PAUL MASON d4 | APOE4 …only higher risk for Alzheimers if metabolically UNHEALTHY

www.DoctorsToTrust.com
@doctorstotrust
presents episode 1889 | DR PAUL MASON
Genetics is often blamed for Alzheimers...
-APOE4 gene found on 19th chromosome, comes in 3
flavors: APOE2, APOE3, APOE4
-everyone gets one from each parent, and if you get
both APOE4, have strongest 5X risk of Alzheimers
"Genetics is not fate”
But whether you get it or not
is dependent upon your
metabolic health
Those in good metabolic health, regardless of their
APOE4 status, do NOT have increased risk of Alzheimers
-the APOE gene serves as blueprint for this protein
which is embedded within the membrane of HDL
cholesterol particles
-HDL in brain act as a
Natural Defense against
beta amyloid plaque
deposition
HDL particles in brain actually Remove beta amyloid…
-APOE3 variant is by far most common
-less common APOE4 gets all the bad press
it is especially susceptible to damage due to its unique
molecular structure
Beta amyloid peptides can be
damaged by sugar stress &
oxidative stress from intake of
oxidized seed oils
APOE protein can also be damaged in the same ways…
-APOE4, due to molecular structure, is especially prone
Clear evidence, from this paper, comparing APOE3
tendency to form advanced glycated end products to
APOE4 protein:
APOE4 is damaged
at 3X that of APOE3
If you carry APOE4, and are not metabolically healthy,
HDL particles in your brain, which remove toxic protein
deposits, are less likely to do that
-this tendency for glycation damage when not healthy
metabolically is
WHY 5X higher
risk of Alzheimers
Consider: 98% of US adults, over 60, are not completely
metabolically healthy--that is why having APOE4 is bad
HOWEVER, if metabolically healthy into old age, then
having APOE4 gene likely does not matter…
-formation of
advanced glycation
end products is a
manifestation of metabolic
disease
Other consequences of having dysfunctional HDL
particles due to glycation and oxidative stress…
Study: activity of an enzyme, matrix metalloproteinase 9
-in normal HDL and in dysfunctional HDL
Clearly shown: when HDL particles are dysfuncational;
the activity of matrix
metalloproteinase 9
increased dramatically
matrix metalloproteinase 9 has been shown to interrupt
the blood-brain barrier...which prevents certain
circulating substances, in our blood, from crossing into
the nervous system
-this disruption is an
early biomarker of
Alzheimers
Paper from last year, in Nature: increases in blood-brain
barrier dysfunction, caused by high matrix
metalloproteinase 9 levels, were higher in those carrying
the APOE4 protein...making their HDL prone to damage
Link: Carry APOE4; HDL more
likely to be damaged; reduces
your ability to remove beta
amyloid plaques & leads to
disruption of blood-brain barrier
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[@proudchristian77]

Yeah baby , we got iffy people's & they helped us ride a bicycle, skinny to this day , beat up inside but skinny ! 💝🚴‍♀️

[@doctorstotrust]

hope it works for you

[@user-hu9sw5zf8j]

APOE 4 apparently is more beneficial if metabolically healthy and in starvation scenarios

[@doctorstotrust]

apparently

[@user-hu9sw5zf8j]

@@doctorstotrust mutation is seen in northern euro populations which historically came from Siberia. So in a low caloric state if you can function mentally better than everyone it's an evolutionary plus