Pathophysiology of Diabetic Nephropathy

Pathophysiology lecture on diabetic nephropathy, focused on the pathology of mesangial cells and mesangial expansion.

[@danstift6024]

Your videos are very helpful. I am a paramedic and RN and they have increased body understanding of so many body systems. I appreciate your investment of time and hope to see more videos!! Thank you!!

[@HealthEdSolutions]

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[@fintessimoni1]

Hello, I am a Paramedic in NJ. I randomly chose a video to post under, but I have spent countless hours reviewing your videos, often taking notes, to help the night pass by during "downtime". Thank you for the commitment you've made to making them.

[@HealthEdSolutions]

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[@judyelibri]

Where have you been all this time? Your videos are so simple to understand and I understand the information much better than when I read my books :-)

[@petagolley8238]

Thank you so much for helping me understand the finer aspects of renal physiology! I HATED it as an undergrad as i didn't understand it. Now as a Masters student, i had no choice but to learn... thanks so much!

[@HealthEdSolutions]

You're welcome!

[@minjoojin]

This was SO HELPFUL!!!

[@dr.seetharamaniyer2444]

Hello. Ur fan from India. Very thankful for ur efforts. GOD bless u :)

[@dr.m.nouman]

thank you very much Dr. Andrew, the video is explained properly

[@HealthEdSolutions]

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[@liatrito3]

would it be possible for you to create a video dealing with URINALYSIS? and what type of findings would you expect to find in urine dipstick and under microscope for a patient with different types of renal disease, such as glumerolonephritis, TN, diabetic nephropathy and others? IT WOULD BE MOST APPRECIATED

[@lumbiwemwanangono8954]

From all sources I've gathered concerning this, only similar thing ive found is stage one. The rest of the stages are different from every source and now i don't know what is true and what is not😳

[@anandtapadar]

Complex topic simplified to a considerable extent.

[@HealthEdSolutions]

Thanks for the feedback!

[@HafizahHoshni]

thank you for the great explanation! Your videos are very helpful.

[@HealthEdSolutions]

You're welcome!

[@thirdeye331]

i do appreciate of your work, understand it more,but i am not pretty clear about mesangial physiology! i wish i can see it more from your video! oh,if it possible for you to upload the pulmonary disorder and its pathophysiology? i think i am capable to understand by your video than other's. thanks before hands!

[@morrisamooti]

Thank you so much,this was pretty helpful

[@HealthEdSolutions]

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[@nellyhoffman6194]

Man you are awesome i love you ! :)

[@HealthEdSolutions]

Thanks for your feedback and thank you for watching.

[@user-de2zj2hj9i]

Thanks for this very good presentation of the mechanism of diabetic nephropathy but it will be good if you include treatment of different stages of diabetic nephropathy .

[@HealthEdSolutions]

Appreciate the feedback!

[@kullyxo]

great video :-)

[@hri888888]

solid,,absolutely clear

[@HealthEdSolutions]

Thank you so much!

[@lauriscarrillo4566]

That was so clear thank you so much

[@HealthEdSolutions]

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[@DoMore93]

Thank you, this was so useful :)

[@HealthEdSolutions]

You're welcome!

[@SuperAeiownu]

Could you go more in depth into how hyperglycemia damages the nephron?

[@fakharzaman539]

thank a lot sharing yours knowledge

[@HealthEdSolutions]

You're welcome!

[@TheAlorado]

thanks for this great and helpful information but i got a question please , does hypertensive nephropathy affect mesangium ? and if not ,why?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@Mbabieeh]

In diabetes type 2 there is a decreased sensitivity and so increased resistance to insulin causing the beta cells of the pancreas to secrete more insulin. That is why often their treatment initially involves drugs that increase sensitivity or decrease resistance, but due to continuous stimulation of the beta cells at some point they get damaged and exhausted, and treatment then often includes insulin therapy. atleast that what I understand from it..

[@BlueCheeseNoFleas]

my second question is that we classify renal failure into 5 main classes according to the GFR of the patient in CKD 5 the GFR is less the 15ml/min so will all these patient's develop uremic syndrome?

[@briekhnaa]

vasoconstriction of efferent arterioles decrease glumerular pressure and filtration

[@HealthEdSolutions]

Thanks for your input!

[@richelroque360]

Thank you for your videos. do you have a video about chronic kidney disease?

[@HealthEdSolutions]

Thanks Richel for the support. More videos being released weekly!

[@jenl2969]

Hello, first of all great videos thank you! My question is about the 5 stages.....at stage 2 you said that people will start developing proteinuria does that also correlate to the GFR being mildly decreased? Along with stage 3 and the hematuria will the GFR be moderately decreased?

[@HealthEdSolutions]

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[@omarm.d2578]

subscribing ! :)

[@asmam93]

Thank you :)

[@HealthEdSolutions]

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[@kenbobca]

Are all the functions of human kidneys basically the same in animals such as fish, dogs, cattle birds and other animals?

[@HealthEdSolutions]

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[@dr.ravikanthmoka3863]

what is the role of podocytes in the pathophysiology of diabetic nephropathy.?? and please can u suggest the recent globally accepted classification of diabetic nephropathy

[@HealthEdSolutions]

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[@asmam93]

That explains it in type 2 diabetes. Type 1 is as I'm sure you know characterized by complete lack of insulin. And yet they develop diabetic nephropathy just as well. In type 2s it is due to a heterogenous group of diseases, dislipidemias, HTN...in addition to to diabetes. In type 1 there is only one initiating factor -that it shares with type 2. Is it the effect of hyperglycemia that causes the nephropathy in this case?

[@HealthEdSolutions]

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[@Phillips1758]

Hi. Is the biggest cause of Diabities high blood sugar and high glucose. Does the High Bp damages the blood vessels of the kidneys leaving them ineffective over long period of high bp?

[@HealthEdSolutions]

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[@LEW_Aleha]

Just to add to the wonderful explanation: Increase in GFR initially is caused due to hyalinization of efferent arteriole,which causes vasoconstriction---predisoposes to hyperfilteration injury Meanwhile non enymatic glycosylation of the basement membrane of the glomerules causes injury and leads to proteinuria esp. called as microalbuminuria. ACE inhibitiors prevent the cond'n as efferent arterilole are under Angiotensin 2 control,which causes vasoconstriction, thus giving an ACE would cause dilation of the hyalinzed efferent arteriole nd improve the GFR as well as hyperfilteraion injury.

[@rendezvous65]

ace inhibitor works on those with this condition provided that the dose is higher than normal and creatinine is between 1.3 to 2.0. it can completely reverse it at those levels with no need for dialysis later on.

[@HealthEdSolutions]

Thanks for the wonderful input

[@HealthEdSolutions]

Appreciate the comment on this

[@dr.rajibchakroborty3674]

why there is increased level of angiotensin 2 in DM?

[@HealthEdSolutions]

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[@kidpanda1993]

you rock !

[@HealthEdSolutions]

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[@BlueCheeseNoFleas]

HI i found your video quite helpful. but was wondering if you could explain kamilstain wilson lesion/nodule my interpretation of it is because of increased mesangial proliferation in response to mesangial and glommerular dammage the mesangial cells proliferate and eventually form small nodules known as kamelstein wilson nodules? wondering if i'm correct cheers

[@HealthEdSolutions]

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[@BlueCheeseNoFleas]

@@HealthEdSolutions are you for real fool. I posted that question almost 10 years ago. I am a specialist doctor now.

[@that_girl_2958]

You ARE A-Mazing

[@HealthEdSolutions]

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[@SuperAeiownu]

Also why does the efferent arteriole constrict? you mentioned free radicals, but what is the reasoning for the efferent arteriole wanting to constrict? or why do the free radicals cause this?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@SuperAeiownu]

@@HealthEdSolutions I asked EIGHT... YEARS... AGO... lol...

[@45Marieme]

Could you please tell me how non enzymatic glycosylation and hyaline arteriolosclerosis relate to diabetic nephropathy?

[@HealthEdSolutions]

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[@tudona]

sound?