?

[@julianinaction96]

THANK YOU FOR EVERYTHING YOU DO ❤❤❤

[@Lucidchronicles]

Did you try 90 days without either? The amount you workout could be sufficient to have optimal NAD levels

[@joannaryan9805]

Watch Scott Carney “The true story of David Sinclair”s longevity lie” before taking these

[@justritasimi]

I heard these specific supplements increase cancer risk ? I bought Tru Niagen but scared to try it after seeing some info ... would live to know if the Blueprint team has heard about the risk or was it debunked ? Thanks !

[@ana419]

I wonder if there is some overarching undiscovered system that kicks back against even the best efforts to stay young, just for going against nature and destiny.

[@Mellon_Musk]

Thank you Bryan for sacrificing as well as sharing.. but could you also conduct it for men n women ..

[@anthonyratledge2177]

I heard he took them for 90 days each - did he continue to take them after? I know Brian’s all about keeping up with things that benefit overall health so needs to be clear if he thought they were worth keeping in his regime

[@steinbakke]

Hi. Should N😅A😮D levels stay at a high level for Men over 55 for a longer of more ore less constant period ? IF that is the case what would them be the best combinatin❤

[@mariuszsch.79]

Would taking niacinamide (an other, way cheaper form of b3) or regular niacin have a similar effect? Did anyone try this?

[@bumpak]

He looks really old for a guy that's only late 40's

[@brahmasiddhi]

Thank you. Any study on Long term effects. Are you still taking it regularly. ❤

[@harmankardon478]

no, they have been tested on human for safety but only short term

[@gauravlakhina8412]

my question is what happened if you stop taking these after few months, it make the things worst for you or you would get back to the original stage where you started taking it

[@TheOldBeef]

The skin on his face looks really weird and thin

[@pedroroque829]

He is looking older than ever

[@Stierenkloot]

I really think the haircut isn’t doing you favors Bryan

[@int_pro]

Love Bryan and everything he's doing for humanity. One question I often have on these and other Blueprint supplements is "can these be given to all age groups?" Specifically, can the elderly take all of these or are there some that are better and some that are less well tolerated? I want to help my parents, but I don't want them to try something that their bodies can't tolerate. Thank you!

[@Leto2ndAtreides]

The question though: What were the benefits? Also seems to need supplementary TMG.

[@ianhesford]

Details matter. Did you try them simultaneously or 90 days each? What were the individual differences?

[@defaultHandle1110]

What about boosting with resveratrol dissolved in olive oil ? Does NMN work better than NR ? Does resveratrol work with NR too similarly ?

[@user-md8588]

I took both, Only NMN works the RB was a huge disappointment

[@joelarpin473]

There's a big question... Taking NMN increases the level in the blood but not in muscle. Has this ever been addressed?

[@michaelvan-vn9ku]

Finally, this guy is not trying to earn a bit if extra cash and everything is tested by his team. So sick of all this scientific evidence, scientists and experts everywhere on the internet. This guy night be a weirdo but there is no money involved and everything is tested by him and his team. Gives me something to work with..

[@robertluntfloridarealestate]

What about high doses of Niacinimide?

[@danh5637]

But genuine question with all the supplements and the Botox etc. why does he look much older than his biological age? I mean it can’t be just my perception?

[@NRV2510]

Love and respect from India , wonderful scientific experiment ❤

[@stelstiak]

An experiment with a sample of 1 is not scientific at all.

[@ronilittle7028]

Oh my goodness! I’ve been taking both at the same time! I thought they were different substances! Am I in any danger?

[@ainahaga]

Why do so many vegan go over to carnivore? I experienced so much sleep issues when beeing vegan after 3 years vegan and then low D3, low iron and psychosis.

[@Private-r3g]

Brilliant map maker serving humanity.

[@evaml11]

Good! I was wondering about this supplement, but I was a bit worried about taking it.

[@LifeAtTheCrossroads]

Is NAD good ? I have NAD and NMN what is the difference? I'm so confused...

[@riteshnayak80]

Bryan, u must gain some weight, you will look more youthful, that is just as importsnt I feel...

[@lorainisrael]

How about the NAD+ injections? They seem to be more potent. I really hoped Bryan tried those.

[@barisveesitlik9310]

I am a 35 years old female. Should I take those supplements? Beside some stomach acid problems I have no medical conditions or illnesses

[@nay.murray6097]

thats great but seeing the number go up is not the end result most people want. did it help any markers of health and did you feel any different ?

[@canucklehead2772]

I hear you can start NMN at any age, wondering if it's pointless when your young?

[@andrewz2854]

Enada NADH is a good product also and affordable. People like to say NAD+ precursors are better than NADH but in reality your body easily converts between NADH and NAD+ as needed all the time, so I speculate this may even be better than a precursor.

[@harmankardon478]

i don't think absorption is good nr nmn are better at raising nad

[@arom1764]

@BryanJohnson what would be the recommended dosage? Does it oscillate based on bodyweight?

[@arom1764]

Nevermind, I figured out that the dosage taken in this video for the NR Tru Niagen is the 300mcg one.

[@harmankardon478]

nmn 250-1000mgs daily