What Pathological Changes May Cause the Symptoms of Long COVID?

November 1, 2022
Bateman Horne Center has partnered with the University of Utah Health to conduct a Long COVID and Post-Viral Syndromes ECHO (Project ECHO). This series delivers information to healthcare professionals utilizing short didactics and case-based learning to enhance their ability to manage patients with long COVID, ME/CFS, FM, and related comorbid conditions.
Anthony Komaroff, MD, Simcox-Clifford Higby Professor of Medicine, Harvard Medical School and Senior Physician at Brigham and Women's Hospital discusses:
- How the symptoms of long COVID are shared with other post-infectious syndromes
- The underlying pathophysiological changes in long COVID
- The possible triggers of long COVID, including reactivation of latent viruses
- How the underlying pathophysiology of long COVID causes its symptoms
Note to community members: We advise viewers to always speak with their medical care team prior to making any adjustments or changes to their current regimen.
Bateman Horne Center’s involvement in this program is made possible with the additional support of the Open Medicine Foundation.

[@BJ-bc7sl]

Finally a doctor that speaks logically, with scientific thought and doesn’t gas light these poor patients struggling to recover.

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@kusamagaming7375]

​@@User98681I did 3 weeks and all my symptoms got worse 😢

[@thorinoakenshield5601]

YES! Water fasting. My life and health destroyed by JJ Covid vaccine and 1st real relief came by water fasting.

[@marciemyers6585]

He’s also the MD who years ago was quoted as saying that “CFS is worse than asthma, cardiac disease or HIV”. He’s been around a long time and on our side. Honor him. M

[@laurabone3228]

To his question on LDN: I am ME/CFS & Long Covid contracted pre vaccine. Yes I use LDN. Took just 8 weeks to normalize CRP levels. Important to me it addressed brain fog. Almost eliminated daily crash naps. Gives me insurance policy against cytokine storm if I get reinfected probably. For now will continue to use. It's so safe we don't need to wait for the pending studies. 60% improvement for me.

[@justritasimi]

I also use LDN for POTS cfs and long covid with same results! Glad it helps you too

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@BJ-bc7sl]

@@justritasimi LDN?

[@kristen1441]

Same. IVIg, lamictal and low dose naltrexone with a low fiber diet are helping.

[@lauragott2122]

Hi Laura, so glad to her your results. How do you find a doctor who will prescribe LDN?

[@oibal60]

TY. I never got Covid19, any variant. My heart goes out to those of you who got this evil infection.

[@atriyakoller136]

I hope you never get it. I've had it 4 times, twice this year and this year's variants are the most vile ones. I haven't been diagnosed with long covid but had to quit both jobs and even sleeping enough doesn't alleviate the fatigue. I can walk and do most daily things, but get so tired after just 10 minutes of walking... absolutely frustrating

[@kristen1441]

I actually got vaccine induced long Covid and am presently in an ongoing NIH study regarding the same. The symptoms are similar to CFS, except I got paralysis, vestibular equilibrium loss, etc. IVIg helps a little, antihistamines helped some, mostly pacing. But, if I get sick, complete rebound. Rather frustrating.

[@jasalyndittmar3529]

My husband has long Covid vaccine induced and it’s been extremely difficult. Have you made any headway since you posted?

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@User98681]

@@jasalyndittmar3529 I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@kristen1441]

@@jasalyndittmar3529 yes. IVIg, lamictal and low dose naltrexone with a low fiber diet are helping. I do rebound if I get sick or too much exertion.

[@user-kv1hy3vu1k]

That is called vax injury!

[@janisedmondson7132]

I listened for treatment…I didn’t hear any. Still thankful for efforts of these people.

[@D-Fens_1632]

I wish I had a real doctor, mine just wanted to give me Paxlovid and antidepressants. I told him to piss off.

[@mamaslomba]

I would rethink your decision if I were you: it sounds like your doctor is trying to help you by seeing if Paxlovid might get rid of possible viral pieces in your body (it is an antiviral medication that they are studying in clinical trials now) and giving you an antidepressant (an SSRI specifically) may help with neuro inflammation and can help with mood too to help cope with being a long hauler which is hard. Partnering with our doctors is all that we can do at this point. Stay strong.

[@bjthinkingclearlygal4968]

My dr did the same thing -- prescribed drug for depression and drug for anxiety. Doctors don't know and don't take long covid fir the gravely debilitating disease it is.

[@Gina-dn6xm]

I don't know if they will find treatment for ME/ CFS in my lifetime, but hopefully, someday in the future. It's like being in purgatory. you're not alive but not dying. You just exist mostly in a darkened room in bed. I'm not Catholic, but I could think of a proper word description. 😊

[@marciemyers6585]

I had a low grade fever every day since CFS in 1994 for 20 years until taking Valcyte 450 BID continuously and no more fever since.other symptoms remain however. Marcie Myers

[@user-kv1hy3vu1k]

So does injury from the shot! Wake up people!

[@GalacticTr4veller]

I won the crappiest lottery, i had 2 vaccines and 2 boosters, and I'm dealing with long COVID :( not fun at all, and not fair either.

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@User98681]

The vaccines are most likely what caused your long covid they are bioweapins

[@leslievalenciano-lopez8887]

Could it be that you have vaccine injuries and not long covid?

[@SteveVon7]

I was'nt vaccinnated at all and got covid and long covid, the long covid being worse than the actual covid, i'm not seeing a difference with the vaccine with my own eyes frankly.

[@maryr7593]

Preservatives in the vaccine are usually what triggers ppl as they are chemicals. Always ask for preservative free vaccine.

[@thorinoakenshield5601]

Patients interest and willingness for studies is out of desperation for help and relief. We’ve already participated in the largest experiment of mankind.

[@bradsalz4084]

There is a related compound called dextro-naltrexone. My understanding is that it is a sterioisomer of naltrexone which is active at microglia receptors (like ordinary naltrexone) but has no activity on opiod receptors. Because of this it is not limited to the same low doses that ordinary naltrexone is prescribed at making it an attractive alternative to LDN. Do you know of any research papers that discuss dextro-naltrexone?

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@bluescrew3124]

Difficult to be vaccinated & double-boosted yet catch omicron in June of 2022 & have Long Covid for now over 1 year.

[@decafmocha211]

Thank you very much Dr. Komaroff. I have 2 goals : 1. To fine the best treatments for long covid. 2. To get in a clinical trial for long covid with the NIH. I think it is quite possible that I have had Post Long Covid Vaccination Syndrome for over 2 years now. It is very debilitating.

[@kusamagaming7375]

I can share what has worked for me

[@kusamagaming7375]

I am also in 2 years struggle

[@JulieTobin-Ruszczyk]

An anti-inflammatory diet is the only thing that keeps my pain and fatigue low. LDN really didn't help me

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@LR-px9ms]

I’ve been needing PT for herniated disc but I have also ME and been crashing with PEM. Are there any recommendations to hand out to physical therapists?

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@kellyschroeder7437]

Hmm. Trying anti inflammatory diet. My CRP ESR LDH IgA all elevated …..

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!!!🙏🏼

[@kristen1441]

IVIg, lamictal and low dose naltrexone with a low fiber diet are helping.

[@sue1657]

wow someones doing something

[@susantisdell1725]

Do you see more people with Blood Type A+ with long covid?

[@ingridfrancois7771]

I'm AB+ I'm long covid

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!🙏🏼

[@kusamagaming7375]

I have RH negative and I also got it :(

[@leslievalenciano-lopez8887]

Does anyone else have long covid with brain fog, extreme fatigue, joint pain(fingers and pelvis), visual migraines and shortness of breath with no diagnostic tests to confirm long covid???

[@lauragott2122]

Yes, I've had EBV and CV infections. Auto immune with psoriasis and neuro antibodies, PEM now worse after CV along with allergies and persistent cough/phlegm that I did not have b4 CV; Balance issues, migraines, ortho hypotension, tachycardia, dizziness and bad brain fog. Short term memory dysfunctional, focus on tasks on bad days quite distractible. The analysis Dr. Kaufman makes that he thinks the patholgy in both long CV and EBV/MECFS are the same, I agree wholeheartedly with. Same symptoms in both. I really feel that the inflammation, esp. in the brain, is attributed to the latent/reactivated infections since symptoms are sooo long term. Most of mine have been ongoing since 1987. Also possibility of micro-clots causing them. I'm doing grain free Paleo diet for gluten sensitivity, has helped the psoriasis.

[@bjthinkingclearlygal4968]

Yes. I have all symptoms except visual migraines though I do experience all day headaches that no medication helps. I also have MS which has many symptoms similar to long covid. Ug!

[@user-qb2th1ck8r]

Long haulers symptoms are horrendous. It' is often lifelong. Fatigue pain depression and more. All are life altering symptoms

[@kellyschroeder7437]

Interesting. Could it be that females have more hormones and it is involved in the autoimmune disease processes ???

[@icedirt9658]

Women have two x chromosomes, which have many genes linked to the immune system. If this sort of thing interests you, I suggest looking into the impact the black plague had on autoimmune disease frequencies in descendants of affected populations.

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!!!🙏🏼

[@RR-kx6xv]

Nerves.

[@richyp64]

Imagine believing it's "long covid" and not damage from the you know what.

[@myhealthobs5290]

Lol, is thst why viruses have caused m.e way before covid vaccines . Try to think logically

[@Jennifer-ic7hg]

Imagine believing that every single person who has long covid has gotten the you know what. Find a hobby buddy.

[@suprcros]

I keep seeing people saying this, I can tell you I am 100% against the shot and I am dealing with Long Covid. Its not just the shot causing it, all though the shot definitely has a whole other set of issues itself.

[@suprcros]

@@jennifermarlow. thanks, I am in my 8th month and doing pretty well, I still am having some symptoms that come and go but a far cry from the early months. I recently started taking a product from melaleuca called longevity. It's technically made for people 50+ but so far I'm am really feeling a difference from it.

[@ianseaweed]

Got Long Covid at the start of the pandemic, long before the vaccines… but Dr. Akiko Kawasaki, Yale medical centre is doing a study on it. A non Covid control group, a vaccine long covid group and a virus long covid group. May be caused by both infection and vaccine, hence the study.

[@michaelshoemaker8440]

NAC

[@davidkruse4030]

Makes me worse

[@carmella88]

@@davidkruse4030 how worse? I've been taking it but idk if its helping or harming since I don't see much change

[@User98681]

I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!!!🙏🏼

[@User98681]

@@davidkruse4030 I reccomend prolonged fasting. DYOR on the topic and make sure your in the right health to do it safely. I have seen a great improvement in my LC after a 3 day water fast paired with supplementing RESVERATROL & QUEURCITIN. This triggers autophagy and clears the blood of spike proteins!!!!🙏🏼