The amazing potential to increase muscle mass via myostatin inhibition | Peter Attia and Derek MPMD

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This clip is from episode 291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more with Derek, More Plates More Dates. Derek is a fitness educator, the entrepreneur behind More Plates More Dates, and an expert in exogenous molecules commonly used and misused by bodybuilders and athletes.
In this clip, Derek and Peter discuss:
- Gene therapy for follistatin
- What does a myostatin knockout look like?
- Is there a certified assay for measuring follistatin?
- And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
Learn more: peterattiamd.com
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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: peterattiamd.com/terms-of-use/

[@Model_Student]

5:33 the side-by-side of the credentials was hilarious. Peter’s M.D. next to Derrick’s MPMD made me laugh

[@srt5musik]

Derek has a degree in muscle protein. Hense mp m.d. lol

[@Brandon-tk2rw]

@srt5musik "hense" 👍👍👍

[@jonathancameron9491]

MPMD is a fake title: More plates, more dates. Not a doctor. Not to say he won't have valuatble information, but it's not a medical degree.

[@chrisbell8418]

I’ve done follistatin with mini circle technology to keep it in my system for 18 months. I did it for my new film Better Stronger Faster. So far it’s done zero after 5 months. It usually costs $25,000 a shot, but they comped it to me for the film. Good thing I didn’t pay for it. I’d be pretty pissed off.

[@skylerwilliams2584]

Imagine the people that paid for it

[@therealnerdyneuron]

Something I used in my video to make Hulk😂

[@therealnerdyneuron]

Zero results for potentially 25,000$ is frustrating. Are you sure they gave you their „best“? The is a lot of variation especially in non FDA approved pharmaceuticals

[@whatintarnation4969]

bruh it’s literally $100 for a vial that has roughly 5-10 doses

[@timwilliams9100]

Bryan Johnson had this done 6 months ago and he has gotten a big bump up in Follistatin and improvement in Muscle mass and BIO age measurements. Considering he was already in the top 1 percent in many health Measurment's for his age that is pretty amazing.

[@Jimbo-vq6cd]

Peter Attia MD and Derek MPMD... took me a second before I realized what MPMD stood for! Lol... I thought Derek was now some kind of medical doctor 😂

[@huddwah]

😅

[@Fraunzi]

Lmao

[@jimmynickles828]

So what does it stand for?

[@StushPothong]

@@jimmynickles828 more plates more dates, Derek's KZbin channel

[@pspking100]

@@jimmynickles828 More Plates More Dates

[@DILFDylF]

Apparently hypertrophic cardiomyopathy was in issue in those mice, so a total knockout of either follistatin or myostatin would be a death sentence.

[@wtonello1]

As a Brazilian I thnak you for the Senna shirts!! Praising our hero

[@eggbenedict-gt7mw]

😂😂😂😂

[@gibbsm]

LEGO makes a Senna race car.

[@15walkingaway]

That sounds great for your heart.

[@SmurffNationn]

Would’ve been nice for the editor to have shown the images of the animals they referenced

[@benrunsacross2935]

I show those to my students, ‘damn I want that mutation!’ Is usually the response.

[@DrSamsHealth]

Just google myostatin and click images PS. I agree that it would be nice to show the images in this video :)

[@srt5musik]

Google it. Look up bully whippets too that's the dog they're referring too

[@megaman7551]

I have fshd and I pretty should they are starting a clinic trial soon for a myostatin inhibitor

[@rmt1]

What about the German kid that supposedly had the mutation “In 2004 we reported on this German child, and to my knowledge, that is the only clear-cut documented case of a mutation in a human," said Dr. Se-Jin Lee, professor of molecular biology and genetics at Johns Hopkins University School of Medicine in Baltimore.

[@iluvmym4]

Isn't that what Yk-11 & epicat suppose to do?

[@Leo.de99]

Im german never heard anything from him

[@rmt1]

@@Leo.de99 Google it He comes up. I think they kept his identity secret

[@microfx]

@@Leo.de99government doesn't want you to know... man this inhibitor is such a game changer but so hard to find good info (there are supplements out there who claim to inhibit >40%) ...

[@bgrutterdds]

My daughter has Type 1 Spinal Muscular Atrophy and my mother has Inclusion Body Miositis. Both are effectively muscle wasting diseases (in addition to other effects). I too am always on the lookout for interventions that might help. This doesn't sound like a 'game changer', but something to at least keep an eye on. Would you agree, Dr. Attia? (I'll understand if you don't reply)

[@joannahood482]

I have myositis tjat affects my lower lims currently so I'm definitely interested in this as well as ACE-031. I look forward to seeing more studies.

[@Nikosmentis]

Well why a small molecule inhibitor hasn’t been developed?

[@leonkennedy9739]

Where me sign up for trials so I can help further reaserch and stuff? We gunna get huge bois.

[@bradlambert7039]

Seems to me like something so important for growth regulation would be super risky to inhibit. In other words, this could be a serious concern for cancer / tumor growth. Same reason why just letting all mTOR signaling be active all the time would be a terrible idea.

[@SecretMarsupial]

Not to mention injuries? Okay lets say it works exactly as proposed and your muscle mass dramatically increases. Are your ligaments, joints and other tissues instantly stronger? If not i think thats the highway to injury city.

[@RHINO.666]

Id take the risk aha

[@bradlambert7039]

@@RHINO.666 it’s not as much of a risk as it is more a guaranteed way shorter life span.

[@RHINO.666]

@@bradlambert7039 yea i could live with that

[@Antonio-ki9yw]

The company Biohaven is also investigating a myostatin inhibitor for obesity

[@eggbenedict-gt7mw]

I sae the dog on ripleys believe it or not when i was a kid

[@IIImykidtvIII]

So what are the hearts on these animals looking like? No one needs double cardiac muscle fibers I don’t think

[@wmroykarlen]

I was thinking of the heart as well. It would seem that it would obviously affect the heart muscle and as you implied... that ain't good. You'll have a very jacked corpse I suppose.

[@eggbenedict-gt7mw]

​@@wmroykarleni wud use beta blockers, problem solved

[@robbienl8176]

Love that senna shirt 👍

[@ramblerwong7642]

senna shirt never gets old

[@balintlosonci3578]

3d alpha Migan: check out his videos on myostatin blocking

[@gdot9046]

My parents did this to me as a child.

[@gdot9046]

@user-rh3ht3nv1cI’ve had lots of injuries strength average I’d say.

[@vancityred1]

Ya, Only $50K !

[@joemagicdeveloper]

What/where is the Follistatin gene therapy mentioned here? The GARM Clinic in Honduras or the (Bioviva Integrated Health System?

[@nickps2251]

Dr Adeel Khan

[@path9494]

MiniCircle Clinic. Dr. Khan is a doctor they work with.

[@joemagicdeveloper]

@@path9494 thanks!

[@nikitaw1982]

Cancer risk? Etc?

[@JungleIsMassiv]

I’d be more worried about hypertrophic cardiomyopathy

[@eggbenedict-gt7mw]

​@@JungleIsMassiv😂😂😂😂 people that drink or smoke get cancer

[@jonz23m]

​@@eggbenedict-gt7mw he ain't talking about long term cancer risk

[@eggbenedict-gt7mw]

@@jonz23m so not talking means u won't get cancer is that it

[@jonz23m]

@@eggbenedict-gt7mw it means that he didn't address it, or did you hear him say there are no long term risks? Comprehension skills are valuable in life.

[@DrBiz-ch6br]

I’d give it 30 days 100mcg per day for, cost around $250 tops all said and done 🤷‍♂️

[@MistressOnyaCox]

😅❤ love when twins cut hair different so we know witch is which 😂 OH WAIT 😂

[@Abu7929]

Years ago I thoughtnof studying science for sole purpose of doing phd on this

[@LaneCodeRedCarnivore]

Creatine and also leucine can reduce myostatin .

[@BigAirDropper666]

Aren’t you growing all muscles in parallel in that case including heart ?

[@Sheo.G]

Yes

[@joe1071]

So possibly if I make it to older age in 50 or so years and my muscle mass is suffering, they will have a myostatin knock out of 90+ percent that can bump my muscle mass by 25 percent… nice

[@BGeezy4sheezy]

The problem with any kind of substance you ingest that helps you grow muscle is gonna have that same effect on your heart. You want a strong heart, but not some giant super muscled thing so large and hard that it can’t even deflate

[@zenithperformancefitness6897]

The dog he mentions is a whippet, it's ridiculous.

[@eggbenedict-gt7mw]

Yes they are runner dog i saw in Ripley believe it or not

[@loopba]

Working in pharma..essentially the evidence so far shows maybe increase in muscle size, but no improvement in strength or function. Product won’t be approved without any actual functional benefit.

[@smlince]

Work in erectile dysfunction. Of partner

[@HkFinn83]

Yeh tren isn’t approved for human use either lol

[@sandrachilds7229]

My grandson has Klinefelters am always looking for some therapy to help muscle mass and strength.

[@huddwah]

Every compounding clinic and their dog will still make and sell it though if it increases size

[@JungleIsMassiv]

For bodybuilding, who cares

[@pokeyouindaeye]

LOL @ M.D. vs MPMD

[@scottkeefe1119]

Maybe try just eating a ufckton of dark chocolate for the Epicatechin?

[@pathologicaldoubt]

Derek made bank riding out the Turk hype train. Even if there’s nothing to this tech, the promise of its gains is enough to make the developers incredibly rich.

[@JungleIsMassiv]

Yea hopefully more people see through influencers shilling supplements and stop buying them.

[@eggbenedict-gt7mw]

That's y i dont buy crap

[@sashafroyland]

Ok. $20k every two years.

[@andrewrivera4029]

I don’t care I just wanna be heathy.

[@joe1071]

Hahaha, Attia had bad biological age values from his personal tests so he instantly quipped, “none. There’s non.” With no rationale or explanation. He’s clearly emotional about the topic.

[@joe1071]

Sorry MPMD, he totally pushes Maui nui venison which he is absolutely an investor in. And it’s a fortune to consume it regularly. Maybe Attias clients that can afford paying $150,000/year retainer to have him as a doctor can afford it. They should get unlimited Maui Nui for free paying that much as a fee to see Attia as a dr.

[@huddwah]

I subscribe to his podcast and I have no idea what you're talking about

[@zenithperformancefitness6897]

You say that as if it has anything to do with the rest of the information presented...

[@JungleIsMassiv]

What does that have to do with anything?

[@bushmaster195]

In 25 years Derek will merge with a cow and become the ultimate Roid Monster!

[@TB-vz5bh]

The first time I hear this guy talking without f word because I was sick of his Chanel and left it

[@SuperDodoe]

amazing how all theses health and longevity doctors are always look for a work around to the simple diet and exercise solution. Pete youre overweight

[@nikitaw1982]

They do that as a base.

[@michaelcarter3004]

@@nikitaw1982and yet, with all his expertise he is overweight and doesn’t look like he exercises

[@nikitaw1982]

@@michaelcarter3004 who? guy on right is ripped as hell. guy on left does rediculous amount of exercise. lives on his cycle. and swims enduros

[@11kwright]

@@michaelcarter3004 Having the knowledge is one thing doing it is another.

[@eggbenedict-gt7mw]

Who cares they have knowledge