Olfactory system anatomy and physiology , pathways | Special senses, sense of smell

[@VaishnaviNaik-y7k]

Thanks ma’am for making physiology interesting and simple to understand.

[@PhysiologyOpen]

It's my pleasure

[@Shutup-xv5wy]

Thank you ma'am, helpful video

[@PhysiologyOpen]

Welcome 😊❤️

[@electronicshomemade4493]

Can you explain it more clearly. Like .How different smell feel differently. The action potential is same for every smell then how brain detect it differently.I understand how action potential work in neuro muscular junction. Because the response is muscular contraction.

[@PhysiologyOpen]

It's because of combinatorial pattern...based on the combination of receptors which are stimulated bhai the odorant... the pattern if receptor stimulation is detected by brain as a particular smell

[@electronicshomemade4493]

Madam can you make a detailed video how cortex make different perception of smell for the same action potential.whatever smell (Odererent) stimulate the neurons, every neurons create action potential in the same way and same neurotransmitter is released (Glutamate),then how every smell is perceived differently by the cortex. What is happening in the cortex

[@electronicshomemade4493]

Madam can you make a detailed video how cortex make different perception of smell for the same action potential.whatever smell (Odererent) stimulate the neurons, every neurons create action potential in the same way and same neurotransmitter is released (Glutamate),then how every smell is perceived differently by the cortex. What is happening in the cortex

[@PhysiologyOpen]

This is combinatorial pattern coding... right now I cannot make a full video though

[@FarhanMohammed3140]

VERY HELPFUL, THANK you

[@PhysiologyOpen]

Most welcome

[@PhysiologyOpen]

Do like and share

[@HansikaAmaraweera]

Thanks ma'am ,helpful

[@PhysiologyOpen]

My pleasure..do like and share

[@xyz-sq6ho]

In case of adaptation.. The continuous exposure to a odorant.. Initially we Percive the smell highly.. While continues exposure and activation of the odorant receptor leads to increase level of calcium in the bipolar cell leads to activation of CAMKiNase and also continuous activation of the receptor also incre cAMP in bipolar cell consequently activate the PKA.. PKA ans Camkinase phosphorylate the odorant receptor and leads to reduction in sensitivity of the receptor for that odorant.. And leads to short term adaptation.. While continuous exposure to the bipolar cell eventually by olfactory pathway activate the prefrontal and orbitofrontal cortex and fiber from here activate granule cell in olfactory bulb and granule cell release gaba and inhibit the mitral and tufted cell that Percive the olfactory stimulation coming from that continuous odorant.. And thus reducing the percetion of smell over time and eventually ceases.. This is long term adaptation. And our brain or olfactory system prevented from overwhelmed response by the continuous odorant exposure and ready to Percive new odor!!

[@PhysiologyOpen]

Wow…great typing and concept

[@bhumikapareek5277]

Just grateful to you ma'am 🫡.....I don't know why it's so underrated channel ....

[@PhysiologyOpen]

Thank you 😊❤️